| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
serotonin's homeostasis involves serotoninergic autoreceptor such as 5-ht1a, 5-ht1b, 5-ht1d, the enzymatic degradation of serotonin by monoamine oxidase a (mao-a), and a transporter (serotoninergic transporter [sert]). |
2017-09-20 |
2023-08-13 |
Not clear |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
in the cns, the sert is a key target for various antidepressant drugs such as selective serotonin reuptake inhibitors (ssri), serotonin norepinephrin reuptake inhibitors (snri) and tricyclics family. |
2017-09-20 |
2023-08-13 |
Not clear |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
however, antidepressant activity of sert inhibitors is not directly mediated by the sert inhibition, but a consequence of postsynaptic 5-ht receptor activation following the increase in 5-ht levels in the synaptic cleft. |
2017-09-20 |
2023-08-13 |
Not clear |
| Ruth Kohen, Julia H Tracy, Eric Haugen, Kevin C Cain, Monica E Jarrett, Margaret M Heitkempe. Rare Variants of the Serotonin Transporter Are Associated With Psychiatric Comorbidity in Irritable Bowel Syndrome. Biological research for nursing. vol 18. issue 4. 2017-09-18. PMID:26912503. |
by modulating the extracellular reuptake of serotonin, the serotonin transporter (sert) acts as a key regulator of the bioavailability of serotonin. |
2017-09-18 |
2023-08-13 |
human |
| Xiaolei Pan, Kavita A Iyer, Hebing Liu, Douglas H Sweet, Małgorzata Duka. A new chemotype inhibitor for the human organic cation transporter 3 (hOCT3). Bioorganic & medicinal chemistry letters. vol 27. issue 18. 2017-09-15. PMID:28811134. |
the serotonin or norepinephrine transporters; sert and net, respectively). |
2017-09-15 |
2023-08-13 |
human |
| Kara Gross Margolis, Zhishan Li, Korey Stevanovic, Virginia Saurman, Narek Israelyan, George M Anderson, Isaac Snyder, Jeremy Veenstra-VanderWeele, Randy D Blakely, Michael D Gersho. Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function. The Journal of clinical investigation. vol 126. issue 6. 2017-09-13. PMID:27111230. |
multiple, rare hyperfunctional coding variants of the serotonin (5-ht) transporter (sert, encoded by slc6a4) have been identified in asd. |
2017-09-13 |
2023-08-13 |
mouse |
| Kara Gross Margolis, Zhishan Li, Korey Stevanovic, Virginia Saurman, Narek Israelyan, George M Anderson, Isaac Snyder, Jeremy Veenstra-VanderWeele, Randy D Blakely, Michael D Gersho. Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function. The Journal of clinical investigation. vol 126. issue 6. 2017-09-13. PMID:27111230. |
expression of the most common sert variant (ala56) in mice increases 5-ht clearance and causes asd-like behaviors. |
2017-09-13 |
2023-08-13 |
mouse |
| Kara Gross Margolis, Zhishan Li, Korey Stevanovic, Virginia Saurman, Narek Israelyan, George M Anderson, Isaac Snyder, Jeremy Veenstra-VanderWeele, Randy D Blakely, Michael D Gersho. Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function. The Journal of clinical investigation. vol 126. issue 6. 2017-09-13. PMID:27111230. |
the reciprocal phenotypes that resulted from increased or decreased sert activity support the idea that 5-ht signaling regulates enteric neuronal development and can, when disturbed, cause long-lasting abnormalities of gi function. |
2017-09-13 |
2023-08-13 |
mouse |
| Stephanie B Linley, Francisco Olucha-Bordonau, Robert P Verte. Pattern of distribution of serotonergic fibers to the amygdala and extended amygdala in the rat. The Journal of comparative neurology. vol 525. issue 1. 2017-09-12. PMID:27213991. |
using immunostaining for the serotonin transporter, sert, we describe the complete pattern of distribution of 5-ht fibers to the amygdala (proper) and to the extended amygdala in the rat. |
2017-09-12 |
2023-08-13 |
rat |
| Maarja Haugas, Laura Tikker, Kaia Achim, Marjo Salminen, Juha Partane. Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe. Development (Cambridge, England). vol 143. issue 23. 2017-09-11. PMID:27789623. |
the newly born serotonergic precursors are segregated into distinct subpopulations expressing vesicular glutamate transporter 3 (vglut3) or serotonin transporter (sert). |
2017-09-11 |
2023-08-13 |
mouse |
| A Frick, F Åhs, Å M Palmquist, A Pissiota, U Wallenquist, M Fernandez, M Jonasson, L Appel, Ö Frans, M Lubberink, T Furmark, L von Knorring, M Fredrikso. Overlapping expression of serotonin transporters and neurokinin-1 receptors in posttraumatic stress disorder: a multi-tracer PET study. Molecular psychiatry. vol 21. issue 10. 2017-09-05. PMID:26619809. |
participants were imaged with the highly selective radiotracers [(11)c]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile (dasb) and [(11)c]gr205171 assessing serotonin transporter (sert) and nk1 receptor availability, respectively. |
2017-09-05 |
2023-08-13 |
human |
| Jacob P R Jacobsen, Andrew D Krystal, K Ranga R Krishnan, Marc G Caro. Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale. Trends in pharmacological sciences. vol 37. issue 11. 2017-09-04. PMID:27692695. |
serotonin transporter (sert) inhibitors treat depression by elevating brain extracellular 5-hydroxytryptamine (5-ht |
2017-09-04 |
2023-08-13 |
Not clear |
| Caleb J Browne, Paul J Fletche. Decreased Incentive Motivation Following Knockout or Acute Blockade of the Serotonin Transporter: Role of the 5-HT2C Receptor. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 10. 2017-08-30. PMID:27125304. |
these experiments examined whether chronic and acute disruptions of serotonin transporter (sert) activity altered incentive motivation, and whether the 5-ht2c receptor mediated the effects of elevated 5-ht on behavior. |
2017-08-30 |
2023-08-13 |
mouse |
| E Latorre, A Pradilla, B Chueca, R Pagán, E Layunta, A I Alcalde, J E Mesoner. Listeria monocytogenes Inhibits Serotonin Transporter in Human Intestinal Caco-2 Cells. Microbial ecology. vol 72. issue 3. 2017-08-28. PMID:27488594. |
the serotonin transporter (sert), located in enterocytes, controls intestinal 5-ht availability and therefore serotonin's effects. |
2017-08-28 |
2023-08-13 |
human |
| E Latorre, A Pradilla, B Chueca, R Pagán, E Layunta, A I Alcalde, J E Mesoner. Listeria monocytogenes Inhibits Serotonin Transporter in Human Intestinal Caco-2 Cells. Microbial ecology. vol 72. issue 3. 2017-08-28. PMID:27488594. |
our results demonstrate that living l. monocytogenes inhibits serotonin uptake by reducing sert expression at the brush border membrane. |
2017-08-28 |
2023-08-13 |
human |
| E Latorre, A Pradilla, B Chueca, R Pagán, E Layunta, A I Alcalde, J E Mesoner. Listeria monocytogenes Inhibits Serotonin Transporter in Human Intestinal Caco-2 Cells. Microbial ecology. vol 72. issue 3. 2017-08-28. PMID:27488594. |
therefore, l. monocytogenes, through tlr10-mediated sert inhibition, may induce increased intestinal serotonin availability and potentially contributing to intestinal physiological changes and the initiation of the inflammatory response. |
2017-08-28 |
2023-08-13 |
human |
| Chih-Hsing Wu, Chin-Sung Chang, Yen Kuang Yang, Lie-Hang Shen, Wei-Jen Ya. Comparison of brain serotonin transporter using [I-123]-ADAM between obese and non-obese young adults without an eating disorder. PloS one. vol 12. issue 2. 2017-08-15. PMID:28182708. |
we used single photon emission computed tomography (spect) with [i-123]-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (adam) to investigate changes in serotonin transporter (sert) availability in 10 morbidly obese young adults without an eating disorder (m/f = 5/5, body mass index (bmi): 40.3 ± 4.1 kg/m2, percentage of body fat (bf%): 46.0 ± 3.9%) and 10 age- and sex-matched non-obese controls (bmi: 20.3 ± 1.2 kg/m2, bf%: 20.6 ± 8.9%). |
2017-08-15 |
2023-08-13 |
human |
| Chih-Hsing Wu, Chin-Sung Chang, Yen Kuang Yang, Lie-Hang Shen, Wei-Jen Ya. Comparison of brain serotonin transporter using [I-123]-ADAM between obese and non-obese young adults without an eating disorder. PloS one. vol 12. issue 2. 2017-08-15. PMID:28182708. |
no significant difference in sert availability in the midbrain between morbidly obese and non-obese young adults without an eating disorder indicates an unmet need for investigating the role of cerebral serotonin in obesity. |
2017-08-15 |
2023-08-13 |
human |
| b' Sid Topiol, Benny Bang-Andersen, Connie Sanchez, Klaus P B\\xc3\\xb8ges\\xc3\\xb. Exploration of insights, opportunities and caveats provided by the X-ray structures of hSERT. Bioorganic & medicinal chemistry letters. vol 26. issue 20. 2017-08-08. PMID:27624075.' |
the recently reported x-ray structures of the human serotonin (5-ht) transporter sert with bound inhibitors open new opportunities for drug discovery at sert, selectivity design with respect to other neurotransmitter sodium transporters, and enhanced understanding of the molecular events involved in sert action. |
2017-08-08 |
2023-08-13 |
human |
| b' Sid Topiol, Benny Bang-Andersen, Connie Sanchez, Klaus P B\\xc3\\xb8ges\\xc3\\xb. Exploration of insights, opportunities and caveats provided by the X-ray structures of hSERT. Bioorganic & medicinal chemistry letters. vol 26. issue 20. 2017-08-08. PMID:27624075.' |
through computational and structural analyses, we explore the binding and migration of 5-ht at sert. |
2017-08-08 |
2023-08-13 |
human |