| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoning Chen, Ran Ye, J Jay Gargus, Randy D Blakely, Kostantin Dobrenis, Ji Ying Sz. Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development. Cell reports. vol 10. issue 3. 2019-11-20. PMID:25600870. |
polymorphisms that alter serotonin transporter sert expression and functionality increase the risks for autism and psychiatric traits. |
2019-11-20 |
2023-08-13 |
mouse |
| Xiaoning Chen, Ran Ye, J Jay Gargus, Randy D Blakely, Kostantin Dobrenis, Ji Ying Sz. Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development. Cell reports. vol 10. issue 3. 2019-11-20. PMID:25600870. |
here, we investigate how sert controls serotonin signaling in developing cns in mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Xiaoning Chen, Ran Ye, J Jay Gargus, Randy D Blakely, Kostantin Dobrenis, Ji Ying Sz. Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development. Cell reports. vol 10. issue 3. 2019-11-20. PMID:25600870. |
sert is transiently expressed in specific sets of glutamatergic neurons and uptakes extrasynaptic serotonin during perinatal cns development. |
2019-11-20 |
2023-08-13 |
mouse |
| Xiaoning Chen, Ran Ye, J Jay Gargus, Randy D Blakely, Kostantin Dobrenis, Ji Ying Sz. Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development. Cell reports. vol 10. issue 3. 2019-11-20. PMID:25600870. |
pharmacological reduction of serotonin synthesis during the first postnatal week rescues sensory maps in sert |
2019-11-20 |
2023-08-13 |
mouse |
| Elyse C Dankoski, Susan Carroll, Robert Mark Wightma. Acute selective serotonin reuptake inhibitors regulate the dorsal raphe nucleus causing amplification of terminal serotonin release. Journal of neurochemistry. vol 136. issue 6. 2019-11-20. PMID:26749030. |
using microinjections, we show that the frequency-dependent enhancement in release is because of sert inhibition in the drn, demonstrating that ssris can enhance serotonin release by inhibiting uptake in a location distal to the terminal release site. |
2019-11-20 |
2023-08-13 |
mouse |
| Elyse C Dankoski, Susan Carroll, Robert Mark Wightma. Acute selective serotonin reuptake inhibitors regulate the dorsal raphe nucleus causing amplification of terminal serotonin release. Journal of neurochemistry. vol 136. issue 6. 2019-11-20. PMID:26749030. |
the novel finding that sert inhibition can disrupt modulatory mechanisms at the level of the drn to facilitate serotonin release will help future studies investigate serotonin's role in depression and motivated behavior. |
2019-11-20 |
2023-08-13 |
mouse |
| Sheng Wei, Xinyang Xiao, Jieqiong Wang, Shiguang Sun, Zifa Li, Kaiyong Xu, Fang Li, Jie Gao, Dehao Zhu, Mingqi Qia. Impact of anger emotional stress before pregnancy on adult male offspring. Oncotarget. vol 8. issue 58. 2019-11-20. PMID:29228731. |
the monoaminergic system was significantly altered in pre-gestationally stressed offspring, and the expression of phosphorylated cyclic adenosine monophosphate response element binding protein (p-creb), brain-derived neurotrophic factor (bdnf), and serotonin transporter (sert) levels in pre-gestational stressed offspring were altered in some brain regions. |
2019-11-20 |
2023-08-13 |
rat |
| Dool-Ri Oh, Yujin Kim, Eun-Jin Choi, Ara Jo, Jawon Shin, Huwon Kang, Seul-Gi Lee, Jaeyong Kim, Young Ran Kim, Chul Yung Cho. Antidepressant Effects of Vaccinium bracteatum via Protection Against Hydrogen Peroxide-Induced Oxidative Stress and Apoptosis. The American journal of Chinese medicine. 2019-11-20. PMID:30284467. |
to evaluate the antidepressant and anti-oxidant effects of vbfw, malondialdehyde (mda), serotonin transporter (sert), and monoamine oxidase a (mao-a) levels were measured in a mouse model of chronic restraint stress (crs). |
2019-11-20 |
2023-08-13 |
mouse |
| Nadine El-Ayache, James J Galliga. 5-HT American journal of physiology. Gastrointestinal and liver physiology. vol 316. issue 1. 2019-11-19. PMID:30359082. |
female serotonin transporter (sert)-gene knockout (ko) rats exhibit hypersensitivity to colorectal balloon distention (crd) that mimics colonic hypersensitivity occurring in female ibs patients. |
2019-11-19 |
2023-08-13 |
rat |
| Kathryn Lanza, Christopher Bisho. Serotonergic targets for the treatment of L-DOPA-induced dyskinesia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 8. 2019-11-04. PMID:29305656. |
this review discusses the rationale for continued investigation of several potential anti-dyskinetic strategies including 5-ht stimulation of 5-ht1a and 5-ht1b receptors and blockade of 5-ht2a receptors and sert. |
2019-11-04 |
2023-08-13 |
Not clear |
| Futao Liu, Lin Zhu, Seok Rye Choi, Karl Plössl, Zhihao Zha, Hank F Kun. Deuterium-substituted 2-(2'-((dimethylamino)methyl)-4'-[ Journal of labelled compounds & radiopharmaceuticals. vol 61. issue 8. 2019-10-24. PMID:29644713. |
deuterium-substituted 2-(2'-((dimethylamino)methyl)-4'-[ positron emission tomography imaging of serotonin transporter (sert) is useful for studying brain diseases with altered serotonergic function. |
2019-10-24 |
2023-08-13 |
Not clear |
| Enrica Saponara, Michele Visentin, Francesco Baschieri, Gitta Seleznik, Paola Martinelli, Irene Esposito, Johanna Buschmann, Rong Chen, Rossella Parrotta, Nathalie Borgeaud, Marta Bombardo, Ermanno Malagola, Amedeo Caflisch, Hesso Farhan, Rolf Graf, Sabrina Sond. Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas. The Journal of pathology. vol 246. issue 3. 2019-10-22. PMID:30058725. |
consistent with the central role played by rac1 in adm formation, inhibition of the 5-ht transporter sert (slc6a4) with fluoxetine reduced adm formation both in vitro and in vivo in a cell-autonomous manner. |
2019-10-22 |
2023-08-13 |
Not clear |
| Eric Edsinger, Gül Döle. A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus. Current biology : CB. vol 28. issue 19. 2019-10-21. PMID:30245101. |
this finding is paralleled by the evolutionary conservation of the serotonin transporter (sert, encoded by the slc6a4 gene) binding site of mdma in the o. bimaculoides genome. |
2019-10-21 |
2023-08-13 |
human |
| Christopher Manzella, Megha Singhal, Waddah A Alrefai, Seema Saksena, Pradeep K Dudeja, Ravinder K Gil. Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR. Scientific reports. vol 8. issue 1. 2019-10-10. PMID:29666456. |
cyp1a1 induction by 5-ht was dependent upon uptake via serotonin transporter (sert). |
2019-10-10 |
2023-08-13 |
Not clear |
| Christopher Manzella, Megha Singhal, Waddah A Alrefai, Seema Saksena, Pradeep K Dudeja, Ravinder K Gil. Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR. Scientific reports. vol 8. issue 1. 2019-10-10. PMID:29666456. |
these results suggest that intracellular accumulation of 5-ht via sert induces cyp1a1 expression via ahr in intestinal epithelial cells, and sert deficiency in vivo impairs activation of ahr. |
2019-10-10 |
2023-08-13 |
Not clear |
| Brian A Bald. Opioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects. Archives of toxicology. vol 92. issue 8. 2019-10-07. PMID:29916050. |
while relevance to human serotonin toxicity of animal models, including many studies on rat brain synaptosomes, is questionable, important insights have recently been forthcoming from research utilizing 5-ht receptors, serotonin transporter (sert), and knockout mice. |
2019-10-07 |
2023-08-13 |
mouse |
| Umberto M Battisti, Ramsey Sitta, Alan Harris, Farhana Sakloth, Donna Walther, Iwona Ruchala, S Stevens Negus, Michael H Baumann, Richard A Glennon, Jose M Elti. Effects of N-Alkyl-4-Methylamphetamine Optical Isomers on Plasma Membrane Monoamine Transporters and Abuse-Related Behavior. ACS chemical neuroscience. vol 9. issue 7. 2019-09-30. PMID:29697951. |
4-methylamphetamine (4-ma) is an emerging drug of abuse that acts as a substrate at plasma membrane transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), thereby causing nonexocytotic release of monoamine transmitters via reverse transport. |
2019-09-30 |
2023-08-13 |
rat |
| Su Bong Nam, Keunyoung Kim, Bum Soo Kim, Hyung-Jun Im, Seung Hun Lee, Seong-Jang Kim, In Joo Kim, Kyoungjune Pa. The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters. Scientific reports. vol 8. issue 1. 2019-09-26. PMID:29563547. |
the authors investigated relations between obesity, age, and sex and the availabilities of striatal dopamine transporter (dat) and extrastriatal serotonin transporter (sert) by |
2019-09-26 |
2023-08-13 |
Not clear |
| Peter S Hasenhuetl, Shreyas Bhat, Felix P Mayer, Harald H Sitte, Michael Freissmuth, Walter Sandtne. A kinetic account for amphetamine-induced monoamine release. The Journal of general physiology. vol 150. issue 3. 2019-09-24. PMID:29439119. |
the plasmalemmal monoamine transporters for dopamine, norepinephrine, and serotonin (sert) are targets for amphetamines. |
2019-09-24 |
2023-08-13 |
Not clear |
| Felix Makolo, Alvaro Viljoen, Clinton G L Veal. Mesembrine: The archetypal psycho-active Sceletium alkaloid. Phytochemistry. vol 166. 2019-09-24. PMID:31299396. |
binding assays have revealed that mesembrine is a more potent inhibitor of the serotonin transporter (sert) than fluoxetine (prozac) which has prompted the commercialization of mesembrine-containing consumer products. |
2019-09-24 |
2023-08-13 |
Not clear |