| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Sander, W Berlin, A Ostapowicz, J Samochowiec, N Gscheidel, M R Hoeh. Variation of the genes encoding the human glutamate EAAT2, serotonin and dopamine transporters and Susceptibility to idiopathic generalized epilepsy. Epilepsy research. vol 41. issue 1. 2000-11-20. PMID:10924870. |
the genotypes of 133 german ige subjects and 223 ethnically matched controls were assessed for dna polymorphisms of genes encoding the glutamate (eaat2), the serotonin (sert), and dopamine (dat) transporters. |
2000-11-20 |
2023-08-12 |
human |
| H M Haughey, A E Fleckenstein, R R Metzger, G R Hanso. The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia. Journal of neurochemistry. vol 75. issue 4. 2000-10-05. PMID:10987842. |
a role for dopamine (da) was suggested by findings that pretreatment with the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine, the d1 antagonist sch-23390, or the d2 antagonist eticlopride attenuated the meth-induced decrease in striatal, but not hippocampal, sert activity. |
2000-10-05 |
2023-08-12 |
rat |
| S Oya, S R Choi, C Hou, M Mu, M P Kung, P D Acton, M Siciliano, H F Kun. 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nuclear medicine and biology. vol 27. issue 3. 2000-09-26. PMID:10832081. |
adam(7) also showed more than 1,000-fold selectivity for sert over norepinephrine transporter (net) and dopamine transporter (dat) ( k(i)=699 and 840 nm, for net and dat, respectively). |
2000-09-26 |
2023-08-12 |
human |
| L Zhao, K M Johnson, M Zhang, J Flippen-Anderson, A P Kozikowsk. Chemical synthesis and pharmacology of 6- and 7-hydroxylated 2-carbomethoxy-3-(p-tolyl)tropanes: antagonism of cocaine's locomotor stimulant effects. Journal of medicinal chemistry. vol 43. issue 17. 2000-09-21. PMID:10966747. |
some of these compounds were found to retain considerable affinity as inhibitors of the dopamine transporter (dat) and the norepinephrine transporter (net), but they were less potent inhibitors of the serotonin transporter (sert). |
2000-09-21 |
2023-08-12 |
rat |
| D H Feldman, W R Harvey, B R Steven. A novel electrogenic amino acid transporter is activated by K+ or Na+, is alkaline pH-dependent, and is Cl--independent. The Journal of biological chemistry. vol 275. issue 32. 2000-09-14. PMID:10829035. |
amino acids such as l-proline, l-threonine, and l-methionine elicited complex current-voltage relationships in alkaline ph-dependent caatch1 that were reminiscent of the behavior of the dopamine, serotonin, and norepinephrine transporters (dat, sert, net) in the presence of their substrates and pharmacological inhibitors such as cocaine or antidepressants. |
2000-09-14 |
2023-08-12 |
xenopus_laevis |
| A A Wilson, N Ginovart, M Schmidt, J H Meyer, P G Threlkeld, S Houl. Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines. Journal of medicinal chemistry. vol 43. issue 16. 2000-09-08. PMID:10956218. |
all four candidates display high affinity for sert and low affinity for the dopamine or norepinephrine transporters using in vitro binding assays. |
2000-09-08 |
2023-08-12 |
human |
| F I Tarazi, K Zhang, R J Baldessarin. Olanzapine, quetiapine, and risperidone: long-term effects on monoamine transporters in rat forebrain. Neuroscience letters. vol 287. issue 2. 2000-08-17. PMID:10854717. |
we compared labeling of dopamine (dat) and serotonin (sert) transporter proteins in subregions of rat corpus striatum by quantitative autoradiography with [(3)h]2-beta-carbomethoxy-3-beta-[4'-iodophenyl]tropane ([(3)h]beta-cit) and [(3)h]paroxetine after 28 days of continuous subcutaneous infusion of olanzapine, quetiapine, risperidone, or vehicle controls. |
2000-08-17 |
2023-08-12 |
rat |
| Z Zhuang, S Choi, C Hou, M Mu, M Kung, P D Acton, H F Kun. A novel serotonin transporter ligand: (5-iodo-2-(2-dimethylaminomethylphenoxy)-benzyl alcohol. Nuclear medicine and biology. vol 27. issue 2. 2000-07-27. PMID:10773546. |
dopamine [dat], norepinephrine [net], and sert, respectively), odam showed a strong inhibition on sert (k(i) = 0.12 +/- 0.02 nm). |
2000-07-27 |
2023-08-12 |
rat |
| G A Siebert, S M Pond, L J Bryan-Lluk. Further characterisation of the interaction of haloperidol metabolites with neurotransmitter transporters in rat neuronal cultures and in transfected COS-7 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 3. 2000-04-13. PMID:10731037. |
we recently showed that haloperidol and its metabolites are inhibitors of the human noradrenaline transporter (nat), dopamine transporter (dat) and serotonin transporter (sert), and determined their ki values for inhibition of the three transporters expressed in transfected cos-7 cells. |
2000-04-13 |
2023-08-12 |
human |
| M Laruelle, A Abi-Dargham, C van Dyck, R Gil, D C D'Souza, J Krystal, J Seibyl, R Baldwin, R Inni. Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [(123)I]beta-CIT. Biological psychiatry. vol 47. issue 5. 2000-03-28. PMID:10704949. |
the aim of this study was to investigate potential alterations of striatal dopamine transporters (dat) and brainstem serotonin transporters (sert) density in schizophrenia. |
2000-03-28 |
2023-08-12 |
Not clear |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
these drug-resistant 5-ht axons that lack sert densely innervate the caudal one-third of the accumbens shell, the same location where dopamine axons are spared after methamphetamine. |
2000-03-09 |
2023-08-12 |
rat |
| Y Smicun, S D Campbell, M A Chen, H Gu, G Rudnic. The role of external loop regions in serotonin transport. Loop scanning mutagenesis of the serotonin transporter external domain. The Journal of biological chemistry. vol 274. issue 51. 2000-01-27. PMID:10593887. |
chimeric transporters did not gain affinity for dopamine, a net substrate, or desipramine, an inhibitor, at the expense of affinity for serotonin or paroxetine, a selective sert inhibitor. |
2000-01-27 |
2023-08-12 |
Not clear |
| A Bocchetta, M P Piccardi, M A Palmas, C Chillotti, A Oi, M Del Zomp. Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia. American journal of medical genetics. vol 88. issue 5. 1999-11-17. PMID:10490710. |
polymorphism at dopamine receptor genes drd2, drd4, and dopamine and serotonin transporter genes (dat, sert) has been used in previous association studies. |
1999-11-17 |
2023-08-12 |
Not clear |
| L J Bryan-Lluka, G A Siebert, S M Pon. Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 2. 1999-11-08. PMID:10494878. |
in this study, the hypothesis was partially investigated by determining the potencies of haloperidol and reduced haloperidol and the corresponding pyridinium and tetrahydropyridine metabolites, compared with mpp+ and mptp, as inhibitors of the noradrenaline transporter (nat), dopamine transporter (dat) and 5-ht transporter (sert). |
1999-11-08 |
2023-08-12 |
human |
| L J Bryan-Lluka, G A Siebert, S M Pon. Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 2. 1999-11-08. PMID:10494878. |
two days after cos-7 cells were transiently transfected with the cdna for the human nat, dat or sert (lipofectamine method), the cells were incubated with 10 nm [3h]noradrenaline, dopamine or 5-ht, respectively, for 2 min at 37 c, in the absence or presence of various concentrations of the eight compounds or a specific uptake inhibitor (nat: nisoxetine 1 microm; dat: gbr 12909 1 microm; sert: citalopram 10 microm). |
1999-11-08 |
2023-08-12 |
human |
| M J Kuhar, K M McGirr, R G Hunter, P D Lambert, B E Garrett, F I Carrol. Studies of selected phenyltropanes at monoamine transporters. Drug and alcohol dependence. vol 56. issue 1. 1999-10-12. PMID:10462087. |
in this study, 18 3-phenyltropane analogues were characterized in uptake and binding studies at dopamine (dat), norepinephrine (net) and serotonin (sert) transporters from the rat, and in binding at dat in rat, rhesus monkey, and human brain tissue. |
1999-10-12 |
2023-08-12 |
human |
| M P Kung, C Hou, S Oya, M Mu, P D Acton, H F Kun. Characterization of [(123)I]IDAM as a novel single-photon emission tomography tracer for serotonin transporters. European journal of nuclear medicine. vol 26. issue 8. 1999-10-07. PMID:10436197. |
in vitro binding study showed that idam displayed an excellent affinity to sert sites (k(i)=0.097 nm, using membrane preparations of llc-pk(1) cells expressing the specific transporter) and showed more than 1000-fold of selectivity for sert over norepinehrine and dopamine (expressed in the same llc-pk(1) cells). |
1999-10-07 |
2023-08-12 |
human |
| P D Acton, M P Kung, M Mu, K Plössl, C Hou, M Siciliano, S Oya, H F Kun. Single-photon emission tomography imaging of serotonin transporters in the non-human primate brain with the selective radioligand [(123)I]IDAM. European journal of nuclear medicine. vol 26. issue 8. 1999-10-07. PMID:10436198. |
in vitro binding studies suggest a high selectivity of idam for sert (k(i)=0.097 nm), with considerably lower affinities for norepinephrine and dopamine transporters (net k(i)= 234 nm and dat k(i)>10 microm, respectively). |
1999-10-07 |
2023-08-12 |
Not clear |
| M Nishimura, K Sato, S Shimada, M Tohyam. Expression of norepinephrine and serotonin transporter mRNAs in the rat superior cervical ganglion. Brain research. Molecular brain research. vol 67. issue 1. 1999-05-21. PMID:10101235. |
we investigated the gene expression of three monoamine transporters (norepinephrine transporter, net; serotonin transporter, sert; and dopamine transporter, dat) in the rat superior cervical ganglion (scg). |
1999-05-21 |
2023-08-12 |
rat |
| E G Jönsson, M M Nöthen, J P Gustavsson, H Neidt, R Bunzel, P Propping, G C Sedval. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Psychiatry research. vol 79. issue 1. 1998-10-06. PMID:9676821. |
we investigated the possible relationships between dna polymorphisms in the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) genes and csf concentrations of homovanillic acid (hva), 5-hydroxyindoleacetic acid (5-hiaa), and 3-methoxy-4-hydroxyphenylglycol (mhpg) in healthy volunteers (n = 66). |
1998-10-06 |
2023-08-12 |
human |