| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Sakloth, R Kolanos, P D Mosier, J S Bonano, M L Banks, J S Partilla, M H Baumann, S S Negus, R A Glenno. Steric parameters, molecular modeling and hydropathic interaction analysis of the pharmacology of para-substituted methcathinone analogues. British journal of pharmacology. vol 172. issue 9. 2016-01-05. PMID:25522019. |
specifically, the steric character (taft's steric es ) of the 4-position substituent affected in vitro potency to induce monoamine release via dopamine and 5-ht transporters (dat and sert) and in vivo modulation of intracranial self-stimulation (icss). |
2016-01-05 |
2023-08-13 |
Not clear |
| Cynthia L Bethea, Arubala P Reddy, Matthew Flowers, Robert A Shapiro, Ricki J Colman, David H Abbott, Jon E Levin. High fat diet decreases beneficial effects of estrogen on serotonin-related gene expression in marmosets. Progress in neuro-psychopharmacology & biological psychiatry. vol 58. 2016-01-05. PMID:25542371. |
the serotonin reuptake transporter (sert), the serotonin 1a receptor (5ht1a), estrogen receptor beta (erβ) and progestin receptor (pr) expressions were not different between groups. |
2016-01-05 |
2023-08-13 |
marmoset |
| Kazunari Tominaga, Chikako Tsumoto, Suzuka Ataka, Kei Mizuno, Kayo Takahashi, Hirokazu Yamagami, Tetsuya Tanigawa, Joji Kawabe, Toshio Watanabe, Yasuhiro Fujiwara, Susumu Shiomi, Yasuyoshi Watanabe, Tetsuo Arakaw. Regional brain disorders of serotonin neurotransmission are associated with functional dyspepsia. Life sciences. vol 137. 2015-12-29. PMID:26232557. |
to elucidate the role of cerebral serotonin neurotransmission in visceral perception in functional dyspepsia (fd), we observationally examined the regional expression level of the serotonin transporter (sert) and its correlation with clinical symptoms. |
2015-12-29 |
2023-08-13 |
Not clear |
| Tania Rivera-Baltanas, Roberto Carlos Agis-Balboa, Raquel Romay-Tallon, Lisa E Kalynchuk, Jose Manuel Olivares, Hector J Carunch. Serotonin transporter clustering in blood lymphocytes predicts the outcome on anhedonia scores in naïve depressive patients treated with antidepressant medication. Annals of general psychiatry. vol 14. 2015-12-23. PMID:26697099. |
we have shown that serotonin transporter (sert) clustering in blood lymphocytes is altered in major depression and correlates with pharmacological therapeutic responses measured with the hamilton scale. |
2015-12-23 |
2023-08-13 |
Not clear |
| M J Herrmann, J Bogon, S Quester, A Cordes, P Stenneken, A Reif, A-C Ehli. Serotonin transporter polymorphism modulates neural correlates of real-life joint action. An investigation with functional near-infrared spectroscopy (fNIRS). Neuroscience. vol 292. 2015-12-16. PMID:25711941. |
a functional polymorphism (5-httlpr) within the serotonin transporter gene (sert) has been associated with personality dimensions such as neuroticism, with emotional reactivity to negative events, and with an increased risk of affective disorders. |
2015-12-16 |
2023-08-13 |
human |
| Anna Rickli, Marius C Hoener, Matthias E Liecht. Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 3. 2015-12-15. PMID:25624004. |
we tested the potency of these compounds to inhibit the norepinephrine (ne), dopamine (da), and serotonin (5-ht) transporters (net, dat, and sert, respectively) using human embryonic kidney 293 cells that express the respective human transporters. |
2015-12-15 |
2023-08-13 |
human |
| K Vijaya Kumar, Anjuman Rudra, M V Sreedhara, T Siva Subramani, Durga Shiva Prasad, Manish Lal Das, Senthil Murugesan, Rajbharan Yadav, Ravi Kumar Trivedi, Justin V Louis, Yu-Wen Li, Linda J Bristow, Pattipati S Naidu, Reeba Kannimel Vikramadithya. Bacillus Calmette-Guérin vaccine induces a selective serotonin reuptake inhibitor (SSRI)-resistant depression like phenotype in mice. Brain, behavior, and immunity. vol 42. 2015-12-14. PMID:25016199. |
the lack of efficacy with acute treatment with ssris could not be explained either by differences in drug exposure or serotonin transporter (sert) occupancy. |
2015-12-14 |
2023-08-13 |
mouse |
| Mahesh Darna, Joshua S Beckmann, Cassandra D Gipson, Michael T Bardo, Linda P Dwoski. Effect of environmental enrichment on dopamine and serotonin transporters and glutamate neurotransmission in medial prefrontal and orbitofrontal cortex. Brain research. vol 1599. 2015-12-01. PMID:25536304. |
the current study extends the previous work and reports on the optimization of dat and serotonin transporter (sert) functional assays, as well as cell surface expression assays using both mpfc and orbitofrontal cortex (ofc) from individual ec or ic rats. |
2015-12-01 |
2023-08-13 |
rat |
| Mahesh Darna, Joshua S Beckmann, Cassandra D Gipson, Michael T Bardo, Linda P Dwoski. Effect of environmental enrichment on dopamine and serotonin transporters and glutamate neurotransmission in medial prefrontal and orbitofrontal cortex. Brain research. vol 1599. 2015-12-01. PMID:25536304. |
in contrast, vmax for [(3)h]serotonin uptake and cellular localization of sert in mpfc and ofc were not different between ec and ic rats. |
2015-12-01 |
2023-08-13 |
rat |
| N Murai, H Fushiki, S Honda, Y Murakami, A Iwashita, M Irie, S Tamura, Y Nagakura, T Aok. Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. Neuroscience. vol 289. 2015-12-01. PMID:25595980. |
in this case, it would be of interest to investigate the correlation of 5-ht transporter (sert) occupancy with in vivo analgesic effect on pain associated with fm. |
2015-12-01 |
2023-08-13 |
rat |
| N Murai, H Fushiki, S Honda, Y Murakami, A Iwashita, M Irie, S Tamura, Y Nagakura, T Aok. Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. Neuroscience. vol 289. 2015-12-01. PMID:25595980. |
here, we investigated the relationship between sert occupancies and the analgesic effects of as1069562, the (+)-isomer of indeloxazine, and duloxetine, which are both 5-ht and ne reuptake inhibitors (snris), on muscular pain in reserpine-induced myalgia (rim) rats, an animal model of fm-like chronic pain. |
2015-12-01 |
2023-08-13 |
rat |
| Barbara Pelosi, Sara Migliarini, Giulia Pacini, Marta Pratelli, Massimo Pasqualett. Generation of Pet1210-Cre transgenic mouse line reveals non-serotonergic expression domains of Pet1 both in CNS and periphery. PloS one. vol 9. issue 8. 2015-11-30. PMID:25098329. |
in the mouse, pet1 mrna expression appears between 10 and 11 days post coitum (dpc) in serotonergic post-mitotic precursors and persists in serotonergic neurons up to adulthood, where it promotes the expression of genes defining the mature serotonergic phenotype such as tryptophan hydroxylase 2 (tph2) and serotonin transporter (sert). |
2015-11-30 |
2023-08-13 |
mouse |
| Pella C Söderhielm, Jacob Andersen, Lachlan Munro, Anne T Nielsen, Anders S Kristense. Substrate and Inhibitor-Specific Conformational Changes in the Human Serotonin Transporter Revealed by Voltage-Clamp Fluorometry. Molecular pharmacology. vol 88. issue 4. 2015-11-16. PMID:26174773. |
the serotonin transporter (sert) regulates neurotransmission by the biogenic monoamine neurotransmitter serotonin (5-ht, 5-hydroxytryptamine) in the central nervous system, and drugs inhibiting sert are widely used for the treatment of a variety of central nervous system diseases. |
2015-11-16 |
2023-08-13 |
human |
| Pella C Söderhielm, Jacob Andersen, Lachlan Munro, Anne T Nielsen, Anders S Kristense. Substrate and Inhibitor-Specific Conformational Changes in the Human Serotonin Transporter Revealed by Voltage-Clamp Fluorometry. Molecular pharmacology. vol 88. issue 4. 2015-11-16. PMID:26174773. |
we used voltage-clamp fluorometry to study conformational changes in human sert (hsert) during 5-ht transport and inhibitor binding. |
2015-11-16 |
2023-08-13 |
human |
| Francisca Gomez, César Venero, María-Paz Viveros, Luis García-Garcí. Short-term fluoxetine treatment induces neuroendocrine and behavioral anxiogenic-like responses in adolescent male rats. Experimental brain research. vol 233. issue 3. 2015-11-05. PMID:25515088. |
for 3-4 days) on hypothalamic-pituitary-adrenal axis activity, serotonin (5-hidroxytriptamine, 5-ht) transporter (sert) mrna expression in the dorsal raphe nucleus (drn), energy balance-related variables and behavioral profiles in the holeboard. |
2015-11-05 |
2023-08-13 |
rat |
| S Roberts, K J Lester, J L Hudson, R M Rapee, C Creswell, P J Cooper, K J Thirlwall, J R I Coleman, G Breen, C C Y Wong, T C Ele. Serotonin transporter [corrected] methylation and response to cognitive behaviour therapy in children with anxiety disorders. Translational psychiatry. vol 4. 2015-11-02. PMID:25226553. |
furthermore, epigenetic alterations at the serotonin transporter (sert) promoter region have been associated with environmental influences such as stressful life experiences. |
2015-11-02 |
2023-08-13 |
Not clear |
| Yi-Wei Yeh, Pei-Shen Ho, Chun-Yen Chen, Shin-Chang Kuo, Chih-Sung Liang, Kuo-Hsing Ma, Chyng-Yann Shiue, Wen-Sheng Huang, Cheng-Yi Cheng, Tzu-Yun Wang, Ru-Band Lu, San-Yuan Huan. Incongruent reduction of serotonin transporter associated with suicide attempts in patients with major depressive disorder: a positron emission tomography study with 4-[18F]-ADAM. The international journal of neuropsychopharmacology. vol 18. issue 3. 2015-10-27. PMID:25522405. |
much evidence supports the role of the serotonin transporter (sert) in the pathophysiology and pharmacotherapy of major depressive disorder (mdd) and suicidal behaviors. |
2015-10-27 |
2023-08-13 |
Not clear |
| Jana Haase, Eric Brow. Integrating the monoamine, neurotrophin and cytokine hypotheses of depression--a central role for the serotonin transporter? Pharmacology & therapeutics. vol 147. 2015-10-26. PMID:25444754. |
the serotonin transporter (sert) is the primary regulator of serotonin levels in the brain and a key target for widely used antidepressant drugs, such as selective serotonin reuptake inhibitors (ssris). |
2015-10-26 |
2023-08-13 |
Not clear |
| Rong Xu, Sarah A Lord, Ryan M Peterson, Emily A Fergason-Cantrell, John R Lever, Susan Z Leve. Ether modifications to 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): effects on binding affinity and selectivity for sigma receptors and monoamine transporters. Bioorganic & medicinal chemistry. vol 23. issue 1. 2015-10-22. PMID:25468036. |
sa4503 and a subset of ether analogs were also evaluated for dopamine transporter (dat) and serotonin transporter (sert) affinity. |
2015-10-22 |
2023-08-13 |
Not clear |
| Ole V Mortensen, Sandhya Kortager. Designing modulators of monoamine transporters using virtual screening techniques. Frontiers in pharmacology. vol 6. 2015-10-20. PMID:26483692. |
the plasma-membrane monoamine transporters (mats), including the serotonin (sert), norepinephrine (net) and dopamine (dat) transporters, serve a pivotal role in limiting monoamine-mediated neurotransmission through the reuptake of their respective monoamine neurotransmitters. |
2015-10-20 |
2023-08-13 |
drosophila_melanogaster |