| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
this study demonstrates that (1) dopamine d1 and d2 receptors in striatum, like nigral d1 receptors, are needed for mamph-induced striatal dat reductions, (2) these same receptors are needed for mamph-induced sert loss, and (3) these widespread influences of striatal dopamine receptor antagonists are likely attributable to circuits connecting basal ganglia to thalamus and cortex. |
2012-06-18 |
2023-08-12 |
Not clear |
| L MacGillivray, K B Reynolds, M Sickand, P I Rosebush, M F Mazure. Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584867. |
these results indicate that sert inhibition can activate microglia and alter the regulation of th, the rate limiting enzyme for dopamine biosynthesis. |
2012-06-18 |
2023-08-12 |
rat |
| Petroula Proitsi, Michelle K Lupton, Suzanne J Reeves, Gillian Hamilton, Nicola Archer, Belinda M Martin, Conrad Iyegbe, Paul Hollingworth, Brian Lawlor, Michael Gill, Carol Brayne, David C Rubinsztein, Michael J Owen, Julie Williams, Simon Lovestone, John F Powel. Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:20685009. |
significant associations were observed between the serotonin transporter gene (sert) polymorphism stin2 and "psychosis"; the dopamine transporter gene (dat) 3' variable number tandem repeats (vntr) and "agitation"; and the dopamine receptor 4 (drd4) vntr and "moods" factors. |
2012-06-15 |
2023-08-12 |
Not clear |
| Petroula Proitsi, Michelle K Lupton, Suzanne J Reeves, Gillian Hamilton, Nicola Archer, Belinda M Martin, Conrad Iyegbe, Paul Hollingworth, Brian Lawlor, Michael Gill, Carol Brayne, David C Rubinsztein, Michael J Owen, Julie Williams, Simon Lovestone, John F Powel. Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:20685009. |
direct associations were identified between the dopamine receptor 3 (drd3) bali polymorphism and depression; the dopamine receptor 1 (drd1) and dopamine transporter gene 3' vntr polymorphisms and aberrant motor behavior; the drd4 vntr and sleep disturbances; and the sert gene vntr 5httlpr and apathy items. |
2012-06-15 |
2023-08-12 |
Not clear |
| Simon Vermeire, Kurt Audenaert, Rudy De Meester, Eva Vandermeulen, Tim Waelbers, Bart De Spiegeleer, Jos Eersels, André Dobbeleir, Kathelijne Pereman. Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder. Psychiatry research. vol 201. issue 1. 2012-06-11. PMID:22285716. |
single photon emission computed tomography was used with (123)i-r91150 and (123)i-fp-cit, in combination with (99m)tc-ecd brain perfusion co-registration, to measure the serotonin (5-ht) 2a receptor, dopamine transporter (dat) and serotonin transporter (sert) availability. |
2012-06-11 |
2023-08-12 |
human |
| A C Meyer, D B Horton, N M Neugebauer, T E Wooters, J R Nickell, L P Dwoskin, M T Bard. Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21669212. |
effects of tbz on function of the dopamine transporter (dat) and serotonin transporter (sert) in striatal and hippocampal synaptosomes, respectively, and on vmat2 function in isolated striatal synaptic vesicles were determined. |
2012-05-25 |
2023-08-12 |
rat |
| Shaine A Cararas, Sari Izenwasser, Dean Wade, Amy Housman, Abha Verma, Stacey A Lomenzo, Mark L Trudel. Further structure-activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters. Bioorganic & medicinal chemistry. vol 19. issue 24. 2012-03-19. PMID:22055716. |
the synthesis and structure-activity relationships of 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives were investigated at the dopamine transporter (dat), the serotonin transporter (sert) and norepinephrine transporter (net). |
2012-03-19 |
2023-08-12 |
Not clear |
| Sarah Hohmann, Nina Schweinfurth, Thorsten Lau, Michael Deuschle, Florian Lederbogen, Tobias Banaschewski, Patrick Schlos. Differential expression of neuronal dopamine and serotonin transporters DAT and SERT in megakaryocytes and platelets generated from human MEG-01 megakaryoblasts. Cell and tissue research. vol 346. issue 2. 2012-03-06. PMID:22006250. |
differential expression of neuronal dopamine and serotonin transporters dat and sert in megakaryocytes and platelets generated from human meg-01 megakaryoblasts. |
2012-03-06 |
2023-08-12 |
human |
| Sarah Hohmann, Nina Schweinfurth, Thorsten Lau, Michael Deuschle, Florian Lederbogen, Tobias Banaschewski, Patrick Schlos. Differential expression of neuronal dopamine and serotonin transporters DAT and SERT in megakaryocytes and platelets generated from human MEG-01 megakaryoblasts. Cell and tissue research. vol 346. issue 2. 2012-03-06. PMID:22006250. |
in the central nervous system, serotonergic and dopaminergic signaling is terminated by the activity of specialized transporter proteins for serotonin (sert) and dopamine (dat). |
2012-03-06 |
2023-08-12 |
human |
| Piotr Tybura, Anna Grzywacz, Agnieszka Samochowiec, Jerzy Samochowie. [Associations between candidate genes with schizophrenia susceptibility and the treatment efficiency]. Psychiatria polska. vol 45. issue 6. 2012-03-06. PMID:22335125. |
we analysed the gene polymorphisms: dopamine receptor--drd2 (taq 1a, in egzon 8,- 141 c ins/del), dopamine transporter--dat, kainate receptor--grik3, serotonine transporter--sert, serotonine receptor--5ht2a, mono amine oxidase a--mao-a, catechol o-methyl transferase--comt. |
2012-03-06 |
2023-08-12 |
Not clear |
| J-W Tian, W-L Jiang, Y Zhong, Q Meng, Y Gai, H-B Zhu, J Hou, Y Xing, Y-X L. Preclinical pharmacology of TP1, a novel potent triple reuptake inhibitor with antidepressant properties. Neuroscience. vol 196. 2012-02-23. PMID:21925241. |
triple reuptake inhibitors (tris) that block the dopamine transporter (dat), norepinephrine transporter (net), and serotonin transporter (sert) are being developed as a new class of antidepressant that may have better efficacy and fewer side effects compared with traditional antidepressants. |
2012-02-23 |
2023-08-12 |
human |
| Kevin H Chen, Edmund A Reese, Hyung-Wook Kim, Stanley I Rapoport, Jagadeesh S Ra. Disturbed neurotransmitter transporter expression in Alzheimer's disease brain. Journal of Alzheimer's disease : JAD. vol 26. issue 4. 2012-01-26. PMID:21743130. |
we hypothesized that altered reuptake of neurotransmitters by vesicular glutamate transporters (vgluts), excitatory amino acid transporters (eaats), the vesicular acetylcholine transporter (vacht), the serotonin reuptake transporter (sert), or the dopamine reuptake transporter (dat) are involved in the neurotransmission imbalance in ad. |
2012-01-26 |
2023-08-12 |
Not clear |
| Meike Heeren, Karin Weissenborn, Dimitrios Arvanitis, Martin Bokemeyer, Annemarie Goldbecker, Argyro Tountopoulou, Thomas Peschel, Julian Grosskreutz, Hartmut Hecker, Ralph Buchert, Georg Berdin. Cerebral glucose utilisation in hepatitis C virus infection-associated encephalopathy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 11. 2011-12-27. PMID:21629258. |
therefore, 15 patients who reported increasing chronic fatigue, mood alterations, and/or cognitive decline since their hcv infection underwent neurologic and neuropsychological examination, magnetic resonance imaging, (18)f-fluoro-deoxy-glucose positron emission tomography of the brain, and single photon emission tomography of striatal dopamine and midbrain serotonin transporter (sert) availability. |
2011-12-27 |
2023-08-12 |
Not clear |
| Meike Heeren, Karin Weissenborn, Dimitrios Arvanitis, Martin Bokemeyer, Annemarie Goldbecker, Argyro Tountopoulou, Thomas Peschel, Julian Grosskreutz, Hartmut Hecker, Ralph Buchert, Georg Berdin. Cerebral glucose utilisation in hepatitis C virus infection-associated encephalopathy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 11. 2011-12-27. PMID:21629258. |
in addition, regression analysis was performed between cognitive deficits, and mood and fatigue scores as dependent variables, and cerebral glucose metabolism, dopamine, or sert availability as predictors. |
2011-12-27 |
2023-08-12 |
Not clear |
| Meike Heeren, Karin Weissenborn, Dimitrios Arvanitis, Martin Bokemeyer, Annemarie Goldbecker, Argyro Tountopoulou, Thomas Peschel, Julian Grosskreutz, Hartmut Hecker, Ralph Buchert, Georg Berdin. Cerebral glucose utilisation in hepatitis C virus infection-associated encephalopathy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 11. 2011-12-27. PMID:21629258. |
patients showed significant cognitive deficits, significantly decreased striatal dopamine and midbrain sert availability, and significantly reduced glucose metabolism in the limbic association cortex, and in the frontal, parietal, and superior temporal cortices, all of which correlated with dopamine transporter availability and psychometric results. |
2011-12-27 |
2023-08-12 |
Not clear |
| Deepangi Pandit, William Roosma, Milind Misra, Kathleen M Gilbert, William J Skawinski, Carol A Venanz. Conformational analysis of piperazine and piperidine analogs of GBR 12909: stochastic approach to evaluating the effects of force fields and solvent. Journal of molecular modeling. vol 17. issue 1. 2011-12-19. PMID:20414792. |
as a first step in the 3d-qsar modeling of the dopamine transporter (dat)/serotonin transporter (sert) selectivity of these compounds, we carried out conformational analyses of two analogs of 1: a piperazine (2) and a related piperidine (3). |
2011-12-19 |
2023-08-12 |
Not clear |
| Emily Karanges, Kong M Li, Craig Motbey, Paul D Callaghan, Andrew Katsifis, Iain S McGrego. Differential behavioural and neurochemical outcomes from chronic paroxetine treatment in adolescent and adult rats: a model of adverse antidepressant effects in human adolescents? The international journal of neuropsychopharmacology. vol 14. issue 4. 2011-12-16. PMID:21329552. |
subsequent ex-vivo analyses examined serum prx concentrations, striatal neurotransmitter content, and regional serotonin and dopamine transporter (sert, dat) binding density. |
2011-12-16 |
2023-08-12 |
human |
| Joanna Solich, Agata Faron-Gorecka, Maciej Kusmider, Paulina Palach, Magdalena Gaska, Marta Dziedzicka-Wasylewsk. Norepinephrine transporter (NET) knock-out upregulates dopamine and serotonin transporters in the mouse brain. Neurochemistry international. vol 59. issue 2. 2011-11-22. PMID:21693154. |
in the present study we demonstrate that the life-long deletion of the noradrenaline transporter (net) induced up-regulation of two other monoamine transporters, dopamine and serotonin (dat and sert, respectively). |
2011-11-22 |
2023-08-12 |
mouse |
| Chiharu Sogawa, Norio Sogawa, Kazumi Ohyama, Ruri Kikura-Hanajiri, Yukihiro Goda, Ichiro Sora, Shigeo Kitayam. Methylone and monoamine transporters: correlation with toxicity. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886563. |
we examined here the effects of methylone on the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), using a heterologous expression system in cho cells, in association with its cytotoxicity. |
2011-11-10 |
2023-08-12 |
Not clear |
| Y Hagino, Y Takamatsu, H Yamamoto, T Iwamura, D L Murphy, G R Uhl, I Sora, K Iked. Effects of MDMA on Extracellular Dopamine and Serotonin Levels in Mice Lacking Dopamine and/or Serotonin Transporters. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886569. |
the present study investigated the effects of mdma on extracellular dopamine (da(ex)) and serotonin (5-ht(ex)) levels in the striatum and prefrontal cortex (pfc) using in vivo microdialysis techniques in mice lacking da transporters (dat) and/or 5-ht transporters (sert). |
2011-11-10 |
2023-08-12 |
mouse |