| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ilmaben S Vahora, Nicholas Tsouklidis, Rajat Kumar, Ravi Soni, Safeera Kha. How Serotonin Level Fluctuation Affects the Effectiveness of Treatment in Irritable Bowel Syndrome. Cureus. vol 12. issue 8. 2020-09-28. PMID:32968548. |
the serotonin reuptake transporter (sert) maintains serotonin levels by regulating its reuptake. |
2020-09-28 |
2023-08-13 |
human |
| Ilmaben S Vahora, Nicholas Tsouklidis, Rajat Kumar, Ravi Soni, Safeera Kha. How Serotonin Level Fluctuation Affects the Effectiveness of Treatment in Irritable Bowel Syndrome. Cureus. vol 12. issue 8. 2020-09-28. PMID:32968548. |
an increase in sert expression causes a decrease in serotonin, which leads to ibs-c (irritable bowel syndrome, constipation-predominant), whereas a decrease in sert transcription causes an increase in serotonin, which leads to ibs-d (irritable bowel syndrome, diarrhea-predominant). |
2020-09-28 |
2023-08-13 |
human |
| Ilmaben S Vahora, Nicholas Tsouklidis, Rajat Kumar, Ravi Soni, Safeera Kha. How Serotonin Level Fluctuation Affects the Effectiveness of Treatment in Irritable Bowel Syndrome. Cureus. vol 12. issue 8. 2020-09-28. PMID:32968548. |
this shows that 5ht and sert both have an important role in ibs pathophysiology so that it would be a better subject to target for the treatment aspect of ibs. |
2020-09-28 |
2023-08-13 |
human |
| Megha Singhal, Benjamin A Turturice, Christopher R Manzella, Ravi Ranjan, Ahmed A Metwally, Juliana Theorell, Yue Huang, Waddah A Alrefai, Pradeep K Dudeja, Patricia W Finn, David L Perkins, Ravinder K Gil. Serotonin Transporter Deficiency is Associated with Dysbiosis and Changes in Metabolic Function of the Mouse Intestinal Microbiome. Scientific reports. vol 9. issue 1. 2020-09-25. PMID:30765765. |
serotonin transporter (sert) plays a critical role in regulating extracellular availability of serotonin (5-ht) in the gut and brain. |
2020-09-25 |
2023-08-13 |
mouse |
| Li Tong, Li-Bin Wu, Nan Li, Hong-Liang Cheng, Rong-Lin Cai, Hao-Ran Ch. [Moxibustion relieves abdominal hypersensitivity and diarrhea by regulating colonic 5-hydroxytryptamine signaling pathway in rats with diarrhea type irritable bowel syndrome]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 7. 2020-09-16. PMID:32705826. |
to observe the effect of moxibustion on visceral pain, diarrhea, colonic 5-hydroxytryptamine (5-ht) content, and expression of tryptophan hydroxylase 1 (tph1), serotonin reup take transporter (sert) and 5-hydroxytryptamine receptor 3 (5-ht3r) in colon tissue of rats with diarrhea irritable bowel syndrome (ibs-d), so as to reveal its underlying mechanisms in treating ibs-d. |
2020-09-16 |
2023-08-13 |
rat |
| Gary Rudnick, Walter Sandtne. Serotonin transport in the 21st century. The Journal of general physiology. vol 151. issue 11. 2020-09-04. PMID:31570504. |
serotonin (5-hydroxytryptamine [5-ht]) is accumulated within nerve endings by the serotonin transporter (sert), which terminates its extracellular action and provides cytoplasmic 5-ht for refilling of synaptic vesicles. |
2020-09-04 |
2023-08-13 |
Not clear |
| Rachel D Slack, Ara M Abramyan, Helen Tang, Sitaram Meena, Bruce A Davis, Alessandro Bonifazi, JoLynn B Giancola, Jeffrey R Deschamps, Sett Naing, Hideaki Yano, Satinder K Singh, Amy Hauck Newman, Lei Sh. A Novel Bromine-Containing Paroxetine Analogue Provides Mechanistic Clues for Binding Ambiguity at the Central Primary Binding Site of the Serotonin Transporter. ACS chemical neuroscience. vol 10. issue 9. 2020-08-31. PMID:31424193. |
the serotonin transporter (sert) is the primary target for the selective serotonin reuptake inhibitors (ssris). |
2020-08-31 |
2023-08-13 |
human |
| Jake Rogers, Feng Chen, Davor Stanic, Farheen Farzana, Shanshan Li, Ariel M Zeleznikow-Johnston, Jess Nithianantharajah, Leonid Churilov, Paul A Adlard, Laurence Lanfumey, Anthony J Hannan, Thibault Renoi. Paradoxical effects of exercise on hippocampal plasticity and cognition in mice with a heterozygous null mutation in the serotonin transporter gene. British journal of pharmacology. vol 176. issue 17. 2020-08-28. PMID:31167040. |
we investigated the potential role of the serotonin (5-ht) transporter (sert) in mediating these effects. |
2020-08-28 |
2023-08-13 |
mouse |
| Chasen J Greig, Lucy Zhang, Robert A Cowle. Potentiated serotonin signaling in serotonin re-uptake transporter knockout mice increases enterocyte mass and small intestinal absorptive function. Physiological reports. vol 7. issue 21. 2020-08-27. PMID:31724827. |
genetic knockout of the serotonin reuptake transporter (sert) potentiates serotonin signaling and increases crypt-cell proliferation, neuroplasticity, and mucosal surface area. |
2020-08-27 |
2023-08-13 |
mouse |
| Takashi Sonobe, Tsuyoshi Akiyama, Cheng-Kun Du, James T Pearso. Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo. Physiological reports. vol 7. issue 22. 2020-08-17. PMID:31782271. |
addition of fluoxetine, a serotonin transporter (sert) inhibitor further increased the 5-ht concentration upon during administration of decynium-22. |
2020-08-17 |
2023-08-13 |
rat |
| Takashi Sonobe, Tsuyoshi Akiyama, Cheng-Kun Du, James T Pearso. Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo. Physiological reports. vol 7. issue 22. 2020-08-17. PMID:31782271. |
these results indicate that pmat and sert independently regulate basal level of interstitial 5-ht, and pmat plays a more important role in the clearance of 5-ht during reperfusion. |
2020-08-17 |
2023-08-13 |
rat |
| Gisela H Maia, Joana I Soares, Sérgio G Almeida, Juliana M Leite, Helena X Baptista, Alisa N Lukoyanova, Cátia S Brazete, Nikolai V Lukoyano. Altered serotonin innervation in the rat epileptic brain. Brain research bulletin. vol 152. 2020-08-14. PMID:31301378. |
four months post-se, the brainstem sections of the animals were immunostained for 5-ht, whereas the forebrain sections were immunostained for serotonin transporter (sert). |
2020-08-14 |
2023-08-13 |
rat |
| K R Müller-Vahl, N Szejko, F Wilke, E Jakubovski, L Geworski, F Bengel, G Berdin. Serotonin transporter binding is increased in Tourette syndrome with Obsessive Compulsive Disorder. Scientific reports. vol 9. issue 1. 2020-08-10. PMID:30700759. |
particularly in ts patients with comorbid ocd (ts + ocd), decreased serotonin transporter (sert) binding has been suggested. |
2020-08-10 |
2023-08-13 |
Not clear |
| Nathaniel W Holton, Megha Singhal, Anoop Kumar, Alexander L Ticho, Christopher R Manzella, Pooja Malhotra, David Jarava, Seema Saksena, Pradeep K Dudeja, Waddah A Alrefai, Ravinder K Gil. Hepatocyte nuclear factor-4α regulates expression of the serotonin transporter in intestinal epithelial cells. American journal of physiology. Cell physiology. vol 318. issue 6. 2020-08-03. PMID:32348179. |
the serotonin transporter (sert) functions to regulate the availability of serotonin (5-ht) in the brain and intestine. |
2020-08-03 |
2023-08-13 |
mouse |
| Yanqing He, Yalikun Suofu, Svitlana Yablonska, Xiaoming Wang, Timothy M Larkin, Jinho Kim, Diane L Carlisle, Robert M Friedlande. Increased Serotonin Transporter Expression in Huntington's Disease Patients Is Not Consistently Replicated in Murine Models. Journal of Huntington's disease. vol 8. issue 4. 2020-07-27. PMID:31594239. |
selective serotonin reuptake inhibitors (ssris) target the serotonin transporter (sert) and are commonly prescribed for depression in huntington's disease (hd) patients. |
2020-07-27 |
2023-08-13 |
mouse |
| Per Plenge, Ara M Abramyan, Gunnar Sørensen, Arne Mørk, Pia Weikop, Ulrik Gether, Benny Bang-Andersen, Lei Shi, Claus J Lolan. The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter. Nature communications. vol 11. issue 1. 2020-07-17. PMID:32198394. |
the serotonin transporter (sert) terminates serotonin signaling by rapid presynaptic reuptake. |
2020-07-17 |
2023-08-13 |
rat |
| Per Plenge, Ara M Abramyan, Gunnar Sørensen, Arne Mørk, Pia Weikop, Ulrik Gether, Benny Bang-Andersen, Lei Shi, Claus J Lolan. The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter. Nature communications. vol 11. issue 1. 2020-07-17. PMID:32198394. |
the sert inhibition by lu af60097 is demonstrated by the potentiated imipramine binding and increased hippocampal serotonin level in rats. |
2020-07-17 |
2023-08-13 |
rat |
| Qiang Lu, Chiaki Murakami, Fumi Hoshino, Yuki Murakami, Fumio Sakan. Diacylglycerol kinase δ destabilizes serotonin transporter protein through the ubiquitin-proteasome system. Biochimica et biophysica acta. Molecular and cell biology of lipids. vol 1865. issue 3. 2020-07-15. PMID:31891772. |
brain-specific diacylglycerol kinase (dgk) δ-knockout mice exhibited serotonin transporter (sert) inhibitor-sensitive obsessive-compulsive disorder-like behaviors. |
2020-07-15 |
2023-08-13 |
mouse |
| Ara M Abramyan, Rachel D Slack, Sitaram Meena, Bruce A Davis, Amy Hauck Newman, Satinder K Singh, Lei Sh. Computation-guided analysis of paroxetine binding to hSERT reveals functionally important structural elements and dynamics. Neuropharmacology. vol 161. 2020-07-14. PMID:30391505. |
the serotonin transporter (sert) is one of the primary targets for medications to treat neuropsychiatric disorders and functions by exploiting pre-existing ion gradients of na |
2020-07-14 |
2023-08-13 |
Not clear |
| Talia Zeppelin, Lucy Kate Ladefoged, Steffen Sinning, Birgit Schiøt. Substrate and inhibitor binding to the serotonin transporter: Insights from computational, crystallographic, and functional studies. Neuropharmacology. vol 161. 2020-07-14. PMID:30807752. |
the serotonin transporter (sert) belongs to the monoamine transporter family, which also includes the dopamine and norepinephrine transporters. |
2020-07-14 |
2023-08-13 |
Not clear |