| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shijun Zhang, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine. Bioorganic & medicinal chemistry. vol 14. issue 11. 2006-08-14. PMID:16481172. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2006-08-14 |
2023-08-12 |
Not clear |
| Terrence L Boos, Elisabeth Greiner, W Jason Calhoun, Thomas E Prisinzano, Barbara Nightingale, Christina M Dersch, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter. Bioorganic & medicinal chemistry. vol 14. issue 11. 2006-08-14. PMID:16563775. |
a series of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-(substituted benzyl) piperidines with substituents at the ortho and meta positions in the aromatic ring of the n-benzyl side chain were synthesized and their affinities and selectivities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) were determined. |
2006-08-14 |
2023-08-12 |
Not clear |
| Dawn D Han, Howard H G. Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC pharmacology. vol 6. 2006-08-03. PMID:16515684. |
the transporters for the monoamines dopamine, norepinephrine, and serotonin (dat, net, and sert) are targets for several popular psychostimulant drugs of abuse. |
2006-08-03 |
2023-08-12 |
mouse |
| Peter Grundt, Theresa A Kopajtic, Jonathan L Katz, Amy Hauck Newma. N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands. Bioorganic & medicinal chemistry letters. vol 15. issue 24. 2006-06-27. PMID:16213721. |
a series of n-8-substituted benztropinamines was synthesized and evaluated for binding at the dopamine (dat), serotonin (sert), norepinephrine (net) transporters, and muscarinic m1 receptors. |
2006-06-27 |
2023-08-12 |
Not clear |
| Elisabeth Greiner, Terrence L Boos, Thomas E Prisinzano, Maria G De Martino, Brian Zeglis, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity. Journal of medicinal chemistry. vol 49. issue 5. 2006-04-25. PMID:16509591. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-piperidines and 4-[2-[(bisphenyl)methoxy]ethyl]-piperidines with different types of substituents in the phenylpropyl side-chain were synthesized and examined for their ability to bind to the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2006-04-25 |
2023-08-12 |
Not clear |
| Aina Westrheim Ravna, Ingebrigt Sylte, Kurt Kristiansen, Svein G Dah. Putative drug binding conformations of monoamine transporters. Bioorganic & medicinal chemistry. vol 14. issue 3. 2006-04-20. PMID:16216517. |
based on the hypothesis that the 12 transmembrane alpha-helix (tmh) secondary transporters belong to a common folding class, the lac permease structure was used for molecular modeling of the serotonin transporter (sert), the dopamine transporter (dat), and the noradrenaline transporter (net). |
2006-04-20 |
2023-08-12 |
Not clear |
| Gilles Tamagnan, David Alagille, Xing Fu, Nora S Kula, Ross J Baldessarini, Robert B Innis, Ronald M Baldwi. Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropanes. Bioorganic & medicinal chemistry letters. vol 16. issue 1. 2006-03-21. PMID:16236497. |
four compounds presented a particularly attractive pharmacological profile, with very high sert affinity (k(i) 0.15-0.5 nm) and selectivity versus the dopamine transporter of 25- to 77-fold. |
2006-03-21 |
2023-08-12 |
Not clear |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
catecholamine homeostasis as reflected in brain tissue concentrations and in synthesis and turnover of dopamine and norepinephrine was unchanged in sert -/- mice. |
2006-03-10 |
2023-08-12 |
mouse |
| Kevin B Freeman, Kenner C Rice, Anthony L Rile. Assessment of monoamine transporter inhibition in the mediation of cocaine-induced conditioned taste aversion. Pharmacology, biochemistry, and behavior. vol 82. issue 3. 2006-03-02. PMID:16337262. |
using the conditioned taste aversion (cta) preparation, the present study examined the role of monoamine uptake inhibition in cocaine's aversive effects by comparing cocaine to three reuptake inhibitors with relative specificity for the transporters of dopamine (dat; gbr 12909), norepinephrine (net; desipramine) and serotonin (sert; clomipramine). |
2006-03-02 |
2023-08-12 |
rat |
| Annabelle M Belcher, Steven J O'Dell, John F Marshal. Impaired object recognition memory following methamphetamine, but not p-chloroamphetamine- or d-amphetamine-induced neurotoxicity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 11. 2006-01-24. PMID:15900317. |
after behavioral testing, the specificity of monoaminergic lesions was determined by postmortem [125i]rti-55 binding to dopamine (dat) and serotonin (sert) transporter proteins. |
2006-01-24 |
2023-08-12 |
rat |
| Swen Hesse, Ulrich Müller, Thomas Lincke, Henryk Barthel, Thomas Villmann, Matthias C Angermeyer, Osama Sabri, Katarina Stengler-Wenzk. Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder. Psychiatry research. vol 140. issue 1. 2006-01-03. PMID:16213689. |
we applied [123i]-2beta-carbomethoxy-3beta-(4-idiophenyl)tropane (beta-cit) and a brain-dedicated high-resolution single photon emission computed tomography (spect) system to quantify dopamine transporter (dat) and serotonin transporter (sert) availability. |
2006-01-03 |
2023-08-12 |
Not clear |
| Oliver Pogarell, Gabriele Poepperl, Christoph Mulert, Christine Hamann, Nikolai Sadowsky, Michael Riedel, Hans-Juergen Moeller, Ulrich Hegerl, Klaus Tatsc. SERT and DAT availabilities under citalopram treatment in obsessive-compulsive disorder (OCD). European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 15. issue 5. 2005-12-30. PMID:16139170. |
serotonin and dopamine transporter (sert, dat) availabilities have prospectively been investigated using [123i]beta-cit and single photon emission computed tomography in subjects with obsessive-compulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. |
2005-12-30 |
2023-08-12 |
human |
| Jill B Rhoden, Maud Bouvet, Sari Izenwasser, Dean Wade, Stacey A Lomenzo, Mark L Trudel. Structure-activity studies of 3'-4'-dichloro-meperidine analogues at dopamine and serotonin transporters. Bioorganic & medicinal chemistry. vol 13. issue 19. 2005-12-23. PMID:15993612. |
the structure-activity relationships of 3',4'-dichloro-meperidine were investigated at dopamine (dat) and serotonin transporters (sert). |
2005-12-23 |
2023-08-12 |
Not clear |
| Jean Logan, Yu-Shin Ding, Kuo-Shyan Lin, Deborah Pareto, Joanna Fowler, Anat Biego. Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region. Nuclear medicine and biology. vol 32. issue 5. 2005-12-07. PMID:15982584. |
the development of positron emission tomography (pet) ligands for the norepinephrine transporter (net) has been slow compared to the development of radiotracers for others systems, such as the dopamine (dat) or the serotonin transporters (sert). |
2005-12-07 |
2023-08-12 |
Not clear |
| Agnes Szilagyi, Krisztina Boór, Anna Székely, Péter Gaszner, Huba Kalász, Mária Sasvári-Székely, Csaba Bart. Combined effect of promoter polymorphisms in the dopamine D4 receptor and the serotonin transporter genes in heroin dependence. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 7. issue 1. 2005-11-01. PMID:16167465. |
dopamine d4 receptor (drd4) and serotonin transporter (sert) gene polymorphisms were studied, as possible genetic risk factors for substance dependence. |
2005-11-01 |
2023-08-12 |
Not clear |
| Paul D Callaghan, Rodney J Irvine, Lynette C Daw. Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry. Neurochemistry international. vol 47. issue 5. 2005-09-08. PMID:15979209. |
in contrast to the striatum where 5-ht is cleared by both the sert and the dopamine transporter (dat), 5-ht is cleared primarily by the sert in the ca3 region. |
2005-09-08 |
2023-08-12 |
rat |
| Anu J Airaksinen, Marko Huotari, Alexander Shvetsov, Pirjo Vainiotalo, Pekka T Männisto, Leena Tuomisto, Kim A Bergström, Jouko Vepsäläine. Synthesis and biological evaluation of 6/7-exo-methyl-3beta-(4-iodo)phenyltropane-2beta-carboxylic acid methyl esters. European journal of medicinal chemistry. vol 40. issue 3. 2005-08-29. PMID:15725499. |
the effect of 6/7-groups was evaluated by in vitro receptor binding to dopamine (dat), serotonin (sert) and norepinephrine (net) transporters. |
2005-08-29 |
2023-08-12 |
mouse |
| Christian Pifl, Gabor Nagy, Sándor Berényi, Alexandra Kattinger, Harald Reither, Sándor Antu. Pharmacological characterization of ecstasy synthesis byproducts with recombinant human monoamine transporters. The Journal of pharmacology and experimental therapeutics. vol 314. issue 1. 2005-08-26. PMID:15831439. |
mdma and eight chemically defined byproducts of mdma synthesis were investigated for their interaction with the primary sites of action of mdma, namely the human plasmalemmal monamine transporters for norepinephrine, serotonin, and dopamine [(norepinephrine transporter (net), serotonin transporter (sert), and dopamine transporter (dat)]. |
2005-08-26 |
2023-08-12 |
human |
| Nachwa Jarkas, Jonathan McConathy, Ronald J Voll, Mark M Goodma. Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands. Journal of medicinal chemistry. vol 48. issue 13. 2005-08-23. PMID:15974579. |
competition binding in cells stably expressing the transfected human sert, dopamine transporter (dat), and norepinephrine transporter (net) using [(3)h]citalopram, [(3)h]win 35,428 or [(125)i]rti-55, and [(3)h]nisoxetine, respectively, demonstrated the following order of sert affinity (k(i) (nm)): 14a (0.25) > 16 (0.49) > 20 (0.57) > 14b (1.12) > 13 (1.59) > 33b (1.94) = 35 (2.04) >> 23 (8.50) = 28 (8.55) > 41 (15.11) >> 22 (51) > 33a (83.43) > 27 (92). |
2005-08-23 |
2023-08-12 |
human |
| Shijun Zhang, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner. Journal of medicinal chemistry. vol 48. issue 15. 2005-08-23. PMID:16033275. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]-5-ht, and [(3)h]ne, respectively. |
2005-08-23 |
2023-08-12 |
Not clear |