| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hernán Pessoa-Mahana, Christian González-Lira, Angélica Fierro, Gerald Zapata-Torres, C David Pessoa-Mahana, Javiera Ortiz-Severin, Patricio Iturriaga-Vásquez, Miguel Reyes-Parada, Paul Silva-Matus, Claudio Saitz-Barría, Ramiro Araya-Maturan. Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor. Bioorganic & medicinal chemistry. vol 21. issue 24. 2014-09-22. PMID:24262884. |
a series of 3-(3-(4-(3-(1h-indol-3-yl)propyl)piperazin-1-yl)propyl)-1h-indole derivatives (3a-d and 5a-f) as homo- and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter (sert) and the 5-ht1a receptor. |
2014-09-22 |
2023-08-12 |
Not clear |
| Rosa-Elena Ulloa, Aliyeri Díaz-Valderrama, Jaime Herrera-Pérez, Martha León-Olea, Lucía Martínez-Mot. Age differences in the impact of forced swimming test on serotonin transporter levels in lateral septum and dorsal raphe. Behavioral and brain functions : BBF. vol 10. 2014-09-19. PMID:24490994. |
forced swimming test (fst) is an animal model which evaluates behavioral despair and the effect of antidepressants such as the selective serotonin reuptake inhibitors; the fst modifies the expression of some receptors related to antidepressant response, but it is not known whether serotonin transporter (sert), their main target, is affected by this test in animals of different ages. |
2014-09-19 |
2023-08-12 |
rat |
| Yang Bai, Han-Ming Wang, Ming Liu, Yun Wang, Guo-Chao Lian, Xin-Hua Zhang, Jian Kang, Huai-Liang Wan. 4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lung inflammation. International journal of molecular medicine. vol 33. issue 2. 2014-09-18. PMID:24337018. |
the levels of tph-1 and serotonin transporter (sert) in the lungs were analyzed by immunohistochemistry and western blot analysis. |
2014-09-18 |
2023-08-12 |
rat |
| Jesper Bornø Jensen, Kristian Gaarn du Jardin, Dekun Song, David Budac, Gennady Smagin, Connie Sanchez, Alan Lars Pehrso. Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 1. 2014-09-12. PMID:24284262. |
the investigational multimodal acting antidepressant vortioxetine is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and 5-ht transporter (sert) inhibitor that enhances memory in normal rats in novel object recognition (nor) and conditioned fear (mørk et al., 2013). |
2014-09-12 |
2023-08-12 |
rat |
| Y-S Ding, M Naganawa, J-D Gallezot, N Nabulsi, S-F Lin, J Ropchan, D Weinzimmer, T J McCarthy, R E Carson, Y Huang, M Laruell. Clinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transports: Implications on treatment of depression and ADHD. NeuroImage. vol 86. 2014-09-03. PMID:23933039. |
atomoxetine (atx), a drug for treatment of depression and adhd, has a high affinity for the norepinephrine transporter (net); however, our previous study showed it had a blocking effect similar to fluoxetine on binding of [(11)c]dasb, a selective serotonin transporter (sert) ligand. |
2014-09-03 |
2023-08-12 |
monkey |
| Yvonne Ritze, Gyöngyi Bárdos, Astrid Hubert, Maureen Böhle, Stephan C Bischof. Effect of tryptophan supplementation on diet-induced non-alcoholic fatty liver disease in mice. The British journal of nutrition. vol 112. issue 1. 2014-09-02. PMID:24708895. |
nafld-related liver parameters (hepatic tag and oil red o staining), intestinal barrier parameters (tight-junction protein occludin and portal plasma lipopolysaccharides (lps)) and 5-ht-related parameters (5-ht, 5-ht transporter (sert) and motility) were measured. |
2014-09-02 |
2023-08-13 |
mouse |
| Hyun Soo Park, In Soon Jung, Nam Hee Lim, Ji Hyun Sung, Sukhyang Lee, Byung Seok Moon, Byung Chul Lee, Kyung Koo Kang, Sang Eun Ki. Proof of mechanism study of a novel serotonin transporter blocker, DA-8031, using [11C]DASB positron emission tomography and in vivo microdialysis. Urology. vol 84. issue 1. 2014-09-01. PMID:24824409. |
to investigate the efficacy of da-8031, a novel compound for the treatment of premature ejaculation, we measured serotonin transporter (sert) occupancy by da-8031, as well as da-8031-induced changes in extracellular serotonin levels, in the rat brain using positron emission tomography (pet) and 11c-n,n-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine ([11c]dasb) and in vivo microdialysis, respectively. |
2014-09-01 |
2023-08-13 |
rat |
| Melissa M Conti, Corinne Y Ostock, David Lindenbach, Adam A Goldenberg, Elias Kampton, Rich Dell'isola, Aaron C Katzman, Christopher Bisho. Effects of prolonged selective serotonin reuptake inhibition on the development and expression of L-DOPA-induced dyskinesia in hemi-parkinsonian rats. Neuropharmacology. vol 77. 2014-08-26. PMID:24067924. |
accumulating evidence has shown that compensatory plasticity in serotonin (5-ht) neurons contributes to lid and recent work has indicated that acute 5-ht transporter (sert) blockade provides anti-dyskinetic protection. |
2014-08-26 |
2023-08-12 |
human |
| Melissa M Conti, Corinne Y Ostock, David Lindenbach, Adam A Goldenberg, Elias Kampton, Rich Dell'isola, Aaron C Katzman, Christopher Bisho. Effects of prolonged selective serotonin reuptake inhibition on the development and expression of L-DOPA-induced dyskinesia in hemi-parkinsonian rats. Neuropharmacology. vol 77. 2014-08-26. PMID:24067924. |
collectively, these findings demonstrate that prolonged sert inhibition provides enduring anti-dyskinetic effects in part via 5-ht(1a) receptors while maintaining l-dopa's anti-parkinsonian efficacy by enhancing striatal da levels. |
2014-08-26 |
2023-08-12 |
human |
| Timothy Lynagh, Tina S Khamu, Lesley J Bryan-Lluk. Extracellular loop 3 of the noradrenaline transporter contributes to substrate and inhibitor selectivity. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 1. 2014-08-25. PMID:24081522. |
the human noradrenaline transporter (net) and 5-hydroxytryptamine (5-ht) transporter (sert) are inhibited by antidepressants and psychoactive drugs such as cocaine. |
2014-08-25 |
2023-08-12 |
human |
| Timothy Lynagh, Tina S Khamu, Lesley J Bryan-Lluk. Extracellular loop 3 of the noradrenaline transporter contributes to substrate and inhibitor selectivity. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 1. 2014-08-25. PMID:24081522. |
we substituted single amino acid residues of the third extracellular loop in net for equivalents from sert, transiently transfected cos-7 cells with wt net, 13 mutant nets and wt sert, and measured [(3)h]noradrenaline uptake, [(3)h]nisoxetine binding and [(3)h]5-ht uptake. |
2014-08-25 |
2023-08-12 |
human |
| Inês Pereira-Figueiredo, Consuelo Sancho, Juan Carro, Orlando Castellano, Dolores E Lópe. The effects of sertraline administration from adolescence to adulthood on physiological and emotional development in prenatally stressed rats of both sexes. Frontiers in behavioral neuroscience. vol 8. 2014-08-22. PMID:25147514. |
sertraline (sert) is a clinically effective selective serotonin reuptake inhibitor (ssri) known to increase and stabilize serotonin levels. |
2014-08-22 |
2023-08-13 |
rat |
| Xiao-Liang Wu, Jian-Hua Sun, Lan-Ying Liu, Hai-Yang Fu, Dai-Yan Jiao, Yan-Ye Shu, Dong Chen, Cheng-Yong Liu, Dao-Wei Zhan, Wei Zhan. [A feasibility analysis on individualized acupuncture treatment of irritable bowel syndrome under help of genetic polymorphism technique]. Zhen ci yan jiu = Acupuncture research. vol 39. issue 3. 2014-08-21. PMID:25069205. |
along with the application of genetic polymorphism techniques to individualized treatment of clinical disorders, the screening of polymorphisms markers of serotonin (5-ht) transporter (sert) is a hot-spot of researches on irritable bowel syndrome (ibs). |
2014-08-21 |
2023-08-13 |
Not clear |
| C Downey, F Daly, K M O'Boyl. An in vitro approach to assessing a potential drug interaction between MDMA (ecstasy) and caffeine. Toxicology in vitro : an international journal published in association with BIBRA. vol 28. issue 2. 2014-08-20. PMID:24211539. |
however, the results show that the inhibition of synaptosomal [(3)h] 5-ht uptake by mdma was greater at 41°c and 25°c than at 37°c which raises the possibility that mdma's effect on sert in vivo may be increased as body temperature increases, contributing to its harmful effects in users. |
2014-08-20 |
2023-08-12 |
rat |
| S Charntikov, N Swalve, S Pittenger, K Fink, S Schepers, G C Hadlock, A E Fleckenstein, G Hu, M Li, R A Bevin. Iptakalim attenuates self-administration and acquired goal-tracking behavior controlled by nicotine. Neuropharmacology. vol 75. 2014-08-19. PMID:23916479. |
neither behavioral effect was due to a non-specific motor effect of iptakalim, nor to an ability of iptakalim to inhibit da transporter (dat) or serotonin transporter (sert) function. |
2014-08-19 |
2023-08-12 |
rat |
| Snjezana Lelas, Yu-Wen Li, Tanya L Wallace-Boone, Matthew T Taber, Amy E Newton, Rick L Pieschl, Carl D Davis, Thaddeus F Molski, Kimberly S Newberry, Michael F Parker, Kevin W Gillman, Joanne J Bronson, John E Macor, Nicholas J Lodg. NK1 receptor antagonism lowers occupancy requirement for antidepressant-like effects of SSRIs in the gerbil forced swim test. Neuropharmacology. vol 73. 2014-08-13. PMID:23770339. |
serotonin transporter (sert) occupancy produced by 1 mg/kg fluoxetine (lowest efficacious dose) was 52 ± 5% and was reduced to 29 ± 4% at 0.3 mg/kg, a dose that was efficacious in combination with 0.3 mg/kg aprepitant or 1 mg/kg cp-122,721; the corresponding nk1r occupancies were 79 ± 4% and 61 ± 4% for aprepitant and cp-122,721, respectively. |
2014-08-13 |
2023-08-12 |
Not clear |
| Enric Alvarez, Victor Perez, Francesc Artiga. Pharmacology and clinical potential of vortioxetine in the treatment of major depressive disorder. Neuropsychiatric disease and treatment. vol 10. 2014-07-30. PMID:25075188. |
vortioxetine is a new multimodal action antidepressant with two types of action: serotonin transporter (sert) blockade and a strong affinity for several serotoninergic receptors. |
2014-07-30 |
2023-08-13 |
Not clear |
| Enric Alvarez, Victor Perez, Francesc Artiga. Pharmacology and clinical potential of vortioxetine in the treatment of major depressive disorder. Neuropsychiatric disease and treatment. vol 10. 2014-07-30. PMID:25075188. |
its combined action on sert and four subtypes of serotoninergic receptors increases the extracellular concentration of serotonin, dopamine, and noradrenaline. |
2014-07-30 |
2023-08-13 |
Not clear |
| Ingvild Wendelbo, Tarek Mazzawi, Magdy El-Salh. Increased serotonin transporter immunoreactivity intensity in the ileum of patients with irritable bowel disease. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24213511. |
the present study aimed to further investigate the immunoreactivity intensity of serotonin and serotonin‑selective reuptake transporter (sert) in the ileum of ibs patients. |
2014-07-29 |
2023-08-12 |
human |
| Ingvild Wendelbo, Tarek Mazzawi, Magdy El-Salh. Increased serotonin transporter immunoreactivity intensity in the ileum of patients with irritable bowel disease. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24213511. |
ileal biopsy specimens were immunostained using the avidin‑biotin (abc) complex method for serotonin and sert. |
2014-07-29 |
2023-08-12 |
human |