| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junchao Tong, Jeffrey H Meyer, Isabelle Boileau, Lee-Cyn Ang, Paul J Fletcher, Yoshiaki Furukawa, Stephen J Kis. Serotonin transporter protein in autopsied brain of chronic users of cocaine. Psychopharmacology. vol 237. issue 9. 2020-12-23. PMID:32494974. |
the long-held speculation that the brain serotonin system mediates some behavioral effects of the psychostimulant cocaine is supported in part by the high affinity of cocaine for the serotonin transporter (sert) and by reports that the serotonin transporter (sert), estimated by sert binding, is increased in brain of human chronic cocaine users. |
2020-12-23 |
2023-08-13 |
human |
| Junchao Tong, Jeffrey H Meyer, Isabelle Boileau, Lee-Cyn Ang, Paul J Fletcher, Yoshiaki Furukawa, Stephen J Kis. Serotonin transporter protein in autopsied brain of chronic users of cocaine. Psychopharmacology. vol 237. issue 9. 2020-12-23. PMID:32494974. |
excessive sert activity and consequent synaptic serotonin deficiency might cause a behavioral (e.g., mood) abnormality in chronic users of the drug. |
2020-12-23 |
2023-08-13 |
human |
| Ruben Miozzo, William W Eaton, O Joseph Bienvenu, Jack Samuels, Gerald Nestad. The serotonin transporter gene polymorphism (SLC6A4) and risk for psychiatric morbidity and comorbidity in the Baltimore ECA follow-up study. Comprehensive psychiatry. vol 102. 2020-12-21. PMID:32911381. |
the human serotonin transporter (sert) gene polymorphism (5httlpr) has been associated with multiple psychiatric disorders, including major depression, anxiety disorders, and substance use disorders. |
2020-12-21 |
2023-08-13 |
human |
| Aleyda M San Hernandez, Chetana Singh, Danel J Valero, Javariya Nisar, Jose I Trujillo Ramirez, Karisma K Kothari, Sasank Isola, Domonick K Gordo. Multiple Sclerosis and Serotonin: Potential Therapeutic Applications. Cureus. vol 12. issue 11. 2020-12-07. PMID:33274166. |
the varying levels of the availability of the 5-ht transporter (sert) in the cns decreasing overall tryptophan (trp) levels, and diversion of the amino acid away from its synthetic pathway constitute some of those. |
2020-12-07 |
2023-08-13 |
human |
| John R Cirrito, Clare E Wallace, Ping Yan, Todd A Davis, Woodrow D Gardiner, Brookelyn M Doherty, Diana King, Carla M Yuede, Jin-Moo Lee, Yvette I Shelin. Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model. Neurology. vol 95. issue 19. 2020-11-30. PMID:32913022. |
we proposed that escitalopram, the most specific selective serotonin reuptake inhibitor (ssri) that inhibits the serotonin transporter sert, would suppress aβ levels in mice. |
2020-11-30 |
2023-08-13 |
mouse |
| Joanna Golebiowska, Małgorzata Hołuj, Agnieszka Potasiewicz, Diana Piotrowska, Agata Kuziak, Piotr Popik, Judith R Homberg, Agnieszka Nikiforu. Serotonin transporter deficiency alters socioemotional ultrasonic communication in rats. Scientific reports. vol 9. issue 1. 2020-11-13. PMID:31889084. |
rodents with a genetic deletion of the serotonin reuptake transporter (sert) are used as a model to study lifelong consequences of increased extracellular 5-ht levels due to its impaired reuptake. |
2020-11-13 |
2023-08-13 |
mouse |
| Yun-Yun Shao, Yi-Ting Guo, Jian-Ping Gao, Jun-Jin Liu, Zhuang-Peng Chang, Xiao-Juan Feng, Ding Xu, Gui-Feng Deng, Rui-Gang Ho. Shaoyao-Gancao Decoction Relieves Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome via Inactivating Transient Receptor Potential Vanilloid Type 1 and Reducing Serotonin Synthesis. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-10-31. PMID:33123210. |
rt-qpcr and western blot analyses were employed to detect the gene and protein level of tryptophan hydroxylase (tph), serotonin reuptake transporter (sert), and transient receptor potential vanilloid 1 (trpv1). |
2020-10-31 |
2023-08-13 |
rat |
| Donatella Marazziti, Laura Betti, Stefano Baroni, Lionella Palego, Federico Mucci, Barbara Carpita, Ivan Mirco Cremone, Ferruccio Santini, Laura Fabbrini, Caterina Pelosini, Alessandro Marsili, Enrico Massimetti, Gino Giannaccini, Liliana Dell'Oss. The complex interactions among serotonin, insulin, leptin, and glycolipid metabolic parameters in human obesity. CNS spectrums. 2020-10-30. PMID:32921339. |
to provide evidence to the link between serotonin (5-ht), energy metabolism, and the human obese phenotype, the present study investigated the binding and function of the platelet 5-ht transporter (sert), in relation to circulating insulin, leptin, and glycolipid metabolic parameters. |
2020-10-30 |
2023-08-13 |
human |
| Lucia Caffino, Michel M M Verheij, Lin Que, Chao Guo, Judith R Homberg, Fabio Fumagall. Increased cocaine self-administration in rats lacking the serotonin transporter: a role for glutamatergic signaling in the habenula. Addiction biology. vol 24. issue 6. 2020-10-28. PMID:30144237. |
using serotonin transporter knockout (sert |
2020-10-28 |
2023-08-13 |
rat |
| Valeria Salinas, Juana Villarroel, Hernán Silva, Luisa Herrera, Sonia Jerez, Alejandra Zazueta, Cristián Montes, Rodrigo Nieto, M Leonor Bustamant. SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder. BMC research notes. vol 13. issue 1. 2020-10-26. PMID:32033618. |
we studied 76 patients diagnosed with borderline personality disorder (bpd), characterized by extreme levels of personality traits, especially neuroticism (n), in which we genotyped two polymorphisms, the 5httlpr of the serotonin transporter (sert) gene, and the val66met of the brain-derived neurotrophic factor (bdnf) gene. |
2020-10-26 |
2023-08-13 |
Not clear |
| Yinshu Wang, Ying Dong, Enkang Wang, Yangyang Meng, Zijuan Bi, Shuai Sun, Chaochao Zhang, Haiting Fan, Jianye Yua. Shugan Decoction Alleviates Colonic Dysmotility in Female SERT-Knockout Rats by Decreasing M Frontiers in pharmacology. vol 11. 2020-10-06. PMID:33013355. |
the serotonin reuptake transporter (sert) is a membrane-embedded transporter involved in ibs pathogenesis that plays an important role in regulating 5-ht signaling. |
2020-10-06 |
2023-08-13 |
rat |
| Ming-Xian Chen, Yu Chen, Rui Fu, Sai-Yue Liu, Qin-Qin Yang, Tang-Biao She. Activation of 5-HT and NR2B contributes to visceral hypersensitivity in irritable bowel syndrome in rats. American journal of translational research. vol 8. issue 12. 2020-10-01. PMID:28078028. |
the expressions of 5-ht, nr2b, 5-ht2ar, 5-ht7r, sert, tnf-α and il-1β in colon, dorsal root ganglion (drg) and hypothalamus, respectively, were measured by immunohistochemical staining, real-time reverse transcription-pcr and western blotting. |
2020-10-01 |
2023-08-13 |
rat |
| Kazusa Katarao, Seiya Murakawa, Masaya Asano, Naoto Usuki, Hikaru Yamamoto, Toshihiko Shirafuji, Shigeru Tanaka, Izumi Hide, Norio Saka. The Development of Screening Methods to Identify Drugs to Limit ER Stress Using Wild-type and Mutant Serotonin Transporter. Acta histochemica et cytochemica. vol 49. issue 6. 2020-10-01. PMID:28127108. |
the function of the serotonin transporter (sert) is regulated by its membrane trafficking. |
2020-10-01 |
2023-08-13 |
Not clear |
| Danielle J Houwing, Bauke Buwalda, Eddy A van der Zee, Sietse F de Boer, Jocelien D A Olivie. The Serotonin Transporter and Early Life Stress: Translational Perspectives. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28491024. |
the interaction between the serotonin transporter (sert) linked polymorphic region (5-httlpr) and adverse early life stressing (els) events is associated with enhanced stress susceptibility and risk to develop mental disorders like major depression, anxiety, and aggressiveness. |
2020-10-01 |
2023-08-13 |
human |
| Nadine Herr, Christoph Bode, Daniel Duerschmie. The Effects of Serotonin in Immune Cells. Frontiers in cardiovascular medicine. vol 4. 2020-10-01. PMID:28775986. |
the functions of serotonin are mediated by members of the 7 known mammalian serotonin receptor subtype classes (15 known subtypes), the serotonin transporter (sert), and by covalent binding of serotonin to different effector proteins. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yang Yang, Zhiying Hu, Xiaoxue Du, Henry Davies, Xue Huo, Marong Fan. miR-16 and Fluoxetine Both Reverse Autophagic and Apoptotic Change in Chronic Unpredictable Mild Stress Model Rats. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28790887. |
it has been suggested that mir-16 regulates serotonin transporters (sert) via raphe nuclei and hippocampal responses to antidepressants. |
2020-10-01 |
2023-08-13 |
rat |
| Ismo Makkonen, Raili Riikonen, Jyrki T Kuikka, Hannu Kokki, Joseph P Bressler, Cathleen Marshall, Walter E Kaufman. Brain derived neurotrophic factor and serotonin transporter binding as markers of clinical response to fluoxetine therapy in children with autism. Journal of pediatric neurology : JPN. vol 9. issue 1. 2020-10-01. PMID:29056860. |
we examined serum brain derived neurotrophic factor (bdnf) concentrations and serotonin transporter (sert) binding in the medial frontal cortex and midbrain, measured by single photon emission computed tomography (spect) scanning, in a group of 13 autistic children and adolescents (12 males, one female; age 5-16 years), who were treated for six months with fluoxetine at a dose range of 10-40 mg/day. |
2020-10-01 |
2023-08-13 |
human |
| Marenka Smit, David Vállez García, Bauke M de Jong, Evelien Zoons, Jan Booij, Rudi A Dierckx, Antoon T Willemsen, Erik F de Vries, Anna L Bartels, Marina A Tijsse. Relationships between Serotonin Transporter Binding in the Raphe Nuclei, Basal Ganglia, and Hippocampus with Clinical Symptoms in Cervical Dystonia: A [ Frontiers in neurology. vol 9. 2020-10-01. PMID:29541052. |
in this molecular imaging study, we assessed whether altered presynaptic serotonin transporter (sert) binding contributes to the pathophysiology of cervical dystonia (cd), concerning both motor and non-motor symptoms (nms). |
2020-10-01 |
2023-08-13 |
Not clear |
| Meiyan Liu, Wanlin Wei, Christopher R Stone, Lijun Zhang, Guoxiang Tian, Jessie N Din. Beneficial effects of trimetazidine on expression of serotonin and serotonin transporter in rats with myocardial infarction and depression. Neuropsychiatric disease and treatment. vol 14. 2020-10-01. PMID:29588593. |
the purpose of this study was to investigate the therapeutic effects of trimetazidine on 5-ht and serotonin transporter (sert) expression in experimentally induced myocardial infarction (mi), depression, and mi + depression. |
2020-10-01 |
2023-08-13 |
rat |
| Gerdien A H Korte-Bouws, Floor van Heesch, Koen G C Westphal, Lisa M J Ankersmit, Edwin M van Oosten, Onur Güntürkün, S Mechiel Kort. Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats. Pharmaceuticals (Basel, Switzerland). vol 11. issue 3. 2020-10-01. PMID:29976854. |
administered lps increased extracellular monoamine metabolite levels in the nucleus accumbens (nac) and medial prefrontal cortex (mpfc), which was completely, or at least partly, prevented by pretreatment with a triple reuptake inhibitor that also blocks the serotonin (5-ht) transporter (sert). |
2020-10-01 |
2023-08-13 |
rat |