| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C L Muller, A M J Anacker, J Veenstra-VanderWeel. The serotonin system in autism spectrum disorder: From biomarker to animal models. Neuroscience. vol 321. 2016-12-13. PMID:26577932. |
a knock-in mouse model of one of these variants, sert gly56ala, recapitulates the hyperserotonemia biomarker and shows increased brain serotonin clearance, increased serotonin receptor sensitivity, and altered social, communication, and repetitive behaviors. |
2016-12-13 |
2023-08-13 |
mouse |
| I-Hsun Li, Kuo-Hsing Ma, Tzu-Jen Kao, Yang-Yi Lin, Shao-Ju Weng, Ting-Yin Yen, Lih-Chi Chen, Yuahn-Sieh Huan. Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine ('ecstasy')-induced serotonergic neurotoxicity. Neurotoxicology. vol 52. 2016-12-13. PMID:26610922. |
in addition, mdma-induced autophagy activation in cultured serotonergic neurons might be mediated by serotonin transporter (sert). |
2016-12-13 |
2023-08-13 |
rat |
| M Andreas B Larsen, Per Plenge, Jacob Andersen, Jonas N N Eildal, Anders S Kristensen, Klaus P Bøgesø, Ulrik Gether, Kristian Strømgaard, Benny Bang-Andersen, Claus J Lolan. Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter. British journal of pharmacology. vol 173. issue 5. 2016-12-13. PMID:26699847. |
the 5-ht transporter (sert) is a target for antidepressant drugs. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jessica A Waller, Fenghua Chen, Connie Sánche. Vortioxetine promotes maturation of dendritic spines in vitro: A comparative study in hippocampal cultures. Neuropharmacology. vol 103. 2016-12-13. PMID:26702943. |
the multimodal-acting antidepressant vortioxetine is an antagonist at 5-ht3, 5-ht7, and 5-ht1d receptors, a partial agonist at 5-ht1b receptors, an agonist at 5-ht1a receptors, and an inhibitor of the serotonin (5-ht) transporter (sert) and has pro-cognitive properties. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yuan-Hwa Chou, Jiing-Feng Lirng, Wen-Chi Hsieh, Yen-Chen Chiu, Yi-An Tu, Shyh-Jen Wan. Neither cortisol nor brain-derived neurotrophic factor is associated with serotonin transporter in bipolar disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 2. 2016-12-13. PMID:26706694. |
the aim of this study was to examine the interaction of cortisol and bdnf on serotonin transporter (sert) in bipolar disorder (bd). |
2016-12-13 |
2023-08-13 |
human |
| Blake A Hutsell, Michael H Baumann, John S Partilla, Matthew L Banks, Rakesh Vekariya, Richard A Glennon, S Stevens Negu. Abuse-related neurochemical and behavioral effects of cathinone and 4-methylcathinone stereoisomers in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 2. 2016-12-13. PMID:26738428. |
for neurochemical studies, drug effects were evaluated on monoamine release through dopamine, norepinephrine, and serotonin transporters (dat, net and sert, respectively) in rat brain synaptosomes. |
2016-12-13 |
2023-08-13 |
rat |
| b' Jan Vevera, Karel Vale\\xc5\\xa1, Zden\\xc4\\x9bk Fi\\xc5\\xa1ar, Jana Hroudov\\xc3\\xa1, Namrata Singh, Ale\\xc5\\xa1 Stuchl\\xc3\\xadk, Petr Ka\\xc4\\x8der, Tereza Nekov\\xc3\\xa1\\xc5\\x99ov\\xc3\\xa. The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model. Physiology & behavior. vol 158. 2016-12-13. PMID:26917054.' |
we demonstrated: 1) a decrease in both serotonin transporter (sert) activity and membrane microviscosity after treatment with simvastatin, 2) lower cholesterol content in all tested brain regions in animals from the simvastatin treated group, and 3) longer time spent in the open arms and a higher number of entrances to the closed arms in the elevated plus maze by animals from the simvastatin group compared to animals from the control group, but no differences in behavior in the open field test. |
2016-12-13 |
2023-08-13 |
rat |
| Yuan-Wei Zhang, Benjamin E Turk, Gary Rudnic. Control of serotonin transporter phosphorylation by conformational state. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 20. 2016-12-13. PMID:27140629. |
serotonin transporter (sert) is responsible for reuptake and recycling of 5-hydroxytryptamine (5-ht; serotonin) after its exocytotic release during neurotransmission. |
2016-12-13 |
2023-08-13 |
human |
| Yuan-Wei Zhang, Benjamin E Turk, Gary Rudnic. Control of serotonin transporter phosphorylation by conformational state. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 20. 2016-12-13. PMID:27140629. |
using membranes from hela cells expressing sert and intact rat basophilic leukemia cells, we show that agents such as na(+) and cocaine that stabilize outward-open conformations of sert decreased phosphorylation and agents that stabilize inward-open conformations (e.g., 5-ht, ibogaine) increased phosphorylation. |
2016-12-13 |
2023-08-13 |
human |
| Yuan-Wei Zhang, Benjamin E Turk, Gary Rudnic. Control of serotonin transporter phosphorylation by conformational state. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 20. 2016-12-13. PMID:27140629. |
the results are consistent with a mechanism of sert regulation that is activated by the transport of 5-ht, which increases the level of inward-open sert and may lead to unwinding of the tm5 helix to allow phosphorylation. |
2016-12-13 |
2023-08-13 |
human |
| A Ferrés-Coy, M Galofré, F Pilar-Cuéllar, R Vidal, V Paz, E Ruiz-Bronchal, L Campa, Á Pazos, J R Caso, J C Leza, G Alvarado, A Montefeltro, E M Valdizán, F Artigas, A Bortolozz. Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration. Molecular psychiatry. vol 21. issue 3. 2016-11-14. PMID:26100539. |
major depression brings about a heavy socio-economic burden worldwide due to its high prevalence and the low efficacy of antidepressant drugs, mostly inhibiting the serotonin transporter (sert). |
2016-11-14 |
2023-08-13 |
mouse |
| Yicong Li, Anthonya Cooper, Imelda N Odibo, Asli Ahmed, Pamela Murphy, Ruston Koonce, Nafisa K Dajani, Curtis L Lowery, Drucilla J Roberts, Luc Maroteaux, Fusun Kili. Discrepancy in Insulin Regulation between Gestational Diabetes Mellitus (GDM) Platelets and Placenta. The Journal of biological chemistry. vol 291. issue 18. 2016-11-10. PMID:26921319. |
earlier findings have identified the requirement of insulin signaling on maturation and the translocation of serotonin (5-ht) transporter, sert to the plasma membrane of the trophoblast in placenta. |
2016-11-10 |
2023-08-13 |
human |
| Yicong Li, Anthonya Cooper, Imelda N Odibo, Asli Ahmed, Pamela Murphy, Ruston Koonce, Nafisa K Dajani, Curtis L Lowery, Drucilla J Roberts, Luc Maroteaux, Fusun Kili. Discrepancy in Insulin Regulation between Gestational Diabetes Mellitus (GDM) Platelets and Placenta. The Journal of biological chemistry. vol 291. issue 18. 2016-11-10. PMID:26921319. |
the maternal blood and the placentas were obtained at the time of cesarean section from the gdm and non-diabetic subjects (n = 6 for each group), and the platelets and trophoblasts were isolated to determine the ir activity, surface level of sert, and their 5-ht uptake rates.interestingly, no significant differences were evident in ir tyrosine phosphorylation or the downstream elements, akt and s6k in platelets and their aggregation rates in both groups. |
2016-11-10 |
2023-08-13 |
human |
| Yicong Li, Anthonya Cooper, Imelda N Odibo, Asli Ahmed, Pamela Murphy, Ruston Koonce, Nafisa K Dajani, Curtis L Lowery, Drucilla J Roberts, Luc Maroteaux, Fusun Kili. Discrepancy in Insulin Regulation between Gestational Diabetes Mellitus (GDM) Platelets and Placenta. The Journal of biological chemistry. vol 291. issue 18. 2016-11-10. PMID:26921319. |
similarly, the 5-ht uptake rates of gdm-trophoblast and the sert expression on their surface were severalfold lower compared with control subjects. |
2016-11-10 |
2023-08-13 |
human |
| Rui Zhao, Shoubao Wang, Zhonglin Huang, Li Zhang, Xiuying Yang, Xiaoyu Bai, Dan Zhou, Zhizhen Qin, Guanhua D. Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor. Bioscience trends. vol 9. issue 6. 2016-11-04. PMID:26781794. |
serotonin transporter (sert) is a critical determinant of synaptic serotonin (5-hydroxytryptamine, 5-ht) inactivation which plays a critical role in the pathology of depression and other mood disorders. |
2016-11-04 |
2023-08-13 |
Not clear |
| Rui Zhao, Shoubao Wang, Zhonglin Huang, Li Zhang, Xiuying Yang, Xiaoyu Bai, Dan Zhou, Zhizhen Qin, Guanhua D. Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor. Bioscience trends. vol 9. issue 6. 2016-11-04. PMID:26781794. |
the 4-(4-(dimethylamino) styryl)-n-methylpyridinium iodide (asp) assay was used to detect dynamic 5-ht uptake as read out of sert activities in rbl-2h3 cells, and cytosol ca(2+) concentrations ([ca(2+)]i) and nitric oxide (no) were examined. |
2016-11-04 |
2023-08-13 |
Not clear |
| Rui Zhao, Shoubao Wang, Zhonglin Huang, Li Zhang, Xiuying Yang, Xiaoyu Bai, Dan Zhou, Zhizhen Qin, Guanhua D. Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor. Bioscience trends. vol 9. issue 6. 2016-11-04. PMID:26781794. |
results showed that 24 h treatment with lps stimulated 5-ht transport and up-regulate plasma membrane distribution of sert in rbl-2h3 cells. |
2016-11-04 |
2023-08-13 |
Not clear |
| Rui Zhao, Shoubao Wang, Zhonglin Huang, Li Zhang, Xiuying Yang, Xiaoyu Bai, Dan Zhou, Zhizhen Qin, Guanhua D. Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor. Bioscience trends. vol 9. issue 6. 2016-11-04. PMID:26781794. |
in conclusion, lps-induced 5-ht uptake and transposition to plasma membrane of sert in rbl-2h3 cells involves camk-ii/inos/pkg-i and p38 mapk activation, which may be partially mediated by a3 adenosine receptor activation. |
2016-11-04 |
2023-08-13 |
Not clear |
| Louis J De Felic. Chloride requirement for monoamine transporters. Pflugers Archiv : European journal of physiology. vol 468. issue 3. 2016-11-04. PMID:26794730. |
this review focuses on the cl(-) requirement for dopamine, serotonin, and norepinephrine (da, 5-ht, and ne) transport and induced current via the transporters for these transmitters, dat, sert, and net. |
2016-11-04 |
2023-08-13 |
Not clear |
| Paola A Spadaro, Helen L Naug, Eugene F DU Toit, Daniel Donner, Natalie J Colso. A refined high carbohydrate diet is associated with changes in the serotonin pathway and visceral obesity. Genetics research. vol 97. 2016-11-01. PMID:26707058. |
real-time pcr was applied to determine any variation in levels of expression of the serotonin (slc6a4 or sert) and dopamine transporter (slc6a3 or dat) genes. |
2016-11-01 |
2023-08-13 |
rat |