| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Les Iversen, Simon Gibbons, Ric Treble, Vincent Setola, Xi-Ping Huang, Bryan L Rot. Neurochemical profiles of some novel psychoactive substances. European journal of pharmacology. vol 700. issue 1-3. 2013-08-05. PMID:23261499. |
thirteen of the test substances acted as inhibitors of monoamine uptake at submicromolar concentrations, including 9 potent inhibitors of the dopamine transporter (dat), 12 potent inhibitors of the norepinephrine transporter (net) and 4 potent inhibitors of the serotonin transporter (sert). |
2013-08-05 |
2023-08-12 |
human |
| Michael H Baumann, John S Partilla, Kurt R Lehne. Psychoactive "bath salts": not so soothing. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23178799. |
similar to other psychomotor stimulants, synthetic cathinones target plasma membrane transporters for dopamine (i.e., dat), norepinephrine (i.e., net) and serotonin (i.e, sert). |
2013-06-10 |
2023-08-12 |
rat |
| Peng Zhang, Trine Nygaard Jørgensen, Claus J Loland, Amy Hauck Newma. A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter. Bioorganic & medicinal chemistry letters. vol 23. issue 1. 2013-05-28. PMID:23168018. |
the resulting rhodamine-labeled ligand 8 inhibited [(3)h]5-ht uptake in cos-7 cells (k(i)=225 nm) with similar potency to the tropane-based jhc 1-064 (1), but with higher specificity towards the sert relative to the transporters for dopamine and norepinephrine. |
2013-05-28 |
2023-08-12 |
Not clear |
| Soumava Santra, Sanjib Gogoi, Bhaskar Gopishetty, Tamara Antonio, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Structural exploration of (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine analogues: identification of potent triple monoamine reuptake inhibitors as potential antidepressants. ChemMedChem. vol 7. issue 12. 2013-04-29. PMID:23060293. |
the new compounds were tested for their affinities for the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net) in rat brain by measuring their capacity to inhibit the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2013-04-29 |
2023-08-12 |
rat |
| Abigail G Schindler, Daniel I Messinger, Jeffrey S Smith, Haripriya Shankar, Richard M Gustin, Selena S Schattauer, Julia C Lemos, Nicholas W Chavkin, Catherine E Hagan, John F Neumaier, Charles Chavki. Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 49. 2013-04-11. PMID:23223282. |
kinetic analysis of several neurotransporters demonstrated that repeated swim stress exposure selectively increased the v(max) but not k(m) of sert without affecting dopamine transport or the high-capacity, low-affinity transporters. |
2013-04-11 |
2023-08-12 |
mouse |
| Clelia Dallanoce, Mara Canovi, Carlo Matera, Tiziana Mennini, Marco De Amici, Marco Gobbi, Carlo De Michel. A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake. Bioorganic & medicinal chemistry. vol 20. issue 21. 2013-04-05. PMID:23022052. |
their interaction with the dopamine and serotonin transporters (dat and sert, respectively) was evaluated through binding experiments. |
2013-04-05 |
2023-08-12 |
rat |
| Philippe Huot, Tom H Johnston, Michael N Gandy, M Gabriela Reyes, Susan H Fox, Matthew J Piggott, Jonathan M Brotchi. The monoamine re-uptake inhibitor UWA-101 improves motor fluctuations in the MPTP-lesioned common marmoset. PloS one. vol 7. issue 9. 2013-03-28. PMID:23029119. |
we recently described the discovery of uwa-101, a dual serotonin (sert) and dopamine (dat) transporter inhibitor, which increases the duration of "good quality" on-time provided by l-dopa in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned primate. |
2013-03-28 |
2023-08-12 |
marmoset |
| Víctor Pérez, Juan Carlos Pascual, Joaquim Soler, Thais Tiana, Anna Cortés, Montserrat Baiget, Ana Martín-Blanco, Enrique Alvare. [Pyschotherapygenetics. Do genes influence psychotherapy adherence?]. Revista de psiquiatria y salud mental. vol 3. issue 2. 2013-03-01. PMID:23445932. |
the aim was to examine the association between polymorphisms of the serotonin transporter gene (sert) and the dopamine 4-receptor gene (drd4) with adherence to psychotherapy. |
2013-03-01 |
2023-08-12 |
Not clear |
| Rachel W S Li, Cui Yang, Y W Kwan, S W Chan, Simon M Y Lee, George P H Leun. Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells. Frontiers in pharmacology. vol 4. 2013-02-15. PMID:23407616. |
the specific serotonin re-uptake transporter (sert) inhibitor citalopram, the specific norepinephrine transporter (net) inhibitor desipramine, and the dopamine transporter (dat) inhibitor gbr12935 inhibited 5-ht uptake in hbvsmcs with ic(50) values of 97.03 ± 40.10, 10.49 ± 5.98, and 2.80 ± 1.04 μm, respectively. |
2013-02-15 |
2023-08-12 |
human |
| Shih-Hsien Lin, Kao Chin Chen, Sheng-Yu Lee, Wei Jen Yao, Nan-Tsing Chiu, I Hui Lee, Po See Chen, Tzung Lieh Yeh, Mei-Hsiu Liao, Ru-Band Lu, Yen Kuang Yan. The association between availability of serotonin transporters and time to relapse in heroin users: a two-isotope SPECT small sample pilot study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 9. 2013-01-17. PMID:22335891. |
in this two-isotope spect small sample (n=9) pilot study, the relationship between the availability of serotonin transporter (sert) and dopamine transporter (dat) and the relapse of heroin users was investigated. |
2013-01-17 |
2023-08-12 |
Not clear |
| Ruth Tellez, Leticia Gómez-Viquez, Gustavo Liy-Salmeron, Alfredo Menese. GABA, glutamate, dopamine and serotonin transporters expression on forgetting. Neurobiology of learning and memory. vol 98. issue 1. 2012-12-03. PMID:22633984. |
notwithstanding several neurotransmission systems are frequently related to memory formation; forgetting process and neurotransmission systems or their transporters; the role of γ-aminobutyric acid (gat1), glutamate (eacc1), dopamine (dat) and serotonin (sert) is poorly understood. |
2012-12-03 |
2023-08-12 |
rat |
| Stephen J Kohut, Kathleen L Decicco-Skinner, Shirin Johari, Zachary E Hurwitz, Michael H Baumann, Anthony L Rile. Differential modulation of cocaine's discriminative cue by repeated and variable stress exposure: relation to monoamine transporter levels. Neuropharmacology. vol 63. issue 2. 2012-11-19. PMID:22516586. |
dopamine (dat), serotonin (sert) and norepinephrine (net) transporter levels in mesocorticolimbic areas were also measured using western blotting after stress exposure to determine if the relative ratio of these proteins may explain differences in behavior. |
2012-11-19 |
2023-08-12 |
rat |
| Joel G Anderson, Paula T Cooney, Keith M Erikso. Inhibition of DAT function attenuates manganese accumulation in the globus pallidus. Environmental toxicology and pharmacology. vol 23. issue 2. 2012-10-02. PMID:17387379. |
our primary goal of this study was to examine the potential roles of the monoamine transporters, dopamine transporter (dat), serotonin transporter (sert) and norepinephrine transporter (net), in neuronal mn transport. |
2012-10-02 |
2023-08-12 |
rat |
| Mari Gabrielsen, Ingebrigt Sylte, Svein G Dahl, Aina W Ravn. A short update on the structure of drug binding sites on neurotransmitter transporters. BMC research notes. vol 4. 2012-10-02. PMID:22192271. |
the dopamine (dat), noradrenalin (net) and serotonin (sert) transporters are molecular targets for different classes of psychotropic drugs. |
2012-10-02 |
2023-08-12 |
Not clear |
| Xue Y Zhu, Jagan R Etukala, Suresh V K Eyunni, Vincent Setola, Bryan L Roth, Seth Y Ablordeppe. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. European journal of medicinal chemistry. vol 53. 2012-09-25. PMID:22520153. |
in addition, compound 20 binds with low affinity to the dopamine transporter (dat), the norepinephrine transporter (net) and 5ht(2c) receptor, which are desirable properties as selectivity for sert (and not dat or net) is associated with an absence of cardiovascular side effects. |
2012-09-25 |
2023-08-12 |
Not clear |
| Simon Bulling, Klaus Schicker, Yuan-Wei Zhang, Thomas Steinkellner, Thomas Stockner, Christian W Gruber, Stefan Boehm, Michael Freissmuth, Gary Rudnick, Harald H Sitte, Walter Sandtne. The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. The Journal of biological chemistry. vol 287. issue 22. 2012-08-15. PMID:22451652. |
ibogaine noncompetitively inhibited transport by both sert and the homologous dopamine transporter (dat). |
2012-08-15 |
2023-08-12 |
Not clear |
| Ruth Tellez, Leticia Gómez-Víquez, Alfredo Menese. GABA, glutamate, dopamine and serotonin transporters expression on memory formation and amnesia. Neurobiology of learning and memory. vol 97. issue 2. 2012-07-05. PMID:22183017. |
notwithstanding several neurotransmission systems are frequently related to memory formation, amnesia and/or therapeutic targets for memory alterations, the role of transporters γ-aminobutyric acid (gaba, gat1), glutamate (neuronal glutamate transporter excitatory amino acid carrier; eacc1), dopamine (dat) and serotonin (sert) is poorly understood. |
2012-07-05 |
2023-08-12 |
rat |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
in animals, binge mamph dosing regimens deplete markers for monoamine nerve terminals, for example, dopamine and serotonin transporters (dat and sert), in striatum and cerebral cortex. |
2012-06-18 |
2023-08-12 |
Not clear |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
the present study examined the contribution of dopamine d1 and d2 receptors in striatum to mamph-induced dat and sert neurotoxicities. |
2012-06-18 |
2023-08-12 |
Not clear |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
blockade of striatal dopamine d1 or d2 receptors during an otherwise neurotoxic binge mamph regimen produced widespread protection against mamph-induced striatal dat loss and cortical, hippocampal, and amygdalar sert loss. |
2012-06-18 |
2023-08-12 |
Not clear |