| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hana Horackova, Rona Karahoda, Lukas Cerveny, Veronika Vachalova, Ronja Ebner, Cilia Abad, Frantisek Stau. Effect of Selected Antidepressants on Placental Homeostasis of Serotonin: Maternal and Fetal Perspectives. Pharmaceutics. vol 13. issue 8. 2021-08-31. PMID:34452265. |
we hypothesize that antidepressants disturb serotonin homeostasis in the fetoplacental unit by inhibiting serotonin transporter (sert) and organic cation transporter 3 (oct3) in the maternal- and fetal-facing placental membranes, respectively. |
2021-08-31 |
2023-08-13 |
human |
| Ángel A Islas, Laura G Moreno, Thomas Scio. Induced fit, ensemble binding space docking and Monte Carlo simulations of MDMA 'ecstasy' and 3D pharmacophore design of MDMA derivatives on the human serotonin transporter (hSERT). Heliyon. vol 7. issue 8. 2021-08-31. PMID:34458620. |
although it is established that mdma exerts its behavioural effects via the serotonin transporter (sert), the ligand-protein molecular interplay remains elusive. |
2021-08-31 |
2023-08-13 |
human |
| Ponnusamy Vinay, Christopher Karen, Krishnaswamy Balamurugan, Koilmani Emmanuvel Raja. Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways. Journal of molecular neuroscience : MN. vol 71. issue 1. 2021-08-27. PMID:32567007. |
this study was designed to test whether the cronobacter sakazakii infection-impaired contextual learning and memory are mediated by the activation of the complement system; subsequent activation of inflammatory signals leads to alternations in serotonin transporter (sert). |
2021-08-27 |
2023-08-13 |
rat |
| Eray Esendir, Verena Burtscher, Jonathan A Coleman, Rong Zhu, Eric Gouaux, Michael Freissmuth, Walter Sandtne. Extracellular loops of the serotonin transporter act as a selectivity filter for drug binding. The Journal of biological chemistry. vol 297. issue 1. 2021-08-26. PMID:34118233. |
the serotonin transporter (sert) shapes serotonergic neurotransmission by retrieving its eponymous substrate from the synaptic cleft. |
2021-08-26 |
2023-08-13 |
Not clear |
| Xin Ye, Bo-Chul Shin, Claire Baldauf, Amit Ganguly, Shubhamoy Ghosh, Sherin U Devaska. Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures. Developmental neuroscience. vol 43. issue 1. 2021-08-25. PMID:33774619. |
serotonin transporter (sert) modulates synaptic 5-ht levels, while the oxt receptor (oxtr) mediates oxt action. |
2021-08-25 |
2023-08-13 |
Not clear |
| Xin Ye, Bo-Chul Shin, Claire Baldauf, Amit Ganguly, Shubhamoy Ghosh, Sherin U Devaska. Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures. Developmental neuroscience. vol 43. issue 1. 2021-08-25. PMID:33774619. |
employing maternal diet restriction (intrauterine growth restriction [iugr]), high-fat (hf) dietary modifications, and prenatal exposure to simulated ap, fetal (e19) murine brain 5-ht was assessed by elisa with sert and oxtr being localized by immunohistochemistry and measured by quantitative western blot analysis. |
2021-08-25 |
2023-08-13 |
Not clear |
| Xin Ye, Bo-Chul Shin, Claire Baldauf, Amit Ganguly, Shubhamoy Ghosh, Sherin U Devaska. Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures. Developmental neuroscience. vol 43. issue 1. 2021-08-25. PMID:33774619. |
in addition, a ∼50% (p = 0.005) decrease in 5-ht and sert concentrations was displayed in fetal iugr brains. |
2021-08-25 |
2023-08-13 |
Not clear |
| Jakub Staroń, Wojciech Pietruś, Ryszard Bugno, Rafał Kurczab, Grzegorz Satała, Dawid Warszycki, Tomasz Lenda, Anna Wantuch, Adam S Hogendorf, Agata Hogendorf, Beata Duszyńska, Andrzej J Bojarsk. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine. European journal of medicinal chemistry. vol 220. 2021-08-23. PMID:34049262. |
the selective serotonin reuptake inhibitors (ssris), acting at the serotonin transporter (sert), are one of the most widely prescribed antidepressant medications. |
2021-08-23 |
2023-08-13 |
Not clear |
| Cheryl S Rosenfel. Placental serotonin signaling, pregnancy outcomes, and regulation of fetal brain development†. Biology of reproduction. vol 102. issue 3. 2021-08-20. PMID:31711155. |
increasing number of pregnant women at risk of depression are being treated with selective serotonin-reuptake inhibitors (ssris) that bind to serotonin transporters (sert), which prevents 5-ht binding and cellular internalization, allowing for accumulation of extracellular 5-ht available to bind to 5-ht(2a) receptor (5-ht(2a)r). |
2021-08-20 |
2023-08-13 |
mouse |
| Janak R Awasthi, Kota Tamada, Eric T N Overton, Toru Takum. Comprehensive topographical map of the serotonergic fibers in the male mouse brain. The Journal of comparative neurology. vol 529. issue 7. 2021-08-16. PMID:32892368. |
in this study, we utilize male mice expressing green fluorescence protein under the serotonin transporter (sert) promoter to map the topography of serotonergic fibers across the rostro-caudal extent of each brain area. |
2021-08-16 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
this study aims to evaluate maternal hfd effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (jnk, pjnk and tnf-α), serotonin system molecules (tryptophan hydroxylase 2 (tph2), key-enzyme of serotonin synthesis, serotonin transporter (sert); 5-ht1a serotonergic receptor (5-ht1a)) and brain derived neurotrophic factor (bdnf) on recently weaned mice offspring hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Rose E Presby, Renee A Rotolo, Erin M Hurley, Sarah M Ferrigno, Cayla E Murphy, Haley P McMullen, Pranally A Desai, Emma M Zorda, Felicita B Kuperwasser, Carla Carratala-Ros, Merce Correa, John D Salamon. Sex differences in lever pressing and running wheel tasks of effort-based choice behavior in rats: Suppression of high effort activity by the serotonin transport inhibitor fluoxetine. Pharmacology, biochemistry, and behavior. vol 202. 2021-08-10. PMID:33493546. |
selective serotonin transport (sert) inhibitors such as fluoxetine are the most commonly prescribed treatments for depression. |
2021-08-10 |
2023-08-13 |
rat |
| Melinda Hersey, Jennifer L Woodruff, Nicholas Maxwell, Alia T Sadek, Maria K Bykalo, Ian Bain, Claudia A Grillo, Gerardo G Piroli, Parastoo Hashemi, Lawrence P Reaga. High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34010713. |
further studies revealed that these neurochemical observations could be explained by increases in serotonin transporter (sert) expression in the hippocampus driven by elevated neuroinflammation. |
2021-08-06 |
2023-08-13 |
human |
| Xianwei Mo, Yuanyuan Li, Xinying Zhu, Xiaolei Li, Haiyan Zhou, Xinzhou Bi, Jing L. Vortioxetine Derivatives with Amino Acid as Promoiety: Synthesis, Activity, Stability and Preliminary Pharmacokinetic Study. Journal of pharmaceutical sciences. vol 110. issue 8. 2021-08-04. PMID:33891948. |
similar or lower binding affinities of the modified compounds to the serotonin transporter (sert) than vot was observed in the 4-(4-(dimethylamino)-styrl)-n-methylpyridinium (asp |
2021-08-04 |
2023-08-13 |
Not clear |
| Joana Pereira-Sousa, Bruna Ferreira-Lomba, Aina Bellver-Sanchis, Daniela Vilasboas-Campos, Jorge H Fernandes, Marta D Costa, Mark A Varney, Adrian Newman-Tancredi, Patrícia Maciel, Andreia Teixeira-Castr. Identification of the 5-HT Neurobiology of disease. vol 152. 2021-07-30. PMID:33516872. |
previous studies pinpointed the modulation of serotonergic signaling, through pharmacological inhibition of the serotonin transporter sert, as a promising therapeutic approach for mjd/sca3. |
2021-07-30 |
2023-08-13 |
Not clear |
| Giulia Sbrini, Paola Brivio, Kari Bosch, Judith Regina Homberg, Francesca Calabres. Enrichment Environment Positively Influences Depression- and Anxiety-Like Behavior in Serotonin Transporter Knockout Rats through the Modulation of Neuroplasticity, Spine, and GABAergic Markers. Genes. vol 11. issue 11. 2021-07-23. PMID:33114023. |
the serotonin transporter (5-htt in humans, sert in rodents) is the main regulator of serotonergic transmission in the brain. |
2021-07-23 |
2023-08-13 |
rat |
| Mohammad Kamely, Mohammad Amir Karimi Torshizi, James West, Theo Niewol. Impacts of caffeine on resistant chicken's performance and cardiovascular gene expression. Journal of animal physiology and animal nutrition. 2021-07-22. PMID:34291833. |
we have also shown a significant upregulation of the serotonin transporter (sert), troponin t2, adenosine a |
2021-07-22 |
2023-08-13 |
chicken |
| Mathis Hildonen, Amanda M Levy, Christina Dahl, Victoria A Bjerregaard, Lisbeth Birk Møller, Per Guldberg, Nanette M Debes, Zeynep Tüme. Elevated Expression of Genes. vol 12. issue 1. 2021-07-21. PMID:33445578. |
in this study, we aimed to investigate whether the serotonin transporter (sert) gene ( |
2021-07-21 |
2023-08-13 |
Not clear |
| Maria Willadsen, Metin Üngör, Anna Sługocka, Rainer K W Schwarting, Judith R Homberg, Markus Wöh. Fear Extinction and Predictive Trait-Like Inter-Individual Differences in Rats Lacking the Serotonin Transporter. International journal of molecular sciences. vol 22. issue 13. 2021-07-21. PMID:34209318. |
the serotonergic system (5-hydroxytryptamine, 5-ht) with the 5-ht transporter (5-htt, sert) is strongly implicated in the regulation of anxiety and fear. |
2021-07-21 |
2023-08-13 |
rat |
| Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yua. Female serotonin transporter-knockout rat: A potential model of irritable bowel syndrome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 7. 2021-07-19. PMID:34143529. |
here, we hypothesize that similar alterations, including vh and colonic motility, induced by serotonin transporter (sert) knockout result from altered serotonin signaling. |
2021-07-19 |
2023-08-13 |
rat |