| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhihong Zhu, Ningning Guo, Raj Narendran, David Erritzoe, Jesper Ekelund, Dah-Ren Hwang, Sung-A Bae, Marc Laruelle, Yiyun Huan. The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics. Nuclear medicine and biology. vol 31. issue 8. 2005-07-05. PMID:15607480. |
binding assays indicated that afe displays high affinity for sert (k(i)=1.80 nm for hsert) and lower affinity for norepinephrine transporter (k(i)=946 nm for hnet) or dopamine transporter (k(i)>10,000 nm for hdat). |
2005-07-05 |
2023-08-12 |
rat |
| Nachwa Jarkas, Jonathan McConathy, John R Votaw, Ronald J Voll, Eugene Malveaux, Vernon M Camp, Larry Williams, Robin R Goodman, Clinton D Kilts, Mark M Goodma. Synthesis and characterization of EADAM: a selective radioligand for mapping the brain serotonin transporters by positron emission tomography. Nuclear medicine and biology. vol 32. issue 1. 2005-06-24. PMID:15691664. |
competition binding assays in cells stably expressing the transfected human dopamine transporter (dat), sert and norepinephrine transporter (net) labeled with [3h]win 35428 or [(125)i]rti-55, [3h]citalopram and [3h]nisoxetine, respectively, indicated the following order of sert affinity: adam>eadam>>fluvoxamine. |
2005-06-24 |
2023-08-12 |
human |
| Chong-Bin Zhu, Ana M Carneiro, Wolfgang R Dostmann, William A Hewlett, Randy D Blakel. p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. The Journal of biological chemistry. vol 280. issue 16. 2005-06-23. PMID:15728187. |
studies with transporter-transfected chinese hamster ovary cells reveal that sert stimulation is shared with the human norepinephrine transporter but not the human dopamine transporter. |
2005-06-23 |
2023-08-12 |
human |
| Gilles Tamagnan, David Alagille, Xing Fu, Nora S Kula, Ross J Baldessarini, Robert B Innis, Ronald M Baldwi. Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency. Bioorganic & medicinal chemistry letters. vol 15. issue 4. 2005-06-15. PMID:15686927. |
among these, compound 4b exhibited very high affinity for the serotonin transporter (sert: k(i)=17 pm) and good selectivity over dopamine (dat: 710-fold) and norepinephrine transporters (net: 11,100-fold). |
2005-06-15 |
2023-08-12 |
Not clear |
| Jochanan Stessman, Yoram Maaravi, Robert Hammerman-Rozenberg, Aaron Cohen, Lubov Nemanov, Inga Gritsenko, Nelly Gruberman, Richard P Ebstei. Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study. Mechanisms of ageing and development. vol 126. issue 2. 2005-06-13. PMID:15621215. |
in an exploratory study, 11 common polymorphisms were examined for contributing to longevity including: apolipoprotein e (apoe), methylenetetrahydrofolate reductase (mthfr), cathepsin d (cad), superoxide dismutase 2 (sod2), angiotensinogen (agt) and insulin-like growth factor 2 (igf2), leiden factor 7, p53 oncogene, dopamine d4 receptor (drd4) and the serotonin transporter (sert). |
2005-06-13 |
2023-08-12 |
human |
| Yiyun Huang, Sung-A Bae, Zhihong Zhu, Ningning Guo, Bryan L Roth, Marc Laruell. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents. Journal of medicinal chemistry. vol 48. issue 7. 2005-05-05. PMID:15801845. |
candidate compounds were assayed for their affinities to the monoamine transporters (sert, norepinephrine transporter (net), and dopamine transporter (dat)) in competitive binding experiments in vitro using cloned human transporters. |
2005-05-05 |
2023-08-12 |
human |
| Markus Mitterhauser, Wolfgang Wadsak, Leonhard-Key Mien, Alexander Hoepping, Helmut Viernstein, Robert Dudczak, Kurt Klette. Synthesis and biodistribution of [18F]FE@CIT, a new potential tracer for the dopamine transporter. Synapse (New York, N.Y.). vol 55. issue 2. 2005-04-25. PMID:15529336. |
an important improvement, yielding in higher affinity to the dopamine transporter (dat) vs. serotonin transporter (sert), can be achieved by a simple replacement of the carboxylic methyl ester group in beta-cit by a fluoroethyl ester. |
2005-04-25 |
2023-08-12 |
rat |
| Shijun Zhang, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters. Bioorganic & medicinal chemistry. vol 12. issue 23. 2005-04-13. PMID:15519172. |
both cis and trans 2,4- and 3,6-disubstituted derivatives were synthesized to determine the positional importance of n-substitution on affinity for monoamine transporters, that is the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net) in rat brain. |
2005-04-13 |
2023-08-12 |
rat |
| Tiffany A Mathews, Denise E Fedele, Francesca M Coppelli, Amy M Avila, Dennis L Murphy, Anne M Andrew. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589347. |
potassium stimulation revealed greater depolarization-induced increases in striatal 5-ht but not dopamine in sert(-/-) mice. |
2005-04-12 |
2023-08-12 |
mouse |
| Tiffany A Mathews, Denise E Fedele, Francesca M Coppelli, Amy M Avila, Dennis L Murphy, Anne M Andrew. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589347. |
overall, these results demonstrate that constitutive reductions in sert are associated with increases in 5-ht in the extracellular signaling space in the absence of changes in dopamine neurochemistry. |
2005-04-12 |
2023-08-12 |
mouse |
| Xuemei Peng, Ao Zhang, Nora S Kula, Ross J Baldessarini, John L Neumeye. Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents. Bioorganic & medicinal chemistry letters. vol 14. issue 22. 2005-03-22. PMID:15482938. |
novel compounds were evaluated for affinity and selectivity in competitive radioligand binding assays selective for cerebral serotonin (5-ht), dopamine (da), and norepinephrine (ne) transporters (sert, dat, and net). |
2005-03-22 |
2023-08-12 |
Not clear |
| Tetsurou Ikeda, Masaru Kurosawa, Chiharu Uchikawa, Shigeo Kitayama, Nobuyuki Nukin. Modulation of monoamine transporter expression and function by repetitive transcranial magnetic stimulation. Biochemical and biophysical research communications. vol 327. issue 1. 2005-03-11. PMID:15629452. |
in contrast to the sert changes, increased mrna levels of dopamine transporter (dat) and norepinephrine transporter (net) were observed. |
2005-03-11 |
2023-08-12 |
mouse |
| Hideki Mochizuki, Taku Amano, Takahiro Seki, Hiroaki Matsubayashi, Chieko Mitsuhata, Katsuya Morita, Shigeo Kitayama, Toshihiro Dohi, Hiromu K Mishima, Norio Saka. Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT). Neurochemistry international. vol 46. issue 2. 2005-03-09. PMID:15627510. |
in addition, the sert c-terminus did not affect dopamine transporter activity. |
2005-03-09 |
2023-08-12 |
rat |
| Taleen Hanania, Andrew C McCreary, Danielle O Salaz, Anne M Lyons, Nancy R Zahnise. Differential regulation of cocaine-induced locomotor activity in inbred long-sleep and short-sleep mice by dopamine and serotonin systems. European journal of pharmacology. vol 502. issue 3. 2005-03-08. PMID:15476748. |
in contrast, 5-ht transporter (sert) or 5-ht(1a) receptor antagonists potentiated cocaine-stimulated activity in iss, but not in ils, mice; this potentiation in iss mice was abolished by dopamine d1 receptor blockade. |
2005-03-08 |
2023-08-12 |
mouse |
| Yiyun Huang, Raj Narendran, Sung-A Bae, David Erritzoe, Ningning Guo, Zhihong Zhu, Dah-Ren Hwang, Marc Laruell. A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA). Nuclear medicine and biology. vol 31. issue 6. 2005-02-25. PMID:15246363. |
in vitro, afa displayed high affinity for sert (ki 1.46 +/- 0.15 nm) and lower affinity for norepinephrine transporter (net, ki 141.7 +/- 47.4 nm) or dopamine transporter (dat, ki > 10,000 nm). |
2005-02-25 |
2023-08-12 |
rat |
| Jonathan B Savitz, Rajkumar S Ramesa. Genetic variants implicated in personality: a review of the more promising candidates. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 131B. issue 1. 2005-02-08. PMID:15389772. |
alleles of the serotonin transporter gene (sert) and the dopamine 4 receptor gene (drd4) were first associated with anxiety-related and novelty-seeking personality traits, respectively, in 1996. |
2005-02-08 |
2023-08-12 |
Not clear |
| Peter Grundt, Theresa A Kopajtic, Jonathan L Katz, Amy Hauck Newma. The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor. Bioorganic & medicinal chemistry letters. vol 14. issue 12. 2005-01-06. PMID:15149693. |
a series of racemic 6-hydroxy and carboalkoxy substituted-4('),4"-difluorobenztropines was synthesized and evaluated for binding at the dopamine (dat), the serotonin (sert), the norepinephrine (net) transporters, and the muscarinic m1 receptor. |
2005-01-06 |
2023-08-12 |
Not clear |
| Tommi Tolmunen, Mikko Joensuu, Pirjo Irmeli Saarinen, Hanna Mussalo, Pasi Ahola, Ritva Vanninen, Jyrki Kuikka, Jari Tiihonen, Johannes Lehtone. Elevated midbrain serotonin transporter availability in mixed mania: a case report. BMC psychiatry. vol 4. 2004-12-30. PMID:15363105. |
results obtained from brain imaging studies indicate that serotonin transporter (sert) and dopamine transporter (dat) densities are altered in major depression. |
2004-12-30 |
2023-08-12 |
Not clear |
| Frederic Bois, Ronald M Baldwin, Nora S Kula, Ross J Baldessarini, Robert B Innis, Gilles Tamagna. Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT). Bioorganic & medicinal chemistry letters. vol 14. issue 9. 2004-12-22. PMID:15080991. |
all 3'-substituted compounds displayed affinity for both serotonin (sert) and dopamine (dat), but much less for norepinephrine transporters (net), with selectivity for rat (r) or human (h) sert over net, but only 3'-iodo-substituted phenyltropanes showed selectivity for sert versus dat. |
2004-12-22 |
2023-08-12 |
human |
| Sandra L Hrometz, Andrew W Brown, David E Nichols, Jon E Spragu. 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated production of hydrogen peroxide in an in vitro model: the role of dopamine, the serotonin-reuptake transporter, and monoamine oxidase-B. Neuroscience letters. vol 367. issue 1. 2004-11-24. PMID:15308297. |
several studies have suggested that dopamine (da) uptake into serotonin (5-ht) terminals by the 5-ht reuptake transporter (sert) and subsequent deamination by monoamine oxidase-b (mao-b) leads to the formation of hydrogen peroxide and may be major contributors to this serotonergic toxicity. |
2004-11-24 |
2023-08-12 |
human |