| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Indira Mendez-David, Laurent Tritschler, Zeina El Ali, Marie-Hélène Damiens, Marc Pallardy, Denis J David, Saadia Kerdine-Römer, Alain M Gardie. Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression. Neuroscience letters. vol 597. 2015-10-19. PMID:25916883. |
taken together, these data suggest that nrf2 signaling contributes to fluoxetine-induced neuroprotection via an unexpected mechanism involving 5-ht transporter sert blockade, and not through enhancement of bdnf expression. |
2015-10-19 |
2023-08-13 |
mouse |
| Eryan Kong, Sonja Sucic, Francisco J Monje, Giorgia Savalli, Weifei Diao, Deeba Khan, Marianne Ronovsky, Maureen Cabatic, Florian Koban, Michael Freissmuth, Daniela D Polla. STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior. Scientific reports. vol 5. 2015-10-16. PMID:25760924. |
these observations demonstrate that il6 directly controls sert levels and consequently serotonin reuptake and identify stat3-dependent regulation of sert as conceivable neurobiological substrate for the involvement of il6 in depression. |
2015-10-16 |
2023-08-13 |
mouse |
| C L Bethea, K Coleman, K Phu, A P Reddy, A Ph. Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience. vol 274. 2015-10-15. PMID:24909896. |
this study reports the expression of serotonin-related genes: tryptophan hydroxylase 2 (tph2), serotonin reuptake transporter (sert) and the serotonin 1a autoreceptor (5ht1a) using digoxigenin-ish and image analysis. |
2015-10-15 |
2023-08-13 |
monkey |
| C L Bethea, K Coleman, K Phu, A P Reddy, A Ph. Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience. vol 274. 2015-10-15. PMID:24909896. |
comparatively, t- and dht + atd-treated groups had elevated tph2 and sert gene expression, but the dht + atd group had markedly suppressed serotonin axon density relative to the t-treated group. |
2015-10-15 |
2023-08-13 |
monkey |
| C L Bethea, K Coleman, K Phu, A P Reddy, A Ph. Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience. vol 274. 2015-10-15. PMID:24909896. |
this suggested that androgen activity increased tph2 and sert gene expression but, aromatase activity, and neural production of estradiol (e), may subserve axonal serotonin and determination of the compartment acted upon by fenfluramine. |
2015-10-15 |
2023-08-13 |
monkey |
| Blanca Gutiérrez, Juan Á Bellón, Margarita Rivera, Esther Molina, Michael King, Louise Marston, Francisco Torres-González, Berta Moreno-Küstner, Patricia Moreno-Peral, Emma Motrico, Carmen Montón-Franco, María J GildeGómez-Barragán, Marta Sánchez-Celaya, Miguel Á Díaz-Barreiros, Catalina Vicens, Juan de Dios Luna, Irwin Nazareth, Jorge Cervill. The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study. Journal of psychiatry & neuroscience : JPN. vol 40. issue 3. 2015-10-15. PMID:25510949. |
there is limited evidence for a moderating role of both serotonin transporter (sert) and brain-derived neurotrophic factor (bdnf) genes on the risk for major depression (md) developing after childhood maltreatment. |
2015-10-15 |
2023-08-13 |
Not clear |
| Ming-Fen Song, Jie-Zheng Dong, Yu-Wen Wang, Jun He, Xuan Ju, Long Zhang, Yong-Hua Zhang, Jian-Fei Shi, Ya-Ying L. CSF miR-16 is decreased in major depression patients and its neutralization in rats induces depression-like behaviors via a serotonin transmitter system. Journal of affective disorders. vol 178. 2015-10-13. PMID:25779937. |
animal and cell line studies demonstrated that mir-16 may be associated with major depressive disorder (mdd) via regulation of the expression of serotonin transporter (sert) gene. |
2015-10-13 |
2023-08-13 |
human |
| Yasufumi Sakakibara, Yoshiyuki Kasahara, F Scott Hall, Klaus-Peter Lesch, Dennis L Murphy, George R Uhl, Ichiro Sor. Developmental alterations in anxiety and cognitive behavior in serotonin transporter mutant mice. Psychopharmacology. vol 231. issue 21. 2015-10-12. PMID:24728652. |
a promoter variant of the serotonin transporter (sert) gene is known to affect emotional and cognitive regulation. |
2015-10-12 |
2023-08-13 |
mouse |
| Jacob P R Jacobsen, Per Plenge, Benjamin D Sachs, Alan L Pehrson, Manuel Cajina, Yunzhi Du, Wendy Roberts, Meghan L Rudder, Prachiti Dalvi, Taylor J Robinson, Sharon P O'Neill, King S Khoo, Connie Sanchez Morillo, Xiaodong Zhang, Marc G Caro. The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse. Psychopharmacology. vol 231. issue 23. 2015-10-07. PMID:24810106. |
it has been hypothesized that binding of r-citalopram to the serotonin transporter (sert) antagonizes escitalopram binding to and inhibition of the sert, there by curtailing the elevation of extracellular 5-hydroxytryptamine (5-htext), and hence anti-depressant efficacy. |
2015-10-07 |
2023-08-13 |
mouse |
| R A Prosser, A Stowie, M Amicarelli, A G Nackenoff, R D Blakely, J D Glas. Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN. Neuroscience. vol 275. 2015-10-07. PMID:24950119. |
although our data are consistent with cocaine acting through enhanced 5-ht signaling, the nonselective actions of cocaine as an antagonist of monoamine transporters raises the question of whether inhibition of the 5-ht transporter (sert) is key to its circadian effects. |
2015-10-07 |
2023-08-13 |
mouse |
| R A Prosser, A Stowie, M Amicarelli, A G Nackenoff, R D Blakely, J D Glas. Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN. Neuroscience. vol 275. 2015-10-07. PMID:24950119. |
here we investigate this issue using transgenic mice expressing a sert that exhibits normal 5-ht recognition and transport but significantly reduced cocaine potency (sert met172). |
2015-10-07 |
2023-08-13 |
mouse |
| George Khelashvili, Harel Weinstei. Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops. Biochimica et biophysica acta. vol 1848. issue 9. 2015-09-30. PMID:25847498. |
recent experimental evidence implicates highly anionic phosphatidylinositol 4,5-biphosphate (pip(2)) lipids in such functions of the serotonin (sert) and dopamine (dat) transporters. |
2015-09-30 |
2023-08-13 |
Not clear |
| Stefanie H Grimm, Georg Höfner, Klaus T Wanne. Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor indatraline enabling its quantification in MS Binding Assays. Analytical and bioanalytical chemistry. vol 407. issue 2. 2015-09-28. PMID:25450050. |
we herein present the first lc-ms/ms quantification method for indatraline, a highly potent nonselective inhibitor of the three monoamine transporters (for dopamine, dat; norepinephrine, net; serotonin, sert), and its application to ms binding assays. |
2015-09-28 |
2023-08-13 |
Not clear |
| Wei Hung Chang, Lan-Ting Lee, I Hui Lee, Mei Hung Chi, Kao Chin Chen, Nan Tsing Chiu, Wei Jen Yao, Po See Chen, Yen Kuang Yan. Which demographic variables are necessary to correct in neuroimaging studies of serotonin transporter availability? A SPECT study with [¹²³I]ADAM. Psychiatry research. vol 231. issue 3. 2015-09-28. PMID:25670644. |
previous studies have shown that many demographic variables influence serotonin transporter (sert) availability as assessed by single photon emission computed tomography (spect). |
2015-09-28 |
2023-08-13 |
human |
| Minjung Seo, Minyoung Oh, Minjung Cho, Sun Ju Chung, Chong Sik Lee, Jae Seung Ki. The Effect of SSRIs on the Binding of (18)F-FP-CIT in Parkinson Patients: A Retrospective Case Control Study. Nuclear medicine and molecular imaging. vol 48. issue 4. 2015-09-23. PMID:26396633. |
since fp-cit shows relatively high affinities for dat and serotonin transporter (sert), its binding can be influenced by selective serotonin reuptake inhibitors (ssris). |
2015-09-23 |
2023-08-13 |
Not clear |
| Bhagavathi S Sivamaruthi, Rajkumar Madhumita, Krishnaswamy Balamurugan, Koilmani E Raja. Cronobacter sakazakii infection alters serotonin transporter and improved fear memory retention in the rat. Frontiers in pharmacology. vol 6. 2015-09-21. PMID:26388777. |
in the present study, we tested whether the c. sakazakii infection alter the learning and memory through serotonin transporter (sert). |
2015-09-21 |
2023-08-13 |
rat |
| Bhagavathi S Sivamaruthi, Rajkumar Madhumita, Krishnaswamy Balamurugan, Koilmani E Raja. Cronobacter sakazakii infection alters serotonin transporter and improved fear memory retention in the rat. Frontiers in pharmacology. vol 6. 2015-09-21. PMID:26388777. |
on the other hand, level of serotonin (5-hydroxytryptamine) and sert protein was down-regulated. |
2015-09-21 |
2023-08-13 |
rat |
| Xiaona Wang, Yuan Tan, Feng Zhan. Ameliorative effect of gastrodin on 3,3'-iminodipropionitrile-induced memory impairment in rats. Neuroscience letters. vol 594. 2015-09-14. PMID:25817367. |
gastrodin treatment prevented the increase of serotonin transporter (sert) and the decrease of serotonin 1a (5-ht1a) receptor expression in the hippocampus of idpn-treated rats. |
2015-09-14 |
2023-08-13 |
rat |
| Walid Tajeddinn, Torbjörn Persson, Silvia Maioli, Javier Calvo-Garrido, Cristina Parrado-Fernandez, Takashi Yoshitake, Jan Kehr, Paul Francis, Bengt Winblad, Kina Höglund, Angel Cedazo-Minguez, Dag Aarslan. 5-HT1B and other related serotonergic proteins are altered in APPswe mutation. Neuroscience letters. vol 594. 2015-09-14. PMID:25841787. |
serotonin 1b receptors (5-ht1b), along with serotonin transporter (sert) are among the regulators of extracellular 5-ht levels. |
2015-09-14 |
2023-08-13 |
mouse |
| Walid Tajeddinn, Torbjörn Persson, Silvia Maioli, Javier Calvo-Garrido, Cristina Parrado-Fernandez, Takashi Yoshitake, Jan Kehr, Paul Francis, Bengt Winblad, Kina Höglund, Angel Cedazo-Minguez, Dag Aarslan. 5-HT1B and other related serotonergic proteins are altered in APPswe mutation. Neuroscience letters. vol 594. 2015-09-14. PMID:25841787. |
we investigated the effect of the familial ad app (amyloid precursor protein) k670n/m671l double mutation, app swedish mutation (appswe), on the expression of 5-ht1b, sert, maoa, p11 and 5-ht and its metabolite 5-hiaa in sh-sy5y human neuroblastoma cell line stably transfected with appswe mutation. |
2015-09-14 |
2023-08-13 |
mouse |