| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Sid Topiol, Benny Bang-Andersen, Connie Sanchez, Klaus P B\\xc3\\xb8ges\\xc3\\xb. Exploration of insights, opportunities and caveats provided by the X-ray structures of hSERT. Bioorganic & medicinal chemistry letters. vol 26. issue 20. 2017-08-08. PMID:27624075.' |
consistent with earlier studies of leucine migration at the bacterial homolog of sert, leut, we find multiple potential 'stopover' sites for 5-ht binding at sert including the two (transmembrane s1 and extracellular vestibule s2) seen in the binding of the ssri (s)-citalopram (s-cit) to sert, as well as other sites. |
2017-08-08 |
2023-08-13 |
human |
| M Danielle McDonal. An AOP analysis of selective serotonin reuptake inhibitors (SSRIs) for fish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 197. 2017-07-24. PMID:28288906. |
using an adverse outcome pathway (aop) framework, this review examines the similarities and differences between the mammalian and teleost fish ssri target, the serotonin transporter (sert; slc6a4), and the downstream impacts of elevated extracellular serotonin (5-ht; 5-hydroxytryptamine), the consequence of sert inhibition, on organ systems and physiological processes within teleost fish. |
2017-07-24 |
2023-08-13 |
Not clear |
| Karolina Noworyta-Sokołowska, Katarzyna Kamińska, Grzegorz Kreiner, Zofia Rogóż, Krystyna Gołembiowsk. Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats. Neurotoxicity research. vol 30. issue 4. 2017-07-18. PMID:27461536. |
in vitro data have shown that 5-meo-dipt acts as a potent serotonin transporter (sert) inhibitor and displays high affinity at serotonin 5-ht1a, 5-ht2a, and 5-ht2c receptors. |
2017-07-18 |
2023-08-13 |
rat |
| Karolina Noworyta-Sokołowska, Katarzyna Kamińska, Grzegorz Kreiner, Zofia Rogóż, Krystyna Gołembiowsk. Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats. Neurotoxicity research. vol 30. issue 4. 2017-07-18. PMID:27461536. |
5-meo-dipt increased 5-ht and decreased 5-hiaa tissue content which seems to result from sert inhibition. |
2017-07-18 |
2023-08-13 |
rat |
| Gavin McLaughlin, Noreen Morris, Pierce V Kavanagh, John D Power, Geraldine Dowling, Brendan Twamley, John O'Brien, Brian Talbot, Donna Walther, John S Partilla, Michael H Baumann, Simon D Brand. Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone. Drug testing and analysis. vol 9. issue 3. 2017-07-18. PMID:27524685. |
all three substances were also studied for their uptake and releasing properties at dopamine transporters (dat), norepinephrine transporters (net) and serotonin transporters (sert) using in vitro monoamine transporter assays in rat brain synaptosomes and compared to mephedrone. |
2017-07-18 |
2023-08-13 |
rat |
| S Stevens Negus, Matthew L Bank. Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs. Current topics in behavioral neurosciences. vol 32. 2017-07-11. PMID:27696217. |
many cathinone analogs act as substrates or inhibitors at dopamine, norepinephrine, and serotonin transporters (dat, net, sert, respectively). |
2017-07-11 |
2023-08-13 |
rat |
| Santhanalakshmi Sundaramurthy, Balasubramaniam Annamalai, Devadoss J Samuvel, Toni S Shippenberg, Lankupalle D Jayanthi, Sammanda Ramamoorth. Modulation of serotonin transporter function by kappa-opioid receptor ligands. Neuropharmacology. vol 113. issue Pt A. 2017-07-11. PMID:27743931. |
presynaptic serotonin transporter (sert) activity is critical in the modulation of synaptic 5-ht and, subsequently, in mood disorders. |
2017-07-11 |
2023-08-13 |
Not clear |
| Melissa M Conti, Samantha M Meadows, Mitchell Melikhov-Sosin, David Lindenbach, Joy Hallmark, David F Werner, Christopher Bisho. Monoamine transporter contributions to l-DOPA effects in hemi-parkinsonian rats. Neuropharmacology. vol 110. issue Pt A. 2017-07-10. PMID:27452719. |
serotonin and norepinephrine transporters (sert and net, respectively) have affinity for dopamine uptake especially when dopamine transporters (dat) are scant. |
2017-07-10 |
2023-08-13 |
rat |
| Maurizio S Riga, Connie Sánchez, Pau Celada, Francesc Artiga. Involvement of 5-HT3 receptors in the action of vortioxetine in rat brain: Focus on glutamatergic and GABAergic neurotransmission. Neuropharmacology. vol 108. 2017-07-07. PMID:27106166. |
the antidepressant vortioxetine is a 5-ht3-r, 5-ht7-r and 5-ht1d-r antagonist, 5-ht1b-r partial agonist, 5-ht1a-r agonist, and serotonin (5-ht) transporter (sert) inhibitor. |
2017-07-07 |
2023-08-13 |
rat |
| Eva Latorre, Elena Layunta, Laura Grasa, Marta Castro, Julián Pardo, Fernando Gomollón, Ana I Alcalde, José E Mesoner. Intestinal Serotonin Transporter Inhibition by Toll-Like Receptor 2 Activation. A Feedback Modulation. PloS one. vol 11. issue 12. 2017-07-05. PMID:28033388. |
since the interaction between tlr2 activation and the intestinal serotoninergic system remains non-investigated, our main aim was to analyze the effect of tlr2 on intestinal serotonin transporter (sert) activity and expression and the intracellular pathways involved. |
2017-07-05 |
2023-08-13 |
mouse |
| Eva Latorre, Elena Layunta, Laura Grasa, Marta Castro, Julián Pardo, Fernando Gomollón, Ana I Alcalde, José E Mesoner. Intestinal Serotonin Transporter Inhibition by Toll-Like Receptor 2 Activation. A Feedback Modulation. PloS one. vol 11. issue 12. 2017-07-05. PMID:28033388. |
caco-2/tc7 cells were used to analyze sert and tlr2 molecular expression and sert activity by measuring 5-ht uptake. |
2017-07-05 |
2023-08-13 |
mouse |
| Xu Deng, Yi-Jing Wu, Ying-Peng Chen, Hong-Hong Zheng, Zhong-Ping Wang, Yan Zhu, Xiu-Mei Gao, Yan-Tong Xu, Hong-Hua W. Nardonaphthalenones A and B from the roots and rhizomes of Nardostachys chinensis Batal. Bioorganic & medicinal chemistry letters. vol 27. issue 4. 2017-07-04. PMID:28094186. |
furthermore, the serotonin transporter (sert)-regulating activities of these isolates were evaluated, among them compound 3 showed the strongest enhancement activity while compound 12 showed a moderate inhibition activity on sert. |
2017-07-04 |
2023-08-13 |
Not clear |
| Carina Kern, Fatma Asli Erdem, Ali El-Kasaby, Walter Sandtner, Michael Freissmuth, Sonja Suci. The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter. The Journal of biological chemistry. vol 292. issue 9. 2017-07-04. PMID:28104804. |
the serotonin transporter (sert) and other monoamine transporters operate in either a forward transport mode where the transporter undergoes a full transport cycle or an exchange mode where the transporter seesaws through half-cycles. |
2017-07-04 |
2023-08-13 |
human |
| Mariarosaria Ferraro, Matteo Masetti, Maurizio Recanatini, Andrea Cavalli, Giovanni Bottegon. Mapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular Dynamics. PloS one. vol 11. issue 12. 2017-07-03. PMID:27907003. |
serotonin transporter (sert) modulates serotonergic signaling via re-uptake of serotonin in pre-synaptic cells. |
2017-07-03 |
2023-08-13 |
Not clear |
| Gennaro Pagano, Flavia Niccolini, Paolo Fusar-Poli, Marios Politi. Serotonin transporter in Parkinson's disease: A meta-analysis of positron emission tomography studies. Annals of neurology. vol 81. issue 2. 2017-06-30. PMID:28019672. |
over the past years, a number of pet studies imaging the serotonin transporter (sert) have been used and provided evidence for the key role of serotonergic pathology in patients with parkinson's disease (pd). |
2017-06-30 |
2023-08-13 |
human |
| Dina Popova, Andréas Forsblad, Sanaz Hashemian, Stig O P Jacobsso. Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. PloS one. vol 11. issue 11. 2017-06-26. PMID:27861613. |
the p19-derived neurons express both the serotonin reuptake transporter (sert), that is functionally active, and the serotonin metabolizing enzyme monoamine oxidase a (mao-a). |
2017-06-26 |
2023-08-13 |
mouse |
| Jacob Andersen, Lucy Kate Ladefoged, Trine N Bjerre Kristensen, Lachlan Munro, Julie Grouleff, Nicolai Stuhr-Hansen, Anders S Kristensen, Birgit Schiøtt, Kristian Strømgaar. Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27425420. |
the transporters for the neurotransmitters serotonin and dopamine (sert and dat, respectively) are targets for drugs used in the treatment of mental disorders and widely used drugs of abuse. |
2017-06-21 |
2023-08-13 |
human |
| Jacob Andersen, Lucy Kate Ladefoged, Trine N Bjerre Kristensen, Lachlan Munro, Julie Grouleff, Nicolai Stuhr-Hansen, Anders S Kristensen, Birgit Schiøtt, Kristian Strømgaar. Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27425420. |
we have designed and employed 24 bivalent ligands possessing a highly systematic combination of substrate moieties (serotonin and/or dopamine) and aliphatic or poly(ethylene glycol) spacers to reveal insight into substrate recognition in sert and dat. |
2017-06-21 |
2023-08-13 |
human |
| Jacob Andersen, Lucy Kate Ladefoged, Trine N Bjerre Kristensen, Lachlan Munro, Julie Grouleff, Nicolai Stuhr-Hansen, Anders S Kristensen, Birgit Schiøtt, Kristian Strømgaar. Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27425420. |
an optimized bivalent ligand comprising two serotonin moieties binds sert with 3,800-fold increased affinity compared to that of serotonin, suggesting that the human transporters have two distinct substrate binding sites. |
2017-06-21 |
2023-08-13 |
human |
| Ronald S Oosting, Johnny S W Chan, Berend Olivier, Pradeep Banerje. Vilazodone does not inhibit sexual behavior in male rats in contrast to paroxetine: A role for 5-HT1A receptors? Neuropharmacology. vol 107. 2017-06-19. PMID:27040795. |
in preclinical studies, vlz had significantly lower sexual side effects than ssris and reduced serotonin transporter (sert) levels in forebrain regions. |
2017-06-19 |
2023-08-13 |
rat |