| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samantha E Yohn, Emily E Errante, Aaron Rosenbloom-Snow, Matthew Somerville, Margaret Rowland, Kristin Tokarski, Nadia Zafar, Merce Correa, John D Salamon. Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology. Neuropharmacology. vol 109. 2017-06-19. PMID:27329556. |
the present studies investigated the ability of drugs that block dopamine transport (dat), norepinephrine transport (net), and serotonin transport (sert) to modulate work output in rats responding on a test of effort-related decision making (i.e., a progressive ratio (prog)/chow feeding choice task). |
2017-06-19 |
2023-08-13 |
rat |
| Carolyn G Sweeney, Bradford P Tremblay, Thomas Stockner, Harald H Sitte, Haley E Melikia. Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities. The Journal of biological chemistry. vol 292. issue 4. 2017-06-05. PMID:27986813. |
extracellular dopamine and serotonin concentrations are determined by the presynaptic dopamine (dat) and serotonin (sert) transporters, respectively. |
2017-06-05 |
2023-08-13 |
Not clear |
| Bruce A Davis, Anu Nagarajan, Lucy R Forrest, Satinder K Sing. Mechanism of Paroxetine (Paxil) Inhibition of the Serotonin Transporter. Scientific reports. vol 6. 2017-02-17. PMID:27032980. |
to provide molecular insight, we constructed sert homology models based on the drosophila melanogaster dopamine transporter and docked paroxetine to these models. |
2017-02-17 |
2023-08-13 |
drosophila_melanogaster |
| Blake A Hutsell, Michael H Baumann, John S Partilla, Matthew L Banks, Rakesh Vekariya, Richard A Glennon, S Stevens Negu. Abuse-related neurochemical and behavioral effects of cathinone and 4-methylcathinone stereoisomers in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 2. 2016-12-13. PMID:26738428. |
for neurochemical studies, drug effects were evaluated on monoamine release through dopamine, norepinephrine, and serotonin transporters (dat, net and sert, respectively) in rat brain synaptosomes. |
2016-12-13 |
2023-08-13 |
rat |
| Louis J De Felic. Chloride requirement for monoamine transporters. Pflugers Archiv : European journal of physiology. vol 468. issue 3. 2016-11-04. PMID:26794730. |
this review focuses on the cl(-) requirement for dopamine, serotonin, and norepinephrine (da, 5-ht, and ne) transport and induced current via the transporters for these transmitters, dat, sert, and net. |
2016-11-04 |
2023-08-13 |
Not clear |
| Paola A Spadaro, Helen L Naug, Eugene F DU Toit, Daniel Donner, Natalie J Colso. A refined high carbohydrate diet is associated with changes in the serotonin pathway and visceral obesity. Genetics research. vol 97. 2016-11-01. PMID:26707058. |
real-time pcr was applied to determine any variation in levels of expression of the serotonin (slc6a4 or sert) and dopamine transporter (slc6a3 or dat) genes. |
2016-11-01 |
2023-08-13 |
rat |
| K Berghauzen-Maciejewska, J Wardas, B Kosmowska, H Domin, M Śmiałowska, U Głowacka, K Ossowsk. Adaptive down-regulation of the serotonin transporter in the 6-hydroxydopamine-induced rat model of preclinical stages of Parkinson's disease and after chronic pramipexole treatment. Neuroscience. vol 314. 2016-10-13. PMID:26628402. |
binding of [(3)h]gbr 12,935 to the dopamine transporter (dat) and [(3)h]citalopram to sert was analyzed autoradiographically. |
2016-10-13 |
2023-08-13 |
rat |
| Ajinkya Sase, Yogesh D Aher, Sivaprakasam R Saroja, Minu Karthika Ganesan, Sunetra Sase, Marion Holy, Harald Höger, Vasiliy Bakulev, Gerhard F Ecker, Thierry Langer, Harald H Sitte, Johann Leban, Gert Lube. A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes. Neuropharmacology. vol 102. 2016-10-07. PMID:26407764. |
binding of ce-103 to the dopamine (dat), serotonin (sert) and norepinephrine (net) transporters and dopamine reuptake inhibition was tested as well as blood brain permeation and a screen for gpcr targets. |
2016-10-07 |
2023-08-13 |
rat |
| Ajinkya Sase, Yogesh D Aher, Sivaprakasam R Saroja, Minu Karthika Ganesan, Sunetra Sase, Marion Holy, Harald Höger, Vasiliy Bakulev, Gerhard F Ecker, Thierry Langer, Harald H Sitte, Johann Leban, Gert Lube. A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes. Neuropharmacology. vol 102. 2016-10-07. PMID:26407764. |
ce-103 was binding to the dat but insignificantly to sert or net and dopamine reuptake was blocked specifically (ic50 = 14.73 μm). |
2016-10-07 |
2023-08-13 |
rat |
| Julie A Marusich, Kateland R Antonazzo, Bruce E Blough, Simon D Brandt, Pierce V Kavanagh, John S Partilla, Michael H Bauman. The new psychoactive substances 5-(2-aminopropyl)indole (5-IT) and 6-(2-aminopropyl)indole (6-IT) interact with monoamine transporters in brain tissue. Neuropharmacology. vol 101. 2016-09-22. PMID:26362361. |
here, the monoamine-releasing properties of 5-it, its structural isomer 6-(2-aminopropyl)indole (6-it), and mdma were compared using in vitro release assays at transporters for dopamine (dat), norepinephrine (net), and serotonin (sert) in rat brain synaptosomes. |
2016-09-22 |
2023-08-13 |
mouse |
| Friederike Matthaeus, Patrick Schloss, Thorsten La. Differential Uptake Mechanisms of Fluorescent Substrates into Stem-Cell-Derived Serotonergic Neurons. ACS chemical neuroscience. vol 6. issue 12. 2016-09-21. PMID:26503837. |
the actions of the neurotransmitters serotonin, dopamine, and norepinephrine are partly terminated by diffusion and in part by their uptake into neurons via the selective, high-affinity transporters for serotonin (sert), dopamine (dat), and norepinephrine (net), respectively. |
2016-09-21 |
2023-08-13 |
Not clear |
| Thomas Kirmeier, Ranganath Gopalakrishnan, Vanessa Gormanns, Anna M Werner, Serena Cuboni, Georg C Rudolf, Georg Höfner, Klaus T Wanner, Stephan A Sieber, Ulrike Schmidt, Florian Holsboer, Theo Rein, Felix Hausc. Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores. PloS one. vol 11. issue 2. 2016-07-14. PMID:26863431. |
to control for this, we evaluated the binding parameters of azidobupramine to known target sites such as the transporters for serotonin (sert), norepinephrine (net), and dopamine (dat). |
2016-07-14 |
2023-08-13 |
Not clear |
| Fabio Del Bello, Farhana Sakloth, John S Partilla, Michael H Baumann, Richard A Glenno. Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine. Bioorganic & medicinal chemistry. vol 23. issue 17. 2016-06-20. PMID:26233799. |
here, we prepared n-methyl-(3,4-ethylenedioxyphenyl)-2-aminopropane (edma; 3), both of its optical isomers, and β-keto edma (i.e., edmc; 4) to examine their effects at transporters for serotonin (sert), dopamine (dat), and norepinephrine (net). |
2016-06-20 |
2023-08-13 |
Not clear |
| J S Bonano, M L Banks, R Kolanos, F Sakloth, M L Barnier, R A Glennon, N V Cozzi, J S Partilla, M H Baumann, S S Negu. Quantitative structure-activity relationship analysis of the pharmacology of para-substituted methcathinone analogues. British journal of pharmacology. vol 172. issue 10. 2016-05-24. PMID:25438806. |
this study examined quantitative structure-activity relationships (qsar) for mcat and six para-substituted mcat analogues on (a) in vitro potency to promote monoamine release via dopamine and serotonin transporters (dat and sert, respectively), and (b) in vivo modulation of intracranial self-stimulation (icss), a behavioural procedure used to evaluate abuse potential. |
2016-05-24 |
2023-08-13 |
Not clear |
| Jeffrey S Stehouwer, Mark M Goodma. Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine. PET clinics. vol 4. issue 1. 2016-05-10. PMID:20216936. |
this review focuses on the development of fluorine-18 radiolabeled pet tracers for imaging the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). |
2016-05-10 |
2023-08-12 |
Not clear |
| Barbara Bottalico, Radovan Pilka, Irene Larsson, Bertil Casslen, Karel Marsal, Stefan R Hansso. Plasma membrane and vesicular monoamine transporters in normal endometrium and early pregnancy decidua. Molecular human reproduction. vol 9. issue 7. 2016-04-23. PMID:12802045. |
extracellular monoamine levels are regulated primarily through re-uptake by specific membrane-bound transporter proteins dopamine transporter (dat), norepinephrine transporter (net) and serotonin transporter (sert). |
2016-04-23 |
2023-08-12 |
Not clear |
| Kusumika Saha, John S Partilla, Kurt R Lehner, Amir Seddik, Thomas Stockner, Marion Holy, Walter Sandtner, Gerhard F Ecker, Harald H Sitte, Michael H Bauman. 'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25502630. |
here we characterized the interactions of 4-mec and 4-meppp with transporters for 5-ht (sert) and dopamine (dat) using molecular, cellular, and whole-animal methods. |
2016-03-29 |
2023-08-13 |
rat |
| Yogesh D Aher, Saraswathi Subramaniyan, Bharanidharan Shanmugasundaram, Ajinkya Sase, Sivaprakasam R Saroja, Marion Holy, Harald Höger, Tetyana Beryozkina, Harald H Sitte, Johann J Leban, Gert Lube. A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System. Frontiers in behavioral neuroscience. vol 10. 2016-03-04. PMID:26941626. |
the efficacy of ce-104 in blocking mat [dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter] was determined using in vitro neurotransmitter uptake assay. |
2016-03-04 |
2023-08-13 |
human |
| Yogesh D Aher, Saraswathi Subramaniyan, Bharanidharan Shanmugasundaram, Ajinkya Sase, Sivaprakasam R Saroja, Marion Holy, Harald Höger, Tetyana Beryozkina, Harald H Sitte, Johann J Leban, Gert Lube. A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System. Frontiers in behavioral neuroscience. vol 10. 2016-03-04. PMID:26941626. |
the drug inhibited dopamine (ic50: 27.88 μm) and norepinephrine uptake (ic50: 160.40 μm), but had a negligible effect on sert. |
2016-03-04 |
2023-08-13 |
human |
| Christian Pifl, Harald Reither, Oleh Hornykiewic. The profile of mephedrone on human monoamine transporters differs from 3,4-methylenedioxymethamphetamine primarily by lower potency at the vesicular monoamine transporter. European journal of pharmacology. vol 755. 2016-02-09. PMID:25771452. |
we therefore compared their effects on the human monoamine transporters using human cell lines stably expressing the human noradrenaline, dopamine and serotonin transporter (net, dat and sert); preparations of synaptic vesicles from human striatum in uptake experiments; and a superfusion system where releasing effects can be reliably measured. |
2016-02-09 |
2023-08-13 |
human |