| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas Steinkellner, Liudmilla Mus, Birgit Eisenrauch, Andreea Constantinescu, Damiana Leo, Lisa Konrad, Mattias Rickhag, Gunnar Sørensen, Evgenia V Efimova, Eryan Kong, Matthäus Willeit, Tatyana D Sotnikova, Oliver Kudlacek, Ulrik Gether, Michael Freissmuth, Daniela D Pollak, Raul R Gainetdinov, Harald H Sitt. In vivo amphetamine action is contingent on αCaMKII. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 11. 2015-06-15. PMID:24871545. |
cocaine acts as a blocker at the transporters for dopamine (dat), serotonin (sert), and norepinephrine (net), but amphetamines are substrates that do not only block the uptake of monoamines but also induce substrate efflux by promoting reverse transport. |
2015-06-15 |
2023-08-13 |
mouse |
| Elena Dale, Hong Zhang, Steven C Leiser, Yixin Xiao, Dunguo Lu, Charles R Yang, Niels Plath, Connie Sanche. Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. Journal of psychopharmacology (Oxford, England). vol 28. issue 10. 2015-06-09. PMID:25122043. |
vortioxetine, a novel antidepressant with multimodal action, is a serotonin (5-ht)3, 5-ht7 and 5-ht1d receptor antagonist, a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist and a 5-ht transporter (sert) inhibitor. |
2015-06-09 |
2023-08-13 |
rat |
| Walter Koch, Marcus Unterrainer, Guoming Xiong, Peter Bartenstein, Markus Diemling, Andrea Varrone, John C Dickson, Livia Tossici-Bolt, Terez Sera, Susanne Asenbaum, Jan Booij, Ozlem L Kapucu, Andreas Kluge, Morten Ziebell, Jacques Darcourt, Flavio Nobili, Marco Pagani, Swen Hesse, Thierry Vander Borght, Koen Van Laere, Klaus Tatsch, Christian la Fougèr. Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls. European journal of nuclear medicine and molecular imaging. vol 41. issue 10. 2015-06-05. PMID:24806112. |
apart from binding to the dopamine transporter (dat), [(123)i]fp-cit shows moderate affinity for the serotonin transporter (sert), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. |
2015-06-05 |
2023-08-13 |
Not clear |
| Giuliana Cerulo, Simona Tafuri, Valeria De Pasquale, Silviana Rea, Simona Romano, Anna Costagliola, Rossella Della Morte, Luigi Avallone, Luigi Michele Pavon. Serotonin activates cell survival and apoptotic death responses in cultured epithelial thyroid cells. Biochimie. vol 105. 2015-05-29. PMID:24997405. |
here, we first demonstrate the expression of serotonin transporter sert and 5-ht2a receptor subtype in rat thyroid epithelial cell line frt both at mrna and protein levels. |
2015-05-29 |
2023-08-13 |
rat |
| Hiromi I Weston, Douglas D Weston, Joshua L Allen, Deborah A Cory-Slecht. Sex-dependent impacts of low-level lead exposure and prenatal stress on impulsive choice behavior and associated biochemical and neurochemical manifestations. Neurotoxicology. vol 44. 2015-05-27. PMID:25010656. |
brains of littermates of behaviorally-trained offspring were utilized to examine corresponding changes in monoamines and in levels of brain derived neurotrophic factor (bdnf), the serotonin transporter (sert) and the n-methyl-d-aspartate receptor (nmdar) 2a in brain regions associated with impulsive choice behavior. |
2015-05-27 |
2023-08-13 |
rat |
| Hiromi I Weston, Douglas D Weston, Joshua L Allen, Deborah A Cory-Slecht. Sex-dependent impacts of low-level lead exposure and prenatal stress on impulsive choice behavior and associated biochemical and neurochemical manifestations. Neurotoxicology. vol 44. 2015-05-27. PMID:25010656. |
consistent with these behavioral changes, pb±ps treated males also showed reductions in brain serotonin function in all mesocorticolimbic regions, broad monoamine changes in nucleus accumbens, and reductions in both bdnf and nmdar 2a levels and increases in sert in frontal cortex, i.e., in regions and neurotransmitter systems known to mediate learning/behavioral flexibility, and which were of greater impact in males. |
2015-05-27 |
2023-08-13 |
rat |
| Magdy El-Salhy, Odd Helge Gilja, Jan Gunnar Hatlebakk, Trygve Hauske. Stomach antral endocrine cells in patients with irritable bowel syndrome. International journal of molecular medicine. vol 34. issue 4. 2015-05-26. PMID:25110039. |
stomach antral biopsy samples obtained from all of the subjects were immunostained using the avidin-biotin-complex method for serotonin, gastrin, somatostatin and serotonin transporter (sert). |
2015-05-26 |
2023-08-13 |
human |
| P C Hsieh, K C Chen, T L Yeh, I H Lee, P S Chen, W J Yao, N-T Chiu, C-C Chen, M-H Liao, Y K Yan. Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder - a preliminary two-ligand SPECT study. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24439516. |
serotonin transporter (sert) and dopamine transporter (dat) levels differ in patients with major depressive disorder (mdd) who are in a depressed state in comparison with healthy controls. |
2015-05-15 |
2023-08-12 |
human |
| Maciej Bieliński, Marta Tomaszewska, Marcin Jaracz, Joanna Pulkowska-Ulfig, Dominika Długosz, Marcin Sikora, Andrzej Tretyn, Anna Kamińska, Roman Junik, Alina Borkowsk. The polymorphisms in serotonin-related genes (5-HT₂A and SERT) and the prevalence of depressive symptoms in obese patients. Neuroscience letters. vol 586. 2015-05-14. PMID:25486590. |
two polymorphisms were tested: a 44-bp insertion/deletion in the serotonin transporter (sert) gene and a single-nucleotide variation (1438g/a) in the serotonin 2a receptor (5-ht2a) gene. |
2015-05-14 |
2023-08-13 |
human |
| Jong-Hoon Kim, Young-Don Son, Jeong-Hee Kim, Eun-Jung Choi, Sang-Yoon Lee, Jee Eun Lee, Zang-Hee Cho, Young-Bo Ki. Serotonin transporter availability in thalamic subregions in schizophrenia: a study using 7.0-T MRI with [(11)C]DASB high-resolution PET. Psychiatry research. vol 231. issue 1. 2015-05-13. PMID:25465315. |
the serotonin transporter (sert) is an integral protein that provides an index of serotonergic innervation. |
2015-05-13 |
2023-08-13 |
human |
| Cristina Fenollar-Ferrer, Thomas Stockner, Thomas C Schwarz, Aritra Pal, Jelena Gotovina, Tina Hofmaier, Kumaresan Jayaraman, Suraj Adhikary, Oliver Kudlacek, Ahmad Reza Mehdipour, Sotiria Tavoulari, Gary Rudnick, Satinder K Singh, Robert Konrat, Harald H Sitte, Lucy R Forres. Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter. Biochemistry. vol 53. issue 33. 2015-04-27. PMID:25093911. |
here, we combined molecular modeling, biochemical, and biophysical approaches in an iterative manner to investigate the structure of the 82-residue n-terminal and 30-residue c-terminal domains of human serotonin transporter (sert). |
2015-04-27 |
2023-08-13 |
human |
| Y Yang, X Cui, Y Chen, Y Wang, X Li, L Lin, H Zhan. Exendin-4, an analogue of glucagon-like peptide-1, attenuates hyperalgesia through serotonergic pathways in rats with neonatal colonic sensitivity. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 65. issue 3. 2015-04-22. PMID:24930506. |
the expressions of serotonin transporter (sert) and tryptophan hydroxylase-1 (tph-1) in colonic tissues were detected by rt-pcr and western blot, respectively. |
2015-04-22 |
2023-08-13 |
rat |
| Yicong Li, Coedy Hadden, Preeti Singh, Charles P Mercado, Pamela Murphy, Nafisa K Dajani, Curtis L Lowery, Drucilla J Roberts, Luc Maroteaux, Fusun Kili. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 52. 2015-04-22. PMID:25512553. |
gdm-associated insulin deficiency hinders the dissociation of sert from erp44 and down-regulates placental 5-ht uptake. |
2015-04-22 |
2023-08-13 |
Not clear |
| Yicong Li, Coedy Hadden, Preeti Singh, Charles P Mercado, Pamela Murphy, Nafisa K Dajani, Curtis L Lowery, Drucilla J Roberts, Luc Maroteaux, Fusun Kili. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 52. 2015-04-22. PMID:25512553. |
serotonin (5-ht) transporter (sert) regulates the level of 5-ht in placenta. |
2015-04-22 |
2023-08-13 |
Not clear |
| Yicong Li, Coedy Hadden, Preeti Singh, Charles P Mercado, Pamela Murphy, Nafisa K Dajani, Curtis L Lowery, Drucilla J Roberts, Luc Maroteaux, Fusun Kili. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 52. 2015-04-22. PMID:25512553. |
initially, we found that in gestational diabetes mellitus (gdm), whereas free plasma 5-ht levels were elevated, the 5-ht uptake rates of trophoblast were significantly down-regulated, due to impairment in the translocation of sert molecules to the cell surface. |
2015-04-22 |
2023-08-13 |
Not clear |
| Yicong Li, Coedy Hadden, Preeti Singh, Charles P Mercado, Pamela Murphy, Nafisa K Dajani, Curtis L Lowery, Drucilla J Roberts, Luc Maroteaux, Fusun Kili. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 52. 2015-04-22. PMID:25512553. |
herein, we show that the decrease in 5-ht uptake rates of gdm trophoblast is the consequence of defective insulin signaling, which entraps sert with erp44 and impairs its glycosylation. |
2015-04-22 |
2023-08-13 |
Not clear |
| Silvia Hoirisch-Clapauch, Antonio E Nardi, Jean-Christophe Gris, Benjamin Brenne. Are the antiplatelet and profibrinolytic properties of selective serotonin-reuptake inhibitors relevant to their brain effects? Thrombosis research. vol 134. issue 1. 2015-04-16. PMID:24661990. |
the serotonin transporter (sert) is found in neuron and platelet membranes. |
2015-04-16 |
2023-08-12 |
Not clear |
| Vibe Gedsoe Frokjaer, David Erritzoe, Klaus Kähler Holst, Kathrine Skak Madsen, Patrick MacDonald Fisher, Jacob Madsen, Claus Svarer, Gitte Moos Knudse. In abstinent MDMA users the cortisol awakening response is off-set but associated with prefrontal serotonin transporter binding as in non-users. The international journal of neuropsychopharmacology. vol 17. issue 8. 2015-04-14. PMID:24524290. |
we have previously observed that in healthy volunteers, prefrontal serotonin transporter (sert) binding is positively associated with hypothalamic-pituitary-adrenal (hpa)-axis output in terms of the cortisol awakening response (car). |
2015-04-14 |
2023-08-12 |
human |
| Vibe Gedsoe Frokjaer, David Erritzoe, Klaus Kähler Holst, Kathrine Skak Madsen, Patrick MacDonald Fisher, Jacob Madsen, Claus Svarer, Gitte Moos Knudse. In abstinent MDMA users the cortisol awakening response is off-set but associated with prefrontal serotonin transporter binding as in non-users. The international journal of neuropsychopharmacology. vol 17. issue 8. 2015-04-14. PMID:24524290. |
in conclusion, our data confirm the recently described positive association between prefrontal sert binding and car, this time in a human model of serotonin deficiency. |
2015-04-14 |
2023-08-12 |
human |
| Lisa M McFadden, Paula L Vieira-Brock, Glen R Hanson, Annette E Fleckenstei. Methamphetamine self-administration attenuates hippocampal serotonergic deficits: role of brain-derived neurotrophic factor. The international journal of neuropsychopharmacology. vol 17. issue 8. 2015-04-14. PMID:24650575. |
preclinical studies suggest that prior treatment with escalating doses of methamphetamine (meth) attenuates the persistent deficits in hippocampal serotonin (5-hydroxytryptamine; 5ht) transporter (sert) function resulting from a subsequent 'binge' meth exposure. |
2015-04-14 |
2023-08-12 |
rat |