| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian J Fehske, Kristina Leuner, Walter E Mülle. Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment. Pharmacological research. vol 60. issue 1. 2009-09-25. PMID:19427589. |
here, we confirm that the norepinephrine (net), the serotonin (sert), the dopamine (dat) uptake transporters and mao activity are inhibited by egb761 in vitro, although rather high concentrations are required for inhibition of mao-a and mao-b activity. |
2009-09-25 |
2023-08-12 |
mouse |
| Gang Zhao, Cheng Bi, Guo-Wei Qin, Li-He Gu. Caulis Sinomenii extracts activate DA/NE transporter and inhibit 5HT transporter. Experimental biology and medicine (Maywood, N.J.). vol 234. issue 8. 2009-09-10. PMID:19491370. |
we assessed whether qft would be biologically active in functionally regulating monoamine transporters using cho cells expressing dopamine transporter (dat), norepinephrine transporter (net), or serotonin transporter (sert) (i.e. |
2009-09-10 |
2023-08-12 |
Not clear |
| Gang Zhao, Xiang-Wei Zheng, Yue Gai, Wen-Jing Chu, Guo-Wei Qin, Li-He Gu. Safflower extracts functionally regulate monoamine transporters. Journal of ethnopharmacology. vol 124. issue 1. 2009-09-09. PMID:19527825. |
our current results showed that all solvent-extracted hh fractions, in different degrees, markedly increased both dopamine uptake by chinese hamster ovary (cho) cells stably expressing dopamine transporter (dat) and norepinephrine uptake by cho cells expressing norepinephrine transporter (net), and also showed that chloroform (hc), ethyl acetate (he), and n-butyl alcohol extract strikingly depressed serotonin uptake by cho cells expressing serotonin transporter (sert); wherein, the potencies of ethanol extract, hc, he, and aqueous extract to up-regulate dopamine/norepinephrine uptake and potency of he to inhibit serotonin uptake were relatively stronger. |
2009-09-09 |
2023-08-12 |
rat |
| Tzung Lieh Yeh, I Hui Lee, Kao Ching Chen, Po See Chen, Wei Jen Yao, Yeng Kuang Yang, Nan Tsing Chiu, Ru Band L. The relationships between daily life events and the availabilities of serotonin transporters and dopamine transporters in healthy volunteers--a dual-isotope SPECT study. NeuroImage. vol 45. issue 2. 2009-05-13. PMID:19130891. |
the aim of this study was to examine the relationships between the daily life events and the availabilities of serotonin transporters (sert) and dopamine transporters (dat) in healthy volunteers. |
2009-05-13 |
2023-08-12 |
human |
| Morgane Thomsen, F Scott Hall, George R Uhl, S Barak Cain. Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 4. 2009-04-08. PMID:19176817. |
we tested the hypotheses that mice lacking the dopamine transporter (dat(-/-)), the serotonin transporter (sert(-/-)), or both (dat(-/-)sert(-/-)) exhibit decreased reinforcing effects of cocaine. |
2009-04-08 |
2023-08-12 |
mouse |
| Michael Y Aksenov, Marina V Aksenova, Janelle M Silvers, Charles F Mactutus, Rosemarie M Booz. Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18606182. |
in this study, we found that the selective inhibitor of dopamine transporter (dat) function, 1-[2-[bis(4-fluorophenyl) methoxy]ethyl]-4-(3-phenylpropyl) piperazine (gbr 12909, vanoxerine), but not the selective inhibitors of serotonin and norepinephrine (sert and net) transporters, sertraline and nizoxetine, emulated cocaine-mediated enhancement of tat neurotoxicity in rat fetal midbrain primary cell cultures. |
2009-03-26 |
2023-08-12 |
rat |
| Lynette C Daw. Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy. Pharmacology & therapeutics. vol 121. issue 1. 2009-03-18. PMID:19022290. |
biogenic amine transporters for serotonin, norepinephrine and dopamine (sert, net and dat respectively), are the key players terminating transmission of these amines in the central nervous system by their high-affinity uptake. |
2009-03-18 |
2023-08-12 |
Not clear |
| Leonard L Howel. Nonhuman primate neuroimaging and cocaine medication development. Experimental and clinical psychopharmacology. vol 16. issue 6. 2009-03-03. PMID:19086766. |
selective serotonin transporter (sert) inhibitors were also effective in reducing cocaine use and blocked cocaine-induced brain activation and increases in extracellular dopamine. |
2009-03-03 |
2023-08-12 |
Not clear |
| Jeffrey S Stehouwer, Nachwa Jarkas, Fanxing Zeng, Ronald J Voll, Larry Williams, Vernon M Camp, Eugene J Malveaux, John R Votaw, Leonard Howell, Michael J Owens, Mark M Goodma. Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. Journal of medicinal chemistry. vol 51. issue 24. 2009-01-22. PMID:19053782. |
in vitro competition binding assays demonstrated that 1-4 have a high affinity for the sert (k(i) values = 0.3-0.4 nm) and are selective for the sert over the dopamine and norepinephrine transporters (dat and net). |
2009-01-22 |
2023-08-12 |
monkey |
| Kelly Lengyel, Rick Pieschl, Todd Strong, Thaddeus Molski, Gail Mattson, Nicholas J Lodge, Yu-Wen L. Ex vivo assessment of binding site occupancy of monoamine reuptake inhibitors: methodology and biological significance. Neuropharmacology. vol 55. issue 1. 2008-11-05. PMID:18538356. |
the goal of this study was to develop and validate ex vivo binding assays for serotonin (sert), norepinephrine (net) and dopamine (dat) transporters, and to use these assays to evaluate the binding site occupancy of triple and double monoamine reuptake inhibitors in rat brains. |
2008-11-05 |
2023-08-12 |
rat |
| Aloke K Dutta, Balaram Ghosh, Swati Biswas, Maarten E A Reit. D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action. European journal of pharmacology. vol 589. issue 1-3. 2008-10-24. PMID:18561912. |
one of our lead molecules, d-161 exhibited triple monoamine transporter inhibitory activity with the highest affinity for norepinephrine transporter (net) followed by its affinity for serotonin transporter (sert) and dopamine transporter (dat). |
2008-10-24 |
2023-08-12 |
mouse |
| Soili M Lehto, Tommi Tolmunen, Jyrki Kuikka, Minna Valkonen-Korhonen, Mikko Joensuu, Pirjo I Saarinen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Johannes Lehtone. Midbrain serotonin and striatum dopamine transporter binding in double depression: a one-year follow-up study. Neuroscience letters. vol 441. issue 3. 2008-10-20. PMID:18588943. |
we examined the striatum dopamine (dat) and midbrain serotonin transporter (sert) binding of [123i] nor-beta-cit in dd patients (n=8) and compared it to that in md patients (n=11) and healthy controls (n=19). |
2008-10-20 |
2023-08-12 |
Not clear |
| Leah Aluisio, Brian Lord, Ann J Barbier, Ian C Fraser, Sandy J Wilson, Jamin Boggs, Lisa K Dvorak, Michael A Letavic, Bruce E Maryanoff, Nicholas I Carruthers, Pascal Bonaventure, Timothy W Lovenber. In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor. European journal of pharmacology. vol 587. issue 1-3. 2008-08-25. PMID:18499098. |
triple reuptake inhibitors, which block the serotonin transporter (sert), norepinephrine transporter (net) and dopamine transporter (dat) in the central nervous system have been described as therapeutic alternatives for classical selective serotonin reuptake inhibitors, with advantages due to their multiple mechanisms of action. |
2008-08-25 |
2023-08-12 |
mouse |
| Christopher D Verrico, Laurie Lynch, Michele A Fahey, Ashley-Kay Fryer, Gregory M Miller, Bertha K Madra. MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor. Journal of psychopharmacology (Oxford, England). vol 22. issue 2. 2008-08-18. PMID:18308800. |
we postulated that mdma will compromise executive function in primates and that an inhibitor of the serotonin transporter (sert) and the norepinephrine transporter (net) but not the dopamine (dat) transporter, will prevent impairment. |
2008-08-18 |
2023-08-12 |
human |
| Vishakantha Murthy, Thomas J Martin, Susy Kim, Huw M L Davies, Steven R Childer. In vivo characterization of a novel phenylisothiocyanate tropane analog at monoamine transporters in rat brain. The Journal of pharmacology and experimental therapeutics. vol 326. issue 2. 2008-08-12. PMID:18492949. |
previous studies have shown that the phenylisothiocyanate tropane analog 2-beta-propanoyl-3-beta-(2-naphthyl)-8-[4-isothiocyanato)benzyl]nortropane (hd-205) binds covalently to dopamine and serotonin transporters (dat and sert, respectively) in rat brain membranes (biochem pharmacol 74:336-344, 2007). |
2008-08-12 |
2023-08-12 |
rat |
| Ling-Wei Hsin, Li-Te Chang, Richard B Rothman, Christina M Dersch, Arthur E Jacobson, Kenner C Ric. Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transporters. Journal of medicinal chemistry. vol 51. issue 9. 2008-07-09. PMID:18393401. |
novel derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (gbr 12909, 1) and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (gbr 12935, 2) with various substituents in positions c2 and c3 of the phenylpropyl side chain were synthesized and evaluated for their ability to bind to the dopamine transporter (dat) and the serotonin transporter (sert). |
2008-07-09 |
2023-08-12 |
Not clear |
| Susanne Jørgensen, Elsebet Østergaard Nielsen, Dan Peters, Tino Dyhrin. Validation of a fluorescence-based high-throughput assay for the measurement of neurotransmitter transporter uptake activity. Journal of neuroscience methods. vol 169. issue 1. 2008-06-23. PMID:18222006. |
pre-synaptic dopamine, norepinephrine and serotonin transporters (dat, net and sert) terminate synaptic catecholamine transmission through reuptake of released neurotransmitter. |
2008-06-23 |
2023-08-12 |
Not clear |
| Manoj Mishra, Rohit Kolhatkar, Juan Zhen, Ingrid Parrington, Maarten E A Reith, Aloke K Dutt. Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. Bioorganic & medicinal chemistry. vol 16. issue 6. 2008-06-13. PMID:18249549. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin (5-ht) transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2008-06-13 |
2023-08-12 |
Not clear |
| Gang Zhao, Shao-Yun Zang, Xiang-Wei Zheng, Xiao-Hua Zhang, Li-He Gu. Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions. Biochemical pharmacology. vol 75. issue 9. 2008-05-27. PMID:18329002. |
monoamine transporter inhibition by delta3,2-hydroxybakuchiol was more selective for the dopamine transporter (dat) (ic50=0.58+/-0.1 microm) and norepinephrine transporter (net) (ic50=0.69+/-0.12 microm) than for the serotonin transporter (sert) (ic50=312.02+/-56.69 microm). |
2008-05-27 |
2023-08-12 |
mouse |
| Iain J A Macdougall, Renate Griffit. Pharmacophore design and database searching for selective monoamine neurotransmitter transporter ligands. Journal of molecular graphics & modelling. vol 26. issue 7. 2008-05-15. PMID:18023378. |
various structural classes of compounds have been synthesized and tested in vitro for activity against transporters of three monoamine signaling molecules: noradrenaline (net); serotonin (sert) and dopamine (dat). |
2008-05-15 |
2023-08-12 |
Not clear |