| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philippe Huot, Tom H Johnston, Katie D Lewis, James B Koprich, M Gabriela Reyes, Susan H Fox, Matthew J Piggott, Jonathan M Brotchi. UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances L-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset. Neuropharmacology. vol 82. 2015-01-09. PMID:24447715. |
uwa-101, a dual, equipotent inhibitor of dopamine (dat) and serotonin (sert) transporters, has previously been shown to successfully extend duration of anti-parkinsonian benefit of l-dopa (on-time), without exacerbating dyskinesia, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned marmoset. |
2015-01-09 |
2023-08-12 |
marmoset |
| Michelle G Baladi, Amy H Newman, Shannon M Nielsen, Glen R Hanson, Annette E Fleckenstei. Dopamine D(3) receptors contribute to methamphetamine-induced alterations in dopaminergic neuronal function: role of hyperthermia. European journal of pharmacology. vol 732. 2014-12-09. PMID:24685638. |
results indicate that the dopamine d3 receptor selective antagonist, pg01037, attenuated methamphetamine-induced decreases in striatal dat, but not hippocampal serotonin (5ht) transporter (sert), function, as assessed 7 days after treatment. |
2014-12-09 |
2023-08-12 |
rat |
| Takuya Yokoyama, Yamaguchi-Yamada Misuzu, Yoshio Yamamot. Immunohistochemical localization of tryptophan hydroxylase and serotonin transporter in the carotid body of the rat. Histochemistry and cell biology. vol 140. issue 2. 2014-11-24. PMID:23266900. |
sert immunoreactivity was also observed in varicose nerve fibers immunoreactive for dopamine beta-hydroxylase, but not in nerve fibers immunoreactive for vesicular acetylcholine transporters or nerve terminals immunoreactive for p2x3 purinoreceptors. |
2014-11-24 |
2023-08-12 |
rat |
| Horrick Sharma, Soumava Santra, Joy Debnath, Tamara Antonio, Maarten Reith, Aloke Dutt. Flexible and biomimetic analogs of triple uptake inhibitor 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Synthesis, biological characterization, and development of a pharmacophore model. Bioorganic & medicinal chemistry. vol 22. issue 1. 2014-11-06. PMID:24315194. |
the model revealed features important for inhibitors to exhibit a balanced activity against dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). |
2014-11-06 |
2023-08-12 |
Not clear |
| Walter Sandtner, Diethart Schmid, Klaus Schicker, Klaus Gerstbrein, Xaver Koenig, Felix P Mayer, Stefan Boehm, Michael Freissmuth, Harald H Sitt. A quantitative model of amphetamine action on the 5-HT transporter. British journal of pharmacology. vol 171. issue 4. 2014-10-14. PMID:24251585. |
amphetamines bind to the plasmalemmal transporters for the monoamines dopamine (dat), noradrenaline (net) and 5-ht (sert); influx of amphetamine leads to efflux of substrates. |
2014-10-14 |
2023-08-12 |
Not clear |
| Enric Alvarez, Victor Perez, Francesc Artiga. Pharmacology and clinical potential of vortioxetine in the treatment of major depressive disorder. Neuropsychiatric disease and treatment. vol 10. 2014-07-30. PMID:25075188. |
its combined action on sert and four subtypes of serotoninergic receptors increases the extracellular concentration of serotonin, dopamine, and noradrenaline. |
2014-07-30 |
2023-08-13 |
Not clear |
| Shuang Liu, Congxiang Zha, Kassoum Nacro, Min Hu, Wenge Cui, Yuh-Lin Yang, Ulhas Bhatt, Aruna Sambandam, Matthew Isherwood, Larry Yet, Michael T Herr, Sarah Ebeltoft, Carla Hassler, Linda Fleming, Anthony D Pechulis, Anne Payen-Fornicola, Nicholas Holman, Dennis Milanowski, Ian Cotterill, Vadim Mozhaev, Yuri Khmelnitsky, Peter R Guzzo, Bruce J Sargent, Bruce F Molino, Richard Olson, Dalton King, Snjezana Lelas, Yu-Wen Li, Kim Johnson, Thaddeus Molski, Anitra Orie, Alicia Ng, Roy Haskell, Wendy Clarke, Robert Bertekap, Jonathan O'Connell, Nicholas Lodge, Michael Sinz, Stephen Adams, Robert Zaczek, John E Maco. Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors. ACS medicinal chemistry letters. vol 5. issue 7. 2014-07-22. PMID:25050161. |
a series of 4-bicyclic heteroaryl 1,2,3,4-tetrahydroisoquinoline inhibitors of the serotonin transporter (sert), norepinephrine transporter (net), and dopamine transporter (dat) was discovered. |
2014-07-22 |
2023-08-13 |
mouse |
| Vivek Kumar, Troels Rahbek-Clemmensen, Christian B Billesbølle, Trine Nygaard Jorgensen, Ulrik Gether, Amy Hauck Newma. Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. ACS medicinal chemistry letters. vol 5. issue 6. 2014-06-19. PMID:24944746. |
novel rhodamine-labeled ligands, based on (s)-citalopram, were synthesized and evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine transporters (hsert, hdat, and hnet, respectively) and for binding at sert, in transiently transfected cos7 cells. |
2014-06-19 |
2023-08-13 |
human |
| Dean G Brown, Peter R Bernstein, Ye Wu, Rebecca A Urbanek, Christopher W Becker, Scott R Throner, Bruce T Dembofsky, Gary B Steelman, Lois A Lazor, Clay W Scott, Michael W Wood, Steven S Wesolowski, David A Nugiel, Stephanie Koch, Jian Yu, Donald E Pivonka, Shuang Li, Carol Thompson, Anna Zacco, Charles S Elmore, Patricia Schroeder, JianWei Liu, Christopher A Hurley, Stuart Ward, Hazel J Hunt, Karen Williams, Joseph McLaughlin, Valerie Hoesch, Simon Sydserff, Donna Maier, David Aharon. Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity. ACS medicinal chemistry letters. vol 4. issue 1. 2014-06-05. PMID:24900562. |
herein, we describe the discovery of inhibitors of norepinephrine (net) and dopamine (dat) transporters with reduced activity relative to serotonin transporters (sert). |
2014-06-05 |
2023-08-13 |
rat |
| Linda D Simmler, Anna Rickli, York Schramm, Marius C Hoener, Matthias E Liecht. Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives. Biochemical pharmacology. vol 88. issue 2. 2014-04-22. PMID:24486525. |
we investigated norepinephrine (ne), dopamine (da), and serotonin (5-hydroxytryptamine [5-ht]) uptake inhibition using human embryonic kidney 293 (hek 293) cells that express the respective human monoamine transporters (net, dat, and sert). |
2014-04-22 |
2023-08-12 |
human |
| Craig P Motbey, Kelly J Clemens, Nadine Apetz, Adam R Winstock, John Ramsey, Kong M Li, Naomi Wyatt, Paul D Callaghan, Michael T Bowen, Jennifer L Cornish, Iain S McGrego. High levels of intravenous mephedrone (4-methylmethcathinone) self-administration in rats: neural consequences and comparison with methamphetamine. Journal of psychopharmacology (Oxford, England). vol 27. issue 9. 2014-04-08. PMID:23739178. |
brains were analyzed ex vivo for striatal serotonin (5-ht) and dopamine (da) levels and metabolites, while autoradiography assessed changes in the regional density of 5-ht and serotonin transporter (sert) and da transporter (dat) and induction of the inflammation marker translocator protein (tspo). |
2014-04-08 |
2023-08-12 |
rat |
| S R Suwijn, H W Berendse, C V M Verschuur, R M A de Bie, J Booi. Serotonin transporter availability in early stage Parkinson's disease and multiple system atrophy. ISRN neurology. vol 2014. 2014-04-02. PMID:24693450. |
we retrospectively assessed baseline midbrain sert availability as well as midbrain sert-to-striatal dopamine transporter (dat) ratios. |
2014-04-02 |
2023-08-13 |
Not clear |
| Hanneke E M den Ouden, Nathaniel D Daw, Guillén Fernandez, Joris A Elshout, Mark Rijpkema, Martine Hoogman, Barbara Franke, Roshan Cool. Dissociable effects of dopamine and serotonin on reversal learning. Neuron. vol 80. issue 4. 2014-01-15. PMID:24267657. |
we studied the role of these neurotransmitters in probabilistic reversal learning in nearly 700 individuals as a function of two polymorphisms in the genes encoding the serotonin and dopamine transporters (sert: 5httlpr plus rs25531; dat1 3'utr vntr). |
2014-01-15 |
2023-08-12 |
Not clear |
| Seyed Khosrow Tayebati, Daniele Tomassoni, Innocent Ejike Nwankwo, Antonio Di Stefano, Piera Sozio, Laura Serafina Cerasa, Francesco Ament. Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain. CNS & neurological disorders drug targets. vol 12. issue 1. 2013-12-23. PMID:23244432. |
the present study was designed to assess the influence of treatment for 7 days with choline-equivalent doses (cdp-choline: 325 mg/kg/day; gpc: 150 mg/kg/day) of these compounds on brain dopamine (da), and serotonin (5-ht) levels and on da plasma membrane transporter (dat), vesicular monoamine transporters (vmat1 and vmat2), serotonin transporter (sert), and norepinephrine transporter (net) in the rat. |
2013-12-23 |
2023-08-12 |
rat |
| Stephen M Stahl, Clara Lee-Zimmerman, Sylvia Cartwright, Debbi Ann Morrissett. Serotonergic drugs for depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23531115. |
the original trend to do this selectively (e.g., with ssris or selective serotonin reuptake inhibitors) has given way to combining various additional pharmacologic mechanisms with sert inhibition, including dual actions by single drugs (e.g., snris or serotonin norepinephrine reuptake inhibitors), or by augmenting ssris with a second drug of a different mechanism (e.g., bupropion with dopamine and norepinephrine reuptake inhibition; trazodone with 5ht2a antagonism; mirtazapine with 5ht2a/5ht2c/5ht3/alpha2 antagonism; buspirone or some atypical antipsychotics with 5ht1a partial agonism; other atypical antipsychotics with 5ht2c/5ht7 antagonism and other mechanisms). |
2013-10-29 |
2023-08-12 |
Not clear |
| Stephen M Stahl, Clara Lee-Zimmerman, Sylvia Cartwright, Debbi Ann Morrissett. Serotonergic drugs for depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23531115. |
novel drugs in development include those that combine multiple simultaneous pharmacologic mechanisms in addition to sert inhibition within the same molecule, such as vilazodone (combining 5ht1a partial agonism with sert inhibition), triple reuptake inhibitors (combining norepinephrine and dopamine reuptake inhibition with sert inhibition), and vortioxetine, a multimodal antidepressant combining actions at the g protein receptor mode (5ht1a and 5ht1b partial agonism and 5ht7 antagonism), at the ion channel mode (5ht3 antagonism) as well as the neurotransmitter transporter mode (sert inhibition). |
2013-10-29 |
2023-08-12 |
Not clear |
| Richard J Karpowicz, Matthew Dunn, David Sulzer, Dalibor Same. APP+, a fluorescent analogue of the neurotoxin MPP+, is a marker of catecholamine neurons in brain tissue, but not a fluorescent false neurotransmitter. ACS chemical neuroscience. vol 4. issue 5. 2013-10-22. PMID:23647019. |
app+ is a substrate for the dopamine transporter (dat), norepinephrine transporter (net), and serotonin transporter (sert), and as such represented a candidate for the development of new ffn probes. |
2013-10-22 |
2023-08-12 |
mouse |
| Marilia Barros, Emma L Dempster, Nicholas Illott, Soha Chabrawi, Rafael S Maior, Carlos Tomaz, Maria A De Souza Silva, Joseph P Huston, Jonathan Mill, Christian P Mülle. Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys. Addiction biology. vol 18. issue 3. 2013-10-17. PMID:22070124. |
here we measured dna methylation at promoter cpg sites of the dopamine transporter (dat1) and serotonin transporter (sert) and neurokinin3-receptor (nk3-r)-receptor (tacr3) coding genes in marmoset monkeys after repeated cocaine injections in a conditioned place preference paradigm. |
2013-10-17 |
2023-08-12 |
monkey |
| Robert A Comley, Cristian A Salinas, Mark Slifstein, Marcella Petrone, Carmine Marzano, Idriss Bennacef, Paul Shotbolt, Jasper Van der Aart, Marta Neve, Laura Iavarone, Roberto Gomeni, Marc Laruelle, Frank A Gray, Roger N Gunn, Eugenii A Rabine. Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography. The Journal of pharmacology and experimental therapeutics. vol 346. issue 2. 2013-09-25. PMID:23685546. |
studies were performed in baboons (papio anubis) to determine the relationship between plasma concentration and occupancy of brain serotonin reuptake transporter (sert), dopamine reuptake transporter (dat), and norepinephrine uptake transporter (net) using the radioligands [(11)c]dasb [(n,n-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine], [(11)c]pe2i [n-(3-iodoprop-2e-enyl)-2β-carbomethoxy-3β-(4-methylphenyl)nortropane], and [(11)c]2-[(2-methoxyphenoxy)phenylmethyl]morpholine (also known as [(11)c]mrb) and in humans using [(11)c]dasb and [(11)c]pe2i. |
2013-09-25 |
2023-08-12 |
Not clear |
| Joseph J Gallagher, Xiaowei Zhang, F Scott Hall, George R Uhl, Elaine L Bearer, Russell E Jacob. Altered reward circuitry in the norepinephrine transporter knockout mouse. PloS one. vol 8. issue 3. 2013-08-27. PMID:23469209. |
this is similar to previous results observed for the dopamine transporter (dat) knockout mouse, but dissimilar from work with serotonin transporter (sert) knockout mice where mn(2+) tracings extended to more posterior structures than in wildtype animals. |
2013-08-27 |
2023-08-12 |
mouse |