| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcin Sochal, Alicja Witkowska, Agata Binienda, Agata Gabryelska, Piotr Białasiewicz, Jakub Fichna, Renata Talar-Wojnarowska, Ewa Małecka-Wojciesk. The Effect of Serotonin Transmission on Depressive and Insomnia Symptoms in Inflammatory Bowel Diseases. Journal of clinical medicine. vol 12. issue 19. 2023-10-14. PMID:37834999. |
patients with ibd had higher 5-ht levels and sert protein expression than the hcs, but not mrna sert levels ( |
2023-10-14 |
2023-10-15 |
human |
| Kristine Salomon, Ara M Abramyan, Per Plenge, Lingle Wang, Christoffer Bundgaard, Benny Bang-Andersen, Claus J Loland, Lei Sh. Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 41. 2023-10-04. PMID:37792512. |
the serotonin transporter (sert) tightly regulates synaptic serotonin levels and has been the primary target of antidepressants. |
2023-10-04 |
2023-10-07 |
human |
| Taeseon Woo, Candice King, Nick I Ahmed, Madison Cordes, Saatvika Nistala, Matthew J Will, Clark Bloomer, Nataliya Kibiryeva, Rocio M Rivera, Zohreh Talebizadeh, David Q Beversdor. microRNA as a Maternal Marker for Prenatal Stress-Associated ASD, Evidence from a Murine Model. Journal of personalized medicine. vol 13. issue 9. 2023-09-28. PMID:37763179. |
the serotonin transporter (sert) gene has been linked to stress reactivity, and the presence of the sert short (s)-allele has been shown to mediate the association between maternal stress exposure and asd. |
2023-09-28 |
2023-10-07 |
mouse |
| Felix P Mayer, Marco Niello, Simon Bulling, Yuan-Wei Zhang, Yang Li, Oliver Kudlacek, Marion Holy, Fatemeh Kooti, Walter Sandtner, Gary Rudnick, Diethart Schmid, Harald H Sitt. Mephedrone induces partial release at human dopamine transporters but full release at human serotonin transporters. Neuropharmacology. 2023-09-13. PMID:37703919. |
the stimulating properties are believed to arise from the ability of mephedrone to interact with the high-affinity transporters for dopamine (da) (dat) and norepinephrine (net), whereas the entactogenic effect presumably relies on its activity at the serotonin (5-ht) transporter (sert). |
2023-09-13 |
2023-10-07 |
human |
| Felix P Mayer, Marco Niello, Simon Bulling, Yuan-Wei Zhang, Yang Li, Oliver Kudlacek, Marion Holy, Fatemeh Kooti, Walter Sandtner, Gary Rudnick, Diethart Schmid, Harald H Sitt. Mephedrone induces partial release at human dopamine transporters but full release at human serotonin transporters. Neuropharmacology. 2023-09-13. PMID:37703919. |
evidence linked drug-induced reverse transport of 5-ht via sert to prosocial effects, whereas activity at dat is strongly correlated with abuse liability. |
2023-09-13 |
2023-10-07 |
human |
| Jonatan Fullerton Støier, Trine Nygaard Jørgensen, Thomas Sparsø, Henrik Berg Rasmussen, Vivek Kumar, Amy Hauck Newman, Randy D Blakely, Thomas Werge, Ulrik Gether, Freja Herbor. Disruptive mutations in the serotonin transporter associate serotonin dysfunction with treatment-resistant affective disorder. medRxiv : the preprint server for health sciences. 2023-09-11. PMID:37693601. |
the serotonin transporter (sert) is a major regulator of serotonin neurotransmission, yet the disease-relevance of impaired sert function remains unknown. |
2023-09-11 |
2023-10-07 |
Not clear |
| Scotti McLaren, Karin Seidler, James Nei. Investigating the Role of 17β-Estradiol on the Serotonergic System, Targeting Soy Isoflavones as a Strategy to Reduce Menopausal Depression: A Mechanistic Review. Journal of the American Nutrition Association. 2023-09-11. PMID:37695875. |
there was less scientific agreement on the effects of e2 on serotonin transporter (sert) and serotonin receptors 1 a and 2 a. |
2023-09-11 |
2023-10-07 |
human |
| Huijuan Guo, Xinxu Liu, Ti Chen, Xiaoping Wang, Xiaojie Zhan. Akkermansia muciniphila Improves Depressive-Like Symptoms by Modulating the Level of 5-HT Neurotransmitters in the Gut and Brain of Mice. Molecular neurobiology. 2023-09-05. PMID:37668965. |
in conclusion, our study demonstrated the antidepressant effect of akk in mice exposed to alcohol exposure and cums, with the potential mechanism that akk implantation might lead to an increased level of 5-ht and inhibited sert expression in the gut, and might alter the gut-to-brain signal through suppression of enteric nerves activation. |
2023-09-05 |
2023-09-07 |
mouse |
| Christopher R Brown, James D Foste. Palmitoylation Regulates Human Serotonin Transporter Activity, Trafficking, and Expression and Is Modulated by Escitalopram. ACS chemical neuroscience. 2023-08-30. PMID:37644775. |
during serotonergic transmission, the synaptic concentration of serotonin is tightly controlled in a spatial and temporal manner by the serotonin transporter (sert). |
2023-08-30 |
2023-09-07 |
human |
| Christopher R Brown, James D Foste. Palmitoylation Regulates Human Serotonin Transporter Activity, Trafficking, and Expression and Is Modulated by Escitalopram. ACS chemical neuroscience. 2023-08-30. PMID:37644775. |
dysregulation of this process is implicated in the pathogenesis of major-depressive, obsessive-compulsive, and autism-spectrum disorders, which makes sert a primary target for prescription therapeutics, most notably selective serotonin reuptake inhibitors (ssris). |
2023-08-30 |
2023-09-07 |
human |
| Jean-Louis Montastru. Drugs and bruxism: a study in the World Health Organization's pharmacovigilance database. British journal of clinical pharmacology. 2023-08-14. PMID:37574820. |
for antidepressants, a negative association was found between ror values and net (norepinephrine transporter) but not sert (serotonin transporter) pki values, suggesting this adr is more closely linked to norepinephrine than serotonin reuptake inhibition. |
2023-08-14 |
2023-08-16 |
Not clear |
| Karla J Suchacki, Lynne E Ramage, T'ng Choong Kwok, Alexandra Kelman, Ben T McNeill, Stewart Rodney, Matthew Keegan, Calum Gray, Gillian MacNaught, Dilip Patel, Alison M Fletcher, Joanna P Simpson, Roderick N Carter, Robert K Semple, Natalie Z M Homer, Nicholas M Morton, Edwin J R van Beek, Sonia J Wakelin, Roland H Stimso. The serotonin transporter sustains human brown adipose tissue thermogenesis. Nature metabolism. 2023-08-03. PMID:37537371. |
here we show that the serotonin transporter (sert), encoded by slc6a4, prevents serotonin-mediated suppression of human bat function. |
2023-08-03 |
2023-08-14 |
human |
| Florian Koban, Michael Freissmut. The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma. EMBO reports. 2023-08-02. PMID:37530743. |
monoamine transporters retrieve serotonin (sert), dopamine (dat), and norepinephrine (net) from the synaptic cleft. |
2023-08-02 |
2023-08-14 |
Not clear |
| Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, Rüdiger Eberhard Scharf, Daniel Duerschmied, Nancy Schanz. Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding. Frontiers in immunology. vol 14. 2023-07-31. PMID:37520561. |
deficiency of the serotonin transporter (sert) is associated with metabolic changes in humans and mice. |
2023-07-31 |
2023-08-14 |
mouse |
| Nina M Alyoshina, Maria D Tkachenko, Yulia O Nikishina, Denis A Nikishi. Serotonin Transporter Activity in Mouse Oocytes Is a Positive Indicator of Follicular Growth and Oocyte Maturity. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511007. |
in maturing mammalian oocytes, the accumulation of exogenous, maternal serotonin occurs due to the activity of the membrane transporter sert. |
2023-07-29 |
2023-08-14 |
mouse |
| Mattias Persson, Svante Vikingsson, Robert Kronstrand, Henrik Gree. Characterization of neurotransmitter inhibition for seven cathinones by a proprietary fluorescent dye method. Drug testing and analysis. 2023-07-25. PMID:37489044. |
to start addressing this need, a method measuring the inhibition of the dopamine, serotonin, and norepinephrine transporters (dat, sert, and net) by stimulant drugs was developed. |
2023-07-25 |
2023-08-14 |
Not clear |
| Cecilia E Villanueva, Bruno Hagenbuc. Palmitoylation of Solute Carriers. Biochemical pharmacology. 2023-07-22. PMID:37481134. |
among the best-characterized transporters are the glucose transporters glut1 (slc2a1) and glut4 (slc2a4), the three monoamine transporters norepinephrine transporter (net; slc6a2), dopamine transporter (dat; slc6a3), and serotonin transporter (sert; slc6a4), and the sodium-calcium exchanger ncx1 (slc8a1). |
2023-07-22 |
2023-08-14 |
Not clear |
| Karina Bravo, Marcelo González-Ortiz, Sebastian Beltrán-Castillo, Daniela Cáceres, Jaime Eugení. Development of the Placenta and Brain Are Affected by Selective Serotonin Reuptake Inhibitor Exposure During Critical Periods. Advances in experimental medicine and biology. vol 1428. 2023-07-19. PMID:37466774. |
ssris block the serotonin transporter (sert), which is required for 5-ht reuptake from the synaptic cleft into the presynaptic neuron. |
2023-07-19 |
2023-08-14 |
Not clear |
| Mirjam Bloemendaal, Ekaterina Veniaminova, Daniel C Anthony, Anna Gorlova, Priscilla Vlaming, Adel Khairetdinova, Raymond Cespuglio, Klaus Peter Lesch, Alejandro Arias Vasquez, Tatyana Strekalov. Serotonin Transporter (SERT) Expression Modulates the Composition of the Western-Diet-Induced Microbiota in Aged Female Mice. Nutrients. vol 15. issue 13. 2023-07-14. PMID:37447374. |
serotonin transporter (sert) expression modulates the composition of the western-diet-induced microbiota in aged female mice. |
2023-07-14 |
2023-08-14 |
mouse |
| Dongxue Yang, Zhiyu Zhao, Emad Tajkhorshid, Eric Gouau. Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 29. 2023-07-13. PMID:37436958. |
the serotonin transporter (sert) is a member of the slc6 neurotransmitter transporter family that mediates serotonin reuptake at presynaptic nerve terminals. |
2023-07-13 |
2023-08-14 |
Not clear |