| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Ye, A M D Carneiro, Q Han, D Airey, E Sanders-Bush, B Zhang, L Lu, R Williams, R D Blakel. Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression. Genes, brain, and behavior. vol 13. issue 3. 2014-11-07. PMID:24405699. |
we quantified sert protein expression levels and identified region- and gender-specific quantitative trait loci (qtls), one of which associated with male midbrain sert protein expression, centered on the protocadherin-15 gene (pcdh15), overlapped with a qtl for midbrain 5-ht levels. |
2014-11-07 |
2023-08-12 |
mouse |
| R Ye, A M D Carneiro, Q Han, D Airey, E Sanders-Bush, B Zhang, L Lu, R Williams, R D Blakel. Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression. Genes, brain, and behavior. vol 13. issue 3. 2014-11-07. PMID:24405699. |
pcdh15 was also the only qtl-associated gene whose midbrain mrna expression significantly associated with both sert protein and 5-ht traits, suggesting an unrecognized role of the cell adhesion protein in the development or function of 5-ht neurons. |
2014-11-07 |
2023-08-12 |
mouse |
| R Ye, A M D Carneiro, Q Han, D Airey, E Sanders-Bush, B Zhang, L Lu, R Williams, R D Blakel. Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression. Genes, brain, and behavior. vol 13. issue 3. 2014-11-07. PMID:24405699. |
to test this hypothesis, we assessed sert protein and 5-ht traits in the pcdh15 functional null line (pcdh15(av-) (3j) ), studies that revealed a strong, negative influence of pcdh15 on these phenotypes. |
2014-11-07 |
2023-08-12 |
mouse |
| Horrick Sharma, Soumava Santra, Joy Debnath, Tamara Antonio, Maarten Reith, Aloke Dutt. Flexible and biomimetic analogs of triple uptake inhibitor 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Synthesis, biological characterization, and development of a pharmacophore model. Bioorganic & medicinal chemistry. vol 22. issue 1. 2014-11-06. PMID:24315194. |
the model revealed features important for inhibitors to exhibit a balanced activity against dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). |
2014-11-06 |
2023-08-12 |
Not clear |
| Noé Dumas, Marcelle Moulin-Sallanon, Nathalie Ginovart, Benjamin B Tournier, Peggy Suzanne, Thomas Cailly, Frédéric Fabis, Sylvain Rault, Yves Charnay, Philippe Mille. Small-animal single-photon emission computed tomographic imaging of the brain serotoninergic systems in wild-type and mdr1a knockout rats. Molecular imaging. vol 13. 2014-11-04. PMID:24622810. |
thus, we compared the performances of 123i-p-mppi, 123i-r91150, 123i-sb207710, and 123i-adam radioligands, for imaging of their respective targets (5-hydroxytryptamine [5-ht]1a, 5-ht2a, 5-ht4, and serotonin transporter [sert]), in wt and mdr1a knockout (ko) rats. |
2014-11-04 |
2023-08-12 |
rat |
| A B Klein, L Ultved, D Adamsen, M A Santini, A Tobeña, A Fernandez-Teruel, P Flores, M Moreno, D Cardona, G M Knudsen, S Aznar, J D Mikkelse. 5-HT(2A) and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains. Neuroscience. vol 263. 2014-10-31. PMID:24412375. |
here, we determined impulsivity using the 5-choice serial reaction time task and levels of serotonin transporter (sert), 5-ht(2a) and 5-ht(1a) receptor binding using highly specific radioligands ((3)h-escitalopram, (3)h-mdl100907 and (3)h-way100635) and mglu2/3 receptor binding ((3)h-ly341495) using receptor autoradiography in fronto-cortical sections from rla-i (n=8) and rha-i (n=8) male rats. |
2014-10-31 |
2023-08-12 |
rat |
| A B Klein, L Ultved, D Adamsen, M A Santini, A Tobeña, A Fernandez-Teruel, P Flores, M Moreno, D Cardona, G M Knudsen, S Aznar, J D Mikkelse. 5-HT(2A) and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains. Neuroscience. vol 263. 2014-10-31. PMID:24412375. |
in the more impulsive rha-i rats, 5-ht(2a), 5-ht(1a) and sert binding in the frontal cortex was significantly higher compared to rla-i rats. |
2014-10-31 |
2023-08-12 |
rat |
| Floor van Heesch, Jolanda Prins, Jan Pieter Konsman, Gerdien A H Korte-Bouws, Koen G C Westphal, Joanna Rybka, Berend Olivier, Aletta D Kraneveld, S Mechiel Kort. Lipopolysaccharide increases degradation of central monoamines: an in vivo microdialysis study in the nucleus accumbens and medial prefrontal cortex of mice. European journal of pharmacology. vol 725. 2014-10-28. PMID:24444442. |
recently, we reported that serotonin transporter (sert) function is required for lps-induced anhedonia. |
2014-10-28 |
2023-08-12 |
mouse |
| Liang Peng, Li Gu, Baoman Li, Leif Hert. Fluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects. Current neuropharmacology. vol 12. issue 4. 2014-10-24. PMID:25342944. |
fluoxetine and other serotonin-specific re-uptake inhibitors (ssris) are generally thought to owe their therapeutic potency to inhibition of the serotonin transporter (sert). |
2014-10-24 |
2023-08-13 |
mouse |
| Pia Baldinger, Georg S Kranz, Daniela Haeusler, Markus Savli, Marie Spies, Cecile Philippe, Andreas Hahn, Anna Höflich, Wolfgang Wadsak, Markus Mitterhauser, Rupert Lanzenberger, Siegfried Kaspe. Regional differences in SERT occupancy after acute and prolonged SSRI intake investigated by brain PET. NeuroImage. vol 88. 2014-10-16. PMID:24121201. |
blocking of the serotonin transporter (sert) represents the initial mechanism of action of selective serotonin reuptake inhibitors (ssris) which can be visualized due to the technical proceedings of sert occupancy studies. |
2014-10-16 |
2023-08-12 |
Not clear |
| Claus Bræstrup, Connie Sanche. Escitalopram: a unique mechanism of action. International journal of psychiatry in clinical practice. vol 8 Suppl 1. 2014-10-15. PMID:24930683. |
the 5-ht (5-hydroxytryptamine, serotonin) transporter (sert) mediates the reuptake of 5-ht from the synaptic cleft into the neuron, and inhibition of this uptake is the target of selective serotonin reuptake inhibitors (ssris). |
2014-10-15 |
2023-08-13 |
rat |
| Walter Sandtner, Diethart Schmid, Klaus Schicker, Klaus Gerstbrein, Xaver Koenig, Felix P Mayer, Stefan Boehm, Michael Freissmuth, Harald H Sitt. A quantitative model of amphetamine action on the 5-HT transporter. British journal of pharmacology. vol 171. issue 4. 2014-10-14. PMID:24251585. |
amphetamines bind to the plasmalemmal transporters for the monoamines dopamine (dat), noradrenaline (net) and 5-ht (sert); influx of amphetamine leads to efflux of substrates. |
2014-10-14 |
2023-08-12 |
Not clear |
| Tania Rivera-Baltanas, Jose Manuel Olivares, Jose Ramon Martinez-Villamarin, Erin Y Fenton, Lisa E Kalynchuk, Hector J Carunch. Serotonin 2A receptor clustering in peripheral lymphocytes is altered in major depression and may be a biomarker of therapeutic efficacy. Journal of affective disorders. vol 163. 2014-10-14. PMID:24836087. |
in a previous report, we showed that the clustering of serotonin (5ht) transporter (sert) protein on cell membranes of peripheral lymphocytes predicts responsivity to antidepressant medication in two subpopulations of naïve depression patients (rivera-baltanas et al., j affect disord, 2012, 137, 46-55). |
2014-10-14 |
2023-08-13 |
Not clear |
| Vahid Mashayekhi Goyonlo, Husameldin Elnour, Klas Nordlin. Serotonin transporter protein overexpression and association to Th17 and T regulatory cells in lupoid leishmaniasis. Archives of dermatological research. vol 306. issue 2. 2014-10-10. PMID:23989888. |
our aim was to study the role of the serotonin transporter protein (sert) and its relation to t cell-related immune responses in lupoid leishmaniasis. |
2014-10-10 |
2023-08-12 |
Not clear |
| Hsiang Yu Huang, I Hui Lee, Kao Chin Chen, Shih-Hsien Lin, Tzung Lieh Yeh, Po See Chen, Nan-Tsing Chiu, We Jen Yao, Chia-Chieh Chen, Mei-Hsiu Liao, Yen Kuang Yan. Serotonin transporter availability in the midbrain and perceived social support in healthy volunteers. Journal of psychosomatic research. vol 75. issue 6. 2014-10-07. PMID:24290049. |
this study aimed to examine the correlation between serotonin transporter (sert) availability and perceived social support scores in healthy volunteers. |
2014-10-07 |
2023-08-12 |
human |
| Sasha Dimitrova-Nakov, Anne Baudry, Yassine Harichane, Corinne Collet, Arnaud Marchadier, Odile Kellermann, Michel Goldber. Deletion of serotonin 2B receptor provokes structural alterations of mouse dental tissues. Calcified tissue international. vol 94. issue 3. 2014-09-30. PMID:24170303. |
rampant caries and periodontal diseases occur in patients treated with antidepressants such as serotonin reuptake inhibitors (sris; e.g., prozac) which target the serotonin transporter (sert). |
2014-09-30 |
2023-08-12 |
mouse |
| Sasha Dimitrova-Nakov, Anne Baudry, Yassine Harichane, Corinne Collet, Arnaud Marchadier, Odile Kellermann, Michel Goldber. Deletion of serotonin 2B receptor provokes structural alterations of mouse dental tissues. Calcified tissue international. vol 94. issue 3. 2014-09-30. PMID:24170303. |
as the serotonin 2b receptor (5ht2br) regulates sert functionality and capacity to recognize sris, we investigated the potential role of 5ht2br on dental tissues by exploiting 5ht2br knockout (ko) mice. |
2014-09-30 |
2023-08-12 |
mouse |
| Monique Ernst, Rista C Plate, Christina O Carlisi, Elena Gorodetsky, David Goldman, Daniel S Pin. Loss aversion and 5HTT gene variants in adolescent anxiety. Developmental cognitive neuroscience. vol 8. 2014-09-29. PMID:24280015. |
finally, loss aversion is expected to be modulated by genotype, particularly the serotonin transporter (sert) gene variant, based on its role in anxiety and impulsivity. |
2014-09-29 |
2023-08-12 |
human |
| Jenifer Sassarini, Rajeev Krishnadas, Jonathan Cavanagh, Alice Nicol, Sally L Pimlott, William Ferrell, Mary Ann Lumsde. Venlafaxine alters microvascular perfusion, [¹²³I]-beta-CIT binding and BDI scores in flushing postmenopausal women. Maturitas. vol 77. issue 3. 2014-09-29. PMID:24411555. |
using single photon emission computed tomography (spect) we studied the central serotonin transporter (sert) in vivo using [(123)i]-beta-carbomethoxy-3-β-(4-iodophenyl)tropane (beta-cit) and, as previous studies have shown that reactivity of the skin blood vessels is enhanced in those who flush, we examined cutaneous microvascular perfusion. |
2014-09-29 |
2023-08-12 |
Not clear |
| Rammohan Shukla, Akiya Watakabe, Tetsuo Yamamor. mRNA expression profile of serotonin receptor subtypes and distribution of serotonergic terminations in marmoset brain. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24904298. |
to better understand serotonin function in the primate brain, we examined the mrna expression patterns of all the 13 members of the serotonin receptor (5htr) family, by in situ hybridization (ish) and the distribution of serotonergic terminations by serotonin transporter (sert) protein immunohistochemical analysis. |
2014-09-24 |
2023-08-13 |
mouse |