| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dongxue Yang, Zhiyu Zhao, Emad Tajkhorshid, Eric Gouau. Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 29. 2023-07-13. PMID:37436958. |
sert is the target of both therapeutic antidepressant drugs and psychostimulant substances such as cocaine and methamphetamines, which are small molecules that perturb normal serotonergic transmission by interfering with serotonin transport. |
2023-07-13 |
2023-08-14 |
Not clear |
| Sofi da Cunha-Bang, Vibe G Frokjaer, Brenda Mc Mahon, Peter Steen Jensen, Claus Svarer, Gitte Moos Knudse. The association between brain serotonin transporter binding and impulsivity and aggression in healthy individuals. Journal of psychiatric research. vol 165. 2023-07-13. PMID:37441926. |
although serotonin transporters (sert) are key in modulating synaptic serotonin levels, few studies have investigated the role of sert levels in human impulsive aggression. |
2023-07-13 |
2023-08-14 |
human |
| Rachel A Davies, Vy T Nguyen, Jose M Eltit, Richard A Glenno. Structure-Activity Relationships for a Recently Controlled Synthetic Cathinone Dopamine Transporter Reuptake Inhibitor: α-Pyrrolidinohexiophenone (α-PHP). ACS chemical neuroscience. 2023-07-05. PMID:37406364. |
here, we examined a series of 4-substituted α-php analogues and found that, with one exception, all behaved as relatively (28- to >300-fold) selective dat versus serotonin transporter (sert) reuptake inhibitors with dat inhibition potencies of most falling within a very narrow (i.e., <3-fold) range. |
2023-07-05 |
2023-08-14 |
Not clear |
| Elena Missir, Patrick Begley, Maryam Jessop, Nitasha Singh, Mark Aplin, Helena McMeekin, Puja Parekh, Malgorzata Raczek, Sabina Dizdarevi. Quantitative [123]I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism. Nuclear medicine communications. 2023-07-03. PMID:37395542. |
[123]i-ioflupane (datscan) binds to the presynaptic dopamine transporter (dat) and with a lower affinity to the serotonin transporter (sert). |
2023-07-03 |
2023-08-14 |
Not clear |
| N J Clauss, F P Mayer, W A Owens, M Vitela, K M Clarke, M A Bowman, R E Horton, D Gründemann, D Schmid, M Holy, G G Gould, W Koek, H H Sitte, L C Daw. Ethanol inhibits dopamine uptake via organic cation transporter 3: Implications for ethanol and cocaine co-abuse. Molecular psychiatry. 2023-06-12. PMID:37308680. |
cocaine increases extracellular monoamines by blocking dopamine (da), norepinephrine (ne) and serotonin (5-ht) transporters (dat, net and sert, respectively). |
2023-06-12 |
2023-08-14 |
mouse |
| Dilpreet Singh, G D Gupt. A Complete Sojourn of Gene Therapy Along with its Targeting Approaches for the Treatment of the Major Depressive Disorder. Current gene therapy. 2023-06-02. PMID:37264624. |
depression has been linked to the malfunctioning of serotonin signaling genes, including p11, sert, etc, according to earlier research. |
2023-06-02 |
2023-08-14 |
Not clear |
| Shufang Xia, Gusonghan Maitiniyazi, Yuan Liu, Yue Chen, Mengting Guo, Jianyun He, Wei Tao, Ziyuan L. Whey protein isolate attenuates depression-like behavior developed in a mouse model of breast tumor. Food research international (Ottawa, Ont.). vol 169. 2023-05-31. PMID:37254425. |
moreover, wpi promoted the hippocampal trp, 5-hydroxytryptophan (5-htp), 5-ht, 5-hydroxyindoleacetic acid (5-hiaa) levels and inhibited kynurenine (kyn) through up-regulating serotonin transporter (sert) and down-regulating indoleamine 2, 3-dioxygenase (ido). |
2023-05-31 |
2023-08-14 |
mouse |
| Berta Buey, Ana Forcén, Laura Grasa, Elena Layunta, Jose Emilio Mesonero, Eva Latorr. Gut Microbiota-Derived Short-Chain Fatty Acids: Novel Regulators of Intestinal Serotonin Transporter. Life (Basel, Switzerland). vol 13. issue 5. 2023-05-27. PMID:37240731. |
serotonin activity is determined mainly by the extracellular availability of 5-ht, which is controlled by the serotonin transporter (sert). |
2023-05-27 |
2023-08-14 |
Not clear |
| Amine Bahi, Jean-Luc Dreye. Anxiety and Ethanol Consumption in Socially Defeated Mice; Effect of Hippocampal Serotonin Transporter Knockdown. Behavioural brain research. 2023-05-27. PMID:37244437. |
the comorbidity of generalized anxiety disorders (gad) with alcohol use disorders (aud) is common and there is an association between the serotonin transporter (sert) genetic variation and the comorbid conditions of gad and aud. |
2023-05-27 |
2023-08-14 |
mouse |
| I-Hsun Li, Tsung-Ta Liu, Ying-Chen Chen, Sheng-Huang Hsiao, Hao-Yuan Hung, Li-Yun Fann, Jui-Hu Shi. Therapeutic effects of methimazole on 3,4-methylenedioxymethamphetamine-induced hyperthermia and serotonergic neurotoxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 164. 2023-05-24. PMID:37224751. |
ihc staining (serotonin transporter, sert) showed the evidence of neurotoxicity caused by mdma (serotonin fiber loss), which was alleviated by mmi. |
2023-05-24 |
2023-08-14 |
rat |
| Christopher R Brown, James D Foste. Palmitoylation regulates human serotonin transporter activity, trafficking, and expression and is modulated by escitalopram. bioRxiv : the preprint server for biology. 2023-05-23. PMID:37214849. |
during neuronal transmission, the synaptic concentration of serotonin is tightly controlled in a spatial and temporal manner by the serotonin transporter (sert). |
2023-05-23 |
2023-08-14 |
human |
| Pooja S Salvi, Matthew P Shaughnessy, Kaelyn D Sumigray, Robert A Cowle. Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner. American journal of physiology. Gastrointestinal and liver physiology. 2023-05-09. PMID:37158470. |
serotonin potentiation was achieved through either genetic knockout of the serotonin transporter (sert) or pharmacologic sert inhibition, and inhibition of serotonin synthesis was achieved with para-chlorophenylalanine. |
2023-05-09 |
2023-08-14 |
mouse |
| Pooja S Salvi, Matthew P Shaughnessy, Kaelyn D Sumigray, Robert A Cowle. Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner. American journal of physiology. Gastrointestinal and liver physiology. 2023-05-09. PMID:37158470. |
in conclusion, host serotonin activity is necessary for microbial depletion-associated changes in villus height and isc proliferation in crypts, and microbial depletion produces a functional serotonin-potentiated state through reduced sert protein expression. |
2023-05-09 |
2023-08-14 |
mouse |
| Ka Wai Chan, Jennifer Hebert, Daniel Radford-Smith, Daniel C Anthony, Philip Wj Burne. Live or heat-killed probiotic administration reduces anxiety and central cytokine expression in BALB/c mice, but differentially alters brain neurotransmitter gene expression. Neuropharmacology. 2023-05-07. PMID:37150398. |
to investigate the psychotropic effects of a multi-species probiotic supplement on emotional behaviour in male balb/c mice, we explored the potential mechanisms of action relating to the temporal changes in the mrna expression of brain cytokines, growth factors, central 5ht receptor and serotonin transporter (sert) and gaba receptor in the context of probiotic induced behavioural changes. |
2023-05-07 |
2023-08-14 |
mouse |
| Isha Singh, Anubha Seth, Christian B Billesbølle, Joao Braz, Ramona M Rodriguiz, Kasturi Roy, Bethlehem Bekele, Veronica Craik, Xi-Ping Huang, Danila Boytsov, Vladimir M Pogorelov, Parnian Lak, Henry O'Donnell, Walter Sandtner, John J Irwin, Bryan L Roth, Allan I Basbaum, William C Wetsel, Aashish Manglik, Brian K Shoichet, Gary Rudnic. Structure-based discovery of conformationally selective inhibitors of the serotonin transporter. Cell. 2023-05-03. PMID:37137306. |
the serotonin transporter (sert) removes synaptic serotonin and is the target of anti-depressant drugs. |
2023-05-03 |
2023-08-14 |
mouse |
| Melissa M Conti Mazza, Ashley Centner, David F Werner, Christopher Bisho. Striatal serotonin transporter gain-of-function in L-DOPA-treated, hemi-parkinsonian rats. Brain research. 2023-05-01. PMID:37127174. |
since serotonin transporters (sert) have some affinity for da uptake, they may serve as a functional compensatory mechanism when da transporters (dat) are scant. |
2023-05-01 |
2023-08-14 |
rat |
| Kana Harada, Ryoma Sho, Hiromiki Takakura, Eri Yokoyama, Reika Koyama, Yuka Yamamoto, Naoko Adachi, Shigeru Tanaka, Izumi Hide, Norio Saka. S-Palmitoylation of the serotonin transporter promotes its cell surface expression and serotonin uptake. Biochemical and biophysical research communications. vol 662. 2023-04-26. PMID:37099811. |
the neurotransmitter serotonin (5-ht) is transported back into serotonergic neurons by the serotonin transporter (sert). |
2023-04-26 |
2023-08-14 |
human |
| Kana Harada, Ryoma Sho, Hiromiki Takakura, Eri Yokoyama, Reika Koyama, Yuka Yamamoto, Naoko Adachi, Shigeru Tanaka, Izumi Hide, Norio Saka. S-Palmitoylation of the serotonin transporter promotes its cell surface expression and serotonin uptake. Biochemical and biophysical research communications. vol 662. 2023-04-26. PMID:37099811. |
furthermore, mutation of cys-147 reduced cellular uptake of a fluorescent sert substrate that mimics 5-ht without decreasing sert on the cell surface. |
2023-04-26 |
2023-08-14 |
human |
| Kana Harada, Ryoma Sho, Hiromiki Takakura, Eri Yokoyama, Reika Koyama, Yuka Yamamoto, Naoko Adachi, Shigeru Tanaka, Izumi Hide, Norio Saka. S-Palmitoylation of the serotonin transporter promotes its cell surface expression and serotonin uptake. Biochemical and biophysical research communications. vol 662. 2023-04-26. PMID:37099811. |
on the other hand, combined mutation of cys-147 and cys-155 inhibited sert surface expression and reduced the uptake of the 5-ht mimic. |
2023-04-26 |
2023-08-14 |
human |
| Kana Harada, Ryoma Sho, Hiromiki Takakura, Eri Yokoyama, Reika Koyama, Yuka Yamamoto, Naoko Adachi, Shigeru Tanaka, Izumi Hide, Norio Saka. S-Palmitoylation of the serotonin transporter promotes its cell surface expression and serotonin uptake. Biochemical and biophysical research communications. vol 662. 2023-04-26. PMID:37099811. |
thus, s-palmitoylation of cys-147 and cys-155 is important for both the cell surface expression and 5-ht uptake capacity of sert. |
2023-04-26 |
2023-08-14 |
human |