| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew L Beckman, Akula Bala Pramod, Danielle Perley, L Keith Henr. Stereoselective inhibition of serotonin transporters by antimalarial compounds. Neurochemistry international. vol 73. 2015-02-02. PMID:24161619. |
in this study, we examined the details of antimalarial inhibition of 5-ht transport in both drosophila (dsert) and human sert (hsert) using electrophysiologic, biochemical and computational approaches. |
2015-02-02 |
2023-08-12 |
human |
| Sylvia Montañez, Jaclyn L Munn, W Anthony Owens, Rebecca E Horton, Lynette C Daw. 5-HT1B receptor modulation of the serotonin transporter in vivo: studies using KO mice. Neurochemistry international. vol 73. 2015-02-02. PMID:24246466. |
the serotonin transporter (sert) controls the strength and duration of serotonergic neurotransmission by the high-affinity uptake of serotonin (5-ht) from extracellular fluid. |
2015-02-02 |
2023-08-12 |
mouse |
| Sylvia Montañez, Jaclyn L Munn, W Anthony Owens, Rebecca E Horton, Lynette C Daw. 5-HT1B receptor modulation of the serotonin transporter in vivo: studies using KO mice. Neurochemistry international. vol 73. 2015-02-02. PMID:24246466. |
serotonin clearance rate, over a range of 5-ht concentrations, did not differ among 5-ht1b receptor genotypes, nor did [(3)h]cyanoimipramine binding to sert in this brain region, suggesting that sert activity is not affected by constitutive reduction or loss of 5-ht1b receptors; alternatively, it might be that other transport mechanisms for 5-ht compensate for loss of 5-ht1b receptors. |
2015-02-02 |
2023-08-12 |
mouse |
| Sylvia Montañez, Jaclyn L Munn, W Anthony Owens, Rebecca E Horton, Lynette C Daw. 5-HT1B receptor modulation of the serotonin transporter in vivo: studies using KO mice. Neurochemistry international. vol 73. 2015-02-02. PMID:24246466. |
likewise, cyanopindolol was without effect on 5-ht clearance in sert-/- mice, demonstrating a requirement for the presence of both sert and 5-ht1b receptors in order for cyanopindolol to inhibit 5-ht clearance in ca3 region of hippocampus. |
2015-02-02 |
2023-08-12 |
mouse |
| Trine Nygaard Jørgensen, Peter Møller Christensen, Ulrik Gethe. Serotonin-induced down-regulation of cell surface serotonin transporter. Neurochemistry international. vol 73. 2015-02-02. PMID:24462583. |
the serotonin transporter (sert) terminates serotonergic signaling and enables refilling of synaptic vesicles by mediating reuptake of serotonin (5-ht) released into the synaptic cleft. |
2015-02-02 |
2023-08-12 |
Not clear |
| Trine Nygaard Jørgensen, Peter Møller Christensen, Ulrik Gethe. Serotonin-induced down-regulation of cell surface serotonin transporter. Neurochemistry international. vol 73. 2015-02-02. PMID:24462583. |
here we demonstrate that the substrate 5-ht itself causes acute down-regulation of sert cell surface expression. |
2015-02-02 |
2023-08-12 |
Not clear |
| Trine Nygaard Jørgensen, Peter Møller Christensen, Ulrik Gethe. Serotonin-induced down-regulation of cell surface serotonin transporter. Neurochemistry international. vol 73. 2015-02-02. PMID:24462583. |
moreover, preincubation with 5-ht lowered the vmax for 5-ht uptake in cultured raphe serotonergic neurons, indicting that endogenous cell-surface resident sert likewise is down-regulated in the presence of substrate. |
2015-02-02 |
2023-08-12 |
Not clear |
| Analia Bortolozzi, Pau Celada, Francesc Artiga. Novel therapeutic strategies in major depression: focus on RNAi and ketamine. Current pharmaceutical design. vol 20. issue 23. 2015-01-30. PMID:24180396. |
in particular, rnai strategies have been used to evoke antidepressant-like effects in laboratory animals by knocking-down the expression of genes involved in antidepressant effects, such as the serotonin transporter (sert) or the 5-ht1a autoreceptor. |
2015-01-30 |
2023-08-12 |
Not clear |
| Bruno P Guiard, Mostafa El Mansari, Dennis L Murphy, Pierre Blie. Altered response to the selective serotonin reuptake inhibitor escitalopram in mice heterozygous for the serotonin transporter: an electrophysiological and neurochemical study. The international journal of neuropsychopharmacology. vol 15. issue 3. 2015-01-22. PMID:21439106. |
a serotonin (5-ht) transporter (5-htt; sert) polymorphism has been associated with depressive states and poor responses to selective serotonin reuptake inhibitors (ssris). |
2015-01-22 |
2023-08-12 |
mouse |
| Bruno P Guiard, Mostafa El Mansari, Dennis L Murphy, Pierre Blie. Altered response to the selective serotonin reuptake inhibitor escitalopram in mice heterozygous for the serotonin transporter: an electrophysiological and neurochemical study. The international journal of neuropsychopharmacology. vol 15. issue 3. 2015-01-22. PMID:21439106. |
nevertheless, the ability of microiontophoretically applied 5-ht to inhibit the firing rate of ca3 pyramidal neurons was not different between sert+/+ and sert+/- mice given escitalopram for 21 d. the data indicate that the poor response to ssris of depressive patients with short allele(s) of sert is not attributable to a lesser increase in 5-ht transmission in the hippocampus. |
2015-01-22 |
2023-08-12 |
mouse |
| Zhang-Jin Zhang, Di Wang, Sui Cheung Man, Roger Ng, Grainne M McAlonan, Hei Kiu Wong, Wendy Wong, Jade Lee, Qing-Rong Ta. Platelet 5-HT(1A) receptor correlates with major depressive disorder in drug-free patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 53. 2015-01-22. PMID:24657886. |
in the present study, platelet expression of 5-ht1a receptors and serotonin transporter (sert) proteins, and serotonin (5-ht) and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) were quantified in 53 patients with mdd and 22 unaffected controls. |
2015-01-22 |
2023-08-12 |
Not clear |
| Heidi Kaastrup Müller, Marie Kragballe, Anja Winther Fjorback, Ove Wibor. Differential regulation of the serotonin transporter by vesicle-associated membrane protein 2 in cells of neuronal versus non-neuronal origin. PloS one. vol 9. issue 5. 2015-01-15. PMID:24878716. |
the serotonin transporter (sert) is a key regulator of serotonergic signalling as it mediates the re-uptake of synaptic serotonin into nerve terminals, thereby terminating or modulating its signal. |
2015-01-15 |
2023-08-13 |
rat |
| Heidi Kaastrup Müller, Marie Kragballe, Anja Winther Fjorback, Ove Wibor. Differential regulation of the serotonin transporter by vesicle-associated membrane protein 2 in cells of neuronal versus non-neuronal origin. PloS one. vol 9. issue 5. 2015-01-15. PMID:24878716. |
however, molecular details on possible coordinated regulation of sert activity and 5-ht release are incomplete. |
2015-01-15 |
2023-08-13 |
rat |
| Heidi Kaastrup Müller, Marie Kragballe, Anja Winther Fjorback, Ove Wibor. Differential regulation of the serotonin transporter by vesicle-associated membrane protein 2 in cells of neuronal versus non-neuronal origin. PloS one. vol 9. issue 5. 2015-01-15. PMID:24878716. |
vamp2 influences 5-ht uptake, cell surface expression and the delivery rate of sert to the plasma membrane differentially in hek-293 msr and pc12 cells. |
2015-01-15 |
2023-08-13 |
rat |
| Heidi Kaastrup Müller, Marie Kragballe, Anja Winther Fjorback, Ove Wibor. Differential regulation of the serotonin transporter by vesicle-associated membrane protein 2 in cells of neuronal versus non-neuronal origin. PloS one. vol 9. issue 5. 2015-01-15. PMID:24878716. |
moreover, sirna-mediated knock-down of endogenous vamp2 reduces 5-ht uptake in cad cells stably expressing low levels of heterologous sert. |
2015-01-15 |
2023-08-13 |
rat |
| Heidi Kaastrup Müller, Marie Kragballe, Anja Winther Fjorback, Ove Wibor. Differential regulation of the serotonin transporter by vesicle-associated membrane protein 2 in cells of neuronal versus non-neuronal origin. PloS one. vol 9. issue 5. 2015-01-15. PMID:24878716. |
our data identify a novel interaction between sert and a synaptic vesicle protein and support a link between 5-ht release and re-uptake. |
2015-01-15 |
2023-08-13 |
rat |
| Brian J Piper, Christina S Henderson, Jerrold S Meye. Adolescent MDMA exposure diminishes the physiological and neurotoxic consequences of an MDMA binge in female rats. Developmental psychobiology. vol 56. issue 5. 2015-01-13. PMID:24752593. |
intermittent mdma pretreatment blocked the reductions in serotonin transporter (sert) binding induced by an mdma binge in a prior study in adolescent male rats. |
2015-01-13 |
2023-08-13 |
rat |
| Peter Chiba, Michael Freissmuth, Thomas Stockne. Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transporters. Pharmacological research. vol 83. 2015-01-12. PMID:24316454. |
in contrast, insights into pharmacochaperoning of slc6 transporters are limited to monoamine transporters - in particular the serotonin transporter (sert) - because of their rich pharmacology. |
2015-01-12 |
2023-08-12 |
Not clear |
| Philippe Huot, Tom H Johnston, Katie D Lewis, James B Koprich, M Gabriela Reyes, Susan H Fox, Matthew J Piggott, Jonathan M Brotchi. UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances L-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset. Neuropharmacology. vol 82. 2015-01-09. PMID:24447715. |
uwa-101, a dual, equipotent inhibitor of dopamine (dat) and serotonin (sert) transporters, has previously been shown to successfully extend duration of anti-parkinsonian benefit of l-dopa (on-time), without exacerbating dyskinesia, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned marmoset. |
2015-01-09 |
2023-08-12 |
marmoset |
| A Yu Morozova, E A Zubkov, F A Koshkin, Z I Storozheva, V P Chekhoni. Expression of genes encoding serotonin receptors and SERT in various brain structures of stressed rats after chronic exposure to ultrasound. Bulletin of experimental biology and medicine. vol 156. issue 3. 2015-01-07. PMID:24771365. |
expression of genes encoding serotonin receptors and sert in various brain structures of stressed rats after chronic exposure to ultrasound. |
2015-01-07 |
2023-08-13 |
rat |