| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rheaclare Fraser-Spears, Anwen M Krause-Heuer, Mohamed Basiouny, Felix P Mayer, Retrouvailles Manishimwe, Naomi A Wyatt, Jeremy C Dobrowolski, Maxine P Roberts, Ivan Greguric, Naresh Kumar, Wouter Koek, Harald H Sitte, Paul D Callaghan, Benjamin H Fraser, Lynette C Daw. Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter. European journal of pharmacology. vol 842. 2019-02-04. PMID:30473490. |
here, we extend these findings to determine the affinity of these analogs for oct2, oct3 and pmat, as well as serotonin, norepinephrine and dopamine transporters (sert, net and dat) using a combination of uptake competition with [ |
2019-02-04 |
2023-08-13 |
mouse |
| Tatiana Bregman, Christina Nona, Julien Volle, Mustansir Diwan, Roger Raymond, Paul J Fletcher, José N Nobrega, Clement Haman. Deep brain stimulation induces antidepressant-like effects in serotonin transporter knockout mice. Brain stimulation. vol 11. issue 2. 2019-01-28. PMID:29174865. |
this is largely different from selective serotonin reuptake inhibitors (ssris), which increase serotonin (5-ht) levels by inhibiting the serotonin transporter (sert). |
2019-01-28 |
2023-08-13 |
mouse |
| Tatiana Bregman, Christina Nona, Julien Volle, Mustansir Diwan, Roger Raymond, Paul J Fletcher, José N Nobrega, Clement Haman. Deep brain stimulation induces antidepressant-like effects in serotonin transporter knockout mice. Brain stimulation. vol 11. issue 2. 2019-01-28. PMID:29174865. |
ssris have limited efficacy when given to sert knockout (ko) mice, or patients with mutations in the serotonin transporter promoter gene (5-httlpr). |
2019-01-28 |
2023-08-13 |
mouse |
| Masaya Asano, Serika Motoike, Chika Yokota, Naoto Usuki, Hikaru Yamamoto, Tomoaki Urabe, Kazusa Katarao, Izumi Hide, Shigeru Tanaka, Masashi Kawamoto, Masahiro Irifune, Norio Saka. SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism. Journal of pharmacological sciences. vol 139. issue 1. 2019-01-24. PMID:30522963. |
the serotonin transporter (sert) is functionally regulated via membrane trafficking. |
2019-01-24 |
2023-08-13 |
Not clear |
| Claudio D'Addario, Maria Carlotta Palazzo, Beatrice Benatti, Benedetta Grancini, Mariangela Pucci, Andrea Di Francesco, Giulia Camuri, Daniela Galimberti, Chiara Fenoglio, Elio Scarpini, A Carlo Altamura, Mauro Maccarrone, Bernardo Dell'Oss. Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor. Progress in neuro-psychopharmacology & biological psychiatry. vol 82. 2019-01-22. PMID:28830794. |
catechol-o-methyltransferase (comt), glutamate decarboxylase (gad67), serotonin transporter (sert) mrna levels remained unaltered. |
2019-01-22 |
2023-08-13 |
human |
| N Hlavacova, Y Li, A Pehrson, C Sanchez, I Bermudez, A Csanova, D Jezova, M Frankli. Effects of vortioxetine on biomarkers associated with glutamatergic activity in an SSRI insensitive model of depression in female rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 82. 2019-01-22. PMID:29269186. |
the aim of this study was to investigate the antidepressant activity of vortioxetine in a tryptophan (trp) depletion female rat model of depression and compare it to that of paroxetine using doses that fully occupy the serotonin transporter (sert). |
2019-01-22 |
2023-08-13 |
rat |
| Wei-Tsung Kao, Chen-Lin Chang, For-Wey Lun. 5-HTT mRNA level as a potential biomarker of treatment response in patients with major depression in a clinical trial. Journal of affective disorders. vol 238. 2019-01-22. PMID:29957477. |
to investigate whether the serotonin transporter (5-htt or sert or slc6a4) mrna level could be used as a biomarker of treatment response in patients with major depression treated with different antidepressants while controlling related factors. |
2019-01-22 |
2023-08-13 |
Not clear |
| Qiong-Yan Shao, Fei You, Yong-Hua Zhang, Lin-Lin Hu, Wen-Juan Liu, Yi Liu, Jing Li, Sheng-Dong Wang, Ming-Fen Son. CSF miR-16 expression and its association with miR-16 and serotonin transporter in the raphe of a rat model of depression. Journal of affective disorders. vol 238. 2019-01-22. PMID:29957478. |
here we reported the cerebrospinal fluid (csf) mir-16 expression and its association with mir-16 and serotonin transporter (sert) in the raphe of a rat model of depression. |
2019-01-22 |
2023-08-13 |
rat |
| Jarosław Walory, Lidia Mielczarek, Małgorzata Jarończyk, Mirosława Koronkiewicz, Jerzy Kossakowski, Ryszard Bugno, Andrzej J Bojarski, Zdzisław Chilmonczy. Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT International journal of molecular sciences. vol 19. issue 10. 2019-01-15. PMID:30347827. |
oncotoxic properties of serotonin transporter inhibitors and 5-ht the cytotoxic activity of several serotonin transporter (sert) inhibitors and subtype of serotonin receptor 1a (5-ht |
2019-01-15 |
2023-08-13 |
Not clear |
| Gabriel Núñez-Vivanco, Angélica Fierro, Pablo Moya, Patricio Iturriaga-Vásquez, Miguel Reyes-Parad. 3D similarities between the binding sites of monoaminergic target proteins. PloS one. vol 13. issue 7. 2019-01-11. PMID:30028869. |
in this work, we evaluated the possible existence of similarities among the binding sites of the serotonin transporter (sert), the dopamine transporter (dat), mao-a and mao-b. |
2019-01-11 |
2023-08-13 |
Not clear |
| Louise Laursen, Kasper Severinsen, Kristina Birch Kristensen, Xavier Periole, Malene Overby, Heidi Kaastrup Müller, Birgit Schiøtt, Steffen Sinnin. Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter. The Journal of biological chemistry. vol 293. issue 10. 2019-01-07. PMID:29352106. |
the serotonin transporter (sert) is important for reuptake of the neurotransmitter serotonin from the synaptic cleft and is also the target of most antidepressants. |
2019-01-07 |
2023-08-13 |
human |
| Alexander V Kulikov, Raul R Gainetdinov, Evgeni Ponimaskin, Allan V Kalueff, Vladimir S Naumenko, Nina K Popov. Interplay between the key proteins of serotonin system in SSRI antidepressants efficacy. Expert opinion on therapeutic targets. vol 22. issue 4. 2019-01-03. PMID:29542343. |
specifically, it discusses: (1) the data on the association between antidepressant drug efficacy and genetically defined characteristics of key proteins in the 5-ht signaling (tph2, maoa, sert and 5-ht |
2019-01-03 |
2023-08-13 |
Not clear |
| Xiaoyin Zhuang, Haiyun Xu, Zeman Fang, Chongtao Xu, Chaobiao Xue, Xiaohong Hon. Platelet serotonin and serotonin transporter as peripheral surrogates in depression and anxiety patients. European journal of pharmacology. vol 834. 2018-12-18. PMID:30031795. |
previous studies suggested that serotonergic neurons and platelets share similarities in serotonin (5-ht) uptake by serotonin transporter (sert), storage, metabolism and release mechanisms, indicating that platelets may be used as a reliable peripheral surrogate to measure central sert activity in neuropsychiatric research. |
2018-12-18 |
2023-08-13 |
human |
| Xiaoyin Zhuang, Haiyun Xu, Zeman Fang, Chongtao Xu, Chaobiao Xue, Xiaohong Hon. Platelet serotonin and serotonin transporter as peripheral surrogates in depression and anxiety patients. European journal of pharmacology. vol 834. 2018-12-18. PMID:30031795. |
in this study, platelet 5-ht content and 5-ht uptake capacity of sert in depression and anxiety patients were measured by elisa and flow cytometry with idt307 at baseline and after serotonin reuptake inhibitors (ssris) treatment for 4 weeks. |
2018-12-18 |
2023-08-13 |
human |
| Xiaoyin Zhuang, Haiyun Xu, Zeman Fang, Chongtao Xu, Chaobiao Xue, Xiaohong Hon. Platelet serotonin and serotonin transporter as peripheral surrogates in depression and anxiety patients. European journal of pharmacology. vol 834. 2018-12-18. PMID:30031795. |
these results provide further evidence supporting the employment of platelet 5-ht content and sert as peripheral surrogates in depression and anxiety patients, and are of help in understanding the several weeks' delay from the initiation of antidepressant medication to their full therapeutic effects in the patients. |
2018-12-18 |
2023-08-13 |
human |
| Anna Maria Górska, Katarzyna Kamińska, Agnieszka Wawrzczak-Bargieła, Giulia Costa, Micaela Morelli, Ryszard Przewłocki, Grzegorz Kreiner, Krystyna Gołembiowsk. Neurochemical and Neurotoxic Effects of MDMA (Ecstasy) and Caffeine After Chronic Combined Administration in Mice. Neurotoxicity research. vol 33. issue 3. 2018-12-11. PMID:29134560. |
mdma acts at dopamine (da) transporter (dat) and serotonin (5-ht) transporter (sert) and is known to induce damage of dopamine and serotonin neurons. |
2018-12-11 |
2023-08-13 |
mouse |
| Anna Maria Górska, Katarzyna Kamińska, Agnieszka Wawrzczak-Bargieła, Giulia Costa, Micaela Morelli, Ryszard Przewłocki, Grzegorz Kreiner, Krystyna Gołembiowsk. Neurochemical and Neurotoxic Effects of MDMA (Ecstasy) and Caffeine After Chronic Combined Administration in Mice. Neurotoxicity research. vol 33. issue 3. 2018-12-11. PMID:29134560. |
to find out whether caffeine aggravates mdma neurotoxicity, the content of da and 5-ht, density of brain dat and sert, and oxidative damage of nuclear dna were determined. |
2018-12-11 |
2023-08-13 |
mouse |
| Matthew J Robson, Meagan A Quinlan, Kara Gross Margolis, Paula A Gajewski-Kurdziel, Jeremy Veenstra-VanderWeele, Michael D Gershon, D Martin Watterson, Randy D Blakel. p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 43. 2018-12-11. PMID:30297392. |
activation of p38 mapk signaling networks has been identified in asd, and p38 mapk signaling elevates serotonin (5-ht) transporter (sert) activity, effects mimicked by multiple, hyperfunctional sert coding variants identified in asd subjects. |
2018-12-11 |
2023-08-13 |
mouse |
| Matthew J Robson, Meagan A Quinlan, Kara Gross Margolis, Paula A Gajewski-Kurdziel, Jeremy Veenstra-VanderWeele, Michael D Gershon, D Martin Watterson, Randy D Blakel. p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 43. 2018-12-11. PMID:30297392. |
mice expressing the most common of these variants (sert ala56) exhibit hyperserotonemia, a biomarker observed in asd subjects, as well as p38 mapk-dependent sert hyperphosphorylation, elevated hippocampal 5-ht clearance, hypersensitivity of cns 5-ht |
2018-12-11 |
2023-08-13 |
mouse |
| Harvey J Kliman, Sarah B Quaratella, Alessandra C Setaro, Erin C Siegman, Zarrin T Subha, Reshef Tal, Kristin M Milano, Theodore L Stec. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology. vol 159. issue 4. 2018-11-27. PMID:29381782. |
we conclude that serotonin is conveyed from the maternal blood stream through syncytiotrophoblasts, cytotrophoblasts and the villus core to the fetus through a physiological pathway that involves at least sert, gap junctions, p-gp, oct3, and maoa. |
2018-11-27 |
2023-08-13 |
mouse |