| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melodi A Bowman, Melissa Vitela, Kyra M Clarke, Wouter Koek, Lynette C Daw. Serotonin Transporter and Plasma Membrane Monoamine Transporter Are Necessary for the Antidepressant-Like Effects of Ketamine in Mice. International journal of molecular sciences. vol 21. issue 20. 2021-02-25. PMID:33066466. |
using high-speed chronoamperometry to measure real-time clearance of serotonin from ca3 region of hippocampus in vivo, we found ketamine robustly inhibited serotonin clearance in wild-type mice, an effect that was lost in mice constitutively lacking sert or pmat. |
2021-02-25 |
2023-08-13 |
mouse |
| Melodi A Bowman, Melissa Vitela, Kyra M Clarke, Wouter Koek, Lynette C Daw. Serotonin Transporter and Plasma Membrane Monoamine Transporter Are Necessary for the Antidepressant-Like Effects of Ketamine in Mice. International journal of molecular sciences. vol 21. issue 20. 2021-02-25. PMID:33066466. |
future research is needed to understand how constitutive loss of either sert or pmat, and compensation that occurs in other systems, is sufficient to void ketamine of its ability to inhibit serotonin clearance and produce antidepressant-like effects. |
2021-02-25 |
2023-08-13 |
mouse |
| Melodi A Bowman, Melissa Vitela, Kyra M Clarke, Wouter Koek, Lynette C Daw. Serotonin Transporter and Plasma Membrane Monoamine Transporter Are Necessary for the Antidepressant-Like Effects of Ketamine in Mice. International journal of molecular sciences. vol 21. issue 20. 2021-02-25. PMID:33066466. |
taken together with existing literature, a critical role for serotonin, and its inhibition of uptake via sert and pmat, cannot be ruled out as important contributing factors to ketamine's antidepressant mechanism of action. |
2021-02-25 |
2023-08-13 |
mouse |
| Ya-Yao Huang, Li-Te Chang, Hsin-Yi Shen, Ying-Heng Chen, Kai-Yuan Tzen, Chyng-Yann Shiue, Ling-Wei Hsi. Synthesis and evaluation of 2-(2'-((dimethylamino)methyl)-4'-(2-fluoroethoxy-substituted)phenylthio)benzenamine derivatives as potential positron emission tomography imaging agents for serotonin transporters. Bioorganic chemistry. vol 97. 2021-02-22. PMID:32088418. |
a series of diphenylsulfide derivatives with various substitutions at the 4-position on phenyl ring a and different lengths of the 2-fluoroethoxy-substituted side-chain at the 4'-position on ring b were synthesized and evaluated as potential positron emission tomography (pet) imaging agents for serotonin transporters (sert). |
2021-02-22 |
2023-08-13 |
Not clear |
| Tuan L A Pham, Tran Duy Binh, Guanchen Liu, Thanh Q C Nguyen, Yen D H Nguyen, Ritsuko Sahashi, Tran Thanh Men, Kaeko Kame. Role of Serotonin Transporter in Eye Development of International journal of molecular sciences. vol 21. issue 11. 2021-02-18. PMID:32521639. |
role of serotonin transporter in eye development of serotonin transporter (sert) in the brain is an important neurotransmitter transporter involved in mental health. |
2021-02-18 |
2023-08-13 |
Not clear |
| Yuanyuan Gu, Dongya Zh. nNOS-mediated protein-protein interactions: promising targets for treating neurological and neuropsychiatric disorders. Journal of biomedical research. vol 35. issue 1. 2021-02-13. PMID:33402546. |
importantly, interactions of several proteins, including post-synaptic density 95 (psd-95), carboxy-terminal pdz ligand of nnos (capon) and serotonin transporter (sert), with the psd/disc-large/zo-1 homologous (pdz) domain of nnos have been demonstrated to influence the subcellular distribution and activity of the enzyme in the brain. |
2021-02-13 |
2023-08-13 |
Not clear |
| Ole Jensen, Muhammad Rafehi, Lukas Gebauer, Jürgen Brockmölle. Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers? Frontiers in pharmacology. vol 11. 2021-02-10. PMID:33551812. |
many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (net, dat, and sert). |
2021-02-10 |
2023-08-13 |
Not clear |
| Concepció Marin, Mercè Bonastre, Mireya Fuentes, Joaquim Mullo. Lack of correlation between dyskinesia and pallidal serotonin transporter expression-induced by L-Dopa and Pramipexole in hemiparkinsonian rats. Pharmacology, biochemistry, and behavior. vol 197. 2021-02-08. PMID:32750392. |
the role of pallidal serotonergic terminals in the development of l-dopa-induced dyskinesias (lids) in parkinson's disease (pd) has been recently highlighted correlating pallidal serotonin transporter (sert) expression levels with dyskinesias severity. |
2021-02-08 |
2023-08-13 |
rat |
| Concepció Marin, Mercè Bonastre, Mireya Fuentes, Joaquim Mullo. Lack of correlation between dyskinesia and pallidal serotonin transporter expression-induced by L-Dopa and Pramipexole in hemiparkinsonian rats. Pharmacology, biochemistry, and behavior. vol 197. 2021-02-08. PMID:32750392. |
however, the role of external globus pallidus (gpe, gp in rodents) serotonergic function in lids is still controversial since several studies have shown no differences in gpe serotonin (ser) and sert levels between dyskinetic and non-dyskinetic pd patients. |
2021-02-08 |
2023-08-13 |
rat |
| Concepció Marin, Mercè Bonastre, Mireya Fuentes, Joaquim Mullo. Globus pallidus, but not entopeduncular nucleus, 6-OHDA-induced lesion attenuates L-Dopa-induced dyskinesia in the rat model of Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 197. 2021-02-08. PMID:32758524. |
four weeks later, animals were treated with l-dopa (6 mg/kg) twice daily for 22 days.. immunohistochemical studies were performed in order to investigate the changes in pallidal ser and serotonin transporter (sert) levels. |
2021-02-08 |
2023-08-13 |
rat |
| Xiufang Cui, Xiaojing Zhao, Ying Wang, Yan Yang, Hongjie Zhan. Glucagon‑like peptide‑1 analogue exendin‑4 modulates serotonin transporter expression in intestinal epithelial cells. Molecular medicine reports. vol 21. issue 4. 2021-02-03. PMID:32319618. |
serotonin‑selective reuptake transporter (sert) regulates extracellular availability of serotonin (5‑hydroxytryptamine; 5‑ht) and participates in the pathogenesis of functional disorders. |
2021-02-03 |
2023-08-13 |
rat |
| Angel Carvajal-Oliveros, Jorge M Campusan. Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly? Frontiers in behavioral neuroscience. vol 14. 2021-01-30. PMID:33510625. |
serotonin actions depend on extracellular levels of this amine, which are regulated by its synthetic enzymes and the plasma membrane transporter, sert. |
2021-01-30 |
2023-08-13 |
Not clear |
| Julio Rodríguez-Lavado, Carlos Gallardo-Garrido, Michael Mallea, Victor Bustos, Rodrigo Osorio, Martín Hödar-Salazar, Hery Chung, Ramiro Araya-Maturana, Marcos Lorca, C David Pessoa-Mahana, Jaime Mella-Raipán, Claudio Saitz, Pablo Jaque, Miguel Reyes-Parada, Patricio Iturriaga-Vásquez, Hernán Pessoa-Mahan. Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease. European journal of medicinal chemistry. vol 198. 2021-01-26. PMID:32388114. |
for such purpose, a new series of indolylpropyl-piperazinyl oxoethyl-benzamido piperazines were synthesized and evaluated as multitarget-directed drugs for the serotonin transporter (sert) and acetylcholinesterase (ache). |
2021-01-26 |
2023-08-13 |
Not clear |
| Giuseppe Bruschetta, Angela D'Ascola, Pietro Medica, Alida Maria Ferlazz. Physical Exercise Affects Serotoninergic System in Horse Leukocytes. Journal of equine veterinary science. vol 88. 2021-01-22. PMID:32303327. |
the aim of the study was to investigate the effect of a racehorse intensive training session on plasma 5-ht levels, serotonin transporter (sert), 5ht |
2021-01-22 |
2023-08-13 |
Not clear |
| Hsin-Ya Kuo, Hsiu-Min Chen, Ching-Chih Lee, Hsuan-Han Lee, Chuan-Jung Kuo, Chun-Sheng Hsu, Chih-Chuan Pan, Ning Su, Che-Sheng Ch. Antidepressants and Risk of Type 2 Diabetes Mellitus: A Population-Based Nested Case-Control Study. Journal of clinical psychopharmacology. vol 40. issue 4. 2021-01-21. PMID:32639288. |
moreover, the relationship between binding affinities of serotonin transporter (sert) of ads and the risk of t2dm is examined. |
2021-01-21 |
2023-08-13 |
Not clear |
| Andrea Davies, Ana Eugenia Rodriguez-Vicente, Gemma Austin, Sandra Loaiza, Letizia Foroni, Richard E Clark, Munir Pirmohame. Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients. Scientific reports. vol 10. issue 1. 2021-01-14. PMID:32439979. |
in this study, we have evaluated whether tki-induced diarrhoea may be related to variation in the serotonin re-uptake transporter (sert) gene. |
2021-01-14 |
2023-08-13 |
Not clear |
| J J van der Zande, M Joling, I G Happach, C Vriend, Ph Scheltens, J Booij, A W Lemstr. Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An NeuroImage. Clinical. vol 25. 2021-01-11. PMID:31790878. |
serotonergic deficits in dementia with lewy bodies with concomitant alzheimer's disease pathology: an to study the influence of concomitant alzheimer's disease (ad) pathology in dementia with lewy bodies (dlb) on dopamine transporter (dat) and serotonin transporter (sert) availability, using |
2021-01-11 |
2023-08-13 |
Not clear |
| Rong Zhu, Walter Sandtner, Joan E A Ahiable, Amy Hauck Newman, Michael Freissmuth, Harald H Sitte, Peter Hinterdorfe. Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy. Frontiers in molecular biosciences. vol 7. 2021-01-10. PMID:32656227. |
these allow for directly measuring the interaction forces between the serotonin transporter (sert) and the antidepressant s-citalopram (s-cit) on the single molecule level: the afm cantilever tips were functionalized with s-cit via a flexible polyethylene glycol (peg) linker. |
2021-01-10 |
2023-08-13 |
Not clear |
| Nina C Donner, Sofia M Davies, Stephanie D Fitz, Drake M Kienzle, Anantha Shekhar, Christopher A Lowr. Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31415826. |
since the bnst projects heavily to the dorsal raphe nucleus (dr), the main source of brain serotonin, we here tested the hypothesis that such repeated, anxiety-inducing activation of crh receptors in the bnst alters the expression of serotonergic genes in the dr, including tph2, the gene encoding the rate-limiting enzyme for brain serotonin synthesis, and slc6a4, the gene encoding the serotonin transporter (sert). |
2021-01-04 |
2023-08-13 |
rat |
| Jonas Woll Jørandli, Silje Thorsvik, Helene Kolstad Skovdahl, Benedikt Kornfeld, Siri Sæterstad, Björn Inge Gustafsson, Arne Kristian Sandvik, Atle van Beelen Granlun. The serotonin reuptake transporter is reduced in the epithelium of active Crohn's disease and ulcerative colitis. American journal of physiology. Gastrointestinal and liver physiology. vol 319. issue 6. 2021-01-04. PMID:32967429. |
in this study, we show a potent and significant downregulation of the dominant serotonin reuptake transporter (sert) mrna ( |
2021-01-04 |
2023-08-13 |
human |