| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carolina Costa, Miguel Semedo, Sandrine P Machado, Virginia Cunha, Marta Ferreira, Ralph Urbatzk. Transcriptional analyses reveal different mechanism of toxicity for a chronic exposure to fluoxetine and venlafaxine on the brain of the marine fish Dicentrarchrus labrax. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 250. 2021-10-08. PMID:34454087. |
both psychopharmaceuticals affected differentially the neurotransmitter mrna expression analyzed by rt-qpcr (serotonin receptors: 5-ht3a, 5-ht3b; dopamine receptors: d2, d3; neurotransmitter transporter: sert, vmat; degrading enzyme: mao). |
2021-10-08 |
2023-08-13 |
Not clear |
| Speranta Avram, Miruna Silvia Stan, Ana Maria Udrea, Cătălin Buiu, Anca Andreea Boboc, Maria Merne. 3D-ALMOND-QSAR Models to Predict the Antidepressant Effect of Some Natural Compounds. Pharmaceutics. vol 13. issue 9. 2021-10-01. PMID:34575524. |
their antidepressant and neuroleptic activities were predicted by 3d-almond-qsar models built by considering three important targets, namely serotonin transporter (sert), 5-hydroxytryptamine receptor 1a (5-ht1a), and dopamine d2 receptor. |
2021-10-01 |
2023-08-13 |
Not clear |
| Zebin Lin, Chenyang Liu, Enshan Fan, Yurong Zhang, Shuiqing Zheng, Yulan Ra. An efficient and label-free LC-MS/MS method for assessing drug's activity at dopamine and serotonin transporters using transporter-transfected HEK293T cells. Journal of psychopharmacology (Oxford, England). vol 35. issue 6. 2021-09-24. PMID:33888022. |
dopamine transporter (dat) and serotonin transporter (sert) are targets for many psychoactive substances. |
2021-09-24 |
2023-08-13 |
Not clear |
| Karolina E Kolaczynska, Jan Thomann, Marius C Hoener, Matthias E Liecht. The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative. International journal of molecular sciences. vol 22. issue 15. 2021-09-08. PMID:34361040. |
we assessed several pyrovalerone and related cathinone derivatives at the human norepinephrine (net), dopamine (dat), and serotonin (sert) uptake transporters using hek293 cells overexpressing each respective transporter. |
2021-09-08 |
2023-08-13 |
human |
| Eray Esendir, Verena Burtscher, Jonathan A Coleman, Rong Zhu, Eric Gouaux, Michael Freissmuth, Walter Sandtne. Extracellular loops of the serotonin transporter act as a selectivity filter for drug binding. The Journal of biological chemistry. vol 297. issue 1. 2021-08-26. PMID:34118233. |
ligands that discriminate between sert and its close relative, the dopamine transporter dat, differ in their association rate constant rather than their dissociation rate. |
2021-08-26 |
2023-08-13 |
Not clear |
| Danusio Pinheiro Sartori, N F Oliveira, José Tiago Valentim, D M A Silva, A S V Mallman, I C M Oliveira, R C Chaves, V C Capibaribe, A M R Carvalho, M O Rebouças, Danielle Silveira Macedo, Adriano José Maia Chaves Filho, M M F Fonteles, S J C Gutierrez, José Maria Barbosa-Filho, Melina Mottin, Carolina Horta Andrade, F C F Sous. Involvement of monoaminergic targets in the antidepressant- and anxiolytic-like effects of the synthetic alkamide riparin IV: Elucidation of further mechanisms through pharmacological, neurochemistry and computational approaches. Behavioural brain research. vol 383. 2021-05-25. PMID:31987932. |
molecular docking demonstrated favorable binding conformation and affinity of ripiv to monoamine oxidase b (mao-b), serotonin transporter (sert), α1 receptor, d2 receptor, dopamine transporter (dat) and at some extent gaba-a receptor. |
2021-05-25 |
2023-08-13 |
mouse |
| Iwona Ruchala, Umberto M Battisti, Vy T Nguyen, Rita Yu-Tzu Chen, Richard A Glennon, Jose M Elti. Functional characterization of N-octyl 4-methylamphetamine variants and related bivalent compounds at the dopamine and serotonin transporters using Ca Toxicology and applied pharmacology. vol 419. 2021-05-11. PMID:33785354. |
functional characterization of n-octyl 4-methylamphetamine variants and related bivalent compounds at the dopamine and serotonin transporters using ca the early characterization of ligands at the dopamine and serotonin transporters, dat and sert, respectively, is important for drug discovery, forensic sciences, and drug abuse research. |
2021-05-11 |
2023-08-13 |
Not clear |
| Marco Niello, Daniela Cintulová, Philip Raithmayr, Marion Holy, Kathrin Jäntsch, Claire Colas, Gerhard F Ecker, Harald H Sitte, Marko D Mihovilovi. Effects of Hydroxylated Mephedrone Metabolites on Monoamine Transporter Activity Frontiers in pharmacology. vol 12. 2021-04-28. PMID:33897439. |
it elicits the release of monoamines via the high affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2021-04-28 |
2023-08-13 |
Not clear |
| Masaru Ihara, Han Zhang, Mariko O Ihara, Daisuke Kato, Hiroaki Tanak. Proposal for fluorescence-based in vitro assay using human and zebrafish monoamine transporters to detect biological activities of antidepressants in wastewater. The Science of the total environment. vol 770. 2021-03-18. PMID:33513512. |
we used app, a fluorescent substrate for monoamine transporters, to measure the activity of wastewater extracts at inhibiting app uptake through the human serotonin transporter (hsert), norepinephrine transporter (hnet), and dopamine transporter, and the zebrafish sert (zsert). |
2021-03-18 |
2023-08-13 |
human |
| Ole Jensen, Muhammad Rafehi, Lukas Gebauer, Jürgen Brockmölle. Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers? Frontiers in pharmacology. vol 11. 2021-02-10. PMID:33551812. |
many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (net, dat, and sert). |
2021-02-10 |
2023-08-13 |
Not clear |
| Concepció Marin, Mercè Bonastre, Mireya Fuentes, Joaquim Mullo. Lack of correlation between dyskinesia and pallidal serotonin transporter expression-induced by L-Dopa and Pramipexole in hemiparkinsonian rats. Pharmacology, biochemistry, and behavior. vol 197. 2021-02-08. PMID:32750392. |
we investigated the pallidal ser and sert expression changes and the abnormal involuntary movements (aims) induced by l-dopa or the d3/d2 dopamine (da) agonist, pramipexole, in partial unilateral 6-hydroxydopamine (6-ohda)-lesioned rats. |
2021-02-08 |
2023-08-13 |
rat |
| J J van der Zande, M Joling, I G Happach, C Vriend, Ph Scheltens, J Booij, A W Lemstr. Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An NeuroImage. Clinical. vol 25. 2021-01-11. PMID:31790878. |
serotonergic deficits in dementia with lewy bodies with concomitant alzheimer's disease pathology: an to study the influence of concomitant alzheimer's disease (ad) pathology in dementia with lewy bodies (dlb) on dopamine transporter (dat) and serotonin transporter (sert) availability, using |
2021-01-11 |
2023-08-13 |
Not clear |
| Raquel Romay-Tallon, Erin Kulhawy, Kyle J Brymer, Josh Allen, Tania Rivera-Baltanas, Jose M Olivares, Lisa E Kalynchuk, Hector J Carunch. Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of Depression. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30374301. |
afterward they underwent the forced swim test to evaluate depression-like behavior, and isolated lymphocytes were analyzed by immunocytochemistry coupled to image-analysis to study clustering parameters of the sert, 5ht2a receptor, dopamine transporter (dat), beta2 adrenergic receptor (β2ar), nmda 2b receptor (nr2b), pannexin 1 (pnx1), and prion cellular protein (prpc). |
2020-10-01 |
2023-08-13 |
human |
| Mark W Burke, Myriam Fillion, Jose Mejia, Frank R Ervin, Roberta M Palmou. Perinatal MAO Inhibition Produces Long-Lasting Impairment of Serotonin Function in Offspring. Brain sciences. vol 8. issue 6. 2020-09-30. PMID:29891804. |
the goal of the present study was to determine the extent to which this treatment influences dopamine and serotonin innervation of murine cortical and subcortical areas, as measured by regional density of dopamine (dat) and serotonin transporters (sert). |
2020-09-30 |
2023-08-13 |
Not clear |
| Wen-Sheng Huang, Guann-Juh Chen, Tung-Han Tsai, Chen-Yi Cheng, Chyng-Yann Shiue, Kuo-Hsing Ma, Skye Hsin-Hsien Ye. In vivo long-lasting alterations of central serotonin transporter activity and associated dopamine synthesis after acute repeated administration of methamphetamine. EJNMMI research. vol 9. issue 1. 2020-09-30. PMID:31535286. |
methamphetamine (meth)-associated alterations in the striatal dopamine (da) system or dopamine transport (dat) have been identified in clinical and preclinical studies with positron emission tomography (pet) imaging but have not been well correlated with in vivo serotonin transporter (sert) availability due to the lack of appropriate imaging agents to assess serts. |
2020-09-30 |
2023-08-13 |
Not clear |
| Prerna Jha, Lotten Ragnarsson, Richard J Lewi. Structure-Function of the High Affinity Substrate Binding Site (S1) of Human Norepinephrine Transporter. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32210813. |
the human norepinephrine transporter (hnet) is a member of the neurotransmitter/sodium symporter family, which also includes the neuronal monoamine transporters for serotonin (sert) and dopamine (dat). |
2020-09-28 |
2023-08-13 |
human |
| Talia Zeppelin, Lucy Kate Ladefoged, Steffen Sinning, Birgit Schiøt. Substrate and inhibitor binding to the serotonin transporter: Insights from computational, crystallographic, and functional studies. Neuropharmacology. vol 161. 2020-07-14. PMID:30807752. |
the serotonin transporter (sert) belongs to the monoamine transporter family, which also includes the dopamine and norepinephrine transporters. |
2020-07-14 |
2023-08-13 |
Not clear |
| Marco Niello, Daniela Cintulova, Eva Hellsberg, Kathrin Jäntsch, Marion Holy, Leila H Ayatollahi, Nicholas V Cozzi, Michael Freissmuth, Walter Sandtner, Gerhard F Ecker, Marko D Mihovilovic, Harald H Sitt. para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter. Neuropharmacology. vol 161. 2020-07-14. PMID:31028773. |
the transporters for dopamine (dat) and serotonin (sert) are important targets in the treatment of psychiatric disorders including major depression, anxiety and attention-deficit hyperactivity disorder. |
2020-07-14 |
2023-08-13 |
Not clear |
| Kamil Łątka, Jakub Jończyk, Marek Bajd. γ-Aminobutyric acid transporters as relevant biological target: Their function, structure, inhibitors and role in the therapy of different diseases. International journal of biological macromolecules. 2020-05-03. PMID:32360967. |
the important structural features were described based on published data, including sequence analysis, mutagenesis studies, and comparison with known slc6 transporters for leucine (leut), dopamine (dat) and serotonin (sert). |
2020-05-03 |
2023-08-13 |
Not clear |
| Juan Pablo González-Gutiérrez, Hernán Armando Pessoa-Mahana, Patricio Ernesto Iturriaga-Vásquez, Miguel Iván Reyes-Parada, Nicolas Esteban Guerra-Díaz, Martin Hodar-Salazar, Franco Viscarra, Pablo Paillali, Gabriel Núñez-Vivanco, Marcos Antonio Lorca-Carvajal, Jaime Mella-Raipán, María Carolina Zúñig. Synthesis of Novel Nicotinic Ligands with Multimodal Action: Targeting Acetylcholine α4β2, Dopamine and Serotonin Transporters. Molecules (Basel, Switzerland). vol 24. issue 20. 2020-04-06. PMID:31652614. |
nicotinic acetylcholine receptors (nachrs), serotonin transporters (sert) and dopamine transporters (dat) represent targets for the development of novel nicotinic derivatives acting as multiligands associated with different health conditions, such as depressive, anxiety and addiction disorders. |
2020-04-06 |
2023-08-13 |
Not clear |