| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyoungjune Pak, Hyun-Yeol Nam, Seunghyeon Shin, Keunyoung Kim, Myung Jun Lee, Eun-Joo Kim, Jae Meen Lee, Seong-Jang Kim, In Joo Ki. Effects of rs591323 on serotonin transporter availability in healthy male subjects. Annals of nuclear medicine. vol 32. issue 7. 2018-11-06. PMID:29774458. |
we aimed to investigate the association between genetic factors of snps dopamine transporter (dat) and serotonin transporter (sert) availabilities in healthy controls. |
2018-11-06 |
2023-08-13 |
human |
| Martina Kristofova, Yogesh D Aher, Marija Ilic, Bojana Radoman, Predrag Kalaba, Vladimir Dragacevic, Nilima Y Aher, Johann Leban, Volker Korz, Lisa Zanon, Winfried Neuhaus, Marcus Wieder, Thierry Langer, Ernst Urban, Harald H Sitte, Harald Hoeger, Gert Lubec, Jana Aradsk. A daily single dose of a novel modafinil analogue CE-123 improves memory acquisition and memory retrieval. Behavioural brain research. vol 343. 2018-09-18. PMID:29410048. |
ce-123 blocked uptake of [3h] dopamine (ic50 = 4.606 μm) while effects on serotonin (sert) and the norepinephrine transporter (net) were negligible. |
2018-09-18 |
2023-08-13 |
human |
| Shaili Aggarwal, Ole V Mortense. Overview of Monoamine Transporters. Current protocols in pharmacology. vol 79. 2018-07-26. PMID:29261228. |
the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters, which are collectively referred to as monoamine transporters (mats), play significant roles in regulating the neuronal response to these neurotransmitters. |
2018-07-26 |
2023-08-13 |
Not clear |
| Patrick Neiens, Angela De Simone, Anna Ramershoven, Georg Höfner, Lars Allmendinger, Klaus T Wanne. Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET. Biomedical chromatography : BMC. vol 32. issue 7. 2018-06-25. PMID:29500932. |
in this study, we present an lc-esi-ms/ms method for the quantification of (r,r)-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol [(r,r)-d-84, (r,r)-1], (s,s)-reboxetine [(s,s)-2], and (s)-citalopram [(s)-3] employed as highly selective nonlabeled reporter ligands in ms binding assays addressing the dopamine [dat, (r,r)-d-84], norepinephrine [net, (s,s)-reboxetine] and serotonin transporter [sert, (s)-citalopram], respectively. |
2018-06-25 |
2023-08-13 |
Not clear |
| E Jaakkola, J Joutsa, E Mäkinen, J Johansson, V Kaasine. Ventral striatal dopaminergic defect is associated with hallucinations in Parkinson's disease. European journal of neurology. vol 24. issue 11. 2018-05-21. PMID:28834102. |
the aim of this study was to investigate the dopaminergic mechanisms of vhs and specifically whether the degree of striatal dopamine transporter (dat) function or extrastriatal serotonin transporter (sert) function can predict the appearance of vhs in patients with pd. |
2018-05-21 |
2023-08-13 |
Not clear |
| Jenna L N Sprowles, Jillian R Hufgard, Arnold Gutierrez, Rebecca A Bailey, Sarah A Jablonski, Michael T Williams, Charles V Vorhee. Differential effects of perinatal exposure to antidepressants on learning and memory, acoustic startle, anxiety, and open-field activity in Sprague-Dawley rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 61. 2018-05-18. PMID:28655626. |
selective serotonin (5-ht) reuptake inhibitors (ssris) act on the 5-ht transporter (sert) whereas norepinephrine-dopamine reuptake inhibitors (ndris) act on the norepinephrine and dopamine transporters. |
2018-05-18 |
2023-08-13 |
rat |
| Hai-Ying Zhang, Guo-Hua Bi, Hong-Ju Yang, Yi He, Gilbert Xue, Jiajing Cao, Gianluigi Tanda, Eliot L Gardner, Amy Hauck Newman, Zheng-Xiong X. The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 9. 2018-05-09. PMID:28266501. |
although at a concentration of 10 μm, there were many hits for jjc8-016, binding affinities in the range of its dat affinity were only observed at the serotonin transporter (sert), dopamine d |
2018-05-09 |
2023-08-13 |
Not clear |
| Ernesto Solis, John S Partilla, Farhana Sakloth, Iwona Ruchala, Kathryn L Schwienteck, Louis J De Felice, Jose M Eltit, Richard A Glennon, S Stevens Negus, Michael H Bauman. N-Alkylated Analogs of 4-Methylamphetamine (4-MA) Differentially Affect Monoamine Transporters and Abuse Liability. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 10. 2018-04-24. PMID:28530234. |
clandestine chemists synthesize novel stimulant drugs by exploiting structural templates known to target monoamine transporters for dopamine, norepinephrine, and serotonin (dat, net, and sert, respectively). |
2018-04-24 |
2023-08-13 |
rat |
| Suraj Adhikary, Daniel J Deredge, Anu Nagarajan, Lucy R Forrest, Patrick L Wintrode, Satinder K Sing. Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 10. 2018-04-10. PMID:28223522. |
the symporters for the biogenic amines serotonin (sert), dopamine (dat), and norepinephrine (net) are targets of multiple psychoactive agents, and their dysfunction has been implicated in numerous neuropsychiatric ailments. |
2018-04-10 |
2023-08-13 |
Not clear |
| Amir Seddik, Daan P Geerke, Thomas Stockner, Marion Holy, Oliver Kudlacek, Nicholas V Cozzi, Arnold E Ruoho, Harald H Sitte, Gerhard F Ecke. Combined Simulation and Mutation Studies to Elucidate Selectivity of Unsubstituted Amphetamine-like Cathinones at the Dopamine Transporter. Molecular informatics. vol 36. issue 5-6. 2017-12-22. PMID:27860344. |
the dopamine and serotonin transporter proteins (dat, sert) play a vital role in behavior and mental illness. |
2017-12-22 |
2023-08-13 |
Not clear |
| Mariana G Fronza, Lucimar M Pinto Brod, Angela Maria Casaril, Manoela Sacramento, Diego Alves, Lucielli Savegnag. Computational and biological evidences on the serotonergic involvement of SeTACN antidepressant-like effect in mice. PloS one. vol 12. issue 11. 2017-12-05. PMID:29091968. |
a series of phenylselanyl-1h-1,2,3-triazole-4-carbonitriles with different substituents were screened for their binding affinity with serotonin transporter (sert) and dopamine transporter (dat) by docking molecular. |
2017-12-05 |
2023-08-13 |
mouse |
| Shyamsunder R Joolakanti, Justin R Nickell, Venumadhav Janganati, Guangrong Zheng, Linda P Dwoskin, Peter A Crook. Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & medicinal chemistry letters. vol 26. issue 10. 2017-11-22. PMID:27080180. |
a series of lobelane and gz-793a analogues that incorporate aromatic 4-hydroxy and 4-(2-fluoroethoxy) substituents were synthesized and evaluated for inhibition of [(3)h]dopamine (da) uptake at the vesicular monoamine transporter-2 (vmat2) and the dopamine transporter (dat), and [(3)h]serotonin uptake at the serotonin transporter (sert). |
2017-11-22 |
2023-08-13 |
Not clear |
| Ruth I Versteeg, Anouk Schrantee, Sofie M Adriaanse, Unga A Unmehopa, Jan Booij, Liesbeth Reneman, Eric Fliers, Susanne E la Fleur, Mireille J Serli. Timing of caloric intake during weight loss differentially affects striatal dopamine transporter and thalamic serotonin transporter binding. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 31. issue 10. 2017-10-19. PMID:28679529. |
we studied the effect of a 4 wk hypocaloric diet with either 50% of daily calories consumed at breakfast (bf group) or at dinner (d group) on hypothalamic and thalamic serotonin transporter (sert) binding and on striatal dopamine transporter (dat) binding. |
2017-10-19 |
2023-08-13 |
Not clear |
| F P Mayer, L Wimmer, O Dillon-Carter, J S Partilla, N V Burchardt, M D Mihovilovic, M H Baumann, H H Sitt. Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters. British journal of pharmacology. vol 173. issue 17. 2017-10-16. PMID:27391165. |
4-methyl-n-methylcathinone (mephedrone) is a synthetic stimulant that acts as a substrate-type releaser at transporters for dopamine (dat), noradrenaline (net) and 5-ht (sert). |
2017-10-16 |
2023-08-13 |
Not clear |
| D Gagnon, L Gregoire, T Di Paolo, Martin Paren. Serotonin hyperinnervation of the striatum with high synaptic incidence in parkinsonian monkeys. Brain structure & function. vol 221. issue 7. 2017-09-29. PMID:26462663. |
the state of striatal serotonin and dopamine innervation was evaluated by means of immunohistochemistry with antibodies against serotonin transporter (sert) and tyrosine hydroxylase. |
2017-09-29 |
2023-08-13 |
monkey |
| Gavin McLaughlin, Noreen Morris, Pierce V Kavanagh, John D Power, Geraldine Dowling, Brendan Twamley, John O'Brien, Brian Talbot, Donna Walther, John S Partilla, Michael H Baumann, Simon D Brand. Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone. Drug testing and analysis. vol 9. issue 3. 2017-07-18. PMID:27524685. |
all three substances were also studied for their uptake and releasing properties at dopamine transporters (dat), norepinephrine transporters (net) and serotonin transporters (sert) using in vitro monoamine transporter assays in rat brain synaptosomes and compared to mephedrone. |
2017-07-18 |
2023-08-13 |
rat |
| S Stevens Negus, Matthew L Bank. Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs. Current topics in behavioral neurosciences. vol 32. 2017-07-11. PMID:27696217. |
many cathinone analogs act as substrates or inhibitors at dopamine, norepinephrine, and serotonin transporters (dat, net, sert, respectively). |
2017-07-11 |
2023-08-13 |
rat |
| Melissa M Conti, Samantha M Meadows, Mitchell Melikhov-Sosin, David Lindenbach, Joy Hallmark, David F Werner, Christopher Bisho. Monoamine transporter contributions to l-DOPA effects in hemi-parkinsonian rats. Neuropharmacology. vol 110. issue Pt A. 2017-07-10. PMID:27452719. |
serotonin and norepinephrine transporters (sert and net, respectively) have affinity for dopamine uptake especially when dopamine transporters (dat) are scant. |
2017-07-10 |
2023-08-13 |
rat |
| Jacob Andersen, Lucy Kate Ladefoged, Trine N Bjerre Kristensen, Lachlan Munro, Julie Grouleff, Nicolai Stuhr-Hansen, Anders S Kristensen, Birgit Schiøtt, Kristian Strømgaar. Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27425420. |
the transporters for the neurotransmitters serotonin and dopamine (sert and dat, respectively) are targets for drugs used in the treatment of mental disorders and widely used drugs of abuse. |
2017-06-21 |
2023-08-13 |
human |
| Jacob Andersen, Lucy Kate Ladefoged, Trine N Bjerre Kristensen, Lachlan Munro, Julie Grouleff, Nicolai Stuhr-Hansen, Anders S Kristensen, Birgit Schiøtt, Kristian Strømgaar. Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27425420. |
we have designed and employed 24 bivalent ligands possessing a highly systematic combination of substrate moieties (serotonin and/or dopamine) and aliphatic or poly(ethylene glycol) spacers to reveal insight into substrate recognition in sert and dat. |
2017-06-21 |
2023-08-13 |
human |