| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gustavo Henrique Marques Sousa, Renan Augusto Gomes, Eliseu Ortega de Oliveira, Gustavo Henrique Goulart Trossin. Machine learning methods applied for the prediction of biological activities of triple reuptake inhibitors. Journal of biomolecular structure & dynamics. 2022-12-22. PMID:36546689. |
thus, major efforts have been made to develop drugs that inhibit serotonin (sert), norepinephrine (net) and dopamine (dat) transporters and increase the availability of these monoamines. |
2022-12-22 |
2023-08-14 |
Not clear |
| David Matuskey, Jean-Dominique Gallezot, Nabeel Nabulsi, Shannan Henry, Kristen Torres, Mark Dias, Gustavo A Angarita, Yiyun Huang, Susan E Shoaf, Richard E Carson, Shailly Mehrotr. Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults. Journal of psychopharmacology (Oxford, England). 2022-12-14. PMID:36515395. |
centanafadine is an inhibitor of reuptake transporters for norepinephrine (net), dopamine (dat) and serotonin (sert). |
2022-12-14 |
2023-08-14 |
Not clear |
| Ayodele Oyadeyi, Folasade Ajao, Temitope Babalola, Yusuf Mustaph. Effects of Ruzu, a Polyherbal Mixture, on Neurobehaviour and Expression of Serotonin and Dopamine Transporters in Rats. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 36. issue 2. 2022-08-10. PMID:35947744. |
animals were subsequently sacrificed and the expression of serotonin transporter (sert) and dopamine transporter (dat) was determined in the striatum by immunofluorescence while specific activities of catalase, alkaline phosphatase and gamma glutamyltransferase were determined. |
2022-08-10 |
2023-08-14 |
rat |
| Rudy Schreiber, Una Campbell, Maria S Quinton, Larry W Hardy, Q Kevin Fang, Robert Le. In vitro and in vivo pharmacological characterization of dasotraline, a dual dopamine and norepinephrine transporter inhibitor in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-07-05. PMID:35785702. |
inhibitors of dopamine transporters (dat), norepinephrine transporters (net) and serotonin transporters (sert) are effective treatments for neuropsychiatric diseases. |
2022-07-05 |
2023-08-14 |
Not clear |
| Jasmin N Beaver, Brady L Weber, Matthew T Ford, Anna E Anello, Sarah K Kassis, T Lee Gilma. Uncovering Functional Contributions of PMAT ( Cells. vol 11. issue 12. 2022-06-24. PMID:35741002. |
uncovering functional contributions of pmat ( plasma membrane monoamine transporter (pmat, slc29a4) transports monoamine neurotransmitters, including dopamine and serotonin, faster than more studied monoamine transporters, e.g., dopamine transporter (dat), or serotonin transporter (sert), but with ~400-600-fold less affinity. |
2022-06-24 |
2023-08-14 |
mouse |
| Daniela Krause, Agnieszka Chrobok, Susanne Karch, Daniel Keeser, Kirsi M Manz, Walter Koch, Matthias Brendel, Axel Rominger, Gabi Koller, Nina Behle, Oliver Pogarel. Binding potential changes of SERT in patients with depression are associated with remission: A prospective [¹²³I]β-CIT-SPECT study. Experimental and clinical psychopharmacology. 2022-05-23. PMID:35604719. |
addressing this challenge, we investigated functional correlates of remission by assessment of serotonin and dopamine transporter availability (sert and dat) using single-photon emission computed tomography (spect). |
2022-05-23 |
2023-08-13 |
human |
| Jesús E Yepez, Jorge Juáre. Modafinil acquires reinforcing effects when combined with citalopram. Pharmacology, biochemistry, and behavior. 2022-05-23. PMID:35605783. |
its action mechanism consists in inhibiting dopamine (dat) and norepinephrine (net) transporters, but it has no affinity for the serotonin transporter (sert). |
2022-05-23 |
2023-08-13 |
rat |
| Dino Luethi, Gerhard J Schütz, Harald H Sitt. Single Molecule Analysis Reveals Dimer Formation of the Norepinephrine Transporter at the Plasma Membrane of Live Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552962. |
using single molecule microscopy, we previously reported that the serotonin transporter (sert) co-exists as monomers, dimers, and higher-order oligomers, while the dopamine transporter (dat) forms monomers and dimers only. |
2022-05-13 |
2023-08-13 |
Not clear |
| Nikki J Clauss, W A Owens, Melissa Vitela, Melodi A Bowman, Felix P Mayer, Diethart Schmid, Marion Holy, Harrold H Sitte, Geogianna G Gould, Wouter Koek, Lynette C Daw. Ethanol Inhibits Dopamine Uptake and Augments Rewarding Effects of Cocaine via Organic Cation Transporter 3. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554677. |
both cocaine (blocker of dopamine (da), norepinephrine and serotonin transporters, dat, net and sert, respectively) and ethanol (etoh) increase extracellular levels of these monoamines. |
2022-05-13 |
2023-08-13 |
Not clear |
| Hongsong Feng, Kaifu Gao, Dong Chen, Li Shen, Alfred J Robison, Edmund Ellsworth, Guo-Wei We. Machine Learning Analysis of Cocaine Addiction Informed by DAT, SERT, and NET-Based Interactome Networks. Journal of chemical theory and computation. 2022-03-16. PMID:35294204. |
among them, the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters are three major targets. |
2022-03-16 |
2023-08-13 |
Not clear |
| Judit Cabana-Domínguez, Bàrbara Torrico, Andreas Reif, Noèlia Fernàndez-Castillo, Bru Corman. Comprehensive exploration of the genetic contribution of the dopaminergic and serotonergic pathways to psychiatric disorders. Translational psychiatry. vol 12. issue 1. 2022-01-11. PMID:35013130. |
to do so, we elaborated four different gene sets: two 'wide' selections for dopamine (da) and for serotonin (sert) using the gene ontology and kegg pathways tools, and two'core' selections for the same systems, manually curated. |
2022-01-11 |
2023-08-13 |
Not clear |
| Thomas J F Angenoorth, Stevan Stankovic, Marco Niello, Marion Holy, Simon D Brandt, Harald H Sitte, Julian Maie. Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1-3 and Human Plasma Membrane Monoamine Transporter. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884800. |
many psychoactive compounds have been shown to primarily interact with high-affinity and low-capacity solute carrier 6 (slc6) monoamine transporters for norepinephrine (net; norepinephrine transporter), dopamine (dat; dopamine transporter) and serotonin (sert; serotonin transporter). |
2021-12-10 |
2023-08-13 |
human |
| Durairaj Ragu Varman, Lankupalle D Jayanthi, Sammanda Ramamoorth. Kappa Opioid Receptor Mediated Differential Regulation of Serotonin and Dopamine Transporters in Mood and Substance Use Disorder. Handbook of experimental pharmacology. vol 271. 2021-11-26. PMID:34136961. |
also, we discuss the recent findings on kor-mediated differential regulation of serotonin and dopamine transporters (sert and dat). |
2021-11-26 |
2023-08-13 |
Not clear |
| Charlotte P Magee, BaoMinh D Le, Yasmeen H Siripathane, Diana G Wilkins, Glen R Hanson, Annette E Fleckenstei. Methcathinone decreases dopamine transporter function: Role of protein kinase C. Journal of neurochemistry. vol 159. issue 1. 2021-11-17. PMID:34320222. |
thus, effects of mcat on 1) striatal dopamine (da) transporter (dat); and 2) striatal and hippocampal serotonin transporter (sert) function, as determined in tissues from adult male rats, were assessed. |
2021-11-17 |
2023-08-13 |
rat |
| Katy A van Galen, Jan Booij, Anouk Schrantee, Sofie M Adriaanse, Unga A Unmehopa, Eric Fliers, Gary J Schwartz, Ralph J DiLeone, Kasper W Ter Horst, Susanne E la Fleur, Mireille J Serli. The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity. Metabolism: clinical and experimental. vol 123. 2021-11-09. PMID:34331964. |
we therefore aimed to evaluate the effects of fasting on hypothalamic/thalamic serotonin transporter (sert) and striatal dopamine transporter (dat) availability in lean subjects and subjects with obesity. |
2021-11-09 |
2023-08-13 |
human |
| Tudor M Ionescu, Mario Amend, Rakibul Hafiz, Bharat B Biswal, Andreas Maurer, Bernd J Pichler, Hans F Wehrl, Kristina Herfer. Striatal and prefrontal D2R and SERT distributions contrastingly correlate with default-mode connectivity. NeuroImage. vol 243. 2021-10-29. PMID:34428573. |
the aim of this study was elucidating interactions between dopamine d2 receptors (d2r) and serotonin transporter (sert) availabilities in the striatum (cpu) and medial prefrontal cortex (mpfc), two of the main dopaminergic and serotonergic projection areas, and the default-mode network. |
2021-10-29 |
2023-08-13 |
rat |
| Olof R Hjorth, Andreas Frick, Malin Gingnell, Johanna M Hoppe, Vanda Faria, Sara Hultberg, Iman Alaie, Kristoffer N T Månsson, Kurt Wahlstedt, My Jonasson, Mark Lubberink, Gunnar Antoni, Mats Fredrikson, Tomas Furmar. Expression and co-expression of serotonin and dopamine transporters in social anxiety disorder: a multitracer positron emission tomography study. Molecular psychiatry. vol 26. issue 8. 2021-10-28. PMID:31822819. |
the aim of this multitracer pet study was to evaluate the regional expression and co-expression of the transporter proteins for serotonin (sert) and dopamine (dat) in patients with social anxiety disorder (sad). |
2021-10-28 |
2023-08-13 |
Not clear |
| Anna Marie Buchanan, Brenna Parke, Parastoo Hashem. Experimental Methods for Investigating Uptake 2 Processes In Vivo. Handbook of experimental pharmacology. vol 266. 2021-10-28. PMID:34196807. |
uptake 1 describes uptake of the monoamine via its designated transporter (sert for serotonin, net for norepinephrine, and dat for dopamine), whereas uptake 2 details multiple transporter types on neurons and glia taking up different types of modulators, not necessarily specific to the monoamine. |
2021-10-28 |
2023-08-13 |
human |
| Lynette C Daw. Organic Cation Transporters in Psychiatric Disorders. Handbook of experimental pharmacology. vol 266. 2021-10-28. PMID:34282486. |
other classes of antidepressant work by blocking the norepinephrine or dopamine transporters (net and dat), the high-affinity, low-capacity uptake-1 transporters for norepinephrine and dopamine, or by blocking combinations of sert, net, and dat. |
2021-10-28 |
2023-08-13 |
Not clear |
| Shreyas Bhat, Marco Niello, Klaus Schicker, Christian Pifl, Harald H Sitte, Michael Freissmuth, Walter Sandtne. Handling of intracellular K eLife. vol 10. 2021-10-19. PMID:34061030. |
handling of intracellular k the concentrative power of the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert) is thought to be fueled by the transmembrane na |
2021-10-19 |
2023-08-13 |
Not clear |