| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne Katrine Z Johansen, Afshan Dean, Ian Morecroft, Katie Hood, Margaret Nilsen, Lynn Loughlin, Aikaterini Anagnostopoulou, Rhian M Touyz, Kevin White, Margaret R MacLea. The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1. Pulmonary circulation. vol 6. issue 1. 2016-05-10. PMID:27162617. |
we hypothesized that an increase in intracellular serotonin via increased sert expression may dysregulate estrogen metabolism via cyp1b1 to facilitate pah. |
2016-05-10 |
2023-08-13 |
mouse |
| Anne Katrine Z Johansen, Afshan Dean, Ian Morecroft, Katie Hood, Margaret Nilsen, Lynn Loughlin, Aikaterini Anagnostopoulou, Rhian M Touyz, Kevin White, Margaret R MacLea. The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1. Pulmonary circulation. vol 6. issue 1. 2016-05-10. PMID:27162617. |
thus, increased intracellular serotonin caused by increased sert expression may contribute to pah pathobiology by dysregulation of estrogen metabolic pathways via increased cyp1b1 activity. |
2016-05-10 |
2023-08-13 |
mouse |
| Cynthia L Bethea, Kenny Phu, Yelena Belikova, Sarah C Bethe. Localization and regulation of reproductive steroid receptors in the raphe serotonin system of male macaques. Journal of chemical neuroanatomy. vol 66-67. 2016-05-05. PMID:25908331. |
we previously showed that tryptophan hydroxylase 2 (tph2) and serotonin reuptake transporter (sert) mrnas are increased by the androgens, testosterone (t) and dihydrotestosterone (dht) in serotonin neurons of male macaques. |
2016-05-05 |
2023-08-13 |
monkey |
| Cynthia L Bethea, Kenny Phu, Yelena Belikova, Sarah C Bethe. Localization and regulation of reproductive steroid receptors in the raphe serotonin system of male macaques. Journal of chemical neuroanatomy. vol 66-67. 2016-05-05. PMID:25908331. |
however, approximately 40% of dorsal raphe serotonin neurons contained erα or erβ⋅ in conclusion, the stimulatory effect of androgens on tph2 and sert mrna expression is mediated indirectly by neighboring neurons contain ar. |
2016-05-05 |
2023-08-13 |
monkey |
| Aurore N Voisin, Ouissame Mnie-Filali, Nicolas Giguère, Guillaume M Fortin, Erika Vigneault, Salah El Mestikawy, Laurent Descarries, Louis-Éric Trudea. Axonal Segregation and Role of the Vesicular Glutamate Transporter VGLUT3 in Serotonin Neurons. Frontiers in neuroanatomy. vol 10. 2016-05-05. PMID:27147980. |
using postnatal mouse raphe neurons in culture, we first observed that in contrast to 5-ht itself, other phenotypic markers of 5-ht axon terminals such as the 5-ht reuptake transporter (sert) show a more restricted localization in the axonal arborization. |
2016-05-05 |
2023-08-13 |
mouse |
| Aurore N Voisin, Ouissame Mnie-Filali, Nicolas Giguère, Guillaume M Fortin, Erika Vigneault, Salah El Mestikawy, Laurent Descarries, Louis-Éric Trudea. Axonal Segregation and Role of the Vesicular Glutamate Transporter VGLUT3 in Serotonin Neurons. Frontiers in neuroanatomy. vol 10. 2016-05-05. PMID:27147980. |
our results demonstrate that raphe 5-ht neurons express sert and vglut3 mainly in segregated axon terminals and that vglut3 regulates the vulnerability of these neurons and the neurochemical identity of their axonal domain, offering new perspectives on the functional connectivity of a cell population involved in anxiety disorders and depression. |
2016-05-05 |
2023-08-13 |
mouse |
| Gavin McLaughlin, Noreen Morris, Pierce V Kavanagh, John D Power, Brendan Twamley, John O'Brien, Brian Talbot, Geraldine Dowling, Olivia Mahony, Simon D Brandt, Julian Patrick, Roland P Archer, John S Partilla, Michael H Bauman. Synthesis, characterization, and monoamine transporter activity of the new psychoactive substance 3',4'-methylenedioxy-4-methylaminorex (MDMAR). Drug testing and analysis. vol 7. issue 7. 2016-05-04. PMID:25331619. |
while cis-4,4'-dmar, cis-mdmar and trans-mdmar were fully efficacious releasing agents at the serotonin transporter (sert), trans-4,4'-dmar acted as a fully efficacious uptake blocker. |
2016-05-04 |
2023-08-13 |
rat |
| Xiu-Jun Liao, Wei-Ming Mao, Qin Wang, Guan-Gen Yang, Wen-Jing Wu, Shu-Xian Sha. MicroRNA-24 inhibits serotonin reuptake transporter expression and aggravates irritable bowel syndrome. Biochemical and biophysical research communications. vol 469. issue 2. 2016-05-02. PMID:26631964. |
the expression levels of mir-24 and serotonin reuptake transporter (sert) were analyzed using real-time pcr and western blot in both human specimen and mice. |
2016-05-02 |
2023-08-13 |
mouse |
| Barbara Bottalico, Radovan Pilka, Irene Larsson, Bertil Casslen, Karel Marsal, Stefan R Hansso. Plasma membrane and vesicular monoamine transporters in normal endometrium and early pregnancy decidua. Molecular human reproduction. vol 9. issue 7. 2016-04-23. PMID:12802045. |
extracellular monoamine levels are regulated primarily through re-uptake by specific membrane-bound transporter proteins dopamine transporter (dat), norepinephrine transporter (net) and serotonin transporter (sert). |
2016-04-23 |
2023-08-12 |
Not clear |
| Klaus-Peter Lesc. When the serotonin transporter gene meets adversity: the contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience. Current topics in behavioral neurosciences. vol 7. 2016-04-23. PMID:21225411. |
for example, a remarkable number of studies reported an association of variation in the human serotonin (5-ht) transporter gene (slc6a4, 5-htt, sert) with emotional and cognitive traits as well as increased risk for depression in interaction with psychosocial adversity. |
2016-04-23 |
2023-08-12 |
mouse |
| Saad Nazir, Anoop Kumar, Ishita Chatterjee, Arivarasu N Anbazhagan, Tarunmeet Gujral, Shubha Priyamvada, Seema Saksena, Waddah A Alrefai, Pradeep K Dudeja, Ravinder K Gil. Mechanisms of Intestinal Serotonin Transporter (SERT) Upregulation by TGF-β1 Induced Non-Smad Pathways. PloS one. vol 10. issue 5. 2016-04-21. PMID:25954931. |
mechanisms of intestinal serotonin transporter (sert) upregulation by tgf-β1 induced non-smad pathways. |
2016-04-21 |
2023-08-13 |
mouse |
| Saad Nazir, Anoop Kumar, Ishita Chatterjee, Arivarasu N Anbazhagan, Tarunmeet Gujral, Shubha Priyamvada, Seema Saksena, Waddah A Alrefai, Pradeep K Dudeja, Ravinder K Gil. Mechanisms of Intestinal Serotonin Transporter (SERT) Upregulation by TGF-β1 Induced Non-Smad Pathways. PloS one. vol 10. issue 5. 2016-04-21. PMID:25954931. |
the influence of tgf-β1 on serotonin transporter (sert) activity, the critical mechanism regulating the extracellular availability of serotonin (5-ht), is not known. |
2016-04-21 |
2023-08-13 |
mouse |
| Dorte Lassen, Per Damkier, Kim Brøse. The Pharmacogenetics of Tramadol. Clinical pharmacokinetics. vol 54. issue 8. 2016-04-20. PMID:25910878. |
the metabolic enzymes cytochrome p450 (cyp) 3a4, cyp2b6, and cyp2d6 and the various transporters [adenosine triphosphate-binding cassette b1/multidrug resistance 1/p-glycoprotein, organic cation transporter 1, serotonin transporter (sert), norepinephrine transporter (net)] and receptor genes (opioid receptor μ 1 gene) give possible genetic differences that might affect the pharmacokinetics and/or pharmacodynamics of tramadol. |
2016-04-20 |
2023-08-13 |
Not clear |
| Steven C Wyler, Lauren J Donovan, Mia Yeager, Evan Deneri. Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25642596. |
coordinated serotonin (5-ht) synthesis and reuptake depends on coexpression of tph2, aadc (ddc), and sert (slc6a4) in brain 5-ht neurons. |
2016-04-19 |
2023-08-13 |
Not clear |
| Steven C Wyler, Lauren J Donovan, Mia Yeager, Evan Deneri. Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25642596. |
our previous studies showed that pet-1 is a critical transcription factor in a regulatory program that controls coexpression of tph2, aadc, and sert in 5-ht neurons. |
2016-04-19 |
2023-08-13 |
Not clear |
| Anna Gomółka, Agnieszka Ciesielska, Martyna Z Wróbel, Andrzej Chodkowski, Jerzy Kleps, Maciej Dawidowski, Agata Siwek, Małgorzata Wolak, Katarzyna Stachowicz, Anna Sławińska, Gabriel Nowak, Grzegorz Satała, Andrzej J Bojarski, Mariusz Belka, Szymon Ulenberg, Tomasz Bączek, Paweł Skowronek, Jadwiga Turło, Franciszek Herol. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. Part 5. European journal of medicinal chemistry. vol 98. 2016-04-12. PMID:26043160. |
affinity of the novel pyrido[1,2-c]pyrimidine derivatives for 5-ht1a, 5-ht2a receptors and serotonin transporter (sert) was evaluated in an in vitro radioligand binding assay. |
2016-04-12 |
2023-08-13 |
mouse |
| Nadia Ayala-Lopez, William F Jackson, Robert Burnett, James N Wilson, Janice M Thompson, Stephanie W Watt. Organic cation transporter 3 contributes to norepinephrine uptake into perivascular adipose tissue. American journal of physiology. Heart and circulatory physiology. vol 309. issue 11. 2016-04-11. PMID:26432838. |
uptake of ne (10 μm) in mesenteric pvat was reduced by the ne transporter (net) inhibitor nisoxetine (1 μm, 73.68 ± 7.62%, all values reported as percentages of vehicle), the 5-hydroxytryptamine transporter (sert) inhibitor citalopram (100 nm) with the organic cation transporter 3 (oct3) inhibitor corticosterone (100 μm, 56.18 ± 5.21%), and the net inhibitor desipramine (10 μm) with corticosterone (100 μm, 61.18 ± 6.82%). |
2016-04-11 |
2023-08-13 |
rat |
| P Y Tseng, I H Lee, K C Chen, P S Chen, N T Chiu, W J Yao, C L Chu, T L Yeh, Y K Yan. The correlation between mid-brain serotonin transporter availability and intelligence quotient in healthy volunteers. European psychiatry : the journal of the Association of European Psychiatrists. vol 30. issue 2. 2016-04-07. PMID:25447350. |
this study was performed to investigate the association between the mid-brain serotonin transporter (sert) availability and intelligence quotient (iq). |
2016-04-07 |
2023-08-13 |
human |
| Pia Baldinger, Christoph Kraus, Christina Rami-Mark, Gregor Gryglewski, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Marie Spies, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage. vol 111. 2016-04-07. PMID:25652393. |
the serotonin transporter (sert), which is responsible for the reuptake of serotonin from the synaptic cleft into the neuron, as well as the serotonin-1a (5-ht1a) and -1b (5-ht1b) receptors, inhibitory auto-receptors in the raphe region and projection areas, respectively, are likely to determine serotonin release. |
2016-04-07 |
2023-08-13 |
human |
| Pia Baldinger, Christoph Kraus, Christina Rami-Mark, Gregor Gryglewski, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Marie Spies, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage. vol 111. 2016-04-07. PMID:25652393. |
this finding suggests that the interaction between two major serotonergic structures involved in serotonin release, specifically the sert and 5-ht1b receptor, results in a modification of the inhibitory serotonergic tone mediated via 5-ht1a receptors. |
2016-04-07 |
2023-08-13 |
human |