| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerdien A H Korte-Bouws, Floor van Heesch, Koen G C Westphal, Lisa M J Ankersmit, Edwin M van Oosten, Onur Güntürkün, S Mechiel Kort. Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats. Pharmaceuticals (Basel, Switzerland). vol 11. issue 3. 2020-10-01. PMID:29976854. |
this suggests indirectly, that lps may enhance sert transporter activity, and consequently, increase removal of 5-ht from the synaptic cleft, and increase metabolism of 5-ht. |
2020-10-01 |
2023-08-13 |
rat |
| Gerdien A H Korte-Bouws, Floor van Heesch, Koen G C Westphal, Lisa M J Ankersmit, Edwin M van Oosten, Onur Güntürkün, S Mechiel Kort. Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats. Pharmaceuticals (Basel, Switzerland). vol 11. issue 3. 2020-10-01. PMID:29976854. |
therefore, the effects of an intraperitoneal lps injection on extracellular concentrations of 5-ht and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) were investigated by in vivo microdialysis in the nac and mpfc of wild type (sert |
2020-10-01 |
2023-08-13 |
rat |
| Diana C Esquivel-Franco, Berend Olivier, Marcel D Waldinger, Gabriel Gutiérrez-Ospina, Jocelien D A Olivie. Tramadol's Inhibitory Effects on Sexual Behavior: Pharmacological Studies in Serotonin Transporter Knockout Rats. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29997507. |
to investigate whether the inhibitory action of tramadol is primarily caused by its selective serotonin reuptake inhibitory (ssri) effects we tested the dose-response effects of tramadol on sexual behavior in serotonin transporter wild type (sert |
2020-10-01 |
2023-08-13 |
human |
| Raquel Romay-Tallon, Erin Kulhawy, Kyle J Brymer, Josh Allen, Tania Rivera-Baltanas, Jose M Olivares, Lisa E Kalynchuk, Hector J Carunch. Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of Depression. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30374301. |
naïve depression patients show alterations in serotonin transporter (sert) and serotonin 2a (5ht2a) receptor clustering in peripheral lymphocytes, and these alterations have been proposed as a biomarker of therapeutic efficacy in major depression. |
2020-10-01 |
2023-08-13 |
human |
| Emily Quentin, Arnauld Belmer, Luc Maroteau. Somato-Dendritic Regulation of Raphe Serotonin Neurons; A Key to Antidepressant Action. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30618598. |
neurotransmission by serotonin is tightly regulated by the serotonin transporter (sert) and by autoreceptors (serotonin receptors expressed by serotonin neurons) through negative feedback inhibition at the cell bodies and dendrites (5-ht |
2020-10-01 |
2023-08-13 |
Not clear |
| Inger Sundström Poromaa, Erika Comasco, Torbjörn Bäckström, Marie Bixo, Peter Jensen, Vibe G Frokjae. Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age. Frontiers in psychology. vol 9. 2020-10-01. PMID:30687199. |
availability of serotonin in the synaptic cleft is regulated by the serotonin transporter (sert), which can be imaged in the living human brain by use of positron emission tomography (pet) and the radiotracer [ |
2020-10-01 |
2023-08-13 |
human |
| Anne Baudry, Mathea Pietri, Jean-Marie Launay, Odile Kellermann, Benoit Schneide. Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30809118. |
serotonin transporter, sert ( |
2020-10-01 |
2023-08-13 |
Not clear |
| Melodi A Bowman, Lynette C Daw. Targeting Serotonin Transporters in the Treatment of Juvenile and Adolescent Depression. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30872996. |
since the high-affinity serotonin transporter (sert) is the primary target of ssris, we then synthesize these reports with studies of sert expression/function during juvenile and adolescent periods. |
2020-10-01 |
2023-08-13 |
Not clear |
| Melodi A Bowman, Lynette C Daw. Targeting Serotonin Transporters in the Treatment of Juvenile and Adolescent Depression. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30872996. |
taken together, fundamental differences in sert, and putatively in other transporters capable of serotonin clearance, may provide a mechanistic basis for the relative inefficiency of ssris to treat pediatric depression, relative to adults. |
2020-10-01 |
2023-08-13 |
Not clear |
| Patricio Sáez-Briones, Vicente Castro-Castillo, Gabriela Díaz-Véliz, Luis Valladares, Rafael Barra, Alejandro Hernández, Bruce K Cassel. Aromatic Bromination Abolishes the Psychomotor Features and Pro-social Responses of MDMA ("Ecstasy") in Rats and Preserves Affinity for the Serotonin Transporter (SERT). Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30873030. |
aromatic bromination abolishes the psychomotor features and pro-social responses of mdma ("ecstasy") in rats and preserves affinity for the serotonin transporter (sert). |
2020-10-01 |
2023-08-13 |
rat |
| Patricio Sáez-Briones, Vicente Castro-Castillo, Gabriela Díaz-Véliz, Luis Valladares, Rafael Barra, Alejandro Hernández, Bruce K Cassel. Aromatic Bromination Abolishes the Psychomotor Features and Pro-social Responses of MDMA ("Ecstasy") in Rats and Preserves Affinity for the Serotonin Transporter (SERT). Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30873030. |
the entactogen mdma (3,4-methylenedioxy-methamphetamine, "ecstasy") exerts its psychotropic effects acting primarily as a substrate of the serotonin transporter (sert) to induce a non-exocytotic release of serotonin. |
2020-10-01 |
2023-08-13 |
rat |
| Danielle J Houwing, Laura Staal, Judith M Swart, Anouschka S Ramsteijn, Markus Wöhr, Sietse F de Boer, Jocelien D A Olivie. Subjecting Dams to Early Life Stress and Perinatal Fluoxetine Treatment Differentially Alters Social Behavior in Young and Adult Rat Offspring. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30914920. |
we exposed heterozygous serotonin transporter (sert) deficient female rats to early life maternal separation stress, and used this as a model for maternal vulnerability. |
2020-10-01 |
2023-08-13 |
rat |
| Danielle J Houwing, Laura Staal, Judith M Swart, Anouschka S Ramsteijn, Markus Wöhr, Sietse F de Boer, Jocelien D A Olivie. Subjecting Dams to Early Life Stress and Perinatal Fluoxetine Treatment Differentially Alters Social Behavior in Young and Adult Rat Offspring. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30914920. |
control and early life stressed heterozygous serotonin transporter knockout (sert) dams were treated with the ssri fluoxetine or vehicle throughout gestation and lactation. |
2020-10-01 |
2023-08-13 |
rat |
| Sara Mercurio, Linda Serra, Alessia Motta, Lorenzo Gesuita, Luisa Sanchez-Arrones, Francesca Inverardi, Benedetta Foglio, Cristiana Barone, Polynikis Kaimakis, Ben Martynoga, Sergio Ottolenghi, Michèle Studer, Francois Guillemot, Carolina Frassoni, Paola Bovolenta, Silvia K Nicoli. Sox2 Acts in Thalamic Neurons to Control the Development of Retina-Thalamus-Cortex Connectivity. iScience. vol 15. 2020-10-01. PMID:31082736. |
reduced expression, in mutants, of sox2 target genes encoding ephrin-a5 and the serotonin transport molecules sert and vmat2 (important for establishment of thalamic connectivity) likely provides a molecular contribution to these defects. |
2020-10-01 |
2023-08-13 |
mouse |
| Arnauld Belmer, Kate Beecher, Angela Jacques, Omkar L Patkar, Florian Sicherre, Selena E Bartlet. Axonal Non-segregation of the Vesicular Glutamate Transporter VGLUT3 Within Serotonergic Projections in the Mouse Forebrain. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31133811. |
serotonin axons are identifiable by immunolabeling of either serotonin (5-ht) or the plasma membrane 5-ht transporter (sert), with sert labeling demonstrated to be only partially overlapping with 5-ht staining. |
2020-10-01 |
2023-08-13 |
mouse |
| Arnauld Belmer, Kate Beecher, Angela Jacques, Omkar L Patkar, Florian Sicherre, Selena E Bartlet. Axonal Non-segregation of the Vesicular Glutamate Transporter VGLUT3 Within Serotonergic Projections in the Mouse Forebrain. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31133811. |
studies investigating the colocalization or segregation of vglut3 within sert or 5-ht immunolabeled boutons have led to inconsistent results. |
2020-10-01 |
2023-08-13 |
mouse |
| Arnauld Belmer, Kate Beecher, Angela Jacques, Omkar L Patkar, Florian Sicherre, Selena E Bartlet. Axonal Non-segregation of the Vesicular Glutamate Transporter VGLUT3 Within Serotonergic Projections in the Mouse Forebrain. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31133811. |
our results demonstrate that about 90% of 5-ht boutons are colocalized with sert in almost all the brain regions studied, which therefore reveals that vglut3 and sert do not segregate. |
2020-10-01 |
2023-08-13 |
mouse |
| Arnauld Belmer, Kate Beecher, Angela Jacques, Omkar L Patkar, Florian Sicherre, Selena E Bartlet. Axonal Non-segregation of the Vesicular Glutamate Transporter VGLUT3 Within Serotonergic Projections in the Mouse Forebrain. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31133811. |
however, in the posterior part of the nac shell, we confirmed the presence of a subtype of 5-ht immunoreactive axons that lack the sert. |
2020-10-01 |
2023-08-13 |
mouse |
| Arnauld Belmer, Kate Beecher, Angela Jacques, Omkar L Patkar, Florian Sicherre, Selena E Bartlet. Axonal Non-segregation of the Vesicular Glutamate Transporter VGLUT3 Within Serotonergic Projections in the Mouse Forebrain. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31133811. |
interestingly, about 90% of the 5-ht/vglut3 boutons were labeled for the sert in this region, suggesting that vglut3 is preferentially located in sert immunoreactive 5-ht boutons. |
2020-10-01 |
2023-08-13 |
mouse |
| Arnauld Belmer, Kate Beecher, Angela Jacques, Omkar L Patkar, Florian Sicherre, Selena E Bartlet. Axonal Non-segregation of the Vesicular Glutamate Transporter VGLUT3 Within Serotonergic Projections in the Mouse Forebrain. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31133811. |
this work demonstrates that vglut3 and sert cannot be used as specific markers to classify the different subtypes of 5-ht axons. |
2020-10-01 |
2023-08-13 |
mouse |