| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher L Muller, Allison Mj Anacker, Tiffany D Rogers, Nick Goeden, Elizabeth H Keller, C Gunnar Forsberg, Travis M Kerr, Carly LA Wender, George M Anderson, Gregg D Stanwood, Randy D Blakely, Alexandre Bonnin, Jeremy Veenstra-VanderWeel. Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 2. 2018-01-05. PMID:27550733. |
maternal sert ala56 genotype was associated with decreased placenta and embryonic forebrain 5-ht levels at e14.5. |
2018-01-05 |
2023-08-13 |
mouse |
| Christopher L Muller, Allison Mj Anacker, Tiffany D Rogers, Nick Goeden, Elizabeth H Keller, C Gunnar Forsberg, Travis M Kerr, Carly LA Wender, George M Anderson, Gregg D Stanwood, Randy D Blakely, Alexandre Bonnin, Jeremy Veenstra-VanderWeel. Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 2. 2018-01-05. PMID:27550733. |
maternal sert ala56 genotype effects on forebrain 5-ht levels were accompanied by a broadening of 5-ht-sensitive thalamocortical axon projections. |
2018-01-05 |
2023-08-13 |
mouse |
| Christopher L Muller, Allison Mj Anacker, Tiffany D Rogers, Nick Goeden, Elizabeth H Keller, C Gunnar Forsberg, Travis M Kerr, Carly LA Wender, George M Anderson, Gregg D Stanwood, Randy D Blakely, Alexandre Bonnin, Jeremy Veenstra-VanderWeel. Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 2. 2018-01-05. PMID:27550733. |
blood 5-ht levels were dynamic across pregnancy and were increased in sert ala56 dams at e14.5. |
2018-01-05 |
2023-08-13 |
mouse |
| Christopher L Muller, Allison Mj Anacker, Tiffany D Rogers, Nick Goeden, Elizabeth H Keller, C Gunnar Forsberg, Travis M Kerr, Carly LA Wender, George M Anderson, Gregg D Stanwood, Randy D Blakely, Alexandre Bonnin, Jeremy Veenstra-VanderWeel. Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 2. 2018-01-05. PMID:27550733. |
collectively, these findings indicate that maternal sert function impacts offspring placental 5-ht levels, forebrain 5-ht levels, and neurodevelopment. |
2018-01-05 |
2023-08-13 |
mouse |
| Alex G Nackenoff, Alexandra B Moussa-Tooks, Austin M McMeekin, Jeremy Veenstra-VanderWeele, Randy D Blakel. Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 7. 2018-01-02. PMID:26514584. |
essential contributions of serotonin transporter inhibition to the acute and chronic actions of fluoxetine and citalopram in the sert met172 mouse. |
2018-01-02 |
2023-08-13 |
mouse |
| Alex G Nackenoff, Alexandra B Moussa-Tooks, Austin M McMeekin, Jeremy Veenstra-VanderWeele, Randy D Blakel. Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 7. 2018-01-02. PMID:26514584. |
although there is much support for 5-ht transporter (sert) antagonism as a basis of antidepressant efficacy, this evidence is indirect and other targets and mechanisms have been proposed. |
2018-01-02 |
2023-08-13 |
mouse |
| Alex G Nackenoff, Alexandra B Moussa-Tooks, Austin M McMeekin, Jeremy Veenstra-VanderWeele, Randy D Blakel. Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 7. 2018-01-02. PMID:26514584. |
in order to distinguish sert-dependent and -independent effects of ssris, we developed a knock-in mouse model whereby high-affinity interactions of many antidepressants at sert have been ablated via knock-in substitution (sert met172) without disrupting 5-ht recognition or uptake. |
2018-01-02 |
2023-08-13 |
mouse |
| Jeong-Hee Kim, Jong-Hoon Kim, Young-Don Son, Yo-Han Joo, Sang-Yoon Lee, Hang-Keun Kim, Myung-Kyun Wo. Altered interregional correlations between serotonin transporter availability and cerebral glucose metabolism in schizophrenia: A high-resolution PET study using [ Schizophrenia research. vol 182. 2018-01-02. PMID:27760700. |
altered interregional correlations between serotonin transporter availability and cerebral glucose metabolism in schizophrenia: a high-resolution pet study using [ the purpose of the present study was to investigate the patterns of interregional correlations of serotonin transporter (sert) availability with glucose metabolism using 7-tesla magnetic resonance imaging (mri) and high-resolution positron emission tomography (pet) with |
2018-01-02 |
2023-08-13 |
Not clear |
| Tae Young Yang, Eun Young Jang, Yeonhee Ryu, Gyu Won Lee, Eun Byeol Lee, Suchan Chang, Jong Han Lee, Jin Suk Koo, Chae Ha Yang, Hee Young Ki. Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus. BMC complementary and alternative medicine. vol 17. issue 1. 2017-12-27. PMID:29228944. |
serotonin transporter (sert) plays an important role in the pathology of anxiety and other mood disorders. |
2017-12-27 |
2023-08-13 |
Not clear |
| Marc Fakhour. Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25823514. |
the 5-ht membrane transporter protein (sert), which helps regulate the serotonergic transmission, is also implicated in mdd and is one of the main targets of antidepressant therapy. |
2017-12-22 |
2023-08-13 |
mouse |
| Marc Fakhour. Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25823514. |
the overarching goal of this review is to present recent findings from studies examining the serotonergic pathway in mdd, with a focus on sert and the serotonin 1a (5-ht1a), serotonin 1b (5-ht1b), and serotonin 2a (5-ht2a) receptors. |
2017-12-22 |
2023-08-13 |
mouse |
| Amir Seddik, Daan P Geerke, Thomas Stockner, Marion Holy, Oliver Kudlacek, Nicholas V Cozzi, Arnold E Ruoho, Harald H Sitte, Gerhard F Ecke. Combined Simulation and Mutation Studies to Elucidate Selectivity of Unsubstituted Amphetamine-like Cathinones at the Dopamine Transporter. Molecular informatics. vol 36. issue 5-6. 2017-12-22. PMID:27860344. |
the dopamine and serotonin transporter proteins (dat, sert) play a vital role in behavior and mental illness. |
2017-12-22 |
2023-08-13 |
Not clear |
| Sivaprakasam R Saroja, Yogesh D Aher, Predrag Kalaba, Nilima Y Aher, Martin Zehl, Volker Korz, Saraswathi Subramaniyan, Andras G Miklosi, Lisa Zanon, Winfried Neuhaus, Harald Höger, Thierry Langer, Ernst Urban, Johann Leban, Gert Lube. A novel heterocyclic compound targeting the dopamine transporter improves performance in the radial arm maze and modulates dopamine receptors D1-D3. Behavioural brain research. vol 312. 2017-12-19. PMID:27288589. |
re-uptake inhibition was tested for dat (ic50=3.2μm), serotonin transporter, sert (ic50=272291μm) and noradrenaline transporter, net (ic50=174μm). |
2017-12-19 |
2023-08-13 |
rat |
| Hidefumi Yoshinaga, Shuji Masumoto, Koji Koyama, Naoya Kinomura, Yuji Matsumoto, Taro Kato, Satoko Baba, Kenji Matsumoto, Tomoko Horisawa, Hitomi Oki, Kazuki Yabuuchi, Toru Kod. Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HT Bioorganic & medicinal chemistry. vol 25. issue 1. 2017-12-19. PMID:27865645. |
discovery of smp-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-ht we report the discovery of a novel benzylpiperidine derivative with serotonin transporter (sert) inhibitory activity and 5-ht |
2017-12-19 |
2023-08-13 |
Not clear |
| Marina Sagud, Matea Nikolac Perkovic, Bjanka Vuksan-Cusa, Anja Maravic, Dubravka Svob Strac, Alma Mihaljevic Peles, Maja Zivkovic, Zorana Kusevic, Nela Piva. A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment. Psychopharmacology. vol 233. issue 17. 2017-12-12. PMID:27356518. |
various antidepressants occupy brain serotonin transporter (sert), decrease platelet serotonin (5-ht) concentration, and normalize reduced plasma brain-derived neurotrophic factor (bdnf) concentrations in depressed patients. |
2017-12-12 |
2023-08-13 |
Not clear |
| Marina Sagud, Matea Nikolac Perkovic, Bjanka Vuksan-Cusa, Anja Maravic, Dubravka Svob Strac, Alma Mihaljevic Peles, Maja Zivkovic, Zorana Kusevic, Nela Piva. A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment. Psychopharmacology. vol 233. issue 17. 2017-12-12. PMID:27356518. |
in addition to sert inhibition, vortioxetine acts via different 5-ht receptors. |
2017-12-12 |
2023-08-13 |
Not clear |
| Mariana G Fronza, Lucimar M Pinto Brod, Angela Maria Casaril, Manoela Sacramento, Diego Alves, Lucielli Savegnag. Computational and biological evidences on the serotonergic involvement of SeTACN antidepressant-like effect in mice. PloS one. vol 12. issue 11. 2017-12-05. PMID:29091968. |
a series of phenylselanyl-1h-1,2,3-triazole-4-carbonitriles with different substituents were screened for their binding affinity with serotonin transporter (sert) and dopamine transporter (dat) by docking molecular. |
2017-12-05 |
2023-08-13 |
mouse |
| Mariana G Fronza, Lucimar M Pinto Brod, Angela Maria Casaril, Manoela Sacramento, Diego Alves, Lucielli Savegnag. Computational and biological evidences on the serotonergic involvement of SeTACN antidepressant-like effect in mice. PloS one. vol 12. issue 11. 2017-12-05. PMID:29091968. |
5-(4methoxyphenyl)-1-(2-(phenylselanyl)phenyl)-1h-1,2,3-triazole-4-carbonitrile (setacn) exhibited the best conformation with sert even higher than fluoxetine and serotonin, suggesting a competitive inhibition. |
2017-12-05 |
2023-08-13 |
mouse |
| S Rzezniczek, M Obuchowicz, W Datka, M Siwek, D Dudek, K Kmiotek, K Oved, N Shomron, D Gurwitz, A Pil. Decreased sensitivity to paroxetine-induced inhibition of peripheral blood mononuclear cell growth in depressed and antidepressant treatment-resistant patients. Translational psychiatry. vol 6. issue 5. 2017-12-04. PMID:27244236. |
ssri-induced inhibition of the growth of peripheral blood mononuclear cells (pbmcs) is mediated via their target, the serotonin transporter (sert). |
2017-12-04 |
2023-08-13 |
human |
| Shyamsunder R Joolakanti, Justin R Nickell, Venumadhav Janganati, Guangrong Zheng, Linda P Dwoskin, Peter A Crook. Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & medicinal chemistry letters. vol 26. issue 10. 2017-11-22. PMID:27080180. |
a series of lobelane and gz-793a analogues that incorporate aromatic 4-hydroxy and 4-(2-fluoroethoxy) substituents were synthesized and evaluated for inhibition of [(3)h]dopamine (da) uptake at the vesicular monoamine transporter-2 (vmat2) and the dopamine transporter (dat), and [(3)h]serotonin uptake at the serotonin transporter (sert). |
2017-11-22 |
2023-08-13 |
Not clear |