| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Ling Wang, Shiliang Zhang, Jia Qi, Huikun Wang, Roger Cachope, Carlos A Mejias-Aponte, Jorge A Gomez, Gabriel E Mateo-Semidey, Gerard M J Beaudoin, Carlos A Paladini, Joseph F Cheer, Marisela Morale. Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons. Cell reports. vol 26. issue 5. 2020-03-13. PMID:30699344. |
here, we show that dr serotonin transporter (sert) neurons establish both asymmetric and symmetric synapses on vta dopamine neurons, but most of these synapses are asymmetric. |
2020-03-13 |
2023-08-13 |
Not clear |
| Cheng-Tsung Liu, Li-Ting Kao, Jui-Hu Shih, Wu-Chien Chien, Chuang-Hsin Chiu, Kuo-Hsing Ma, Yuahn-Sieh Huang, Cheng-Yi Cheng, Chyng-Yann Shiue, I-Hsun L. The effect of dextromethorphan use in Parkinson's disease: A 6-hydroxydopamine rat model and population-based study. European journal of pharmacology. vol 862. 2020-03-05. PMID:31491406. |
the availability of dopamine transporter (dat) and serotonin transporter (sert) in the striatum of the rat brain was measured using positron emission tomography. |
2020-03-05 |
2023-08-13 |
human |
| Donna Walther, Abdelrahman R Shalabi, Michael H Baumann, Richard A Glenno. Systematic Structure-Activity Studies on Selected 2-, 3-, and 4-Monosubstituted Synthetic Methcathinone Analogs as Monoamine Transporter Releasing Agents. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30354055. |
to formulate structure-activity relationship (sar) generalities, we examined the releasing ability of several simple methcathinone analogs at the three monoamine transporters (i.e., the dopamine, norepinephrine, and serotonin transporters, dat, net, and sert, respectively) using in vitro assay methods. |
2020-02-18 |
2023-08-13 |
Not clear |
| Anna Rickli, Marius C Hoener, Matthias E Liecht. Pharmacological profiles of compounds in preworkout supplements ("boosters"). European journal of pharmacology. vol 859. 2020-01-28. PMID:31265842. |
we investigated whether substances that are contained in commercially available athletic multiple-ingredient preworkout supplements exert amphetamine-type activity at norepinephrine, dopamine, and serotonin transporters (net, dat, and sert, respectively). |
2020-01-28 |
2023-08-13 |
human |
| Merijn Joling, Chris Vriend, Pieter G H M Raijmakers, Jessica J van der Zande, Afina W Lemstra, Henk W Berendse, Jan Booij, Odile A van den Heuve. Striatal DAT and extrastriatal SERT binding in early-stage Parkinson's disease and dementia with Lewy bodies, compared with healthy controls: An NeuroImage. Clinical. vol 22. 2020-01-17. PMID:30884365. |
we aimed to study degeneration of terminals with dopamine and serotonin transporter (dat and sert, respectively) in patients with early-stage pd and dlb relative to healthy controls, using |
2020-01-17 |
2023-08-13 |
Not clear |
| Felix P Mayer, Daniela Cintulova, Dorothea A Pittrich, Laurin Wimmer, Dino Luethi, Marion Holy, Kathrin Jaentsch, Sonja Tischberger, Guenter Gmeiner, Marius C Hoener, Matthias E Liechti, Marko D Mihovilovic, Harald H Sitt. Stereochemistry of phase-1 metabolites of mephedrone determines their effectiveness as releasers at the serotonin transporter. Neuropharmacology. vol 148. 2019-12-27. PMID:30610839. |
mephedrone (4-methyl-n-methylcathinone) is a psychostimulant that promotes release of monoamines via the high affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2019-12-27 |
2023-08-13 |
human |
| Felix P Mayer, Diethart Schmid, Marion Holy, Lynette C Daws, Harald H Sitt. "Polytox" synthetic cathinone abuse: A potential role for organic cation transporter 3 in combined cathinone-induced efflux. Neurochemistry international. vol 123. 2019-12-26. PMID:30248432. |
mdpv and mephedrone interfere with the function of the high affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert), resulting in increased extracellular levels of these monoamines, though their mechanism of action differs. |
2019-12-26 |
2023-08-13 |
Not clear |
| Umberto M Battisti, Ramsey Sitta, Alan Harris, Farhana Sakloth, Donna Walther, Iwona Ruchala, S Stevens Negus, Michael H Baumann, Richard A Glennon, Jose M Elti. Effects of N-Alkyl-4-Methylamphetamine Optical Isomers on Plasma Membrane Monoamine Transporters and Abuse-Related Behavior. ACS chemical neuroscience. vol 9. issue 7. 2019-09-30. PMID:29697951. |
4-methylamphetamine (4-ma) is an emerging drug of abuse that acts as a substrate at plasma membrane transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), thereby causing nonexocytotic release of monoamine transmitters via reverse transport. |
2019-09-30 |
2023-08-13 |
rat |
| Su Bong Nam, Keunyoung Kim, Bum Soo Kim, Hyung-Jun Im, Seung Hun Lee, Seong-Jang Kim, In Joo Kim, Kyoungjune Pa. The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters. Scientific reports. vol 8. issue 1. 2019-09-26. PMID:29563547. |
the authors investigated relations between obesity, age, and sex and the availabilities of striatal dopamine transporter (dat) and extrastriatal serotonin transporter (sert) by |
2019-09-26 |
2023-08-13 |
Not clear |
| Peter S Hasenhuetl, Shreyas Bhat, Felix P Mayer, Harald H Sitte, Michael Freissmuth, Walter Sandtne. A kinetic account for amphetamine-induced monoamine release. The Journal of general physiology. vol 150. issue 3. 2019-09-24. PMID:29439119. |
the plasmalemmal monoamine transporters for dopamine, norepinephrine, and serotonin (sert) are targets for amphetamines. |
2019-09-24 |
2023-08-13 |
Not clear |
| Jose Luiz Costa, Kelly Francisco Cunha, Rafael Lanaro, Ricardo Leal Cunha, Donna Walther, Michael H Bauman. Analytical quantification, intoxication case series, and pharmacological mechanism of action for N-ethylnorpentylone (N-ethylpentylone or ephylone). Drug testing and analysis. vol 11. issue 3. 2019-08-27. PMID:30207090. |
the activity of n-ethylnorpentylone at plasma membrane transporters for dopamine (dat), norepinephrine (net) and 5-ht (sert) was assessed using in vitro assays measuring uptake inhibition and evoked release of [ |
2019-08-27 |
2023-08-13 |
human |
| J A Suyama, M L Banks, S S Negu. Effects of repeated treatment with methcathinone, mephedrone, and fenfluramine on intracranial self-stimulation in rats. Psychopharmacology. vol 236. issue 3. 2019-08-27. PMID:30232529. |
synthetic cathinones constitute a class of abused drugs that can act at dopamine, norepinephrine, and serotonin transporters (dat, net, and sert, respectively). |
2019-08-27 |
2023-08-13 |
rat |
| Jordan T Lloyd, Alessandro Martini, Alice McDouall, Rahul Sood, Peter S Freestone, Nicola B Mercuri, Janusz Lipsk. Electrophysiological Characterization of Novel Effects of the Uptake-2 Blocker Decynium-22 (D-22) on Dopaminergic Neurons in the Substantia Nigra Pars Compacta. Neuroscience. vol 396. 2019-04-01. PMID:30447392. |
extracellular levels of dopamine (da) and other monoamines in the brain depend not only on the classic transporters encoded by slc6a gene family such as dat, net and sert, but also a more recently identified group of low-affinity/high-capacity 'uptake-2' transporters, mainly oct3 and pmat. |
2019-04-01 |
2023-08-13 |
mouse |
| Brenda M Gannon, Michael H Baumann, Donna Walther, Cristian Jimenez-Morigosa, Agnieszka Sulima, Kenner C Rice, Gregory T Collin. The abuse-related effects of pyrrolidine-containing cathinones are related to their potency and selectivity to inhibit the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 12. 2019-03-11. PMID:30305739. |
synthetic cathinones are common constituents of abused "bath salts" preparations and represent a large family of structurally related compounds that function as cocaine-like inhibitors or amphetamine-like substrates of dopamine (dat), norepinephrine (net), and serotonin (sert) transporters. |
2019-03-11 |
2023-08-13 |
rat |
| Julian Maier, Felix P Mayer, Dino Luethi, Marion Holy, Kathrin Jäntsch, Harald Reither, Lena Hirtler, Marius C Hoener, Matthias E Liechti, Christian Pifl, Simon D Brandt, Harald H Sitt. The psychostimulant (±)-cis-4,4'-dimethylaminorex (4,4'-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters. Neuropharmacology. vol 138. 2019-02-13. PMID:29908239. |
we used in vitro uptake inhibition and transporter release assays to determine the effects of 4,4'-dmar on human high-affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2019-02-13 |
2023-08-13 |
human |
| Rheaclare Fraser-Spears, Anwen M Krause-Heuer, Mohamed Basiouny, Felix P Mayer, Retrouvailles Manishimwe, Naomi A Wyatt, Jeremy C Dobrowolski, Maxine P Roberts, Ivan Greguric, Naresh Kumar, Wouter Koek, Harald H Sitte, Paul D Callaghan, Benjamin H Fraser, Lynette C Daw. Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter. European journal of pharmacology. vol 842. 2019-02-04. PMID:30473490. |
here, we extend these findings to determine the affinity of these analogs for oct2, oct3 and pmat, as well as serotonin, norepinephrine and dopamine transporters (sert, net and dat) using a combination of uptake competition with [ |
2019-02-04 |
2023-08-13 |
mouse |
| Gabriel Núñez-Vivanco, Angélica Fierro, Pablo Moya, Patricio Iturriaga-Vásquez, Miguel Reyes-Parad. 3D similarities between the binding sites of monoaminergic target proteins. PloS one. vol 13. issue 7. 2019-01-11. PMID:30028869. |
in this work, we evaluated the possible existence of similarities among the binding sites of the serotonin transporter (sert), the dopamine transporter (dat), mao-a and mao-b. |
2019-01-11 |
2023-08-13 |
Not clear |
| Anna Maria Górska, Katarzyna Kamińska, Agnieszka Wawrzczak-Bargieła, Giulia Costa, Micaela Morelli, Ryszard Przewłocki, Grzegorz Kreiner, Krystyna Gołembiowsk. Neurochemical and Neurotoxic Effects of MDMA (Ecstasy) and Caffeine After Chronic Combined Administration in Mice. Neurotoxicity research. vol 33. issue 3. 2018-12-11. PMID:29134560. |
mdma acts at dopamine (da) transporter (dat) and serotonin (5-ht) transporter (sert) and is known to induce damage of dopamine and serotonin neurons. |
2018-12-11 |
2023-08-13 |
mouse |
| Felix P Mayer, Nadine V Burchardt, Ann M Decker, John S Partilla, Yang Li, Gavin McLaughlin, Pierce V Kavanagh, Walter Sandtner, Bruce E Blough, Simon D Brandt, Michael H Baumann, Harald H Sitt. Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family. Neuropharmacology. vol 134. issue Pt A. 2018-11-07. PMID:28988906. |
here we tested 3-fpm and its positional isomers, 2-fpm and 4-fpm, for their abilities to interact with plasma membrane monoamine transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2018-11-07 |
2023-08-13 |
Not clear |
| Katarzyna Kamińska, Karolina Noworyta-Sokołowska, Anna Górska, Joanna Rzemieniec, Agnieszka Wnuk, Adam Wojtas, Grzegorz Kreiner, Małgorzata Kajta, Krystyna Gołembiowsk. The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:29713996. |
mephedrone by its interaction with transporters for dopamine (dat) and serotonin (sert) stimulates their release to the synaptic cleft. |
2018-11-06 |
2023-08-13 |
mouse |