| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ingvild Wendelbo, Tarek Mazzawi, Magdy El-Salh. Increased serotonin transporter immunoreactivity intensity in the ileum of patients with irritable bowel disease. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24213511. |
it was concluded that the increase in ileal epithelial content of sert increases the intracellular uptake of serotonin and its degradation in the gut epithelial cells and consequently decreases the availability of serotonin within the gut mucosa. |
2014-07-29 |
2023-08-12 |
human |
| Henricus G Ruhé, Michiel Koster, Jan Booij, Marcel van Herk, Dick J Veltman, Aart H Schen. Occupancy of serotonin transporters in the amygdala by paroxetine in association with attenuation of left amygdala activation by negative faces in major depressive disorder. Psychiatry research. vol 221. issue 2. 2014-07-28. PMID:24406081. |
we hypothesized that higher amygdala serotonin transporter (sert) occupancy by paroxetine results in greater attenuation of amygdala activation by negative facial expressions in mdd patients. |
2014-07-28 |
2023-08-12 |
Not clear |
| Shuang Liu, Congxiang Zha, Kassoum Nacro, Min Hu, Wenge Cui, Yuh-Lin Yang, Ulhas Bhatt, Aruna Sambandam, Matthew Isherwood, Larry Yet, Michael T Herr, Sarah Ebeltoft, Carla Hassler, Linda Fleming, Anthony D Pechulis, Anne Payen-Fornicola, Nicholas Holman, Dennis Milanowski, Ian Cotterill, Vadim Mozhaev, Yuri Khmelnitsky, Peter R Guzzo, Bruce J Sargent, Bruce F Molino, Richard Olson, Dalton King, Snjezana Lelas, Yu-Wen Li, Kim Johnson, Thaddeus Molski, Anitra Orie, Alicia Ng, Roy Haskell, Wendy Clarke, Robert Bertekap, Jonathan O'Connell, Nicholas Lodge, Michael Sinz, Stephen Adams, Robert Zaczek, John E Maco. Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors. ACS medicinal chemistry letters. vol 5. issue 7. 2014-07-22. PMID:25050161. |
a series of 4-bicyclic heteroaryl 1,2,3,4-tetrahydroisoquinoline inhibitors of the serotonin transporter (sert), norepinephrine transporter (net), and dopamine transporter (dat) was discovered. |
2014-07-22 |
2023-08-13 |
mouse |
| Patrick S Hosford, Steve W Mifflin, Andrew G Ramag. 5-hydroxytryptamine-mediated neurotransmission modulates spontaneous and vagal-evoked glutamate release in the nucleus of the solitary tract effect of uptake blockade. The Journal of pharmacology and experimental therapeutics. vol 349. issue 2. 2014-07-18. PMID:24618127. |
the effect of blockade of either 5-hydroxytryptamine (5-ht)/serotonin transporter (sert) with citalopram or the organic cation transporter 3 (oct3)/plasma membrane monoamine transporter (pmat) with decynium-22 (d-22) on spontaneous and evoked release of 5-ht in the nucleus tractus solitarius (nts) was investigated in rat brainstem slices treated with gabazine. |
2014-07-18 |
2023-08-12 |
rat |
| R J Lamb, L C Daw. Ethanol self-administration in serotonin transporter knockout mice: unconstrained demand and elasticity. Genes, brain, and behavior. vol 12. issue 7. 2014-07-16. PMID:23927813. |
mice with one or two deletions of the serotonin transporter (sert) gene have increased extracellular serotonin. |
2014-07-16 |
2023-08-12 |
mouse |
| Jeffrey S Stehouwer, Mark M Goodma. (11) C and (18) F PET radioligands for the serotonin transporter (SERT). Journal of labelled compounds & radiopharmaceuticals. vol 56. issue 3-4. 2014-07-16. PMID:24285317. |
(11) c and (18) f pet radioligands for the serotonin transporter (sert). |
2014-07-16 |
2023-08-12 |
human |
| Jeffrey S Stehouwer, Mark M Goodma. (11) C and (18) F PET radioligands for the serotonin transporter (SERT). Journal of labelled compounds & radiopharmaceuticals. vol 56. issue 3-4. 2014-07-16. PMID:24285317. |
the serotonin transporter (sert) has been implicated in a variety of neuropsychiatric disorders including depression, anxiety, and suicide, and is the target of the selective serotonin reuptake inhibitor (ssri) class of antidepressants. |
2014-07-16 |
2023-08-12 |
human |
| Luigi Michele Pavone, Russell A Norri. Distinct signaling pathways activated by "extracellular" and "intracellular" serotonin in heart valve development and disease. Cell biochemistry and biophysics. vol 67. issue 3. 2014-07-15. PMID:23605455. |
additional functions of serotonin have recently been reported in which internalization of serotonin, through the serotonin transporter sert, can exert important cytoskeletal functions in lieu of simply being degraded. |
2014-07-15 |
2023-08-12 |
Not clear |
| M A Fox, M G Panessiti, P R Moya, T J Tolliver, K Chen, J C Shih, D L Murph. Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans. The pharmacogenomics journal. vol 13. issue 6. 2014-07-14. PMID:22964922. |
these exaggerated responses are in line with the exaggerated responses following serotonin-enhancing drugs that we previously observed in mice lacking the serotonin transporter (sert). |
2014-07-14 |
2023-08-12 |
mouse |
| M A Fox, M G Panessiti, P R Moya, T J Tolliver, K Chen, J C Shih, D L Murph. Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans. The pharmacogenomics journal. vol 13. issue 6. 2014-07-14. PMID:22964922. |
these findings provide a second genetic mouse model suggestive of possible human vulnerability to the serotonin syndrome in individuals with lesser-expressing mao or sert polymorphisms that confer serotonergic system changes. |
2014-07-14 |
2023-08-12 |
mouse |
| Chi Yan, Liu Xin-Guang, Wang Hua-Hong, Li Jun-Xia, Li Yi-Xua. Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 10. 2014-07-13. PMID:22832600. |
the present study was designed to evaluate the expression of the 5-ht(4) receptor and the serotonin transporter (sert) as well as their roles in chronic visceral hypersensitivity using a rat model. |
2014-07-13 |
2023-08-12 |
rat |
| Chi Yan, Liu Xin-Guang, Wang Hua-Hong, Li Jun-Xia, Li Yi-Xua. Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 10. 2014-07-13. PMID:22832600. |
the 5-ht(4) receptor and sert expression of the ascending colon were monitored using immunohistochemistry and western blot analyses; the plasma 5-ht levels were measured using an elisa method. |
2014-07-13 |
2023-08-12 |
rat |
| Chi Yan, Liu Xin-Guang, Wang Hua-Hong, Li Jun-Xia, Li Yi-Xua. Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 10. 2014-07-13. PMID:22832600. |
using this model, we found reduced sert expression (0.298 ± 0.038 vs 0.634 ± 0.200, p < 0.05) and increased 5-ht(4) receptor expression (0.308 ± 0.017 vs 0.298 ± 0.021, p < 0.05). |
2014-07-13 |
2023-08-12 |
rat |
| Chi Yan, Liu Xin-Guang, Wang Hua-Hong, Li Jun-Xia, Li Yi-Xua. Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 10. 2014-07-13. PMID:22832600. |
fluoxetine treatment increased 5-ht(4) receptor expression (0.322 ± 0.020 vs 0.308 ± 0.017, p < 0.01) but not sert expression (0.219 ± 0.039 vs 0.298 ± 0.038, p = 0.654). |
2014-07-13 |
2023-08-12 |
rat |
| Chi Yan, Liu Xin-Guang, Wang Hua-Hong, Li Jun-Xia, Li Yi-Xua. Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 10. 2014-07-13. PMID:22832600. |
these results indicate that both the 5-ht(4) receptor and sert play a role in the pathogenesis of visceral hypersensitivity, and its mechanism may be involved in the local 5-ht level. |
2014-07-13 |
2023-08-12 |
rat |
| Shigeyuki Yamamoto, Hiroyuki Ohba, Shingo Nishiyama, Norihiro Harada, Takeharu Kakiuchi, Hideo Tsukada, Edward F Domin. Subanesthetic doses of ketamine transiently decrease serotonin transporter activity: a PET study in conscious monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 13. 2014-07-01. PMID:23880871. |
five young monkeys underwent four positron emission tomography measurements with [(11)c]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)benzonitrile ([(11)c]dasb) for the serotonin transporter (sert), during and after intravenous infusion of vehicle or ketamine hydrochloride in a dose of 0.5 or 1.5 mg/kg for 40 min, and 24 h post infusion. |
2014-07-01 |
2023-08-12 |
human |
| De Wet Wolmarans, Linda Brand, Dan J Stein, Brian H Harve. Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (OCD): response to escitalopram treatment and basal serotonin transporter (SERT) density. Behavioural brain research. vol 256. 2014-06-26. PMID:24013013. |
reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (ocd): response to escitalopram treatment and basal serotonin transporter (sert) density. |
2014-06-26 |
2023-08-12 |
mouse |
| Yan Li, Kasper F Raaby, Connie Sánchez, Maria Gulinell. Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats. Behavioural brain research. vol 256. 2014-06-26. PMID:24016840. |
the study included fluoxetine, duloxetine, amitriptyline and an investigational multimodal antidepressant, vortioxetine (5-ht(3), 5-ht(7) and 5-ht(1d) receptor antagonist; 5-ht(1b) receptor partial agonist; 5-ht(1a) receptor agonist; inhibitor of the serotonin transporter (sert)). |
2014-06-26 |
2023-08-12 |
rat |
| Flavia Macchi, Judith R Homberg, Francesca Calabrese, Claudia Zecchillo, Giorgio Racagni, Marco A Riva, Raffaella Molten. Altered inflammatory responsiveness in serotonin transporter mutant rats. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24050835. |
in order to characterize the link between depression and inflammation, we aimed to investigate whether an altered inflammatory system is present in a genetic model of vulnerability for depression, namely rats with partial or total deletion of the serotonin transporter (sert) gene. |
2014-06-25 |
2023-08-12 |
rat |
| M Moroto, A Nishimura, M Morimoto, K Isoda, T Morita, M Yoshida, S Morioka, T Tozawa, T Hasegawa, T Chiyonobu, K Yoshimoto, H Hoso. Altered somatosensory barrel cortex refinement in the developing brain of Mecp2-null mice. Brain research. vol 1537. 2014-06-25. PMID:24060648. |
5-ht levels were measured by high performance liquid chromatography with electrochemical detection (hplc/ec), and serotonin transporter (sert) and 5-ht1b receptor mrnas were measured in the somatosensory cortex, thalamus and striatum on postnatal days (p) 10, p20 and p40. |
2014-06-25 |
2023-08-12 |
mouse |