| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Moroto, A Nishimura, M Morimoto, K Isoda, T Morita, M Yoshida, S Morioka, T Tozawa, T Hasegawa, T Chiyonobu, K Yoshimoto, H Hoso. Altered somatosensory barrel cortex refinement in the developing brain of Mecp2-null mice. Brain research. vol 1537. 2014-06-25. PMID:24060648. |
levels of 5-ht, and sert and 5-ht1b receptor mrna expression in the somatosensory cortex did not differ significantly between the mecp2-null and wild-type mice on p10. |
2014-06-25 |
2023-08-12 |
mouse |
| Jerrold S Meye. 3,4-methylenedioxymethamphetamine (MDMA): current perspectives. Substance abuse and rehabilitation. vol 4. 2014-06-24. PMID:24648791. |
animal studies have demonstrated that high doses of mdma can lead to long-term decreases in forebrain 5-ht concentrations, tryptophan hydroxylase activity, serotonin transporter (sert) expression, and visualization of axons immunoreactive for 5-ht or sert. |
2014-06-24 |
2023-08-12 |
Not clear |
| Jerrold S Meye. 3,4-methylenedioxymethamphetamine (MDMA): current perspectives. Substance abuse and rehabilitation. vol 4. 2014-06-24. PMID:24648791. |
these neurotoxic effects may reflect either a drug-induced degeneration of serotonergic fibers or a long-lasting downregulation in 5-ht and sert biosynthesis. |
2014-06-24 |
2023-08-12 |
Not clear |
| Therese R Montgomery, Thomas Steinkellner, Sonja Sucic, Florian Koban, Stefan Schüchner, Egon Ogris, Harald H Sitte, Michael Freissmut. Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 18. 2014-06-23. PMID:24790205. |
export of the serotonin transporter (sert) from the endoplasmic reticulum (er) is mediated by the sec24c isoform of the coatomer protein-ii complex. |
2014-06-23 |
2023-08-13 |
human |
| Therese R Montgomery, Thomas Steinkellner, Sonja Sucic, Florian Koban, Stefan Schüchner, Egon Ogris, Harald H Sitte, Michael Freissmut. Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 18. 2014-06-23. PMID:24790205. |
sert must enter the axonal compartment and reach the presynaptic specialization to perform its function, i.e., the inward transport of serotonin. |
2014-06-23 |
2023-08-13 |
human |
| Vivek Kumar, Troels Rahbek-Clemmensen, Christian B Billesbølle, Trine Nygaard Jorgensen, Ulrik Gether, Amy Hauck Newma. Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. ACS medicinal chemistry letters. vol 5. issue 6. 2014-06-19. PMID:24944746. |
novel rhodamine-labeled ligands, based on (s)-citalopram, were synthesized and evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine transporters (hsert, hdat, and hnet, respectively) and for binding at sert, in transiently transfected cos7 cells. |
2014-06-19 |
2023-08-13 |
human |
| Hsin Chun Tsai, Shih-Hsien Lin, I Hui Lee, Po See Chen, Kao Chin Chen, Tzung Lieh Yeh, Wei Jen Yao, Nan-Tsing Chiu, Ru-Band Lu, Yen Kuang Yan. Probing the association between dexamethasone-induced cortisol suppression and serotonin transporter availability among drug-free patients with major depressive disorder--a small-sample SPECT study with [¹²³I]ADAM. Psychoneuroendocrinology. vol 38. issue 11. 2014-06-13. PMID:23816429. |
the aim of the present study was to probe the association between dexamethasone suppression test response and serotonin transporter (sert) availability in drug-free patients with major depressive disorder (mdd). |
2014-06-13 |
2023-08-12 |
human |
| Giulia Schillani, Serena Goljevscek, Davide Carlino, Maurizio De Vanna, Eugenio Aguglia, Tullio Girald. Repeated suicidal behaviour: Stressful life events and 5-HTTLPR genetic polymorphism. International journal of psychiatry in clinical practice. vol 13. issue 3. 2014-06-12. PMID:24916825. |
the aim of this investigation was to analyze suicidal behaviour in multiple attempters in relation to the stressful life events, and to the polymorphism of the serotonin transporter (sert) gene. |
2014-06-12 |
2023-08-13 |
human |
| Marko Uutela, Jesse Lindholm, Tomi Rantamäki, Juzoh Umemori, Kerri Hunter, Vootele Võikar, Maija L Castré. Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome. Frontiers in cellular neuroscience. vol 8. 2014-06-06. PMID:24904293. |
the postnatal mrna expression of serotonin transporter (sert) was reduced in the thalamic nuclei of fmr1 ko mice during the time of transient innervation of somatosensory neurons suggesting that developmental changes of sert expression were involved in the differential cellular and behavioral responses to fluoxetine in wild-type and fmr1 mice. |
2014-06-06 |
2023-08-13 |
mouse |
| K Oved, A Morag, M Pasmanik-Chor, M Rehavi, N Shomron, D Gurwit. Genome-wide expression profiling of human lymphoblastoid cell lines implicates integrin beta-3 in the mode of action of antidepressants. Translational psychiatry. vol 3. 2014-06-05. PMID:24129413. |
itgb3 is crucial for the activity of the serotonin transporter (sert), the drug target of ssris. |
2014-06-05 |
2023-08-12 |
human |
| K Oved, A Morag, M Pasmanik-Chor, M Rehavi, N Shomron, D Gurwit. Genome-wide expression profiling of human lymphoblastoid cell lines implicates integrin beta-3 in the mode of action of antidepressants. Translational psychiatry. vol 3. 2014-06-05. PMID:24129413. |
surprisingly, the expression of sert or serotonin receptors was not modified. |
2014-06-05 |
2023-08-12 |
human |
| Dean G Brown, Peter R Bernstein, Ye Wu, Rebecca A Urbanek, Christopher W Becker, Scott R Throner, Bruce T Dembofsky, Gary B Steelman, Lois A Lazor, Clay W Scott, Michael W Wood, Steven S Wesolowski, David A Nugiel, Stephanie Koch, Jian Yu, Donald E Pivonka, Shuang Li, Carol Thompson, Anna Zacco, Charles S Elmore, Patricia Schroeder, JianWei Liu, Christopher A Hurley, Stuart Ward, Hazel J Hunt, Karen Williams, Joseph McLaughlin, Valerie Hoesch, Simon Sydserff, Donna Maier, David Aharon. Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity. ACS medicinal chemistry letters. vol 4. issue 1. 2014-06-05. PMID:24900562. |
herein, we describe the discovery of inhibitors of norepinephrine (net) and dopamine (dat) transporters with reduced activity relative to serotonin transporters (sert). |
2014-06-05 |
2023-08-13 |
rat |
| Lin Zhu, Genxun Li, Seok Rye Choi, Karl Plössl, Piu Chan, Hongwen Qiao, Zhihao Zha, Hank F Kun. An improved preparation of [18F]FPBM: a potential serotonin transporter (SERT) imaging agent. Nuclear medicine and biology. vol 40. issue 8. 2014-06-02. PMID:24035549. |
an improved preparation of [18f]fpbm: a potential serotonin transporter (sert) imaging agent. |
2014-06-02 |
2023-08-12 |
Not clear |
| Lin Zhu, Genxun Li, Seok Rye Choi, Karl Plössl, Piu Chan, Hongwen Qiao, Zhihao Zha, Hank F Kun. An improved preparation of [18F]FPBM: a potential serotonin transporter (SERT) imaging agent. Nuclear medicine and biology. vol 40. issue 8. 2014-06-02. PMID:24035549. |
in vivo positron emission tomography (pet) imaging of the serotonin transporter (sert) is a valuable tool in drug development and in monitoring brain diseases with altered serotonergic function. |
2014-06-02 |
2023-08-12 |
Not clear |
| Jonathon A Nye, David Purselle, Christophe Plisson, Ronald J Voll, Jeffrey S Stehouwer, John R Votaw, Clinton D Kilts, Mark M Goodman, Charles B Nemerof. Decreased brainstem and putamen SERT binding potential in depressed suicide attempters using [11C]-zient PET imaging. Depression and anxiety. vol 30. issue 10. 2014-05-30. PMID:23526784. |
the present study utilized a novel positron-emission tomography (pet) ligand to quantitate and compare brain regional serotonin transporter (sert) binding potential in depressed patients with a past history of suicide attempts to that of healthy comparison subjects. |
2014-05-30 |
2023-08-12 |
human |
| Anke J Borgers, Karin E Koopman, Peter H Bisschop, Mireille J Serlie, Dick F Swaab, Eric Fliers, Susanne E la Fleur, Anneke Alkemad. Decreased serotonin transporter immunoreactivity in the human hypothalamic infundibular nucleus of overweight subjects. Frontiers in neuroscience. vol 8. 2014-05-26. PMID:24860418. |
serotonin transporters (sert) play a crucial role in serotonin signaling by regulating its availability in the synaptic cleft. |
2014-05-26 |
2023-08-13 |
human |
| Matilde Medina-Martel, Mary Urbina, Fili Fazzino, Lucimey Lim. Serotonin transporter in lymphocytes of rats exposed to physical restraint stress. Neuroimmunomodulation. vol 20. issue 6. 2014-05-19. PMID:24022686. |
glucocorticoids and stress cause transcriptional and functional changes on the serotonin transporter (sert) in the central nervous system. |
2014-05-19 |
2023-08-12 |
rat |
| Matilde Medina-Martel, Mary Urbina, Fili Fazzino, Lucimey Lim. Serotonin transporter in lymphocytes of rats exposed to physical restraint stress. Neuroimmunomodulation. vol 20. issue 6. 2014-05-19. PMID:24022686. |
the aim of this study was to evaluate the effect of a physical restraint stress protocol on (1) rat lymphocyte proliferation in the presence of the selective serotonin reuptake inhibitor fluoxetine and (2) sert kinetic parameters, i.e. |
2014-05-19 |
2023-08-12 |
rat |
| Keiko Iwata, Hideo Matsuzaki, Taro Tachibana, Koji Ohno, Saori Yoshimura, Hironori Takamura, Kohei Yamada, Shinsuke Matsuzaki, Kazuhiko Nakamura, Kenji J Tsuchiya, Kaori Matsumoto, Masatsugu Tsujii, Toshirou Sugiyama, Taiichi Katayama, Norio Mor. N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism. Molecular autism. vol 5. 2014-05-16. PMID:24834316. |
changes in serotonin transporter (sert) function have been implicated in autism. |
2014-05-16 |
2023-08-13 |
human |
| Jacob Andersen, Nicolai Stuhr-Hansen, Linda Grønborg Zachariassen, Heidi Koldsø, Birgit Schiøtt, Kristian Strømgaard, Anders S Kristense. Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (Prozac). Molecular pharmacology. vol 85. issue 5. 2014-05-15. PMID:24516100. |
inhibitors of the serotonin transporter (sert) are widely used antidepressant agents, but the structural mechanism for inhibitory activity and selectivity over the closely related norepinephrine transporter (net) is not well understood. |
2014-05-15 |
2023-08-12 |
human |