| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Talia Zeppelin, Lucy Kate Ladefoged, Steffen Sinning, Birgit Schiøt. Substrate and inhibitor binding to the serotonin transporter: Insights from computational, crystallographic, and functional studies. Neuropharmacology. vol 161. 2020-07-14. PMID:30807752. |
sert is essential for regulating serotonergic signaling by the reuptake of serotonin from the synaptic cleft back into the presynaptic neuron. |
2020-07-14 |
2023-08-13 |
Not clear |
| Ameya Sanjay Kasture, Daniela Bartel, Thomas Steinkellner, Sonja Sucic, Thomas Hummel, Michael Freissmut. Distinct contribution of axonal and somatodendritic serotonin transporters in drosophila olfaction. Neuropharmacology. vol 161. 2020-07-14. PMID:30851308. |
the serotonin transporter (sert) regulates serotonergic neurotransmission by retrieving released serotonin and replenishing vesicular stores. |
2020-07-14 |
2023-08-13 |
human |
| Marco Niello, Daniela Cintulova, Eva Hellsberg, Kathrin Jäntsch, Marion Holy, Leila H Ayatollahi, Nicholas V Cozzi, Michael Freissmuth, Walter Sandtner, Gerhard F Ecker, Marko D Mihovilovic, Harald H Sitt. para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter. Neuropharmacology. vol 161. 2020-07-14. PMID:31028773. |
the transporters for dopamine (dat) and serotonin (sert) are important targets in the treatment of psychiatric disorders including major depression, anxiety and attention-deficit hyperactivity disorder. |
2020-07-14 |
2023-08-13 |
Not clear |
| Mary Hongying Cheng, Luca Ponzoni, Tatiana Sorkina, Ji Young Lee, She Zhang, Alexander Sorkin, Ivet Baha. Trimerization of dopamine transporter triggered by AIM-100 binding: Molecular mechanism and effect of mutations. Neuropharmacology. vol 161. 2020-07-14. PMID:31228486. |
despite the neurobiological significance of these events, the molecular mechanisms that underlie the stabilization of dat trimer and the key interactions that modulate the trimerization of dat, and not serotonin transporter sert, remain unclear. |
2020-07-14 |
2023-08-13 |
Not clear |
| Abdeslam Mouihate, Samah Kalakh, Rawan AlMutairi, Abdelrahman Alashqa. Prenatal Inflammation Dampens Neurogenesis and Enhances Serotonin Transporter Expression in the Hippocampus of Adult Female Rats. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. vol 28. issue 4. 2020-06-30. PMID:30884483. |
furthermore, blocking serotonin transporters (sert) promotes adult neurogenesis. |
2020-06-30 |
2023-08-13 |
rat |
| Anna Sophie Thue Hvilsom, Thea P Lillethorup, Peter Iversen, Doris J Doudet, Gregers Wegener, Anne M Landa. Cortical and striatal serotonin transporter binding in a genetic rat model of depression and in response to electroconvulsive stimuli. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 4. 2020-06-17. PMID:30826156. |
the serotonergic system plays an important role in depression and alterations in the serotonin transporter (sert) are seen both in depression and response to antidepressant pharmacotherapies. |
2020-06-17 |
2023-08-13 |
rat |
| Meagan A Quinlan, Danielle Krout, Rania M Katamish, Matthew J Robson, Catherine Nettesheim, Paul J Gresch, Deborah C Mash, L Keith Henry, Randy D Blakel. Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30668912. |
the antidepressant-sensitive serotonin (5-ht) transporter (sert) dictates rapid, high-affinity clearance of the neurotransmitter in both the brain and periphery. |
2020-06-11 |
2023-08-13 |
mouse |
| Meagan A Quinlan, Danielle Krout, Rania M Katamish, Matthew J Robson, Catherine Nettesheim, Paul J Gresch, Deborah C Mash, L Keith Henry, Randy D Blakel. Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30668912. |
in a study of families with multiple individuals diagnosed with autism spectrum disorder (asd), we previously identified several, rare, missense coding variants that impart elevated 5-ht transport activity, relative to wild-type sert, upon heterologous expression as well as in asd subject lymphoblasts. |
2020-06-11 |
2023-08-13 |
mouse |
| Meagan A Quinlan, Danielle Krout, Rania M Katamish, Matthew J Robson, Catherine Nettesheim, Paul J Gresch, Deborah C Mash, L Keith Henry, Randy D Blakel. Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30668912. |
the most common of these variants, sert ala56, located in the transporter's cytosolic n-terminus, has been found to confer in transgenic mice hyperserotonemia, an asd-associated biochemical trait, an elevated brain 5-ht clearance rate, and asd-aligned behavioral changes. |
2020-06-11 |
2023-08-13 |
mouse |
| Meagan A Quinlan, Danielle Krout, Rania M Katamish, Matthew J Robson, Catherine Nettesheim, Paul J Gresch, Deborah C Mash, L Keith Henry, Randy D Blakel. Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30668912. |
hyperfunction of sert ala56 has been ascribed to a change in 5-ht |
2020-06-11 |
2023-08-13 |
mouse |
| Linda D Simmler, Randy D Blakel. The SERT Met172 Mouse: An Engineered Model To Elucidate the Contributions of Serotonin Signaling to Cocaine Action. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30817127. |
the sert met172 mouse: an engineered model to elucidate the contributions of serotonin signaling to cocaine action. |
2020-06-11 |
2023-08-13 |
mouse |
| Linda D Simmler, Randy D Blakel. The SERT Met172 Mouse: An Engineered Model To Elucidate the Contributions of Serotonin Signaling to Cocaine Action. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30817127. |
in particular, a significant body of work points to altered serotonin (5-ht) signaling as one such component, not surprising given that, relative to dat, cocaine acts as potently to block the 5-ht transporter (sert) as to block dat, and thereby elevates extracellular 5-ht levels throughout the brain when reward-eliciting da elevations occur. |
2020-06-11 |
2023-08-13 |
mouse |
| Yuma Nagai, Naoya Nishitani, Masaharu Yasuda, Yasumasa Ueda, Yuto Fukui, Chihiro Andoh, Hisashi Shirakawa, Takayuki Nakagawa, Ken-Ichi Inoue, Kazuki Nagayasu, Sergey Kasparov, Kae Nakamura, Shuji Kanek. Identification of neuron-type specific promoters in monkey genome and their functional validation in mice. Biochemical and biophysical research communications. vol 518. issue 4. 2020-06-09. PMID:31451217. |
immunohistochemical analysis revealed that transgene expression induced by the promoter sequences for somatostatin (sst), cholecystokinin (cck), parvalbumin (pv), serotonin transporter (sert), vesicular acetylcholine transporter (vacht), substance p (sp) and proenkephalin (penk) was largely colocalized with specific markers for the targeted neuronal populations. |
2020-06-09 |
2023-08-13 |
mouse |
| Cheng-Tsung Liu, Yuahn-Sieh Huang, Hsin-Chien Chen, Kuo-Hsing Ma, Chih-Hung Wang, Chuang-Hsin Chiu, Jui-Hu Shih, Hsiao-Hsien Kang, Chyng-Yann Shiue, I-Hsun L. Evaluation of brain SERT with 4-[ Toxicology and applied pharmacology. vol 378. 2020-05-20. PMID:31153898. |
serotonin transporter (sert) expression was determined through micro-positron emission tomography (pet) using n,n-dimethyl-2-(2-amino-4- |
2020-05-20 |
2023-08-13 |
rat |
| Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M Landau, Bente Finse. Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease. Alzheimer's research & therapy. vol 11. issue 1. 2020-05-08. PMID:31043179. |
neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (sert) activity in a transgenic model of familial alzheimer's disease. |
2020-05-08 |
2023-08-13 |
Not clear |
| Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M Landau, Bente Finse. Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease. Alzheimer's research & therapy. vol 11. issue 1. 2020-05-08. PMID:31043179. |
discrepant and often contradictory results have accumulated regarding the antidepressant and pro-cognitive effects of serotonin transporter (sert) antagonists in alzheimer's disease. |
2020-05-08 |
2023-08-13 |
Not clear |
| Karolina Domingues, Fernanda Barbosa Lima, Aurea Elizabeth Linder, Fernando Falkenburger Melleu, Anicleto Poli, Inaê Spezia, Patrick Remus Suman, Laís Cristina Theindl, Cilene Lino de Oliveir. Sexually dimorphic responses of rats to fluoxetine in the forced swimming test are unrelated to the function of the serotonin transporter in the brain. Synapse (New York, N.Y.). vol 74. issue 1. 2020-05-05. PMID:31449695. |
in male rats, fluoxetine inhibited the serotonin (5-hydroxytryptamine, 5-ht) transporter (sert) which is reducing the immobility time in the repeated forced swimming test (rfst). |
2020-05-05 |
2023-08-13 |
rat |
| Kyoungjune Pak, Seunghyeon Shin, Keunyoung Kim, Ju Won Seok, Seong Jang Kim, In Joo Ki. Memory performance associates with serotonin transporter in midbrain and pons in healthy subjects. Hellenic journal of nuclear medicine. vol 22. issue 3. 2020-05-04. PMID:31587029. |
we aimed to evaluate the association between the availability of serotonin transporter (sert) measured by ioflupane-datscan ( |
2020-05-04 |
2023-08-13 |
human |
| Kamil Łątka, Jakub Jończyk, Marek Bajd. γ-Aminobutyric acid transporters as relevant biological target: Their function, structure, inhibitors and role in the therapy of different diseases. International journal of biological macromolecules. 2020-05-03. PMID:32360967. |
the important structural features were described based on published data, including sequence analysis, mutagenesis studies, and comparison with known slc6 transporters for leucine (leut), dopamine (dat) and serotonin (sert). |
2020-05-03 |
2023-08-13 |
Not clear |
| Weibin Zha, Tao Hu, Mary F Hebert, Joanne Wan. Effect of Pregnancy on Paroxetine-Induced Adiposity and Glucose Intolerance in Mice. The Journal of pharmacology and experimental therapeutics. vol 371. issue 1. 2020-04-20. PMID:31308195. |
long-term use of selective serotonin reuptake inhibitors (ssris) targeting the serotonin transporter (sert) has been suggested to be associated with an increased risk for obesity and type 2 diabetes. |
2020-04-20 |
2023-08-13 |
mouse |