| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luise Liebig, Andreas von Ameln-Mayerhofer, Harald Hentschk. MDMA modulates spontaneous firing of subthalamic nucleus neurons in vitro. Experimental brain research. vol 233. issue 1. 2015-09-10. PMID:25234400. |
effects of mdma on transporters for serotonin (sert) and norepinephrine (net) were investigated by coapplication of the reuptake inhibitors citalopram and desipramine, respectively. |
2015-09-10 |
2023-08-13 |
Not clear |
| Luise Liebig, Andreas von Ameln-Mayerhofer, Harald Hentschk. MDMA modulates spontaneous firing of subthalamic nucleus neurons in vitro. Experimental brain research. vol 233. issue 1. 2015-09-10. PMID:25234400. |
similar to the effects of 5-ht(2a) receptor blockade, antagonism of sert and net bestowed an inhibitory effect on mdma. |
2015-09-10 |
2023-08-13 |
Not clear |
| Ekrem Dere, Daniela Winkler, Caroline Ritter, Anja Ronnenberg, Giulia Poggi, Julia Patzig, Manuela Gernert, Christian Müller, Klaus-Armin Nave, Hannelore Ehrenreich, Hauke B Werne. Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A/C receptor agonist. Behavioural brain research. vol 277. 2015-09-08. PMID:24768641. |
it interacts with the n-terminal domain of the serotonin transporter (sert) and decreases cell-surface expression of sert. |
2015-09-08 |
2023-08-13 |
mouse |
| Yasemin Karabacak, Sunetra Sase, Yogesh D Aher, Ajinkya Sase, Sivaprakasam R Saroja, Ana Cicvaric, Harald Höger, Michael Berger, Vasiliy Bakulev, Harald H Sitte, Johann Leban, Francisco J Monje, Gert Lube. The effect of modafinil on the rat dopamine transporter and dopamine receptors D1-D3 paralleling cognitive enhancement in the radial arm maze. Frontiers in behavioral neuroscience. vol 9. 2015-09-08. PMID:26347626. |
reuptake inhibition of dopamine, serotonin (sert) and norepinephrine (net) by modafinil was tested. |
2015-09-08 |
2023-08-13 |
rat |
| Moe Igari, Hao-Wei Shen, Yoko Hagino, Setsu Fukushima, Yoshiyuki Kasahara, Klaus-Peter Lesch, Dennis L Murphy, Frank Scott Hall, George R Uhl, Kazutaka Ikeda, Nobuo Yaegashi, Ichiro Sor. Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25485646. |
the present experiments examined serotonergic roles in meth-induced locomotor sensitization by assessing: (a) the effect of serotonin transporter (sert; slc6a4) knockout (ko) on meth-induced locomotor sensitization; (b) extracellular monoamine levels in meth-treated animals as determined by in-vivo microdialysis; and (c) effects of serotonin (5-ht) receptor antagonists on meth-induced behavioral sensitization, with focus on effects of the 5-ht1b receptor antagonist sb 216641 and a comparison with the 5-ht2 receptor antagonist ketanserin. |
2015-09-03 |
2023-08-13 |
mouse |
| Moe Igari, Hao-Wei Shen, Yoko Hagino, Setsu Fukushima, Yoshiyuki Kasahara, Klaus-Peter Lesch, Dennis L Murphy, Frank Scott Hall, George R Uhl, Kazutaka Ikeda, Nobuo Yaegashi, Ichiro Sor. Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25485646. |
meth-induced increases in extracellular 5-ht (5-htex) levels were substantially reduced in sert-/- mice, although sert genotype had no effect on meth-induced increases in extracellular dopamine. |
2015-09-03 |
2023-08-13 |
mouse |
| Florian Koban, Ali El-Kasaby, Cornelia Häusler, Thomas Stockner, Benedikt M Simbrunner, Harald H Sitte, Michael Freissmuth, Sonja Suci. A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter. The Journal of biological chemistry. vol 290. issue 21. 2015-09-01. PMID:25869136. |
here we examined the contribution of the c terminus in supporting folding of the serotonin transporter (sert; slc6a4). |
2015-09-01 |
2023-08-13 |
Not clear |
| Connie Sanchez, Karen E Asin, Francesc Artiga. Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacology & therapeutics. vol 145. 2015-08-31. PMID:25016186. |
vortioxetine, a novel antidepressant for the treatment of major depressive disorder (mdd), is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and serotonin (5-ht) transporter (sert) inhibitor. |
2015-08-31 |
2023-08-13 |
Not clear |
| Hajime Minakuchi, Chiharu Sogawa, Emilio Satoshi Hara, Haruna Miki, Kenji Maekawa, Norio Sogawa, Shigeo Kitayama, Yoshizo Matsuka, Glenn T Clark, Takuo Kubok. Comparison of platelet serotonin transporter activity in subjects with severe sleep bruxism and control. Journal of prosthodontic research. vol 58. issue 4. 2015-08-31. PMID:25127373. |
the aim of this study was to evaluate the correlation between sleep bruxism (sb) frequency and serotonin transporter (sert)-driven serotonin (5-ht)-uptake in platelets. |
2015-08-31 |
2023-08-13 |
human |
| Bruno D Arbo, Susie Andrade, Gabriela Osterkamp, Rosane Gomez, Maria Flávia Ribeir. Asymmetric effects of low doses of progesterone on GABA(A) receptor α4 subunit protein expression in the olfactory bulb of female rats. Canadian journal of physiology and pharmacology. vol 92. issue 12. 2015-08-31. PMID:25380418. |
the aim of this study was to evaluate the effect of progesterone on the protein expression of α4 subunit of gaba(a) receptor, serotonin transporter (sert), akt, erk, and caspase-3 in the olfactory bulb (ob) of female rats exposed to the forced swimming test (fst). |
2015-08-31 |
2023-08-13 |
rat |
| José Jaime Herrera-Pérez, Alonso Fernández-Guasti, Lucía Martínez-Mot. Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution. Neuroscience journal. vol 2013. 2015-08-28. PMID:26317087. |
we hypothesize that such impairment is explained by an age-related decrease in brain serotonin transporter (sert) expression associated with low testosterone (t) levels. |
2015-08-28 |
2023-08-13 |
rat |
| Hafsteinn Rannversson, Pamela Wilson, Kristina Birch Kristensen, Steffen Sinning, Anders Skov Kristensen, Kristian Strømgaard, Jacob Anderse. Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation. The Journal of biological chemistry. vol 290. issue 23. 2015-08-24. PMID:25903124. |
the serotonin transporter (sert) terminates serotonergic neurotransmission by performing reuptake of released serotonin, and sert is the primary target for antidepressants. |
2015-08-24 |
2023-08-13 |
human |
| Hafsteinn Rannversson, Pamela Wilson, Kristina Birch Kristensen, Steffen Sinning, Anders Skov Kristensen, Kristian Strømgaard, Jacob Anderse. Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation. The Journal of biological chemistry. vol 290. issue 23. 2015-08-24. PMID:25903124. |
sert mediates the reuptake of serotonin through an alternating access mechanism, implying that a central substrate site is connected to both sides of the membrane by permeation pathways, of which only one is accessible at a time. |
2015-08-24 |
2023-08-13 |
human |
| H Bielas, P Arck, C A Bruenahl, S Walitza, E Grünblat. Prenatal stress increases the striatal and hippocampal expression of correlating c-FOS and serotonin transporters in murine offspring. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 38. 2015-08-21. PMID:25102410. |
prenatal stress (ps) is a known risk factor for several psychiatric diagnoses, including schizophrenia, attention deficit hyperactivity disorder, autism, anxiety, and depression which have been associated with serotonin transporter (sert) dysregulation. |
2015-08-21 |
2023-08-13 |
mouse |
| Thomas Steinkellner, Therese R Montgomery, Tina Hofmaier, Oliver Kudlacek, Jae-Won Yang, Mattias Rickhag, Gangsoo Jung, Gert Lubec, Ulrik Gether, Michael Freissmuth, Harald H Sitt. Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 21. 2015-08-20. PMID:26019340. |
serotonergic neurotransmission is terminated by reuptake of extracellular serotonin (5-ht) by the high-affinity serotonin transporter (sert). |
2015-08-20 |
2023-08-13 |
mouse |
| Thomas Steinkellner, Therese R Montgomery, Tina Hofmaier, Oliver Kudlacek, Jae-Won Yang, Mattias Rickhag, Gangsoo Jung, Gert Lubec, Ulrik Gether, Michael Freissmuth, Harald H Sitt. Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 21. 2015-08-20. PMID:26019340. |
selective 5-ht reuptake inhibitors (ssris) such as fluoxetine or escitalopram inhibit sert and are currently the principal treatment for depression and anxiety disorders. |
2015-08-20 |
2023-08-13 |
mouse |
| Peter S Hasenhuetl, Klaus Schicker, Xaver Koenig, Yang Li, Subhodeep Sarker, Thomas Stockner, Sonja Sucic, Harald H Sitte, Michael Freissmuth, Walter Sandtne. Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction. Molecular pharmacology. vol 88. issue 1. 2015-08-11. PMID:25873594. |
the membrane transporters for the monoamines serotonin (sert) and dopamine (dat) are prominent targets of various psychoactive substances, including competitive inhibitors, such as tricyclic antidepressants, methylphenidate, and cocaine. |
2015-08-11 |
2023-08-13 |
Not clear |
| Alfredo Menese. Serotonin, neural markers, and memory. Frontiers in pharmacology. vol 6. 2015-08-10. PMID:26257650. |
5-ht1a, 5-ht4, 5-ht5, 5-ht6, and 5-ht7 receptors as well as sert (serotonin transporter) seem to be useful neural markers and/or therapeutic targets. |
2015-08-10 |
2023-08-13 |
Not clear |
| Nicolas Morin, Marc Morissette, Laurent Grégoire, Thérèse Di Paol. Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25046277. |
serotonin (5-ht) receptors and transporter (sert) are also implicated in lid and we hypothesize that antiglutamatergic drugs can also regulate brain serotoninergic activity. |
2015-07-31 |
2023-08-13 |
monkey |
| Nicolas Morin, Marc Morissette, Laurent Grégoire, Thérèse Di Paol. Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25046277. |
our aim was to investigate the long-term effect of the prototypal metabotropic glutamate 5 (mglu5) receptor antagonist 2-methyl-6-(phenylethynyl)pyridine (mpep) with l-dopa on basal ganglia sert, 5-ht(1a) and 5-ht(2a) receptor levels in monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2015-07-31 |
2023-08-13 |
monkey |