| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shunichi Oya, Seok Rye Choi, Heinz Coenen, Hank F Kun. New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine). Journal of medicinal chemistry. vol 45. issue 21. 2002-11-05. PMID:12361398. |
in vitro binding assays using cell membrane homogenates of llc cells expressing sert, dopamine transporters (dat), or norepinephrine transporters (net) showed excellent binding affinity and selectivity for sert (k(i) = 0.05, 3020, and 650 nm for sert, dat, and net, respectively). |
2002-11-05 |
2023-08-12 |
rat |
| Thomas Prisinzano, Elisabeth Greiner, Edward M Johnson, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter. Journal of medicinal chemistry. vol 45. issue 19. 2002-10-01. PMID:12213078. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethylpiperidines were examined for their ability to bind to the dopamine transporter (dat), the norepinephrine transporter, and the serotonin transporter (sert). |
2002-10-01 |
2023-08-12 |
Not clear |
| Paolo Benedetti, Raimund Mannhold, Gabriele Cruciani, Manuel Pasto. GBR compounds and mepyramines as cocaine abuse therapeutics: chemometric studies on selectivity using grid independent descriptors (GRIND). Journal of medicinal chemistry. vol 45. issue 8. 2002-05-06. PMID:11931612. |
the aim of the study is to gain insight into the structural requirements that determine the affinity of the data set molecules to the dat and the serotonin transporter (sert) as well as their inhibitory potency on dopamine uptake. |
2002-05-06 |
2023-08-12 |
Not clear |
| Patrick Emond, Johnny Vercouillie, Robert Innis, Sylvie Chalon, Sylvie Mavel, Yves Frangin, Christer Halldin, Jean-Claude Besnard, Denis Guillotea. Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation. Journal of medicinal chemistry. vol 45. issue 6. 2002-04-26. PMID:11881994. |
a series of diphenyl sulfide derivatives substituted at the 1-, 2'-, and 4'-positions has been synthesized and evaluated for their in vitro affinities at the dopamine, serotonin (sert), and norepinephrine transporters. |
2002-04-26 |
2023-08-12 |
Not clear |
| Ling-Wei Hsin, Christina M Dersch, Michael H Baumann, David Stafford, John R Glowa, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine. Journal of medicinal chemistry. vol 45. issue 6. 2002-04-26. PMID:11882001. |
the s enantiomers displayed higher dopamine transporter (dat) affinity and the r enantiomers were found to interact at the serotonin transporter (sert) with higher affinity. |
2002-04-26 |
2023-08-12 |
monkey |
| D Martinez, A Broft, M Laruell. Imaging neurochemical endophenotypes: promises and pitfalls. Pharmacogenomics. vol 2. issue 3. 2002-04-18. PMID:11535111. |
this paper reviews brain imaging studies designed to evaluate the significance of polymorphisms in genes coding for important drug targets (e.g., the serotonin transporter [sert], the dopamine transporter [dat] and the dopamine d(2) receptor) in terms of expression or function. |
2002-04-18 |
2023-08-12 |
human |
| C D Cook, I F Carroll, P M Beardsle. Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat. Psychopharmacology. vol 159. issue 1. 2002-03-13. PMID:11797070. |
although cocaine is an indirect da agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (dat) than norepinephrine (net) and serotonin (sert) transporters in the behavioral effects of cocaine. |
2002-03-13 |
2023-08-12 |
rat |
| X H Gu, R Zong, N S Kula, R J Baldessarini, J L Neumeye. Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 11. issue 23. 2002-03-05. PMID:11714608. |
a series of novel fluoroalkyl-containing tropane derivatives was synthesized, and their binding affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) were determined via competitive binding assays. |
2002-03-05 |
2023-08-12 |
Not clear |
| S K Michelhaugh, C Fiskerstrand, E Lovejoy, M J Bannon, J P Quin. The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739616. |
the dopamine (dat) and serotonin (sert) transporter genes both contain variable number of tandem repeats (vntr) in non-coding gene regions which have been correlated with a predisposition to a variety of cns disorders. |
2002-01-17 |
2023-08-12 |
human |
| K Yoshimoto, B Kato, S Ueda, K Noritake, K Sakai, M Shibata, M Hori, H Kawano, Y Takeuchi, Y Wakabayashi, M Yasuhar. Dopamine and serotonin uptake inhibitors on the release of dopamine and serotonin in the nucleus accumbens of young and aged rats. Mechanisms of ageing and development. vol 122. issue 15. 2001-12-07. PMID:11557275. |
nucleus accumbens (acc) of young (4 months old) and aged (24 months old) wistar rats were perfused with dopamine (da) uptake blocker, cocaine, or the serotonin (5-ht) selective reuptake inhibitor, fluoxetine, through the microdialysis probe membrane, used to assess the dopamine transporter (dat) or serotonin transporter (sert) modulation. |
2001-12-07 |
2023-08-12 |
rat |
| M Sas. [Function of monoamine neurotransmitter transporters]. Nihon rinsho. Japanese journal of clinical medicine. vol 59. issue 8. 2001-10-18. PMID:11519142. |
antiepileptic drugs such as ssri and tricyclic antidepressants bind with serotonin transporter(sert), noradrenaline transporter(net) and/or dopamine transporters(dat) to inhibit transport of monoamines into the cytoplasma, thereby increasing monoamine levels within the synaptic cleft. |
2001-10-18 |
2023-08-12 |
Not clear |
| X Liu, S Nuwayhid, M J Christie, M Kassiou, L L Werlin. Trishomocubanes: novel sigma-receptor ligands modulate amphetamine-stimulated [3H]dopamine release. European journal of pharmacology. vol 422. issue 1-3. 2001-09-13. PMID:11430911. |
several trishomocubane analogues of the type 4-azahexacyclo [5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane exhibited moderate to high affinity at sigma-receptor subtypes and low or negligible affinity at dopamine and serotonin transporters (sert). |
2001-09-13 |
2023-08-12 |
Not clear |
| G M Miller, S M Yatin, R De La Garza, M Goulet, B K Madra. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain research. Molecular brain research. vol 87. issue 1. 2001-08-09. PMID:11223167. |
we used rt-pcr to clone monoamine transporters from macaca mulatta, macaca fasicularis and saimiri sciureus (dopamine transporter; dat) and macaca mulatta (norepinephrine transporter; net and serotonin transporter; sert). |
2001-08-09 |
2023-08-12 |
human |
| M J Millan, A Gobert, F Lejeune, A Newman-Tancredi, J M Rivet, A Auclair, J L Peglio. S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. The Journal of pharmacology and experimental therapeutics. vol 298. issue 2. 2001-08-09. PMID:11454918. |
s33005 displayed marked affinity for native, rat, and cloned human serotonin (5-ht) transporters (sert) and less pronounced affinity for norepinephrine (ne) transporters (net), while its affinity at dopamine (da) transporters and >50 other sites was negligible. |
2001-08-09 |
2023-08-12 |
human |
| A L Bauman, S Apparsundaram, S Ramamoorthy, B E Wadzinski, R A Vaughan, R D Blakel. Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 20. 2001-06-07. PMID:11027216. |
recent studies reveal that dopamine (da), norepinephrine (ne), and serotonin (5-ht) transporters (dat, net, and sert, respectively) are rapidly regulated by direct or receptor-mediated activation of cellular kinases, particularly protein kinase c (pkc). |
2001-06-07 |
2023-08-12 |
human |
| I Sora, F S Hall, A M Andrews, M Itokawa, X F Li, H B Wei, C Wichems, K P Lesch, D L Murphy, G R Uh. Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 9. 2001-05-21. PMID:11320258. |
cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (dat), serotonin (sert), and norepinephrine (net). |
2001-05-21 |
2023-08-12 |
mouse |
| A K Dutta, M E Reith, B K Madra. Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter. Synapse (New York, N.Y.). vol 39. issue 2. 2001-04-19. PMID:11180505. |
the compound 1b was characterized for its binding both in monkey and rat striatum tissue, which demonstrated its high selectivity for the dopamine transporter (dat) when its binding was compared with that at the serotonin transporter (sert). |
2001-04-19 |
2023-08-12 |
rat |
| R A Lea, A Dohy, K Jordan, S Quinlan, P J Brimage, L R Griffith. Evidence for allelic association of the dopamine beta-hydroxylase gene (DBH) with susceptibility to typical migraine. Neurogenetics. vol 3. issue 1. 2001-02-22. PMID:11085595. |
polymorphisms within the dopamine beta-hydroxylase (dbh) gene, serotonin transporter gene (sert), and dopamine receptor gene (drd2) were tested in 177 unrelated caucasian migraineurs and 182 control individuals. |
2001-02-22 |
2023-08-12 |
Not clear |
| L H Miner, S Schroeter, R D Blakely, S R Sesac. Ultrastructural localization of the serotonin transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to dopamine terminals. The Journal of comparative neurology. vol 427. issue 2. 2001-01-04. PMID:11054690. |
dopamine levels within the prefrontal cortex (pfc) can be manipulated by selective inhibitors of the serotonin transporter (sert). |
2001-01-04 |
2023-08-12 |
rat |
| L H Miner, S Schroeter, R D Blakely, S R Sesac. Ultrastructural localization of the serotonin transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to dopamine terminals. The Journal of comparative neurology. vol 427. issue 2. 2001-01-04. PMID:11054690. |
the present study sought to examine the distribution of immunogold-silver labeling for sert (sert-ir) in the rat prelimbic pfc and to describe its ultrastructural spatial relationship to dopamine axons labeled by immunoperoxidase staining for tyrosine hydroxylase (th-ir). |
2001-01-04 |
2023-08-12 |
rat |