| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lan-Ting Lee, Hsin Chun Tsai, Mei Hung Chi, Wei Hung Chang, Kao Chin Chen, I Hui Lee, Po See Chen, Wei Jen Yao, Nan Tsing Chiu, Yen Kuang Yan. Lower availability of striatal dopamine transporter in generalized anxiety disorder: a preliminary two-ligand SPECT study. International clinical psychopharmacology. vol 30. issue 3. 2016-01-15. PMID:25647452. |
the aims of this study were to examine the availabilities of the striatal dopamine transporter (dat) and the midbrain serotonin transporter (sert) in patients with gad. |
2016-01-15 |
2023-08-13 |
human |
| Ying-Shan Piao, Frank Scott Hall, Yuki Moriya, Miki Ito, Arihisa Ohara, Ruri Kikura-Hanajiri, Yukihiro Goda, Klaus-Peter Lesch, Dennis L Murphy, George R Uhl, Ichiro Sor. Methylone-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. Behavioural pharmacology. vol 26. issue 4. 2016-01-13. PMID:25794333. |
methylone has been assumed to induce hyperthermic effects through inhibition of serotonin and/or dopamine transporters (sert and dat, respectively). |
2016-01-13 |
2023-08-13 |
mouse |
| F Sakloth, R Kolanos, P D Mosier, J S Bonano, M L Banks, J S Partilla, M H Baumann, S S Negus, R A Glenno. Steric parameters, molecular modeling and hydropathic interaction analysis of the pharmacology of para-substituted methcathinone analogues. British journal of pharmacology. vol 172. issue 9. 2016-01-05. PMID:25522019. |
specifically, the steric character (taft's steric es ) of the 4-position substituent affected in vitro potency to induce monoamine release via dopamine and 5-ht transporters (dat and sert) and in vivo modulation of intracranial self-stimulation (icss). |
2016-01-05 |
2023-08-13 |
Not clear |
| Anna Rickli, Marius C Hoener, Matthias E Liecht. Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 3. 2015-12-15. PMID:25624004. |
we tested the potency of these compounds to inhibit the norepinephrine (ne), dopamine (da), and serotonin (5-ht) transporters (net, dat, and sert, respectively) using human embryonic kidney 293 cells that express the respective human transporters. |
2015-12-15 |
2023-08-13 |
human |
| Rong Xu, Sarah A Lord, Ryan M Peterson, Emily A Fergason-Cantrell, John R Lever, Susan Z Leve. Ether modifications to 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): effects on binding affinity and selectivity for sigma receptors and monoamine transporters. Bioorganic & medicinal chemistry. vol 23. issue 1. 2015-10-22. PMID:25468036. |
sa4503 and a subset of ether analogs were also evaluated for dopamine transporter (dat) and serotonin transporter (sert) affinity. |
2015-10-22 |
2023-08-13 |
Not clear |
| Ole V Mortensen, Sandhya Kortager. Designing modulators of monoamine transporters using virtual screening techniques. Frontiers in pharmacology. vol 6. 2015-10-20. PMID:26483692. |
the plasma-membrane monoamine transporters (mats), including the serotonin (sert), norepinephrine (net) and dopamine (dat) transporters, serve a pivotal role in limiting monoamine-mediated neurotransmission through the reuptake of their respective monoamine neurotransmitters. |
2015-10-20 |
2023-08-13 |
drosophila_melanogaster |
| George Khelashvili, Harel Weinstei. Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops. Biochimica et biophysica acta. vol 1848. issue 9. 2015-09-30. PMID:25847498. |
recent experimental evidence implicates highly anionic phosphatidylinositol 4,5-biphosphate (pip(2)) lipids in such functions of the serotonin (sert) and dopamine (dat) transporters. |
2015-09-30 |
2023-08-13 |
Not clear |
| Stefanie H Grimm, Georg Höfner, Klaus T Wanne. Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor indatraline enabling its quantification in MS Binding Assays. Analytical and bioanalytical chemistry. vol 407. issue 2. 2015-09-28. PMID:25450050. |
we herein present the first lc-ms/ms quantification method for indatraline, a highly potent nonselective inhibitor of the three monoamine transporters (for dopamine, dat; norepinephrine, net; serotonin, sert), and its application to ms binding assays. |
2015-09-28 |
2023-08-13 |
Not clear |
| Yasemin Karabacak, Sunetra Sase, Yogesh D Aher, Ajinkya Sase, Sivaprakasam R Saroja, Ana Cicvaric, Harald Höger, Michael Berger, Vasiliy Bakulev, Harald H Sitte, Johann Leban, Francisco J Monje, Gert Lube. The effect of modafinil on the rat dopamine transporter and dopamine receptors D1-D3 paralleling cognitive enhancement in the radial arm maze. Frontiers in behavioral neuroscience. vol 9. 2015-09-08. PMID:26347626. |
reuptake inhibition of dopamine, serotonin (sert) and norepinephrine (net) by modafinil was tested. |
2015-09-08 |
2023-08-13 |
rat |
| Yasemin Karabacak, Sunetra Sase, Yogesh D Aher, Ajinkya Sase, Sivaprakasam R Saroja, Ana Cicvaric, Harald Höger, Michael Berger, Vasiliy Bakulev, Harald H Sitte, Johann Leban, Francisco J Monje, Gert Lube. The effect of modafinil on the rat dopamine transporter and dopamine receptors D1-D3 paralleling cognitive enhancement in the radial arm maze. Frontiers in behavioral neuroscience. vol 9. 2015-09-08. PMID:26347626. |
modafinil was binding to the dat but insignificantly to sert or net and dopamine reuptake was blocked specifically (ic50 = 11.11 μm; sert 1547 μm; net 182 μm). |
2015-09-08 |
2023-08-13 |
rat |
| Moe Igari, Hao-Wei Shen, Yoko Hagino, Setsu Fukushima, Yoshiyuki Kasahara, Klaus-Peter Lesch, Dennis L Murphy, Frank Scott Hall, George R Uhl, Kazutaka Ikeda, Nobuo Yaegashi, Ichiro Sor. Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25485646. |
meth-induced increases in extracellular 5-ht (5-htex) levels were substantially reduced in sert-/- mice, although sert genotype had no effect on meth-induced increases in extracellular dopamine. |
2015-09-03 |
2023-08-13 |
mouse |
| Peter S Hasenhuetl, Klaus Schicker, Xaver Koenig, Yang Li, Subhodeep Sarker, Thomas Stockner, Sonja Sucic, Harald H Sitte, Michael Freissmuth, Walter Sandtne. Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction. Molecular pharmacology. vol 88. issue 1. 2015-08-11. PMID:25873594. |
the membrane transporters for the monoamines serotonin (sert) and dopamine (dat) are prominent targets of various psychoactive substances, including competitive inhibitors, such as tricyclic antidepressants, methylphenidate, and cocaine. |
2015-08-11 |
2023-08-13 |
Not clear |
| Mariane Cristovão Bagatin, Camila Santos Suniga Tozatti, Layara Akemi Abiko, Diego Alberto dos Santos Yamazaki, Priscila Rebeca Alves Silva, Leonardo Martins Perego, Elisabeth Aparecida Audi, Flavio Augusto Vicente Seixas, Ernani Abicht Basso, Gisele de Freitas Gauz. Molecular docking and panicolytic effect of 8-prenylnaringenin in the elevated T-maze. Chemical & pharmaceutical bulletin. vol 62. issue 12. 2015-07-14. PMID:25450631. |
to evaluate the interactions of 8-pn with monoamine transporters, a docking study was performed for both the r and s configurations of 8-pn towards sert, norepinephrine (net) and dopamine transporters (dat). |
2015-07-14 |
2023-08-13 |
rat |
| Javier A Urra, Franz Villaroel-Espíndola, Alejandra A Covarrubias, Joan Enric Rodríguez-Gil, Alfredo Ramírez-Reveco, Ilona I Conch. Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity. PloS one. vol 9. issue 11. 2015-07-08. PMID:25402186. |
in the present study, using immunodetection methods, we revealed the presence of several proteins important for the dopamine uptake and signalling in mammalian sperm, specifically monoamine transporters as dopamine (dat), serotonin (sert) and norepinephrine (net) transporters in equine sperm. |
2015-07-08 |
2023-08-13 |
Not clear |
| Javier A Urra, Franz Villaroel-Espíndola, Alejandra A Covarrubias, Joan Enric Rodríguez-Gil, Alfredo Ramírez-Reveco, Ilona I Conch. Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity. PloS one. vol 9. issue 11. 2015-07-08. PMID:25402186. |
in summary, our results revealed the presence of monoamine transporter dat, net and sert in equine sperm, and that the dopamine uptake by dat can regulate sperm function, specifically acrosomal integrity and sperm motility. |
2015-07-08 |
2023-08-13 |
Not clear |
| Thomas Steinkellner, Liudmilla Mus, Birgit Eisenrauch, Andreea Constantinescu, Damiana Leo, Lisa Konrad, Mattias Rickhag, Gunnar Sørensen, Evgenia V Efimova, Eryan Kong, Matthäus Willeit, Tatyana D Sotnikova, Oliver Kudlacek, Ulrik Gether, Michael Freissmuth, Daniela D Pollak, Raul R Gainetdinov, Harald H Sitt. In vivo amphetamine action is contingent on αCaMKII. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 11. 2015-06-15. PMID:24871545. |
cocaine acts as a blocker at the transporters for dopamine (dat), serotonin (sert), and norepinephrine (net), but amphetamines are substrates that do not only block the uptake of monoamines but also induce substrate efflux by promoting reverse transport. |
2015-06-15 |
2023-08-13 |
mouse |
| Walter Koch, Marcus Unterrainer, Guoming Xiong, Peter Bartenstein, Markus Diemling, Andrea Varrone, John C Dickson, Livia Tossici-Bolt, Terez Sera, Susanne Asenbaum, Jan Booij, Ozlem L Kapucu, Andreas Kluge, Morten Ziebell, Jacques Darcourt, Flavio Nobili, Marco Pagani, Swen Hesse, Thierry Vander Borght, Koen Van Laere, Klaus Tatsch, Christian la Fougèr. Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls. European journal of nuclear medicine and molecular imaging. vol 41. issue 10. 2015-06-05. PMID:24806112. |
apart from binding to the dopamine transporter (dat), [(123)i]fp-cit shows moderate affinity for the serotonin transporter (sert), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. |
2015-06-05 |
2023-08-13 |
Not clear |
| P C Hsieh, K C Chen, T L Yeh, I H Lee, P S Chen, W J Yao, N-T Chiu, C-C Chen, M-H Liao, Y K Yan. Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder - a preliminary two-ligand SPECT study. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24439516. |
serotonin transporter (sert) and dopamine transporter (dat) levels differ in patients with major depressive disorder (mdd) who are in a depressed state in comparison with healthy controls. |
2015-05-15 |
2023-08-12 |
human |
| Simon D Brandt, Michael H Baumann, John S Partilla, Pierce V Kavanagh, John D Power, Brian Talbot, Brendan Twamley, Olivia Mahony, John O'Brien, Simon P Elliott, Roland P Archer, Julian Patrick, Kuldip Singh, Nicola M Dempster, Simon H Cosbe. Characterization of a novel and potentially lethal designer drug (±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or 'Serotoni'). Drug testing and analysis. vol 6. issue 7-8. 2015-03-30. PMID:24841869. |
(±)-cis-4,4'-dmar was a potent, efficacious substrate-type releaser at transporters for dopamine, norepinephrine and serotonin with ec50 values of 8.6 ± 1.1 nm (dat), 26.9 ± 5.9 nm (net) and 18.5 ± 2.8 nm (sert), respectively. |
2015-03-30 |
2023-08-13 |
rat |
| Philippe Huot, Susan H Fox, Jonathan M Brotchi. Monoamine reuptake inhibitors in Parkinson's disease. Parkinson's disease. vol 2015. 2015-03-26. PMID:25810948. |
despite wide discrepancy in the methodology of the studies reviewed, the following conclusions can be drawn: (1) selective serotonin transporter (sert), selective noradrenaline transporter (net), and dual sert/net inhibitors are effective against pd depression; (2) selective dopamine transporter (dat) and dual dat/net inhibitors exert an anti-parkinsonian effect when administered as monotherapy but do not enhance the anti-parkinsonian actions of l-3,4-dihydroxyphenylalanine (l-dopa); (3) dual dat/sert inhibitors might enhance the anti-parkinsonian actions of l-dopa without worsening dyskinesia; (4) triple dat/net/sert inhibitors might exert an anti-parkinsonian action as monotherapy and might enhance the anti-parkinsonian effects of l-dopa, though at the expense of worsening dyskinesia. |
2015-03-26 |
2023-08-13 |
Not clear |