| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Durairaj Ragu Varman, Koilmani Emmanuvel Raja. Environmental Enrichment Reduces Anxiety by Differentially Activating Serotonergic and Neuropeptide Y (NPY)-Ergic System in Indian Field Mouse (Mus booduga): An Animal Model of Post-Traumatic Stress Disorder. PloS one. vol 10. issue 5. 2016-04-05. PMID:26016844. |
subsequently, the serotonin transporter (sert) and 5-ht1a receptor were up-regulated significantly, but the same did not occur in the 5-ht2c receptor, which is associated with the activation of calmodulin-dependent protein kinase-ii (camkii) and a transcription factor camp response element binding protein (creb). |
2016-04-05 |
2023-08-13 |
mouse |
| Preeti Jaiswal, Kochupurackal P Mohanakumar, Usha Rajamm. Serotonin mediated immunoregulation and neural functions: Complicity in the aetiology of autism spectrum disorders. Neuroscience and biobehavioral reviews. vol 55. 2016-04-04. PMID:26021727. |
serotonin transporter (sert) regulates serotonin level in lymphoid tissues to ensure its proper functioning in innate and adaptive responses. |
2016-04-04 |
2023-08-13 |
Not clear |
| Kusumika Saha, John S Partilla, Kurt R Lehner, Amir Seddik, Thomas Stockner, Marion Holy, Walter Sandtner, Gerhard F Ecker, Harald H Sitte, Michael H Bauman. 'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25502630. |
here we characterized the interactions of 4-mec and 4-meppp with transporters for 5-ht (sert) and dopamine (dat) using molecular, cellular, and whole-animal methods. |
2016-03-29 |
2023-08-13 |
rat |
| Kusumika Saha, John S Partilla, Kurt R Lehner, Amir Seddik, Thomas Stockner, Marion Holy, Walter Sandtner, Gerhard F Ecker, Harald H Sitte, Michael H Bauman. 'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25502630. |
in vitro transporter assays revealed that 4-mec displays unusual 'hybrid' activity as a sert substrate (ie, 5-ht releaser) and dat blocker, whereas 4-meppp is a blocker at both transporters but more potent at dat. |
2016-03-29 |
2023-08-13 |
rat |
| Stefanie C Altieri, Hongyan Yang, Hannah J O'Brien, Hannah M Redwine, Damla Senturk, Julie G Hensler, Anne M Andrew. Perinatal vs genetic programming of serotonin states associated with anxiety. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25523893. |
rodents exposed to serotonin transporter (sert)-inhibiting antidepressants during development show changes in adult emotion-like behavior. |
2016-03-29 |
2023-08-13 |
mouse |
| Stefanie C Altieri, Hongyan Yang, Hannah J O'Brien, Hannah M Redwine, Damla Senturk, Julie G Hensler, Anne M Andrew. Perinatal vs genetic programming of serotonin states associated with anxiety. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25523893. |
adult behavioral changes resulting from early fluoxetine (prozac) exposure were different from those of esc and, although somewhat similar to sert deficiency, were not associated with changes in hippocampal serotonin transmission in late adulthood. |
2016-03-29 |
2023-08-13 |
mouse |
| Justin R Yates, Mahesh Darna, Cassandra D Gipson, Linda P Dwoskin, Michael T Bard. Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency. Behavioural brain research. vol 291. 2016-03-28. PMID:26005123. |
extracellular da and 5-ht concentrations are regulated by da transporters (dat) and 5-ht transporters (sert); thus, these transporters may be important molecular mechanisms underlying individual differences in negative urgency. |
2016-03-28 |
2023-08-13 |
rat |
| Mei-Yan Liu, Yan-Ping Ren, Wan-Lin Wei, Guo-Xiang Tian, Guo L. Changes of Serotonin (5-HT), 5-HT2A Receptor, and 5-HT Transporter in the Sprague-Dawley Rats of Depression, Myocardial Infarction and Myocardial Infarction Co-exist with Depression. Chinese medical journal. vol 128. issue 14. 2016-03-15. PMID:26168831. |
to evaluate whether serotonin (5-ht), 5-ht2a receptor (5-ht2ar), and 5-ht transporter (serotonin transporter [sert]) are associated with different disease states of depression, myocardial infarction (mi) and mi co-exist with depression in sprague-dawley rats. |
2016-03-15 |
2023-08-13 |
rat |
| Jillon S Vander Wa. The Treatment of Night Eating Syndrome: A Review and Theoretical Model. Current obesity reports. vol 3. issue 1. 2016-03-12. PMID:26626475. |
the biobehavioral model proposes that a genetic predisposition, coupled with stress, enhances midbrain serotonin transporter (sert) binding, which results in lower post-synaptic serotonin, dysregulating circadian rhythms and decreasing satiety. |
2016-03-12 |
2023-08-13 |
Not clear |
| Jillon S Vander Wa. The Treatment of Night Eating Syndrome: A Review and Theoretical Model. Current obesity reports. vol 3. issue 1. 2016-03-12. PMID:26626475. |
selective serotonin reuptake inhibitors should therefore decrease sert binding, increase postsynaptic serotonin, and restore circadian function and satiety regulation. |
2016-03-12 |
2023-08-13 |
Not clear |
| Matthew Mazalouskas, Tammy Jessen, Seth Varney, James S Sutcliffe, Jeremy Veenstra-VanderWeele, Edwin H Cook, Ana M D Carneir. Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25684064. |
converging lines of evidence have identified genetic interactions between the serotonin transporter (sert) gene and itgb3, which encodes the β3 subunit that forms the αiibβ3 and αvβ3 integrin receptor complexes. |
2016-03-08 |
2023-08-13 |
mouse |
| Matthew Mazalouskas, Tammy Jessen, Seth Varney, James S Sutcliffe, Jeremy Veenstra-VanderWeele, Edwin H Cook, Ana M D Carneir. Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25684064. |
here we examine the consequences of haploinsufficiency in the mouse integrin β3 subunit gene (itgb3) on sert function and selective 5-hydroxytryptamine (5-ht) reuptake inhibitor (ssri) effectiveness in vivo. |
2016-03-08 |
2023-08-13 |
mouse |
| Matthew Mazalouskas, Tammy Jessen, Seth Varney, James S Sutcliffe, Jeremy Veenstra-VanderWeele, Edwin H Cook, Ana M D Carneir. Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25684064. |
notably, we establish that loss of a single allele of itgb3 in murine neurons is sufficient to decrease 5-ht uptake by sert in midbrain synaptosomes. |
2016-03-08 |
2023-08-13 |
mouse |
| Matthew Mazalouskas, Tammy Jessen, Seth Varney, James S Sutcliffe, Jeremy Veenstra-VanderWeele, Edwin H Cook, Ana M D Carneir. Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25684064. |
these data are consistent with the existence of a subpopulation of serts that are tightly modulated by integrin αvβ3 and significantly contribute to global sert function at 5-ht synapses in the midbrain. |
2016-03-08 |
2023-08-13 |
mouse |
| Boris Mlinar, Alberto Montalbano, Gilda Baccini, Francesca Tatini, Rolando Berlinguer Palmini, Renato Corradett. Nonexocytotic serotonin release tonically suppresses serotonergic neuron activity. The Journal of general physiology. vol 145. issue 3. 2016-03-04. PMID:25712017. |
although it is well established that reuptake of 5-hto is mediated by 5-ht transporters (sert), the release mechanism has remained unclear. |
2016-03-04 |
2023-08-13 |
Not clear |
| Yogesh D Aher, Saraswathi Subramaniyan, Bharanidharan Shanmugasundaram, Ajinkya Sase, Sivaprakasam R Saroja, Marion Holy, Harald Höger, Tetyana Beryozkina, Harald H Sitte, Johann J Leban, Gert Lube. A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System. Frontiers in behavioral neuroscience. vol 10. 2016-03-04. PMID:26941626. |
the efficacy of ce-104 in blocking mat [dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter] was determined using in vitro neurotransmitter uptake assay. |
2016-03-04 |
2023-08-13 |
human |
| Eunkyung Park, Yu Mi Hwang, Min Kyung Chu, Ki-Young Jun. Increased Brainstem Serotonergic Transporter Availability in Adult Migraineurs: an [(18)F]FP-CIT PET Imaging Pilot Study. Nuclear medicine and molecular imaging. vol 50. issue 1. 2016-03-04. PMID:26941862. |
we investigated serotonin transporter (sert) availability in migraineurs using f-18-n-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([(18)f]fp-cit) positron emission tomography (pet). |
2016-03-04 |
2023-08-13 |
Not clear |
| Michiel Alexander de Raaf, Yvet Kroeze, Anthonieke Middelman, Frances S de Man, Helma de Jong, Anton Vonk-Noordegraaf, Chris de Korte, Norbert F Voelkel, Judith Homberg, Harm Jan Bogaar. Serotonin transporter is not required for the development of severe pulmonary hypertension in the Sugen hypoxia rat model. American journal of physiology. Lung cellular and molecular physiology. vol 309. issue 10. 2016-02-25. PMID:26386116. |
an intact serotonin system, which critically depends on a normal function of the serotonin transporter (sert), is required for the development of experimental pulmonary hypertension in rodents exposed to hypoxia or monocrotaline. |
2016-02-25 |
2023-08-13 |
human |
| S E Cremer, N E Zois, S G Moesgaard, N Ravn, S Cirera, J L Honge, M H Smerup, J M Hasenkam, E Sloth, P S Leifsson, T Falk, M A Oyama, C Orton, T Martinussen, L H Olse. Serotonin markers show altered transcription levels in an experimental pig model of mitral regurgitation. Veterinary journal (London, England : 1997). vol 203. issue 2. 2016-02-22. PMID:25599900. |
based on increased tryptophan hydroxylase-1 (tph-1) and decreased serotonin re-uptake transporter (sert) in mmvd-affected valves, increased valvular 5-ht synthesis and decreased clearance have been suggested. |
2016-02-22 |
2023-08-13 |
Not clear |
| Risako Kon, Nobutomo Ikarashi, Akio Hayakawa, Yusuke Haga, Aika Fueki, Yoshiki Kusunoki, Masataka Tajima, Wataru Ochiai, Yoshiaki Machida, Kiyoshi Sugiyam. Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion. Toxicological sciences : an official journal of the Society of Toxicology. vol 145. issue 2. 2016-02-22. PMID:25766885. |
the degree of constipation was analyzed after the combined administration of hgcl(2) (aqp3 inhibitor) or fluoxetine (5-ht reuptake transporter [sert] inhibitor) and morphine. |
2016-02-22 |
2023-08-13 |
rat |