| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Felicia Russ. [Full functional recovery in depression treatment. Clinical cases treated with vortioxetina]. Rivista di psichiatria. vol 52. issue 3. 2018-05-30. PMID:28692076. |
a novel antidepressant, with a multimodal mechanism of action that combines the classical inhibition of serotonin transporter (sert) with the modulation of serotonin receptor activity, is vortioxetine. |
2018-05-30 |
2023-08-13 |
Not clear |
| E Jaakkola, J Joutsa, E Mäkinen, J Johansson, V Kaasine. Ventral striatal dopaminergic defect is associated with hallucinations in Parkinson's disease. European journal of neurology. vol 24. issue 11. 2018-05-21. PMID:28834102. |
the aim of this study was to investigate the dopaminergic mechanisms of vhs and specifically whether the degree of striatal dopamine transporter (dat) function or extrastriatal serotonin transporter (sert) function can predict the appearance of vhs in patients with pd. |
2018-05-21 |
2023-08-13 |
Not clear |
| Jenna L N Sprowles, Jillian R Hufgard, Arnold Gutierrez, Rebecca A Bailey, Sarah A Jablonski, Michael T Williams, Charles V Vorhee. Differential effects of perinatal exposure to antidepressants on learning and memory, acoustic startle, anxiety, and open-field activity in Sprague-Dawley rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 61. 2018-05-18. PMID:28655626. |
selective serotonin (5-ht) reuptake inhibitors (ssris) act on the 5-ht transporter (sert) whereas norepinephrine-dopamine reuptake inhibitors (ndris) act on the norepinephrine and dopamine transporters. |
2018-05-18 |
2023-08-13 |
rat |
| Kara Gross Margoli. A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure. Journal of chemical neuroanatomy. vol 83-84. 2018-05-11. PMID:28213183. |
serotonin (5-ht) and the serotonin reuptake transporter (sert) have increasingly been shown to play important roles in both brain and intestinal development and long-term function. |
2018-05-11 |
2023-08-13 |
Not clear |
| Kara Gross Margoli. A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure. Journal of chemical neuroanatomy. vol 83-84. 2018-05-11. PMID:28213183. |
5-ht and sert may thus modulate critical functions in the development and perpetuation of brain-gut axis disease. |
2018-05-11 |
2023-08-13 |
Not clear |
| Kara Gross Margoli. A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure. Journal of chemical neuroanatomy. vol 83-84. 2018-05-11. PMID:28213183. |
we discuss the potential roles of 5-ht and sert in the brain and intestinal manifestations of autism spectrum disorders and developmental antidepressant exposure. |
2018-05-11 |
2023-08-13 |
Not clear |
| Hai-Ying Zhang, Guo-Hua Bi, Hong-Ju Yang, Yi He, Gilbert Xue, Jiajing Cao, Gianluigi Tanda, Eliot L Gardner, Amy Hauck Newman, Zheng-Xiong X. The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 9. 2018-05-09. PMID:28266501. |
although at a concentration of 10 μm, there were many hits for jjc8-016, binding affinities in the range of its dat affinity were only observed at the serotonin transporter (sert), dopamine d |
2018-05-09 |
2023-08-13 |
Not clear |
| Magdalena Sowa-Kućma, Patrycja Pańczyszyn-Trzewik, Paulina Misztak, Rafał R Jaeschke, Katherine Sendek, Krzysztof Styczeń, Wojciech Datka, Magdalena Kopern. Vortioxetine: A review of the pharmacology and clinical profile of the novel antidepressant. Pharmacological reports : PR. vol 69. issue 4. 2018-05-09. PMID:28499187. |
based on its pharmacodynamics profile and preclinical studies, it is believe that the drug's clinical action is mediated mainly by selective blockade of serotonin reuptake (by inhibiting the serotonin transporter [sert]) and direct modulation of 5-ht receptors activity (such as 5-ht |
2018-05-09 |
2023-08-13 |
Not clear |
| Yasmina Martí, Friederike Matthaeus, Thorsten Lau, Patrick Schlos. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Molecular and cellular neurosciences. vol 83. 2018-05-03. PMID:28673772. |
mpp+ is also a high affinity substrate for the serotonin transporter (sert), however little is known about possible toxic effects of mpp+ on serotonergic (5-ht) neurons. |
2018-05-03 |
2023-08-13 |
mouse |
| Yasmina Martí, Friederike Matthaeus, Thorsten Lau, Patrick Schlos. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Molecular and cellular neurosciences. vol 83. 2018-05-03. PMID:28673772. |
most importantly we show that mpp+ induces dat externalization in da neurons, but internalization of sert in 5-ht neurons. |
2018-05-03 |
2023-08-13 |
mouse |
| Anna Czopek, Agnieszka Zagorska, Marcin Kolaczkowski, Adam Bucki, Beata Gryzlo, Joanna Rychtyk, Maciej Pawlowsk, Agata Siwek, Grzegorz Satala, Andrzej Bojarski, Monika Kubacka, Barbara Filipe. NEW SPIROHYDANTOIN DERIVATIVES - SYNTHESIS, PHARMACOLOGICAL EVALUATION, AND MOLECULAR MODELING STUDY. Acta poloniae pharmaceutica. vol 73. issue 6. 2018-05-03. PMID:29634109. |
a series of new arylpiperazinylpropyl derivatives of 8/6-phenyl-1,3-diazaspiro[4.5]decan-2,4-dione and spiro[imidazolidine-4,1'-indene/naphthalene]-2,5-dione was synthesized and their affinity was evaluated toward serotonin 5-htia, 5-ht2a, 5-ht7 receptors, dopaminergic d2, d3 receptors, adrenergic ox, receptors, and serotonin transporter (sert). |
2018-05-03 |
2023-08-13 |
Not clear |
| Lucas V Lima, Josimari M DeSantana, Lynn A Rasmussen, Kathleen A Sluk. Short-duration physical activity prevents the development of activity-induced hyperalgesia through opioid and serotoninergic mechanisms. Pain. vol 158. issue 9. 2018-05-02. PMID:28621702. |
we examined response frequency to mechanical stimulation of the paw, muscle withdrawal thresholds, and expression of phosphorylation of the nr1 subunit of the n-methyl-d-aspartate receptor (p-nr1) and serotonin transporter (sert) in the rvm. |
2018-05-02 |
2023-08-13 |
mouse |
| Maria C Cartolano, Molly H B Amador, Velislava Tzaneva, William K Milsom, M Danielle McDonal. Extrinsic nerves are not involved in branchial 5-HT dynamics or pulsatile urea excretion in Gulf toadfish, Opsanus beta. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 214. 2018-05-02. PMID:28887162. |
nerve sectioning also had no effect on toadfish urea transporter (tut), 5-ht transporter (sert), or 5-ht |
2018-05-02 |
2023-08-13 |
Not clear |
| Abdelrahman R Shalabi, Donna Walther, Michael H Baumann, Richard A Glenno. Deconstructed Analogues of Bupropion Reveal Structural Requirements for Transporter Inhibition versus Substrate-Induced Neurotransmitter Release. ACS chemical neuroscience. vol 8. issue 6. 2018-05-01. PMID:28220701. |
deconstructed analogues of 1 were synthesized and compared for their ability to interact with dat, net, and the serotonin transporter (sert) using in vitro assay methods. |
2018-05-01 |
2023-08-13 |
Not clear |
| Grazyna Rajkowska, Gouri Mahajan, Beata Legutko, Lavanya Challagundla, Michael Griswold, Paul R Albert, Mireille Daigle, Jose J Miguel-Hidalgo, Mark C Austin, Randy D Blakely, David C Steffens, Craig A Stockmeie. Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression. Neuroscience. vol 359. 2018-04-30. PMID:28711621. |
studies of major depressive disorder (mdd) in postmortem brain tissue report enhanced binding to inhibitory serotonin-1a autoreceptors in midbrain dorsal raphe and reductions in length of axons expressing the serotonin transporter (sert) in dorsolateral prefrontal cortex. |
2018-04-30 |
2023-08-13 |
human |
| Grazyna Rajkowska, Gouri Mahajan, Beata Legutko, Lavanya Challagundla, Michael Griswold, Paul R Albert, Mireille Daigle, Jose J Miguel-Hidalgo, Mark C Austin, Randy D Blakely, David C Steffens, Craig A Stockmeie. Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression. Neuroscience. vol 359. 2018-04-30. PMID:28711621. |
greater length of axons expressing sert in younger subjects with mdd may result in a significant deficit in serotonin availability in ofc. |
2018-04-30 |
2023-08-13 |
human |
| Masahiro Yahata, Koji Chiba, Takao Watanabe, Yuichi Sugiyam. Possibility of Predicting Serotonin Transporter Occupancy From the In Vitro Inhibition Constant for Serotonin Transporter, the Clinically Relevant Plasma Concentration of Unbound Drugs, and Their Profiles for Substrates of Transporters. Journal of pharmaceutical sciences. vol 106. issue 9. 2018-04-27. PMID:28501470. |
in this review, we discuss the predictability of serotonin transporter (sert) occupancy in human brain estimated from in vitro k |
2018-04-27 |
2023-08-13 |
human |
| Ekaterina Y Bazhenova, Nadezhda A Sinyakova, Elizabeth A Kulikova, Irina A Kazarinova, Daria V Bazovkina, Raul R Gainetdinov, Alexander V Kuliko. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience letters. vol 653. 2018-04-27. PMID:28579486. |
selective serotonin reuptake inhibitors (ssris) are antidepressants that block serotonin transporter (sert) and increase serotonin (5-ht) level in the synaptic cleft. |
2018-04-27 |
2023-08-13 |
mouse |
| Ekaterina Y Bazhenova, Nadezhda A Sinyakova, Elizabeth A Kulikova, Irina A Kazarinova, Daria V Bazovkina, Raul R Gainetdinov, Alexander V Kuliko. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience letters. vol 653. 2018-04-27. PMID:28579486. |
the interaction between sert and the key enzyme of 5-ht synthesis in the brain, tryptophan hydroxylase 2 (tph2), is essential to maintain the brain 5-ht level. |
2018-04-27 |
2023-08-13 |
mouse |
| Jennifer M Panlilio, Sara Marin, Marissa B Lobl, M Danielle McDonal. Treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response. Scientific reports. vol 6. 2018-04-26. PMID:27499056. |
the selective serotonin reuptake inhibitor (ssri) fluoxetine (flx), the active ingredient of the antidepressant drug prozac, inhibits reuptake of the neurotransmitter, serotonin (5-ht; 5-hydroxytryptamine), into cells by the 5-ht transporter (sert). |
2018-04-26 |
2023-08-13 |
Not clear |