| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dániel Szöllősi, Thomas Stockne. Investigating the Mechanism of Sodium Binding to SERT Using Direct Simulations. Frontiers in cellular neuroscience. vol 15. 2021-05-28. PMID:34040506. |
the serotonin transporter (sert) terminates neurotransmission by transporting serotonin from the synapse into the pre-synaptic nerve terminal. |
2021-05-28 |
2023-08-13 |
Not clear |
| Dániel Szöllősi, Thomas Stockne. Investigating the Mechanism of Sodium Binding to SERT Using Direct Simulations. Frontiers in cellular neuroscience. vol 15. 2021-05-28. PMID:34040506. |
transport of serotonin by sert is energized by the transmembrane electrochemical gradient of sodium. |
2021-05-28 |
2023-08-13 |
Not clear |
| Dániel Szöllősi, Thomas Stockne. Investigating the Mechanism of Sodium Binding to SERT Using Direct Simulations. Frontiers in cellular neuroscience. vol 15. 2021-05-28. PMID:34040506. |
we used extensive molecular dynamics simulations to investigate the process of sodium binding to sert, which is the first step in the transport cycle that leads to serotonin uptake. |
2021-05-28 |
2023-08-13 |
Not clear |
| Junchao Wang, Wenjuan Xu, Rongjuan Wang, Rongrong Cheng, Zhengquan Tang, Min Zhan. The outer membrane protein Amuc_1100 of Food & function. vol 12. issue 8. 2021-05-27. PMID:33900345. |
this study demonstrated that amuc_1100 could promote the expression of the 5-ht synthesis rate-limiting enzyme tph1 in rin-14b cells and reduce the expression of the serotonin reuptake transporter (sert) in caco-2 cells through direct interaction with tlr2, thereby improving 5-ht biosynthesis and extracellular availability. |
2021-05-27 |
2023-08-13 |
mouse |
| Danusio Pinheiro Sartori, N F Oliveira, José Tiago Valentim, D M A Silva, A S V Mallman, I C M Oliveira, R C Chaves, V C Capibaribe, A M R Carvalho, M O Rebouças, Danielle Silveira Macedo, Adriano José Maia Chaves Filho, M M F Fonteles, S J C Gutierrez, José Maria Barbosa-Filho, Melina Mottin, Carolina Horta Andrade, F C F Sous. Involvement of monoaminergic targets in the antidepressant- and anxiolytic-like effects of the synthetic alkamide riparin IV: Elucidation of further mechanisms through pharmacological, neurochemistry and computational approaches. Behavioural brain research. vol 383. 2021-05-25. PMID:31987932. |
molecular docking demonstrated favorable binding conformation and affinity of ripiv to monoamine oxidase b (mao-b), serotonin transporter (sert), α1 receptor, d2 receptor, dopamine transporter (dat) and at some extent gaba-a receptor. |
2021-05-25 |
2023-08-13 |
mouse |
| Ke Zhang, Xue Li, Xian Wang, Hongyu Zheng, Shusheng Tang, Lin Lu, Xi M. Gut Barrier Proteins Mediate Liver Regulation by the Effects of Serotonin on the Non-Alcoholic Fatty Liver Disease. Current protein & peptide science. vol 21. issue 10. 2021-05-25. PMID:32538722. |
in addition, increasing the expression of serotonin reuptake transporter (sert) and decreasing the expression of tryptophan hydroxylase1 (tph1) can relieve the symptoms of nafld. |
2021-05-25 |
2023-08-13 |
mouse |
| Hera Wu, DeVon Herr, Nancie J MacIver, Jeffrey C Rathmell, Valerie A Gerriet. CD4 T cells differentially express cellular machinery for serotonin signaling, synthesis, and metabolism. International immunopharmacology. vol 88. 2021-05-25. PMID:32866787. |
we therefore examined the serotonergic-related machinery in teff and treg and found differential expression of the serotonin transporter sert and 5-ht1a and 5-ht2 receptors. |
2021-05-25 |
2023-08-13 |
Not clear |
| Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M M Verheij, Judith Homberg, Fabio Fumagall. Long access to cocaine self-administration dysregulates the glutamate synapse in the nucleus accumbens core of serotonin transporter knockout rats. British journal of pharmacology. 2021-05-21. PMID:33880773. |
we have previously demonstrated that rats with ablation of the serotonin (5-ht) transporter (sert |
2021-05-21 |
2023-08-13 |
rat |
| Yen-Chen Chiu, Bang-Hung Yang, Kai-Chin Yang, Mu-N Liu, Li-Yu Hu, Ying-Jay Liou, Li-Yi Chan, Yuan-Hwa Cho. A study of tryptophan, kynurenine and serotonin transporter in first-episode drug-naïve major depressive disorder. Psychiatry research. Neuroimaging. vol 312. 2021-05-20. PMID:33945927. |
the serotonin system is mainly modulated by the serotonin transporter (sert) which regulates serotonin uptake and the metabolism of its precursor, tryptophan and following kynurenine pathway. |
2021-05-20 |
2023-08-13 |
Not clear |
| Subramanian Thangaleela, Durairaj Ragu Varman, Karunanithi Sivasangari, Koilmani Emmanuvel Raja. Inhibition of monoamine oxidase attenuates social defeat-induced memory impairment in goldfish, (Carassius auratus): A possible involvement of synaptic proteins and BDNF. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 239. 2021-05-19. PMID:32805442. |
in addition, we noted that the expression of monoamine oxidase-a (mao-a) was up-regulated and level of serotonin (5-hydroxytryptamine; 5-ht), expression of serotonin transporter (sert), synaptophysin (syp), synaptotagmin -1 (syt-1), n-methyl-d-asparate (nmda) receptors subunits (nr2a and nr2b), postsynaptic density-95 (psd-95) and brain-derived neurotrophic factor (bdnf) were reduced by sd, while maois pretreatment protects the effect of sd. |
2021-05-19 |
2023-08-13 |
Not clear |
| Patrik Fazio, Daniel Ferreira, Per Svenningsson, Christer Halldin, Lars Farde, Eric Westman, Andrea Varron. High-resolution PET imaging reveals subtle impairment of the serotonin transporter in an early non-depressed Parkinson's disease cohort. European journal of nuclear medicine and molecular imaging. vol 47. issue 10. 2021-05-14. PMID:32020370. |
the serotonin transporter (sert) is a biochemical marker for monoaminergic signaling in brain and has been suggested to be involved inthe pathophysiology of parkinson's disease (pd). |
2021-05-14 |
2023-08-13 |
Not clear |
| Kally C O'Reilly, Allison M J Anacker, Tiffany D Rogers, C Gunnar Forsberg, Jing Wang, Bing Zhang, Randy D Blakely, Jeremy Veenstra-VanderWeel. A social encounter drives gene expression changes linked to neuronal function, brain development, and related disorders in mice expressing the serotonin transporter Ala56 variant. Neuroscience letters. vol 730. 2021-05-14. PMID:32437898. |
in mice, knock-in of a rare gly56ala substitution in the serotonin transporter (sert) causes elevated whole blood 5-ht levels, increased 5-ht clearance in the brain, and altered social and repetitive behavior. |
2021-05-14 |
2023-08-13 |
mouse |
| Joseph B Lesnak, Shinsuke Inoue, Lucas Lima, Lynn Rasmussen, Kathleen A Sluk. Testosterone protects against the development of widespread muscle pain in mice. Pain. vol 161. issue 12. 2021-05-14. PMID:32658149. |
prior studies show that the serotonin transporter (sert) is increased in the nucleus raphe magnus (nrm) in models of chronic pain, and that blockade of sert in the nrm reduces hyperalgesia. |
2021-05-14 |
2023-08-13 |
mouse |
| Michael Longley, John Ballard, Maria Andres-Alonso, Rebecca Constance Varatharajah, Hadleigh Cuthbert, Christopher H Ye. A Patterned Architecture of Monoaminergic Afferents in the Cerebellar Cortex: Noradrenergic and Serotonergic Fibre Distributions within Lobules and Parasagittal Zones. Neuroscience. vol 462. 2021-05-14. PMID:32949672. |
immunohistochemistry for the serotonin transporter (sert) and for the noradrenaline transporter (net) revealed strong anisotropy of these afferent fibres in the molecular layer of rat cerebellar cortex. |
2021-05-14 |
2023-08-13 |
rat |
| Kai-Chun Yang, Mu-N Liu, Ying-Jay Liou, Li-Yu Hu, Bang-Hung Yang, Yuan-Hwa Cho. Interleukin-1 family and serotonin transporter in first-episode, drug-naive major depressive disorder: A pilot study. Journal of psychiatric research. vol 135. 2021-05-14. PMID:33493946. |
the serotonin transporter (sert) availability in midbrain, thalamus, caudate, and putamen was examined by single-photon emission computed tomography with |
2021-05-14 |
2023-08-13 |
Not clear |
| Jean-Louis Montastruc, Vanessa Rousseau, Claire de Canecaude, Anne Roussin, François Montastru. Role of serotonin and norepinephrine transporters in antidepressant-induced arterial hypertension: a pharmacoepidemiological-pharmacodynamic study. European journal of clinical pharmacology. vol 76. issue 9. 2021-05-12. PMID:32483650. |
the mechanism remains discussed, some authors suggesting a role of sert (serotonin transporter) inhibition whereas others discussing net (norepinephrine transporter) involvement. |
2021-05-12 |
2023-08-13 |
Not clear |
| Iwona Ruchala, Umberto M Battisti, Vy T Nguyen, Rita Yu-Tzu Chen, Richard A Glennon, Jose M Elti. Functional characterization of N-octyl 4-methylamphetamine variants and related bivalent compounds at the dopamine and serotonin transporters using Ca Toxicology and applied pharmacology. vol 419. 2021-05-11. PMID:33785354. |
functional characterization of n-octyl 4-methylamphetamine variants and related bivalent compounds at the dopamine and serotonin transporters using ca the early characterization of ligands at the dopamine and serotonin transporters, dat and sert, respectively, is important for drug discovery, forensic sciences, and drug abuse research. |
2021-05-11 |
2023-08-13 |
Not clear |
| Merve Demirbugen Oz, Bora Baskak, Zuhal Uckun, Nazan Yuce Artun, Hatice Ozdemir, Tugba Kizil Ozel, Halise Devrimci Ozguven, H Sinan Suze. Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients. The pharmacogenomics journal. vol 20. issue 3. 2021-05-07. PMID:31792367. |
the present study aimed to determine the relationship between serotonin-2a receptor (htr2a) gene -1438a/g and 102t/c polymorphisms, serotonin transporter gene (slc6a4) 5-htt-linked polymorphic region (5-httlpr) insertion/deletion variant and brain-derived neurotrophic factor (bdnf) gene val66met polymorphisms and the occurrence of sd adverse effect in major depressive disorder patients treated with citalopram (cit) or sertraline (sert). |
2021-05-07 |
2023-08-13 |
human |
| Lucas Rischka, Gregor Gryglewski, Neydher Berroterán-Infante, Ivo Rausch, Gregory Miles James, Manfred Klöbl, Helen Sigurdardottir, Markus Hartenbach, Andreas Hahn, Wolfgang Wadsak, Markus Mitterhauser, Thomas Beyer, Siegfried Kasper, Daniela Prayer, Marcus Hacker, Rupert Lanzenberge. Attenuation Correction Approaches for Serotonin Transporter Quantification With PET/MRI. Frontiers in physiology. vol 10. 2021-05-07. PMID:31824335. |
therefore, our aim was to investigate the accuracy of segmentation- and atlas-based mr ac approaches on serotonin transporter (sert) distribution volumes and occupancy after a drug challenge. |
2021-05-07 |
2023-08-13 |
Not clear |
| Durairaj Ragu Varman, Lankupalle D Jayanthi, Sammanda Ramamoorth. Glycogen synthase kinase-3ß supports serotonin transporter function and trafficking in a phosphorylation-dependent manner. Journal of neurochemistry. vol 156. issue 4. 2021-05-04. PMID:32797733. |
serotonin (5-ht) transporter (sert) plays a crucial role in serotonergic transmission in the central nervous system, and any aberration causes serious mental illnesses. |
2021-05-04 |
2023-08-13 |
mouse |