| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samantha E Yohn, Emily E Errante, Aaron Rosenbloom-Snow, Matthew Somerville, Margaret Rowland, Kristin Tokarski, Nadia Zafar, Merce Correa, John D Salamon. Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology. Neuropharmacology. vol 109. 2017-06-19. PMID:27329556. |
the present studies investigated the ability of drugs that block dopamine transport (dat), norepinephrine transport (net), and serotonin transport (sert) to modulate work output in rats responding on a test of effort-related decision making (i.e., a progressive ratio (prog)/chow feeding choice task). |
2017-06-19 |
2023-08-13 |
rat |
| Victoria S Marshe, Malgorzata Maciukiewicz, Soham Rej, Arun K Tiwari, Etienne Sibille, Daniel M Blumberger, Jordan F Karp, Eric J Lenze, Charles F Reynolds, James L Kennedy, Benoit H Mulsant, Daniel J Mülle. Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults. The American journal of psychiatry. vol 174. issue 5. 2017-06-19. PMID:28068779. |
the primary objective of this study was to investigate five putatively functional variants of the norepinephrine transporter (slc6a2, net) and serotonin transporter (slc6a4, sert) genes and remission in depressed older adults treated with venlafaxine. |
2017-06-19 |
2023-08-13 |
Not clear |
| Po-Han Chou, Che-Sheng Chu, Yi-Huei Chen, Min-Yen Hsu, Min-Wei Huang, Tsuo-Hung Lan, Ching-Heng Li. Antidepressants and risk of cataract development: A population-based, nested case-control study. Journal of affective disorders. vol 215. 2017-06-13. PMID:28342338. |
moreover, the relationship between binding affinities of serotonin transporter (sert) of antidepressant and the risk of cataracts is examined. |
2017-06-13 |
2023-08-13 |
Not clear |
| M Y Liu, L J Zhang, M C Li. [Effect of ginsenoside pre-treatment on 5-hydroxytryptamine system in SD rats with myocardial infarction and depression]. Zhonghua nei ke za zhi. vol 55. issue 9. 2017-06-08. PMID:27586978. |
to evaluate the effect of ginsenoside pre-treatment on serotonin (5-hydroxytryptamine, 5-ht), 5-ht2a receptor (5-ht2ar), and 5-ht transporter (serotonin transporter, sert) in serum, platelet lysate and brain tissue homogenates in sd rats with myocardial infarction (mi) or depression. |
2017-06-08 |
2023-08-13 |
rat |
| Carolyn G Sweeney, Bradford P Tremblay, Thomas Stockner, Harald H Sitte, Haley E Melikia. Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities. The Journal of biological chemistry. vol 292. issue 4. 2017-06-05. PMID:27986813. |
extracellular dopamine and serotonin concentrations are determined by the presynaptic dopamine (dat) and serotonin (sert) transporters, respectively. |
2017-06-05 |
2023-08-13 |
Not clear |
| Chunhong Liu, Yuting Lai, Junyan Ouyang, Tongwang Yang, Youting Guo, Jie Yang, Shaowen Huan. Influence of nonylphenol and octylphenol exposure on 5-HT, 5-HT transporter, and 5-HT Environmental science and pollution research international. vol 24. issue 9. 2017-06-01. PMID:28160177. |
a 28-day oral toxicity study was performed to observe the impact of single and combined exposure to np and op on 5-ht transporter (sert) as well as 5-ht |
2017-06-01 |
2023-08-13 |
human |
| Nathan C Mitchell, Georgianna G Gould, Wouter Koek, Lynette C Daw. Ontogeny of SERT Expression and Antidepressant-like Response to Escitalopram in Wild-Type and SERT Mutant Mice. The Journal of pharmacology and experimental therapeutics. vol 358. issue 2. 2017-05-26. PMID:27288483. |
to this end, we compared the antidepressant-like response to the ssri escitalopram using the tail suspension test and saturation binding of [(3)h]citalopram to the serotonin transporter (sert), the primary target of ssris, in juvenile [postnatal day (p)21], adolescent (p28), and adult (p90) wild-type (sert+/+) mice. |
2017-05-26 |
2023-08-13 |
mouse |
| Peter S Hasenhuetl, Michael Freissmuth, Walter Sandtne. Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter. The Journal of biological chemistry. vol 291. issue 50. 2017-05-26. PMID:27756841. |
here, we report an electrophysiological investigation of intracellular solute-binding to the human serotonin transporter (sert) expressed in hek-293 cells. |
2017-05-26 |
2023-08-13 |
human |
| Nathan C Mitchell, Melodi A Bowman, Georgianna G Gould, Wouter Koek, Lynette C Daw. Ontogeny of Norepinephrine Transporter Expression and Antidepressant-Like Response to Desipramine in Wild-Type and Serotonin Transporter Mutant Mice. The Journal of pharmacology and experimental therapeutics. vol 360. issue 1. 2017-05-26. PMID:27831486. |
moreover, therapeutic benefits of ssris are often especially limited in certain subpopulations of depressed patients, including children and carriers of low-expressing serotonin transporter (sert) gene variants. |
2017-05-26 |
2023-08-13 |
mouse |
| Duo-Chen Jin, Hai-Long Cao, Meng-Que Xu, Si-Nan Wang, Yu-Ming Wang, Fang Yan, Bang-Mao Wan. Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome. World journal of gastroenterology. vol 22. issue 36. 2017-05-19. PMID:27688655. |
serotonin (5-ht) and the serotonin transporter (sert) have earned a tremendous amount of attention regarding the pathogenesis of irritable bowel syndrome (ibs). |
2017-05-19 |
2023-08-13 |
Not clear |
| Duo-Chen Jin, Hai-Long Cao, Meng-Que Xu, Si-Nan Wang, Yu-Ming Wang, Fang Yan, Bang-Mao Wan. Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome. World journal of gastroenterology. vol 22. issue 36. 2017-05-19. PMID:27688655. |
higher 5-ht availability is commonly associated with depressed sert mrna in patients with ibs compared with healthy controls. |
2017-05-19 |
2023-08-13 |
Not clear |
| Yasumasa Tada, Shunji Ishihara, Kousaku Kawashima, Nobuhiko Fukuba, Hiroki Sonoyama, Ryusaku Kusunoki, Akihiko Oka, Yoshiyuki Mishima, Naoki Oshima, Ichiro Moriyama, Takafumi Yuki, Noriyoshi Ishikawa, Asuka Araki, Yuji Harada, Riruke Maruyama, Yoshikazu Kinoshit. Downregulation of serotonin reuptake transporter gene expression in healing colonic mucosa in presence of remaining low-grade inflammation in ulcerative colitis. Journal of gastroenterology and hepatology. vol 31. issue 8. 2017-05-15. PMID:26676714. |
the serotonin reuptake transporter (sert) terminates serotonin activity by removing it from interstitial space. |
2017-05-15 |
2023-08-13 |
Not clear |
| Pascal Seyer, Franck Vandermoere, Elisabeth Cassier, Joël Bockaert, Philippe Mari. Physical and functional interactions between the serotonin transporter and the neutral amino acid transporter ASCT2. The Biochemical journal. vol 473. issue 13. 2017-05-15. PMID:27143784. |
the activity of serotonergic systems depends on the reuptake of extracellular serotonin via its plasma membrane serotonin [5-ht (5-hydroxytryptamine)] transporter (sert), a member of the na(+)/cl(-)-dependent solute carrier 6 family. |
2017-05-15 |
2023-08-13 |
human |
| Pascal Seyer, Franck Vandermoere, Elisabeth Cassier, Joël Bockaert, Philippe Mari. Physical and functional interactions between the serotonin transporter and the neutral amino acid transporter ASCT2. The Biochemical journal. vol 473. issue 13. 2017-05-15. PMID:27143784. |
co-expression of asct2 with sert in hek (human embryonic kidney)-293 cells affects glycosylation and cell-surface localization of sert with a concomitant reduction in its 5-ht uptake activity. |
2017-05-15 |
2023-08-13 |
human |
| Pascal Seyer, Franck Vandermoere, Elisabeth Cassier, Joël Bockaert, Philippe Mari. Physical and functional interactions between the serotonin transporter and the neutral amino acid transporter ASCT2. The Biochemical journal. vol 473. issue 13. 2017-05-15. PMID:27143784. |
collectively, these findings provide evidence for a complex assembly involving sert and a member of another solute carrier family, which strongly influences the subcellular distribution of sert and the reuptake of 5-ht. |
2017-05-15 |
2023-08-13 |
human |
| Kendra H Oliver, Matthew T Duvernay, Heidi E Hamm, Ana M D Carneir. Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein αIIbβ3 Activation through Dysregulation of the 5-HT2A Receptor. The Journal of biological chemistry. vol 291. issue 38. 2017-05-12. PMID:27422820. |
however, it remains unclear how ssris, which inhibit the plasma membrane serotonin transporter (sert), modulate hemostasis. |
2017-05-12 |
2023-08-13 |
mouse |
| Kendra H Oliver, Matthew T Duvernay, Heidi E Hamm, Ana M D Carneir. Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein αIIbβ3 Activation through Dysregulation of the 5-HT2A Receptor. The Journal of biological chemistry. vol 291. issue 38. 2017-05-12. PMID:27422820. |
pharmaceutical blockade (citalopram dosing) or genetic ablation (sert(-/-)) of sert function in vivo led to reduced serotonin (5-hydroxytryptamine (5-ht)) blood levels that paralleled a mild bleeding phenotype in mice. |
2017-05-12 |
2023-08-13 |
mouse |
| Kendra H Oliver, Matthew T Duvernay, Heidi E Hamm, Ana M D Carneir. Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein αIIbβ3 Activation through Dysregulation of the 5-HT2A Receptor. The Journal of biological chemistry. vol 291. issue 38. 2017-05-12. PMID:27422820. |
additionally, synergistic potentiation of αiibβ3 activation by adp and 5-ht is lost in sert(-/-) platelets. |
2017-05-12 |
2023-08-13 |
mouse |
| Kendra H Oliver, Matthew T Duvernay, Heidi E Hamm, Ana M D Carneir. Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein αIIbβ3 Activation through Dysregulation of the 5-HT2A Receptor. The Journal of biological chemistry. vol 291. issue 38. 2017-05-12. PMID:27422820. |
taken together, these data demonstrate that sustained sert loss of function reduces 5-ht2ar surface expression that is critical for the synergistic activation of αiibβ3 by 5-ht and adp. |
2017-05-12 |
2023-08-13 |
mouse |
| Takeshi Tsuruta, Shinichi Saito, Yosuke Osaki, Akihiro Hamada, Ayako Aoki-Yoshida, Kei Sonoyam. Organoids as an ex vivo model for studying the serotonin system in the murine small intestine and colon epithelium. Biochemical and biophysical research communications. vol 474. issue 1. 2017-05-08. PMID:27105910. |
reverse transcription-polymerase chain reaction (rt-pcr) analysis showed that small intestinal and colonic organoids express mrnas encoding tryptophan hydroxylase-1 (tph1) (the rate-limiting enzyme of 5-ht synthesis), serotonin reuptake transporter (sert), 5-ht receptor (htr)2a, htr2b, and htr4. |
2017-05-08 |
2023-08-13 |
Not clear |