| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nick Van Laeken, Olivia Taylor, Ingeborgh Polis, Sara Neyt, Ken Kersemans, Andre Dobbeleir, Jimmy Saunders, Ingeborg Goethals, Kathelijne Peremans, Filip De Vo. In Vivo Evaluation of Blood Based and Reference Tissue Based PET Quantifications of [11C]DASB in the Canine Brain. PloS one. vol 11. issue 2. 2016-07-19. PMID:26859850. |
this first-in-dog study evaluates the use of the pet-radioligand [11c]dasb to image the density and availability of the serotonin transporter (sert) in the canine brain. |
2016-07-19 |
2023-08-13 |
human |
| Thomas Kirmeier, Ranganath Gopalakrishnan, Vanessa Gormanns, Anna M Werner, Serena Cuboni, Georg C Rudolf, Georg Höfner, Klaus T Wanner, Stephan A Sieber, Ulrike Schmidt, Florian Holsboer, Theo Rein, Felix Hausc. Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores. PloS one. vol 11. issue 2. 2016-07-14. PMID:26863431. |
to control for this, we evaluated the binding parameters of azidobupramine to known target sites such as the transporters for serotonin (sert), norepinephrine (net), and dopamine (dat). |
2016-07-14 |
2023-08-13 |
Not clear |
| Elisabeth Y Bijlsma, Hendrikus Hendriksen, Johanna M P Baas, Mark J Millan, Lucianne Groenin. Lifelong disturbance of serotonin transporter functioning results in fear learning deficits: Reversal by blockade of CRF1 receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 10. 2016-07-12. PMID:26302762. |
to further study the role of the serotonin transporter (sert) in fear learning, classical fear conditioning was studied in sert knockout rats (sert(-/-)) using fear potentiation of the startle reflex. |
2016-07-12 |
2023-08-13 |
rat |
| Elisabeth Y Bijlsma, Hendrikus Hendriksen, Johanna M P Baas, Mark J Millan, Lucianne Groenin. Lifelong disturbance of serotonin transporter functioning results in fear learning deficits: Reversal by blockade of CRF1 receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 10. 2016-07-12. PMID:26302762. |
considering the known interactions between serotonin and corticotropin-releasing factor (crf), we studied the effect of the crfr1 antagonist cp154,526 on behavioral changes observed and determined crf1 receptor levels in sert(-/-) rats. |
2016-07-12 |
2023-08-13 |
rat |
| S Frazer, K Otomo, A Daye. Early-life serotonin dysregulation affects the migration and positioning of cortical interneuron subtypes. Translational psychiatry. vol 5. 2016-07-11. PMID:26393490. |
early-life deficiency of the serotonin transporter (sert) gives rise to a wide range of psychiatric-relevant phenotypes; however, the molecular and cellular targets of serotonin dyregulation during neural circuit formation remain to be identified. |
2016-07-11 |
2023-08-13 |
mouse |
| Lindsey W Young, Emma S Darios, Stephanie W Watt. An immunohistochemical analysis of SERT in the blood-brain barrier of the male rat brain. Histochemistry and cell biology. vol 144. issue 4. 2016-06-29. PMID:26223876. |
because the serotonin transporter (sert) can function bidirectionally, we must consider whether 5-ht can be transported from the bloodstream to the central nervous system (cns) in facilitating the fall in blood pressure. |
2016-06-29 |
2023-08-13 |
rat |
| Lindsey W Young, Emma S Darios, Stephanie W Watt. An immunohistochemical analysis of SERT in the blood-brain barrier of the male rat brain. Histochemistry and cell biology. vol 144. issue 4. 2016-06-29. PMID:26223876. |
this requires us to determine whether the bbb of the rat, the species in which we first observed a fall in blood pressure to infused 5-ht, expresses sert. |
2016-06-29 |
2023-08-13 |
rat |
| Lindsey W Young, Emma S Darios, Stephanie W Watt. An immunohistochemical analysis of SERT in the blood-brain barrier of the male rat brain. Histochemistry and cell biology. vol 144. issue 4. 2016-06-29. PMID:26223876. |
the expression of sert in the rat bbb means that 5-ht entry into the cns must be considered a potential mechanism when investigating 5-ht-induced fall in blood pressure. |
2016-06-29 |
2023-08-13 |
rat |
| Sook Wah Yee, Lawrence Lin, Matthew Merski, Michael J Keiser, Aakash Gupta, Youcai Zhang, Huan-Chieh Chien, Brian K Shoichet, Kathleen M Giacomin. Prediction and validation of enzyme and transporter off-targets for metformin. Journal of pharmacokinetics and pharmacodynamics. vol 42. issue 5. 2016-06-27. PMID:26335661. |
the effects of metformin on histamine and serotonin uptake were evaluated in cell lines overexpressing several amine transporters (oct1, oct3 and sert). |
2016-06-27 |
2023-08-13 |
Not clear |
| Sook Wah Yee, Lawrence Lin, Matthew Merski, Michael J Keiser, Aakash Gupta, Youcai Zhang, Huan-Chieh Chien, Brian K Shoichet, Kathleen M Giacomin. Prediction and validation of enzyme and transporter off-targets for metformin. Journal of pharmacokinetics and pharmacodynamics. vol 42. issue 5. 2016-06-27. PMID:26335661. |
metformin inhibited histamine and serotonin uptake by oct1, oct3 and sert in a dose-dependent manner, with oct1-mediated amine uptake being most potently inhibited (ic50 = 1.5 mm). |
2016-06-27 |
2023-08-13 |
Not clear |
| Steven C Leiser, Deborah Iglesias-Bregna, Ligia Westrich, Alan L Pehrson, Connie Sanche. Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism. Journal of psychopharmacology (Oxford, England). vol 29. issue 10. 2016-06-23. PMID:26174134. |
vortioxetine, a multimodal antidepressant acting through serotonin (5-ht) transporter (sert) inhibition, 5-ht3, 5-ht7 and 5-ht1d receptor antagonism, 5-ht1b receptor partial agonism, and 5-ht1a receptor agonism, had fewer incidences of sleep-related adverse events reported in depressed patients. |
2016-06-23 |
2023-08-13 |
human |
| Evan M Green, Jonathan A Coleman, Eric Gouau. Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation. PloS one. vol 10. issue 12. 2016-06-23. PMID:26695939. |
modulation of serotonergic signaling occurs, in part, by uptake of the transmitter by the serotonin transporter (sert). |
2016-06-23 |
2023-08-13 |
human |
| Evan M Green, Jonathan A Coleman, Eric Gouau. Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation. PloS one. vol 10. issue 12. 2016-06-23. PMID:26695939. |
in the brain, sert is the target for numerous antidepressants including tricyclic antidepressants and selective serotonin reuptake inhibitors (ssris). |
2016-06-23 |
2023-08-13 |
human |
| Kadri Andre, Olli Kampman, Ari Illi, Merja Viikki, Eija Setälä-Soikkeli, Nina Mononen, Terho Lehtimäki, Susann Haraldsson, Pasi A Koivisto, Esa Leinone. SERT and NET polymorphisms, temperament and antidepressant response. Nordic journal of psychiatry. vol 69. issue 7. 2016-06-22. PMID:25739526. |
the genetic variations in norepinephrine transporter (net) and serotonin transporter (sert) genes have been associated with personality traits, several psychiatric disorders and the efficacy of antidepressant treatment. |
2016-06-22 |
2023-08-13 |
Not clear |
| Hyun-Jung Park, Hyun-Soo Shim, Kyungeh An, Angela Starkweather, Kyung Soo Kim, Insop Shi. IL-4 Inhibits IL-1β-Induced Depressive-Like Behavior and Central Neurotransmitter Alterations. Mediators of inflammation. vol 2015. 2016-06-21. PMID:26417153. |
also, il-4 reduced il-1β-induced 5-ht levels by inhibiting tryptophan hydroxylase (tph) mrna and activating serotonin transporter (sert) in the hippocampus, and levels of ne were increased by activating tyrosine hydroxylase (th) mrna expression. |
2016-06-21 |
2023-08-13 |
rat |
| L R Cataldo, V A Cortés, M L Mizgier, E Aranda, D Mezzano, P Olmos, J E Galgani, J Suazo, J L Santo. Fluoxetine impairs insulin secretion without modifying extracellular serotonin levels in MIN6 β-cells. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 123. issue 8. 2016-06-20. PMID:26011169. |
however, it is unknown whether this effect results from changes in extracellular 5ht concentration owed to the blockade of 5ht transporter (sert) or from non-5ht dependent actions. |
2016-06-20 |
2023-08-13 |
Not clear |
| L R Cataldo, V A Cortés, M L Mizgier, E Aranda, D Mezzano, P Olmos, J E Galgani, J Suazo, J L Santo. Fluoxetine impairs insulin secretion without modifying extracellular serotonin levels in MIN6 β-cells. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 123. issue 8. 2016-06-20. PMID:26011169. |
the aims of this work were: 1) to quantify extracellular 5ht levels and gsis in β-cell lines, 2) to determine whether extracellular 5ht levels and gsis are changed by fluoxetine or 5-hydroxytryptophan (5htp, the immediate 5ht biosynthetic precursor), and 3) to quantify the expression of slc6a4 gene (encoding sert) in β-cell lines in relation to other genes involved in 5ht system. |
2016-06-20 |
2023-08-13 |
Not clear |
| Fabio Del Bello, Farhana Sakloth, John S Partilla, Michael H Baumann, Richard A Glenno. Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine. Bioorganic & medicinal chemistry. vol 23. issue 17. 2016-06-20. PMID:26233799. |
here, we prepared n-methyl-(3,4-ethylenedioxyphenyl)-2-aminopropane (edma; 3), both of its optical isomers, and β-keto edma (i.e., edmc; 4) to examine their effects at transporters for serotonin (sert), dopamine (dat), and norepinephrine (net). |
2016-06-20 |
2023-08-13 |
Not clear |
| Nathan C Mitchell, Wouter Koek, Lynette C Daw. Antidepressant-like effects and basal immobility depend on age and serotonin transporter genotype. Genes, brain, and behavior. vol 14. issue 7. 2016-06-17. PMID:26250357. |
two factors that are commonly linked to clinical outcome are age and serotonin transporter (sert) genotype. |
2016-06-17 |
2023-08-13 |
mouse |
| Fabienne Gourand, Nahid Amini, Zhisheng Jia, Sharon Stone-Elander, Denis Guilloteau, Louisa Barré, Christer Halldi. [11C]MADAM Used as a Model for Understanding the Radiometabolism of Diphenyl Sulfide Radioligands for Positron Emission Tomography (PET). PloS one. vol 10. issue 9. 2016-06-17. PMID:26367261. |
diphenyl sulfide compounds are promising pet and spect radioligands for in vivo quantification of the serotonin transporter (sert) and it is therefore important to investigate their radiometabolism. |
2016-06-17 |
2023-08-13 |
human |