| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katharina Domschke, Nicola Tidow, Kathrin Schwarte, Jürgen Deckert, Klaus-Peter Lesch, Volker Arolt, Peter Zwanzger, Bernhard T Baun. Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response. The international journal of neuropsychopharmacology. vol 17. issue 8. 2015-04-14. PMID:24679990. |
variation in the serotonin transporter gene (5-htt; sert; slc6a4) has been suggested to pharmacogenetically drive interindividual differences in antidepressant treatment response. |
2015-04-14 |
2023-08-12 |
Not clear |
| Takayuki Matsumoto, Shun Watanabe, Kumiko Taguchi, Tsuneo Kobayash. Mechanisms underlying increased serotonin-induced contraction in carotid arteries from chronic type 2 diabetic Goto-Kakizaki rats. Pharmacological research. vol 87. 2015-04-13. PMID:25034165. |
carotid arterial expressions of monoamine oxidase-a (mao-a), serotonin transporter (sert), and 5-ht2a were detected by immunoblotting. |
2015-04-13 |
2023-08-13 |
rat |
| Bruno D Arbo, Susie Andrade, Gabriela Osterkamp, Rosane Gomez, Maria Flávia M Ribeir. Effect of low doses of progesterone in the expression of the GABA(A) receptor α4 subunit and procaspase-3 in the hypothalamus of female rats. Endocrine. vol 46. issue 3. 2015-04-02. PMID:24366640. |
the aim of this study was to verify the effect of progesterone on the protein expression of the gaba(a) receptor α4 subunit, serotonin transporter (sert), akt, extracellular signal-regulated kinase (erk), and caspase-3 in the hypothalamus of diestrus ii female rats exposed to the fst. |
2015-04-02 |
2023-08-12 |
rat |
| Jalal Soubhye, Iyas Aldib, Martine Prévost, Betina Elfving, Michel Gelbcke, Manuel Podrecca, Raphaël Conotte, Jean-Marie Colet, Paul G Furtmüller, Cédric Delporte, Alexandre Rousseau, Michel Vanhaeverbeek, Jean Nève, Christian Obinger, Karim Zouaoui-Boudjeltia, Pierre Van Antwerpen, François Dufrasn. Hybrid molecules inhibiting myeloperoxidase activity and serotonin reuptake: a possible new approach of major depressive disorders with inflammatory syndrome. The Journal of pharmacy and pharmacology. vol 66. issue 8. 2015-03-30. PMID:24673477. |
the aim of our study was to find compounds that inhibit both mpo and serotonin transporter (sert) for treating mdd associated with cardiovascular diseases. |
2015-03-30 |
2023-08-12 |
Not clear |
| Simon D Brandt, Michael H Baumann, John S Partilla, Pierce V Kavanagh, John D Power, Brian Talbot, Brendan Twamley, Olivia Mahony, John O'Brien, Simon P Elliott, Roland P Archer, Julian Patrick, Kuldip Singh, Nicola M Dempster, Simon H Cosbe. Characterization of a novel and potentially lethal designer drug (±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or 'Serotoni'). Drug testing and analysis. vol 6. issue 7-8. 2015-03-30. PMID:24841869. |
(±)-cis-4,4'-dmar was a potent, efficacious substrate-type releaser at transporters for dopamine, norepinephrine and serotonin with ec50 values of 8.6 ± 1.1 nm (dat), 26.9 ± 5.9 nm (net) and 18.5 ± 2.8 nm (sert), respectively. |
2015-03-30 |
2023-08-13 |
rat |
| Swen Hesse, Elsmarieke van de Giessen, Franziska Zientek, David Petroff, Karsten Winter, John C Dickson, Livia Tossici-Bolt, Terez Sera, Susanne Asenbaum, Jacques Darcourt, Umit O Akdemir, Gitte M Knudsen, Flavio Nobili, Marco Pagani, Thierry Vander Borght, Koen Van Laere, Andrea Varrone, Klaus Tatsch, Osama Sabri, Jan Booi. Association of central serotonin transporter availability and body mass index in healthy Europeans. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 8. 2015-03-30. PMID:24976619. |
serotonin-mediated mechanisms, in particular via the serotonin transporter (sert), are thought to have an effect on food intake and play an important role in the pathophysiology of obesity. |
2015-03-30 |
2023-08-13 |
human |
| Philippe Huot, Susan H Fox, Jonathan M Brotchi. Monoamine reuptake inhibitors in Parkinson's disease. Parkinson's disease. vol 2015. 2015-03-26. PMID:25810948. |
despite wide discrepancy in the methodology of the studies reviewed, the following conclusions can be drawn: (1) selective serotonin transporter (sert), selective noradrenaline transporter (net), and dual sert/net inhibitors are effective against pd depression; (2) selective dopamine transporter (dat) and dual dat/net inhibitors exert an anti-parkinsonian effect when administered as monotherapy but do not enhance the anti-parkinsonian actions of l-3,4-dihydroxyphenylalanine (l-dopa); (3) dual dat/sert inhibitors might enhance the anti-parkinsonian actions of l-dopa without worsening dyskinesia; (4) triple dat/net/sert inhibitors might exert an anti-parkinsonian action as monotherapy and might enhance the anti-parkinsonian effects of l-dopa, though at the expense of worsening dyskinesia. |
2015-03-26 |
2023-08-13 |
Not clear |
| Monika Kloza, Marta Baranowska-Kuczko, Anna Pędzińska-Betiuk, Konrad Jackowski, Hanna Kozłowsk. [Serotonin hypothesis and pulmonary artery hypertension]. Postepy higieny i medycyny doswiadczalnej (Online). vol 68. 2015-03-25. PMID:24934532. |
previously, serotonin hypothesis was linked to the anorexigens, derivatives of fenfluramine, which are serotonin transporter (sert) substrates. |
2015-03-25 |
2023-08-13 |
Not clear |
| Monika Kloza, Marta Baranowska-Kuczko, Anna Pędzińska-Betiuk, Konrad Jackowski, Hanna Kozłowsk. [Serotonin hypothesis and pulmonary artery hypertension]. Postepy higieny i medycyny doswiadczalnej (Online). vol 68. 2015-03-25. PMID:24934532. |
5-ht is also transported into pulmonary arterial smooth muscle cells via sert and through activation of reactive oxygen species and rho-kinase may contribute to contraction or/and, via stimulation of transcription factors, lead to proliferation and remodelling. |
2015-03-25 |
2023-08-13 |
Not clear |
| Leif Hertz, Douglas L Rothman, Baoman Li, Liang Pen. Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift. Frontiers in behavioral neuroscience. vol 9. 2015-03-09. PMID:25750618. |
it is firmly believed that the mechanism of action of ssris in major depression is to inhibit the serotonin transporter, sert, and increase extracellular concentration of serotonin. |
2015-03-09 |
2023-08-13 |
mouse |
| H Yamanaka, C Yokoyama, H Mizuma, S Kurai, S J Finnema, C Halldin, H Doi, H Ono. A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques. Translational psychiatry. vol 4. 2015-03-06. PMID:24399045. |
four rhesus monkeys underwent pet studies with two serotonin (5-ht)-related pet radioligands, [(11)c]az10419369 and [(11)c]dasb, which are highly selective for the 5-ht1b receptor and serotonin transporter (sert), respectively. |
2015-03-06 |
2023-08-12 |
monkey |
| M Wankerl, R Miller, C Kirschbaum, J Hennig, T Stalder, N Alexande. Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles. Translational psychiatry. vol 4. 2015-03-06. PMID:24937096. |
the serotonin transporter (sert) gene-linked polymorphic region (5-httlpr) has been implicated in moderating the link between life stress and depression. |
2015-03-06 |
2023-08-13 |
human |
| Andreas Hahn, Daniela Haeusler, Christoph Kraus, Anna S Höflich, Georg S Kranz, Pia Baldinger, Markus Savli, Markus Mitterhauser, Wolfgang Wadsak, Georgios Karanikas, Siegfried Kasper, Rupert Lanzenberge. Attenuated serotonin transporter association between dorsal raphe and ventral striatum in major depression. Human brain mapping. vol 35. issue 8. 2015-02-27. PMID:24443158. |
however, previous investigations of the serotonin transporter (sert) focused on regional differences with varying results depending on the clinical syndrome. |
2015-02-27 |
2023-08-12 |
human |
| Francesca Calabrese, Rick H A van der Doelen, Gianluigi Guidotti, Giorgio Racagni, Tamas Kozicz, Judith R Homberg, Marco A Riv. Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion. Journal of neurochemistry. vol 132. issue 1. 2015-02-19. PMID:25087780. |
in this study, we investigated the impact of chronic maternal separation (ms) on the expression of the neurotrophin brain-derived neurotrophic factor (bdnf) in serotonin transporter (sert) knockout rats in the ventral and dorsal hippocampus as well as the ventromedial and dorsomedial prefrontal cortex (pfc). |
2015-02-19 |
2023-08-13 |
rat |
| Brian Lord, Leah Aluisio, James R Shoblock, Robert A Neff, Elena I Varlinskaya, Marc Ceusters, Timothy W Lovenberg, Nicholas Carruthers, Pascal Bonaventure, Michael A Letavic, Terrence Deak, Wilhelmus Drinkenburg, Anindya Bhattachary. Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432. The Journal of pharmacology and experimental therapeutics. vol 351. issue 3. 2015-02-17. PMID:25271258. |
at higher doses/exposure, jnj-42253432 also increased serotonin levels in the rat brain, which is due to antagonism of the serotonin transporter (sert) resulting in an ed50 of 10 mg/kg for sert occupancy. |
2015-02-17 |
2023-08-13 |
human |
| Swen Hesse, Franziska Moeller, David Petroff, Donald Lobsien, Julia Luthardt, Ralf Regenthal, Georg-Alexander Becker, Marianne Patt, Eva Thomae, Anita Seese, Philipp M Meyer, Florian Then Bergh, Osama Sabr. Altered serotonin transporter availability in patients with multiple sclerosis. European journal of nuclear medicine and molecular imaging. vol 41. issue 5. 2015-02-09. PMID:24562640. |
modulation of the immune system by the cns may involve serotonergic regulation via the brain serotonin transporters (sert). |
2015-02-09 |
2023-08-12 |
Not clear |
| Katarina Nikolic, Slavica Filipic, Danica Agbaba, Holger Star. Procognitive properties of drugs with single and multitargeting H3 receptor antagonist activities. CNS neuroscience & therapeutics. vol 20. issue 7. 2015-02-06. PMID:24836924. |
dual target drugs displaying h3 r antagonism/inverse agonism with inhibition of acetylcholine esterase (ache), histamine n-methyltransferase (hmt), or serotonin transporter (sert) are novel class of procognitive agents. |
2015-02-06 |
2023-08-13 |
Not clear |
| Alonzo Whyte, Tammy Jessen, Seth Varney, Ana M D Carneir. Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain. Neurochemistry international. vol 73. 2015-02-02. PMID:24083985. |
convergent evidence from genetic analyses of human subjects has implicated the integrin β3 subunit gene (itgb3) as a modulator of serotonergic systems via genetic interactions with the 5-ht transporter gene (slc6a4, sert). |
2015-02-02 |
2023-08-12 |
mouse |
| Alonzo Whyte, Tammy Jessen, Seth Varney, Ana M D Carneir. Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain. Neurochemistry international. vol 73. 2015-02-02. PMID:24083985. |
expecting corresponding changes to sert function, we also measured 5-ht uptake activity in synaptoneurosomal preparations. |
2015-02-02 |
2023-08-12 |
mouse |
| Matthew L Beckman, Akula Bala Pramod, Danielle Perley, L Keith Henr. Stereoselective inhibition of serotonin transporters by antimalarial compounds. Neurochemistry international. vol 73. 2015-02-02. PMID:24161619. |
the serotonin (5-ht) transporter (sert) is an integral membrane protein that functions to reuptake 5-ht released into the synapse following neurotransmission. |
2015-02-02 |
2023-08-12 |
human |