| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicolas Morin, Marc Morissette, Laurent Grégoire, Thérèse Di Paol. Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25046277. |
[(3)h]-8-oh-dpat and [(3)h]-citalopram specific binding levels to 5-ht(1a) receptors and sert respectively remained unchanged in the striatum and globus pallidus of all mptp monkeys compared to controls and no difference was observed between groups of mptp monkeys. |
2015-07-31 |
2023-08-13 |
monkey |
| Preeti Jaiswal, Subhrangshu Guhathakurta, Asem Surindro Singh, Deepak Verma, Mritunjay Pandey, Merina Varghese, Swagata Sinha, Saurabh Ghosh, Kochupurackal P Mohanakumar, Usha Rajamm. SLC6A4 markers modulate platelet 5-HT level and specific behaviors of autism: a study from an Indian population. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25261775. |
slc6a4, the gene encoding serotonin transporter (sert) is considered as a potential susceptibility gene for asd, since it is a quantitative trait locus for blood 5-ht levels. |
2015-07-31 |
2023-08-13 |
Not clear |
| María Belén Poretti, Mathias Rask-Andersen, Praveen Kumar, Susana Rubiales de Barioglio, Marta Fiol de Cuneo, Helgi B Schiöth, Valeria Paola Carlin. Ghrelin effects expression of several genes associated with depression-like behavior. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25286107. |
ghr administration on the expression of hypothalamic genes related to depression and mood (delta opioid receptor (dor), mu opioid receptor (mor) and kappa opioid receptor (kor), lutropin-choriogonadotropic hormone receptor (lhcgr), serotonin transporter (sert), interleukin 1 beta (il-1b), vasopressin (avp) and corticotrophin releasing hormone (crh)) in ob animals, as well as changes in plasma levels of avp, crh and adenocorticotropic hormone (acth). |
2015-07-31 |
2023-08-13 |
mouse |
| Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology. vol 89. 2015-07-24. PMID:25261781. |
enhanced 5-ht1a receptor-dependent feedback control over dorsal raphe serotonin neurons in the sert knockout mouse. |
2015-07-24 |
2023-08-13 |
mouse |
| Aloke K Dutta, Soumava Santra, Horrick Sharma, Chandrashekhar Voshavar, Liping Xu, Omar Mabrouk, Tamara Antonio, Maarten E A Reit. Pharmacological and behavioral characterization of D-473, an orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters. PloS one. vol 9. issue 11. 2015-07-20. PMID:25427177. |
the monoamine uptake inhibition activity in the cloned human transporters expressed in hek-293 cells (70.4, 9.18 and 39.7 for dat, sert and net, respectively) indicates a serotonin preferring triple reuptake inhibition profile for this drug. |
2015-07-20 |
2023-08-13 |
human |
| Jeyaganesh Rajamanickam, Balasubramaniam Annamalai, Troels Rahbek-Clemmensen, Santhanalakshmi Sundaramurthy, Ulrik Gether, Lankupalle D Jayanthi, Sammanda Ramamoorth. Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation. The Biochemical journal. vol 468. issue 1. 2015-07-20. PMID:25761794. |
the serotonin [5-ht (5-hydroxytryptamine)] transporter (sert) controls serotonergic neurotransmission in the brain by rapid clearance of 5-ht from the synaptic cleft into presynaptic neurons. |
2015-07-20 |
2023-08-13 |
Not clear |
| Bronwyn Kivell, Zeljko Uzelac, Santhanalakshmi Sundaramurthy, Jeyaganesh Rajamanickam, Amy Ewald, Vladimir Chefer, Vanaja Jaligam, Elizabeth Bolan, Bridget Simonson, Balasubramaniam Annamalai, Padmanabhan Mannangatti, Thomas E Prisinzano, Ivone Gomes, Lakshmi A Devi, Lankupalle D Jayanthi, Harald H Sitte, Sammanda Ramamoorthy, Toni S Shippenber. Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism. Neuropharmacology. vol 86. 2015-07-14. PMID:25107591. |
while sala increased dat activity, sala treatment decreased serotonin transporter (sert) activity and had no effect on norepinephrine transporter (net) activity. |
2015-07-14 |
2023-08-13 |
Not clear |
| Mariane Cristovão Bagatin, Camila Santos Suniga Tozatti, Layara Akemi Abiko, Diego Alberto dos Santos Yamazaki, Priscila Rebeca Alves Silva, Leonardo Martins Perego, Elisabeth Aparecida Audi, Flavio Augusto Vicente Seixas, Ernani Abicht Basso, Gisele de Freitas Gauz. Molecular docking and panicolytic effect of 8-prenylnaringenin in the elevated T-maze. Chemical & pharmaceutical bulletin. vol 62. issue 12. 2015-07-14. PMID:25450631. |
the selective serotonin (sert) reuptake inhibitor fluoxetine was used as a positive control. |
2015-07-14 |
2023-08-13 |
rat |
| Javier A Urra, Franz Villaroel-Espíndola, Alejandra A Covarrubias, Joan Enric Rodríguez-Gil, Alfredo Ramírez-Reveco, Ilona I Conch. Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity. PloS one. vol 9. issue 11. 2015-07-08. PMID:25402186. |
in the present study, using immunodetection methods, we revealed the presence of several proteins important for the dopamine uptake and signalling in mammalian sperm, specifically monoamine transporters as dopamine (dat), serotonin (sert) and norepinephrine (net) transporters in equine sperm. |
2015-07-08 |
2023-08-13 |
Not clear |
| Syed Mohd Danish Rizvi, Sibhghatulla Shaikh, Mahiuddin Khan, Deboshree Biswas, Nida Hameed, Shazi Shaki. Fetzima (levomilnacipran), a drug for major depressive disorder as a dual inhibitor for human serotonin transporters and beta-site amyloid precursor protein cleaving enzyme-1. CNS & neurological disorders drug targets. vol 13. issue 8. 2015-07-02. PMID:25345508. |
pharmacological management of major depressive disorder includes the use of serotonin reuptake inhibitors which targets serotonin transporters (sert) to increase the synaptic concentrations of serotonin. |
2015-07-02 |
2023-08-13 |
human |
| Syed Mohd Danish Rizvi, Sibhghatulla Shaikh, Mahiuddin Khan, Deboshree Biswas, Nida Hameed, Shazi Shaki. Fetzima (levomilnacipran), a drug for major depressive disorder as a dual inhibitor for human serotonin transporters and beta-site amyloid precursor protein cleaving enzyme-1. CNS & neurological disorders drug targets. vol 13. issue 8. 2015-07-02. PMID:25345508. |
levomilnacipran was found to interact with s438, known to be the most important amino acid residue of serotonin binding site of sert during 'levomilnacipran-sert' interaction. |
2015-07-02 |
2023-08-13 |
human |
| Henriette Bjerregaard, Kasper Severinsen, Saida Said, Ove Wiborg, Steffen Sinnin. A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin. The Journal of biological chemistry. vol 290. issue 12. 2015-07-02. PMID:25614630. |
serotonergic neurotransmission is modulated by the membrane-embedded serotonin transporter (sert). |
2015-07-02 |
2023-08-13 |
human |
| Henriette Bjerregaard, Kasper Severinsen, Saida Said, Ove Wiborg, Steffen Sinnin. A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin. The Journal of biological chemistry. vol 290. issue 12. 2015-07-02. PMID:25614630. |
sert mediates the reuptake of serotonin into the presynaptic neurons. |
2015-07-02 |
2023-08-13 |
human |
| Henriette Bjerregaard, Kasper Severinsen, Saida Said, Ove Wiborg, Steffen Sinnin. A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin. The Journal of biological chemistry. vol 290. issue 12. 2015-07-02. PMID:25614630. |
conformational changes in sert occur upon binding of ions and substrate and are crucial for translocation of serotonin across the membrane. |
2015-07-02 |
2023-08-13 |
human |
| Henriette Bjerregaard, Kasper Severinsen, Saida Said, Ove Wiborg, Steffen Sinnin. A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin. The Journal of biological chemistry. vol 290. issue 12. 2015-07-02. PMID:25614630. |
here we show that serotonin induces a dualistic conformational response in sert. |
2015-07-02 |
2023-08-13 |
human |
| Henriette Bjerregaard, Kasper Severinsen, Saida Said, Ove Wiborg, Steffen Sinnin. A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin. The Journal of biological chemistry. vol 290. issue 12. 2015-07-02. PMID:25614630. |
we found a novel high affinity outward-facing conformational state of the human sert induced by serotonin. |
2015-07-02 |
2023-08-13 |
human |
| Henriette Bjerregaard, Kasper Severinsen, Saida Said, Ove Wiborg, Steffen Sinnin. A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin. The Journal of biological chemistry. vol 290. issue 12. 2015-07-02. PMID:25614630. |
furthermore, we found that membrane cholesterol plays a role in the dualistic conformational response in sert induced by serotonin. |
2015-07-02 |
2023-08-13 |
human |
| Henriette Bjerregaard, Kasper Severinsen, Saida Said, Ove Wiborg, Steffen Sinnin. A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin. The Journal of biological chemistry. vol 290. issue 12. 2015-07-02. PMID:25614630. |
our results indicate the existence of a subpopulation of sert responding differently to serotonin binding than hitherto believed and that membrane cholesterol plays a role in this subpopulation of sert. |
2015-07-02 |
2023-08-13 |
human |
| Lena Sørensen, Kristian Strømgaard, Anders S Kristense. Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites. ACS chemical biology. vol 9. issue 4. 2015-07-01. PMID:24450286. |
in the central nervous system, synaptic levels of the monoamine neurotransmitter serotonin are mainly controlled by the serotonin transporter (sert), and drugs used in the treatment of various psychiatric diseases have sert as primary target. |
2015-07-01 |
2023-08-12 |
human |
| Xiu-Fang Cui, Wei-Mei Zhou, Yan Yang, Jun Zhou, Xue-Liang Li, Lin Lin, Hong-Jie Zhan. Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome. World journal of gastroenterology. vol 20. issue 37. 2015-06-24. PMID:25309082. |
to investigate the role of epidermal growth factor (egf) in visceral hypersensitivity and its effect on the serotonin transporter (sert). |
2015-06-24 |
2023-08-13 |
Not clear |