| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Gourand, P Emond, J P Bergström, A Takano, B Gulyás, D Guilloteau, L Barré, C Halldi. A radiometabolite study of the serotonin transporter PET radioligand [(11)C]MADAM. Nuclear medicine and biology. vol 41. issue 6. 2015-01-05. PMID:24857865. |
(11)c]madam is a radioligand suitable for pet studies of the serotonin transporter (sert). |
2015-01-05 |
2023-08-13 |
human |
| Lucina E Lizarraga, Andy V Phan, Aram B Cholanians, Joseph M Herndon, Serrine S Lau, Terrence J Monk. Serotonin reuptake transporter deficiency modulates the acute thermoregulatory and locomotor activity response to 3,4-(±)-methylenedioxymethamphetamine, and attenuates depletions in serotonin levels in SERT-KO rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 139. issue 2. 2014-12-29. PMID:24595820. |
mdma toxicity is in part mediated by an ability to inhibit the presynaptic 5-ht reuptake transporter (sert). |
2014-12-29 |
2023-08-12 |
rat |
| Ali El-Kasaby, Florian Koban, Harald H Sitte, Michael Freissmuth, Sonja Suci. A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter. The Journal of biological chemistry. vol 289. issue 42. 2014-12-22. PMID:25202009. |
mutations in the c terminus of the serotonin transporter (sert) disrupt folding and export from the endoplasmic reticulum. |
2014-12-22 |
2023-08-13 |
Not clear |
| Ju-Wei Hsu, Jiing-Feng Lirng, Shyh-Jen Wang, Chun-Lung Lin, Kai-Chun Yang, Mei-Hsiu Liao, Yuan-Hwa Cho. Association of thalamic serotonin transporter and interleukin-10 in bipolar I disorder: a SPECT study. Bipolar disorders. vol 16. issue 3. 2014-12-17. PMID:24372850. |
the aim of this study was to investigate the interaction of brain serotonin transporter (sert) and cytokines in bd. |
2014-12-17 |
2023-08-12 |
Not clear |
| Troels Rahbek-Clemmensen, Tina Bay, Jacob Eriksen, Ulrik Gether, Trine Nygaard Jørgense. The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation. The Journal of biological chemistry. vol 289. issue 33. 2014-12-16. PMID:24973209. |
the serotonin transporter (sert) plays a critical role in regulating serotonin signaling by mediating reuptake of serotonin from the extracellular space. |
2014-12-16 |
2023-08-13 |
Not clear |
| Michael H Baumann, Simon Bulling, Tova S Benaderet, Kusumika Saha, Mario A Ayestas, John S Partilla, Syed F Ali, Thomas Stockner, Richard B Rothman, Walter Sandtner, Harald H Sitt. Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 6. 2014-12-15. PMID:24287719. |
serotonin (5-ht) transporter (sert) substrates like fenfluramine and 3,4-methylenedioxymethamphetamine cause long-term depletion of brain 5-ht, while certain other substrates do not. |
2014-12-15 |
2023-08-12 |
human |
| Michael H Baumann, Simon Bulling, Tova S Benaderet, Kusumika Saha, Mario A Ayestas, John S Partilla, Syed F Ali, Thomas Stockner, Richard B Rothman, Walter Sandtner, Harald H Sitt. Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 6. 2014-12-15. PMID:24287719. |
the 5-ht deficits produced by sert substrates are dependent upon transporter proteins, but the exact mechanisms responsible are unclear. |
2014-12-15 |
2023-08-12 |
human |
| Michael H Baumann, Simon Bulling, Tova S Benaderet, Kusumika Saha, Mario A Ayestas, John S Partilla, Syed F Ali, Thomas Stockner, Richard B Rothman, Walter Sandtner, Harald H Sitt. Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 6. 2014-12-15. PMID:24287719. |
here, we compared the pharmacology of several sert substrates: fenfluramine, d-fenfluramine, 1-(m-chlorophenyl)piperazine (mcpp) and 1-(m-trifluoromethylphenyl)piperainze (tfmpp), to establish relationships between acute drug mechanisms and the propensity for long-term 5-ht depletions. |
2014-12-15 |
2023-08-12 |
human |
| Michelle G Baladi, Amy H Newman, Shannon M Nielsen, Glen R Hanson, Annette E Fleckenstei. Dopamine D(3) receptors contribute to methamphetamine-induced alterations in dopaminergic neuronal function: role of hyperthermia. European journal of pharmacology. vol 732. 2014-12-09. PMID:24685638. |
results indicate that the dopamine d3 receptor selective antagonist, pg01037, attenuated methamphetamine-induced decreases in striatal dat, but not hippocampal serotonin (5ht) transporter (sert), function, as assessed 7 days after treatment. |
2014-12-09 |
2023-08-12 |
rat |
| Saloua Benmansour, Anthony A Privratsky, Opeyemi S Adeniji, Alan Fraze. Signaling mechanisms involved in the acute effects of estradiol on 5-HT clearance. The international journal of neuropsychopharmacology. vol 17. issue 5. 2014-12-01. PMID:24423185. |
in vivo chronoamperometry was used to measure serotonin transporter (sert) function. |
2014-12-01 |
2023-08-12 |
rat |
| Anchalee Prasansuklab, Yong Poovorawan, Tewin Tencomna. Modulation of human serotonin transporter expression by 5-HTTLPR in colon cells. International journal of molecular sciences. vol 12. issue 10. 2014-11-28. PMID:22072907. |
known as a primary target for psychoactive drug development, the 5-ht transporter (5-htt, sert) plays a critical role in the regulation of serotonergic function by reuptaking 5-ht. |
2014-11-28 |
2023-08-12 |
human |
| James N Wilson, Lucy Kate Ladefoged, W Michael Babinchak, Birgit Schiøt. Binding-induced fluorescence of serotonin transporter ligands: A spectroscopic and structural study of 4-(4-(dimethylamino)phenyl)-1-methylpyridinium (APP(+)) and APP(+) analogues. ACS chemical neuroscience. vol 5. issue 4. 2014-11-28. PMID:24460204. |
the binding-induced fluorescence of 4-(4-(dimethylamino)-phenyl)-1-methylpyridinium (app(+)) and two new serotonin transporter (sert)-binding fluorescent analogues, 1-butyl-4-[4-(1-dimethylamino)phenyl]-pyridinium bromide (bpp(+)) and 1-methyl-4-[4-(1-piperidinyl)phenyl]-pyridinium (ppp(+)), has been investigated. |
2014-11-28 |
2023-08-12 |
Not clear |
| Kacper A Wojtal, Alexandra Cee, Silvia Lang, Oliver Götze, Heiko Frühauf, Andreas Geier, Marçal Pastor-Anglada, Javier Torres-Torronteras, Ramon Martí, Michael Fried, Thomas A Lutz, Marco Maggiorini, Max Gassmann, Gerhard Rogler, Stephan R Vavrick. Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans. American journal of physiology. Gastrointestinal and liver physiology. vol 307. issue 7. 2014-11-28. PMID:24970780. |
in the duodenum of volunteers exposed to high altitude we observed decreased mrna levels of apical sodium-dependent bile acid transporter (asbt), concentrative nucleoside transporters 1/2 (cnt1/2), organic anion transporting polypeptide 2b1 (oatp2b1), organic cation transporter 2 (octn2), peptide transporter 1 (pept1), serotonin transporter (sert), and higher levels of ifn-γ, il-6, and il-17a. |
2014-11-28 |
2023-08-13 |
human |
| Takuya Yokoyama, Yamaguchi-Yamada Misuzu, Yoshio Yamamot. Immunohistochemical localization of tryptophan hydroxylase and serotonin transporter in the carotid body of the rat. Histochemistry and cell biology. vol 140. issue 2. 2014-11-24. PMID:23266900. |
in the present study, we investigated mrna expression and immunohistochemical localization of the 5-ht synthetic enzyme isoforms, tryptophan hydroxylase 1 (tph1) and tph2, and the 5-ht plasma membrane transport protein, 5-ht transporter (sert), in the cb of the rat. |
2014-11-24 |
2023-08-12 |
rat |
| Mari Gabrielsen, Rafał Kurczab, Agata Siwek, Małgorzata Wolak, Aina W Ravna, Kurt Kristiansen, Irina Kufareva, Ruben Abagyan, Gabriel Nowak, Zdzisław Chilmonczyk, Ingebrigt Sylte, Andrzej J Bojarsk. Identification of novel serotonin transporter compounds by virtual screening. Journal of chemical information and modeling. vol 54. issue 3. 2014-11-24. PMID:24521202. |
the serotonin (5-hydroxytryptamine, 5-ht) transporter (sert) plays an essential role in the termination of serotonergic neurotransmission by removing 5-ht from the synaptic cleft into the presynaptic neuron. |
2014-11-24 |
2023-08-12 |
Not clear |
| Johanna Nyffeler, Susanne Walitza, Elise Bobrowski, Ronnie Gundelfinger, Edna Grünblat. Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism. Journal of molecular psychiatry. vol 2. issue 1. 2014-11-21. PMID:25408912. |
the serotonergic and oxytocinergic systems are of interest in autism for several reasons: (i) both systems are implicated in social behavior, and abnormal levels of serotonin and oxytocin have been found in people with asd; (ii) treatment with selective serotonin reuptake inhibitors and oxytocin can yield improvements; and (iii) previous association studies have linked the serotonin transporter (sert; slc6a4), serotonin receptor 2a (htr2a), and oxytocin receptor (oxtr) genes with asd. |
2014-11-21 |
2023-08-13 |
Not clear |
| Jing Yuan, ChuanYuan Kang, Min Wang, Qiang Wang, PeiKai Li, Hua Liu, Yu Hou, Ping Su, Fan Yang, YuJun Wei, JianZhong Yan. Association study of serotonin transporter SLC6A4 gene with Chinese Han irritable bowel syndrome. PloS one. vol 9. issue 1. 2014-11-18. PMID:24392134. |
solute carrier family 6 member 4 (slc6a4) gene encode serotonin transporter (sert) which function is to rapidly reuptake the most of 5-ht. |
2014-11-18 |
2023-08-12 |
Not clear |
| Aaron M Marshall, Laura L Hernandez, Nelson D Horsema. Serotonin and serotonin transport in the regulation of lactation. Journal of mammary gland biology and neoplasia. vol 19. issue 1. 2014-11-11. PMID:24136337. |
the conventional components of a classic 5-ht system are found within the mammary gland; synthetic enzymes (tryptophan hydroxylase i, aromatic amino acid decarboxylase), several 5-ht receptors and the 5-ht reuptake transporter (sert). |
2014-11-11 |
2023-08-12 |
Not clear |
| Aaron M Marshall, Laura L Hernandez, Nelson D Horsema. Serotonin and serotonin transport in the regulation of lactation. Journal of mammary gland biology and neoplasia. vol 19. issue 1. 2014-11-11. PMID:24136337. |
here, we review the role of 5-ht in mammary gland function, review the biochemistry, genetics and physiology of sert, and discuss how sert is vital to the function of the mammary gland. |
2014-11-11 |
2023-08-12 |
Not clear |
| R Ye, A M D Carneiro, Q Han, D Airey, E Sanders-Bush, B Zhang, L Lu, R Williams, R D Blakel. Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression. Genes, brain, and behavior. vol 13. issue 3. 2014-11-07. PMID:24405699. |
presynaptic serotonin (5-hydroxytryptamine, 5-ht) transporters (sert) regulate 5-ht signaling via antidepressant-sensitive clearance of released neurotransmitter. |
2014-11-07 |
2023-08-12 |
mouse |