| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brigitte Lavoie, Jane B Lian, Gary M Maw. Regulation of Bone Metabolism by Serotonin. Advances in experimental medicine and biology. vol 1033. 2018-04-26. PMID:29101650. |
osteoblasts, osteoclasts, and osteocytes all have the machinery to synthesize serotonin, and they also express the serotonin-reuptake transporter (sert). |
2018-04-26 |
2023-08-13 |
Not clear |
| Ernesto Solis, John S Partilla, Farhana Sakloth, Iwona Ruchala, Kathryn L Schwienteck, Louis J De Felice, Jose M Eltit, Richard A Glennon, S Stevens Negus, Michael H Bauman. N-Alkylated Analogs of 4-Methylamphetamine (4-MA) Differentially Affect Monoamine Transporters and Abuse Liability. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 10. 2018-04-24. PMID:28530234. |
clandestine chemists synthesize novel stimulant drugs by exploiting structural templates known to target monoamine transporters for dopamine, norepinephrine, and serotonin (dat, net, and sert, respectively). |
2018-04-24 |
2023-08-13 |
rat |
| Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakel. Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. British journal of pharmacology. vol 174. issue 16. 2018-04-23. PMID:28585320. |
to elucidate 5-ht transporter (sert)-specific contributions to cocaine action, we evaluated cocaine effects in the sert met172 knock-in mouse, which expresses a sert coding substitution that eliminates high-affinity cocaine recognition. |
2018-04-23 |
2023-08-13 |
mouse |
| C-B Yeh, S-J Weng, K-W Chang, J Y-H Chan, S-M Huang, T-H Chu, N-K Wei, H-S Ma, J-T Cheng, K-H Ma, T-H Chen, J-F Shy. Calcitonin alleviates hyperalgesia in osteoporotic rats by modulating serotonin transporter activity. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. vol 27. issue 11. 2018-04-17. PMID:27260496. |
this suggests that the anti-nociceptive effects of calcitonin in the treatment of osteoporosis may be mediated by alterations in neural serotonin transporter (sert) activity. |
2018-04-17 |
2023-08-13 |
rat |
| Jia Zhang, Yan Fan, Muhammad U Raza, Yanqiang Zhan, Xiang-Dong Du, Paresh D Patel, Meng-Yang Zh. The regulation of corticosteroid receptors in response to chronic social defeat. Neurochemistry international. vol 108. 2018-04-13. PMID:28577990. |
our previous studies demonstrated that chronic social defeat (csd) up-regulated expression of the serotonin transporter (sert) and norepinephrine transporter (net) in the brain, which was mediated by corticosteroid receptors. |
2018-04-13 |
2023-08-13 |
Not clear |
| Mustapha Riad, Antonia Kobert, Laurent Descarries, Sandra Boye, Pierre-Paul Rompré, Jean-Claude Lacaill. Chronic fluoxetine rescues changes in plasma membrane density of 5-HT1A autoreceptors and serotonin transporters in the olfactory bulbectomy rodent model of depression. Neuroscience. vol 356. 2018-04-12. PMID:28528967. |
the serotonin transporter (sert) and 5-ht1a auto-receptors act in concert to ensure homeostasis of serotonin (5-ht) neurotransmission and regulation of their cell surface expression represent efficient mechanisms to maintain this homeostasis. |
2018-04-12 |
2023-08-13 |
rat |
| Mustapha Riad, Antonia Kobert, Laurent Descarries, Sandra Boye, Pierre-Paul Rompré, Jean-Claude Lacaill. Chronic fluoxetine rescues changes in plasma membrane density of 5-HT1A autoreceptors and serotonin transporters in the olfactory bulbectomy rodent model of depression. Neuroscience. vol 356. 2018-04-12. PMID:28528967. |
thus, we investigated the changes in the subcellular distribution of sert and 5-ht1a receptors (5-ht1ar) in the rat olfactory bulbectomy model of depression using immuno-gold labeling and electron microscopy, and examined the effect of chronic treatment with the antidepressant, fluoxetine, a serotonin reuptake inhibitor, on the subcellular distribution of sert and 5-ht1ar. |
2018-04-12 |
2023-08-13 |
rat |
| Suraj Adhikary, Daniel J Deredge, Anu Nagarajan, Lucy R Forrest, Patrick L Wintrode, Satinder K Sing. Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 10. 2018-04-10. PMID:28223522. |
the symporters for the biogenic amines serotonin (sert), dopamine (dat), and norepinephrine (net) are targets of multiple psychoactive agents, and their dysfunction has been implicated in numerous neuropsychiatric ailments. |
2018-04-10 |
2023-08-13 |
Not clear |
| Qiang Lu, Suguru Komenoi, Takako Usuki, Daisuke Takahashi, Fumio Sakan. Abnormalities of the serotonergic system in diacylglycerol kinase δ-deficient mouse brain. Biochemical and biophysical research communications. vol 497. issue 4. 2018-04-10. PMID:29486157. |
we previously reported that brain-specific diacylglycerol kinase (dgk) δ-knockout (ko) mice showed obsessive-compulsive disorder (ocd)-like behaviors, which were alleviated by a serotonin (5-ht) transporter (sert) inhibitor. |
2018-04-10 |
2023-08-13 |
mouse |
| D A Nikishin, N M Alyoshina, Y B Shmukle. Synthesis and Membrane Transport of Serotonin in the Developing Ovarian Follicle of Mouse. Doklady. Biochemistry and biophysics. vol 478. issue 1. 2018-04-09. PMID:29536299. |
the membrane serotonin transporter sert is expressed in follicular cells and oocytes. |
2018-04-09 |
2023-08-13 |
mouse |
| Ismail Erol, Busecan Aksoydan, Isik Kantarcioglu, Ramin E Salmas, Serdar Durdag. Identification of novel serotonin reuptake inhibitors targeting central and allosteric binding sites: A virtual screening and molecular dynamics simulations study. Journal of molecular graphics & modelling. vol 74. 2018-03-21. PMID:28499269. |
the serotonin (5-hydroxytryptamine, 5ht) transporter (sert) is a member of neurotransmitter sodium symporter (nss) family, which maintains neurotransmitter by reuptaking 5ht into synapses. |
2018-03-21 |
2023-08-13 |
Not clear |
| Chieh Chang, Susan Shur-Fen Gau, Wen-Sheng Huang, Chyng-Yann Shiue, Chin-Bin Ye. Abnormal serotonin transporter availability in the brains of adults with conduct disorder. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 116. issue 6. 2018-03-07. PMID:27771175. |
the aims of the current study were to determine whether patients with conduct disorder (cd) showed an abnormal availability of serotonin reuptake transporter (sert), and if their hyperkinetic symptoms, impulsivity, and quality of life were correlated with the availability of sert. |
2018-03-07 |
2023-08-13 |
Not clear |
| Jasmine I Caulfield, Michael J Caruso, Kerry C Michael, Rebecca A Bourne, Nicole R Chirichella, Laura C Klein, Timothy Craig, Robert H Bonneau, Avery August, Sonia A Cavigell. Peri-adolescent asthma symptoms cause adult anxiety-related behavior and neurobiological processes in mice. Behavioural brain research. vol 326. 2018-03-07. PMID:28284954. |
compared to controls, mice that experienced methacholine-induced labored breathing during adolescence displayed a ∼20% decrease in time on open arms of the elevated plus maze in early adulthood (p60), a ∼30% decrease in brainstem serotonin transporter (sert) mrna expression and a ∼50% increase in hippocampal serotonin receptor 1a (5htr1a) and corticotropin releasing hormone receptor 1 (crhr1) expression in adulthood (p75). |
2018-03-07 |
2023-08-13 |
mouse |
| Alfredo Menese. Frameworking memory and serotonergic markers. Reviews in the neurosciences. vol 28. issue 5. 2018-03-05. PMID:28343185. |
serotonin (5-hydroxytryptamine [5-ht]) has multiple pharmacological tools, well-characterized downstream signaling in mammals' species, and established 5-ht neural markers showing new insights about memory functions and dysfunctions, including receptors (5-ht1a/1b/1d, 5-ht2a/2b/2c, and 5-ht3-7), transporter (serotonin transporter [sert]) and volume transmission present in brain areas involved in memory. |
2018-03-05 |
2023-08-13 |
Not clear |
| William D Gwynne, Robin M Hallett, Adele Girgis-Gabardo, Bojana Bojovic, Anna Dvorkin-Gheva, Craig Aarts, Kay Dias, Anita Bane, John A Hassel. Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts. Oncotarget. vol 8. issue 19. 2018-03-05. PMID:28404880. |
notably, inhibitors of tryptophan hydroxylase 1 (tph1), required for 5-ht biosynthesis in select non-neuronal cells, the serotonin reuptake transporter (sert) and several 5-ht receptors compromised btic activity as assessed by functional sphere-forming assays. |
2018-03-05 |
2023-08-13 |
mouse |
| William D Gwynne, Robin M Hallett, Adele Girgis-Gabardo, Bojana Bojovic, Anna Dvorkin-Gheva, Craig Aarts, Kay Dias, Anita Bane, John A Hassel. Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts. Oncotarget. vol 8. issue 19. 2018-03-05. PMID:28404880. |
consistent with these findings, human breast tumor cells express tph1, 5-ht and sert independent of their molecular or clinical subtype. |
2018-03-05 |
2023-08-13 |
mouse |
| G Gryglewski, L Rischka, C Philippe, A Hahn, G M James, E Klebermass, M Hienert, L Silberbauer, T Vanicek, A Kautzky, N Berroterán-Infante, L Nics, T Traub-Weidinger, M Mitterhauser, W Wadsak, M Hacker, S Kasper, R Lanzenberge. Simple and rapid quantification of serotonin transporter binding using [ NeuroImage. vol 149. 2018-02-27. PMID:28119137. |
simple and rapid quantification of serotonin transporter binding using [ in-vivo quantification of serotonin transporters (sert) in human brain has been a mainstay of molecular imaging in the field of neuropsychiatric disorders and helped to explore the underpinnings of several medical conditions, therapeutic and environmental influences. |
2018-02-27 |
2023-08-13 |
human |
| Rebecca L Brindley, Mary Beth Bauer, Randy D Blakely, Kevin P M Curri. An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:27544824. |
an interplay between the serotonin transporter (sert) and 5-ht receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells. |
2018-02-22 |
2023-08-13 |
mouse |
| Rebecca L Brindley, Mary Beth Bauer, Randy D Blakely, Kevin P M Curri. An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:27544824. |
although accs do not synthesize 5-ht, they express the serotonin transporter (sert). |
2018-02-22 |
2023-08-13 |
mouse |
| Rebecca L Brindley, Mary Beth Bauer, Randy D Blakely, Kevin P M Curri. An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:27544824. |
adrenal glands from wild-type mice contained 5-ht at ≈ 750 fold lower abundance than adrenaline, and in sert(-/-) mice this was reduced by ≈80% with no change in catecholamines. |
2018-02-22 |
2023-08-13 |
mouse |