| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew Mazalouskas, Tammy Jessen, Seth Varney, James S Sutcliffe, Jeremy Veenstra-VanderWeele, Edwin H Cook, Ana M D Carneir. Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25684064. |
converging lines of evidence have identified genetic interactions between the serotonin transporter (sert) gene and itgb3, which encodes the β3 subunit that forms the αiibβ3 and αvβ3 integrin receptor complexes. |
2016-03-08 |
2023-08-13 |
mouse |
| Matthew Mazalouskas, Tammy Jessen, Seth Varney, James S Sutcliffe, Jeremy Veenstra-VanderWeele, Edwin H Cook, Ana M D Carneir. Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25684064. |
here we examine the consequences of haploinsufficiency in the mouse integrin β3 subunit gene (itgb3) on sert function and selective 5-hydroxytryptamine (5-ht) reuptake inhibitor (ssri) effectiveness in vivo. |
2016-03-08 |
2023-08-13 |
mouse |
| Matthew Mazalouskas, Tammy Jessen, Seth Varney, James S Sutcliffe, Jeremy Veenstra-VanderWeele, Edwin H Cook, Ana M D Carneir. Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25684064. |
notably, we establish that loss of a single allele of itgb3 in murine neurons is sufficient to decrease 5-ht uptake by sert in midbrain synaptosomes. |
2016-03-08 |
2023-08-13 |
mouse |
| Matthew Mazalouskas, Tammy Jessen, Seth Varney, James S Sutcliffe, Jeremy Veenstra-VanderWeele, Edwin H Cook, Ana M D Carneir. Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25684064. |
these data are consistent with the existence of a subpopulation of serts that are tightly modulated by integrin αvβ3 and significantly contribute to global sert function at 5-ht synapses in the midbrain. |
2016-03-08 |
2023-08-13 |
mouse |
| Boris Mlinar, Alberto Montalbano, Gilda Baccini, Francesca Tatini, Rolando Berlinguer Palmini, Renato Corradett. Nonexocytotic serotonin release tonically suppresses serotonergic neuron activity. The Journal of general physiology. vol 145. issue 3. 2016-03-04. PMID:25712017. |
although it is well established that reuptake of 5-hto is mediated by 5-ht transporters (sert), the release mechanism has remained unclear. |
2016-03-04 |
2023-08-13 |
Not clear |
| Yogesh D Aher, Saraswathi Subramaniyan, Bharanidharan Shanmugasundaram, Ajinkya Sase, Sivaprakasam R Saroja, Marion Holy, Harald Höger, Tetyana Beryozkina, Harald H Sitte, Johann J Leban, Gert Lube. A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System. Frontiers in behavioral neuroscience. vol 10. 2016-03-04. PMID:26941626. |
the efficacy of ce-104 in blocking mat [dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter] was determined using in vitro neurotransmitter uptake assay. |
2016-03-04 |
2023-08-13 |
human |
| Eunkyung Park, Yu Mi Hwang, Min Kyung Chu, Ki-Young Jun. Increased Brainstem Serotonergic Transporter Availability in Adult Migraineurs: an [(18)F]FP-CIT PET Imaging Pilot Study. Nuclear medicine and molecular imaging. vol 50. issue 1. 2016-03-04. PMID:26941862. |
we investigated serotonin transporter (sert) availability in migraineurs using f-18-n-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([(18)f]fp-cit) positron emission tomography (pet). |
2016-03-04 |
2023-08-13 |
Not clear |
| Michiel Alexander de Raaf, Yvet Kroeze, Anthonieke Middelman, Frances S de Man, Helma de Jong, Anton Vonk-Noordegraaf, Chris de Korte, Norbert F Voelkel, Judith Homberg, Harm Jan Bogaar. Serotonin transporter is not required for the development of severe pulmonary hypertension in the Sugen hypoxia rat model. American journal of physiology. Lung cellular and molecular physiology. vol 309. issue 10. 2016-02-25. PMID:26386116. |
an intact serotonin system, which critically depends on a normal function of the serotonin transporter (sert), is required for the development of experimental pulmonary hypertension in rodents exposed to hypoxia or monocrotaline. |
2016-02-25 |
2023-08-13 |
human |
| S E Cremer, N E Zois, S G Moesgaard, N Ravn, S Cirera, J L Honge, M H Smerup, J M Hasenkam, E Sloth, P S Leifsson, T Falk, M A Oyama, C Orton, T Martinussen, L H Olse. Serotonin markers show altered transcription levels in an experimental pig model of mitral regurgitation. Veterinary journal (London, England : 1997). vol 203. issue 2. 2016-02-22. PMID:25599900. |
based on increased tryptophan hydroxylase-1 (tph-1) and decreased serotonin re-uptake transporter (sert) in mmvd-affected valves, increased valvular 5-ht synthesis and decreased clearance have been suggested. |
2016-02-22 |
2023-08-13 |
Not clear |
| Risako Kon, Nobutomo Ikarashi, Akio Hayakawa, Yusuke Haga, Aika Fueki, Yoshiki Kusunoki, Masataka Tajima, Wataru Ochiai, Yoshiaki Machida, Kiyoshi Sugiyam. Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion. Toxicological sciences : an official journal of the Society of Toxicology. vol 145. issue 2. 2016-02-22. PMID:25766885. |
the degree of constipation was analyzed after the combined administration of hgcl(2) (aqp3 inhibitor) or fluoxetine (5-ht reuptake transporter [sert] inhibitor) and morphine. |
2016-02-22 |
2023-08-13 |
rat |
| Risako Kon, Nobutomo Ikarashi, Akio Hayakawa, Yusuke Haga, Aika Fueki, Yoshiki Kusunoki, Masataka Tajima, Wataru Ochiai, Yoshiaki Machida, Kiyoshi Sugiyam. Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion. Toxicological sciences : an official journal of the Society of Toxicology. vol 145. issue 2. 2016-02-22. PMID:25766885. |
this study also showed that morphine-induced 5-ht secreted from the colon was taken into cells by sert and activated pparγ, which subsequently increased aqp3 expression levels. |
2016-02-22 |
2023-08-13 |
rat |
| Andras David Nagy, Ayaka Iwamoto, Misato Kawai, Ryosei Goda, Haruka Matsuo, Tsuyoshi Otsuka, Mao Nagasawa, Mitsuhiro Furuse, Shinobu Yasu. Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. Chronobiology international. vol 32. issue 4. 2016-02-16. PMID:25515595. |
melatonin treatments altered the expression of genes of serotonergic neurotransmission in the dorsal raphe (tph2, sert, vmat2 and 5ht1a) and serotonin contents in the amygdala. |
2016-02-16 |
2023-08-13 |
mouse |
| Shih-Hsien Lin, I Hui Lee, Kao Chin Chen, Po See Chen, Nan Tsing Chiu, Wei Jen Yao, Yen Kuang Yan. Serotonin transporter availability may moderate the association between perceiving stress and depressive tendencies - A SPECT with 5-HTTLPR genotyping study. Progress in neuro-psychopharmacology & biological psychiatry. vol 61. 2016-02-16. PMID:25816791. |
it was found that serotonin transporter (sert) gene (5-httlpr) polymorphism may moderate the association between perceiving stress and depressive tendency. |
2016-02-16 |
2023-08-13 |
human |
| Shih-Hsien Lin, I Hui Lee, Kao Chin Chen, Po See Chen, Nan Tsing Chiu, Wei Jen Yao, Yen Kuang Yan. Serotonin transporter availability may moderate the association between perceiving stress and depressive tendencies - A SPECT with 5-HTTLPR genotyping study. Progress in neuro-psychopharmacology & biological psychiatry. vol 61. 2016-02-16. PMID:25816791. |
this study aimed to investigate whether there is a sert availability×environmental stress interaction effect, as well as a gene-by-environmental (g×e) interaction effect, using single-photon emission computed tomography (spect) with a serotonin transporter radiotracer, [(123)i]adam. |
2016-02-16 |
2023-08-13 |
human |
| Christian Pifl, Harald Reither, Oleh Hornykiewic. The profile of mephedrone on human monoamine transporters differs from 3,4-methylenedioxymethamphetamine primarily by lower potency at the vesicular monoamine transporter. European journal of pharmacology. vol 755. 2016-02-09. PMID:25771452. |
we therefore compared their effects on the human monoamine transporters using human cell lines stably expressing the human noradrenaline, dopamine and serotonin transporter (net, dat and sert); preparations of synaptic vesicles from human striatum in uptake experiments; and a superfusion system where releasing effects can be reliably measured. |
2016-02-09 |
2023-08-13 |
human |
| Yi-Wei Yeh, Pei-Shen Ho, Shin-Chang Kuo, Chun-Yen Chen, Chih-Sung Liang, Che-Hung Yen, Chang-Chih Huang, Kuo-Hsing Ma, Chyng-Yann Shiue, Wen-Sheng Huang, Jia-Fwu Shyu, Fang-Jung Wan, Ru-Band Lu, San-Yuan Huan. Disproportionate Reduction of Serotonin Transporter May Predict the Response and Adherence to Antidepressants in Patients with Major Depressive Disorder: A Positron Emission Tomography Study with 4-[18F]-ADAM. The international journal of neuropsychopharmacology. vol 18. issue 7. 2016-02-05. PMID:25568284. |
many lines of evidence suggest the role of serotonin transporter (sert)-mediated reuptake of serotonin in the pathophysiology and treatment of major depressive disorder (mdd). |
2016-02-05 |
2023-08-13 |
Not clear |
| Rodrigo Arreola, Enrique Becerril-Villanueva, Carlos Cruz-Fuentes, Marco Antonio Velasco-Velázquez, María Eugenia Garcés-Alvarez, Gabriela Hurtado-Alvarado, Saray Quintero-Fabian, Lenin Pavó. Immunomodulatory effects mediated by serotonin. Journal of immunology research. vol 2015. 2016-02-01. PMID:25961058. |
three classes of genes regulating 5-ht function are constitutively expressed or induced in these cells: (a) membrane proteins that regulate the response to 5-ht, such as sert, 5htr-gpcr, and the 5ht3-ion channels; (b) downstream signaling transduction proteins; and (c) enzymes controlling 5-ht metabolism, such as ido and mao, which can generate biologically active catabolites, including melatonin, kynurenines, and kynurenamines. |
2016-02-01 |
2023-08-13 |
Not clear |
| Rui Zhao, Jian-song Fang, Ai-lin Liu, Guan-hua D. [Development of HTS model on SERT inhibitors combined biological screening model with HTVS]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 50. issue 9. 2016-01-22. PMID:26757547. |
in order to improve the efficiency of drug screening on serotonin transporter (sert) inhibitors, a high-throughput screening (hts) model is established in rbl-2h3 cells. |
2016-01-22 |
2023-08-13 |
Not clear |
| Rui Zhao, Jian-song Fang, Ai-lin Liu, Guan-hua D. [Development of HTS model on SERT inhibitors combined biological screening model with HTVS]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 50. issue 9. 2016-01-22. PMID:26757547. |
the rbl-2h3 cells are very similar to the serotonin genetic neuro, in modulation of post-receptor mechanisms and transduction pathway of sert reactivated. |
2016-01-22 |
2023-08-13 |
Not clear |
| Ran Ye, Meagan A Quinlan, Hideki Iwamoto, Hsiao-Huei Wu, Noah H Green, Christopher S Jetter, Douglas G McMahon, Jeremy Veestra-VanderWeele, Pat Levitt, Randy D Blakel. Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters. Frontiers in synaptic neuroscience. vol 7. 2016-01-21. PMID:26793096. |
efficient clearance of 5-ht after release is achieved by the antidepressant-sensitive 5-ht transporter (sert, slc6a4). |
2016-01-21 |
2023-08-13 |
mouse |