| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao-Wei Shen, Yoko Hagino, Hideaki Kobayashi, Keiko Shinohara-Tanaka, Kazutaka Ikeda, Hideko Yamamoto, Toshifumi Yamamoto, Klaus-Peter Lesch, Dennis L Murphy, F Scott Hall, George R Uhl, Ichiro Sor. Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15226739. |
cocaine conditioned place preference (cpp) is intact in dopamine transporter (dat) knockout (ko) mice and enhanced in serotonin transporter (sert) ko mice. |
2004-11-22 |
2023-08-12 |
mouse |
| Oliver Pogarell, Klaus Tatsch, Georg Juckel, Christine Hamann, Christoph Mulert, Gabriele Pöpperl, Malte Folkerts, Martina Choukèr, Michael Riedel, Michael Zaudig, Hans-Jürgen Möller, Ulrich Heger. Serotonin and dopamine transporter availabilities correlate with the loudness dependence of auditory evoked potentials in patients with obsessive-compulsive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15292904. |
the loudness dependence (ld) of the n1/p2 component of auditory evoked potentials has been proposed as a noninvasive indicator of central serotonergic function, whereas single photon emission computed tomography (spect) and [123i]beta-cit can be used to visualize both serotonin (sert) and dopamine transporters (dat). |
2004-11-22 |
2023-08-12 |
human |
| Teijamari Laasonen-Balk, Heimo Viinamäki, Jyrki T Kuikka, Minna Husso-Saastamoinen, Johannes Lehtonen, Jari Tiihone. 123I-beta-CIT binding and recovery from depression. A six-month follow-up study. European archives of psychiatry and clinical neuroscience. vol 254. issue 3. 2004-08-30. PMID:15205968. |
eighteen depressive outpatients were investigated using single-photon emission computerized tomography (spect) with a high-affinity dopamine (da) and serotonin transporter (sert) specific radioligand, (123)i-labeled beta-cit (2 beta-carbomethoxy-3 beta-(4-iodophenyl)-tropane). |
2004-08-30 |
2023-08-12 |
Not clear |
| Annalina Lapucci, Susanna Nencetti, Gian Carlo Demonti. Synthesis and affinity for serotonin and dopamine transporters of some benzophenone oxime ether derivatives. Farmaco (Societa chimica italiana : 1989). vol 58. issue 9. 2004-08-24. PMID:13679194. |
the present study describes the preparation of some new oxime derivatives and their capacity to inhibit serotonin (sert) and dopamine (dat) transporters expressed at the level of the rabbit cortex and the striatal membranes, respectively. |
2004-08-24 |
2023-08-12 |
rabbit |
| Richard B Rothman, Michael H Bauman. Monoamine transporters and psychostimulant drugs. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612135. |
we conclude that the brain contains high abundance nonclassical binding sites for cocaine-like drugs that have micromolar affinity for cocaine and that none of the clinically available amphetamine-type appetite suppressants are equipotent substrates for dopamine transporter (dat) and serotonin transporter (sert) proteins. |
2004-07-20 |
2023-08-12 |
Not clear |
| Claus Juul Loland, Kristine Norgaard-Nielsen, Ulrik Gethe. Probing dopamine transporter structure and function by Zn2+-site engineering. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612149. |
the biogenic amine transporters belong to the class of na+/cl--coupled solute carriers and include the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert). |
2004-07-20 |
2023-08-12 |
human |
| Lifen Xu, Santosh S Kulkarni, Sari Izenwasser, Jonathan L Katz, Theresa Kopajtic, Stacey A Lomenzo, Amy Hauck Newman, Mark L Trudel. Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives. Journal of medicinal chemistry. vol 47. issue 7. 2004-05-10. PMID:15027858. |
3 beta-aryltropane analogues wherein the 2-position was substituted with various diarylmethoxyalkyl groups were synthesized and evaluated for binding at the dopamine transporter (dat), serotonin transporter (sert), norepinephrine transporter (net), and muscarinic (m(1)) receptors. |
2004-05-10 |
2023-08-12 |
Not clear |
| Shannon N Saldaña, Eric L Barke. Temperature and 3,4-methylenedioxymethamphetamine alter human serotonin transporter-mediated dopamine uptake. Neuroscience letters. vol 354. issue 3. 2004-03-08. PMID:14700733. |
dopamine and serotonin uptake by human sert expressed in hek-293 cells was compared at 37 and 40 degrees c. elevated temperature was found to alter serotonin transport, but had no significant effect on dopamine transport. |
2004-03-08 |
2023-08-12 |
human |
| Christian A Heidbreder, Massimiliano Bianchi, Laurent P Lacroix, Stefania Faedo, Elisabetta Perdona, Rosaria Remelli, Paolo Cavanni, Francesco Cresp. Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo. Synapse (New York, N.Y.). vol 50. issue 4. 2003-12-19. PMID:14556231. |
accordingly, we first examined the potency of mpep to bind to or inhibit uptake at the net as well as the dopamine and serotonin transporters (dat and sert, respectively). |
2003-12-19 |
2023-08-12 |
human |
| David Lewis, Ying Zhang, Thomas Prisinzano, Christina M Dersch, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter. Bioorganic & medicinal chemistry letters. vol 13. issue 7. 2003-11-03. PMID:12657288. |
a series of n-aromatic, n-heteroaromatic, and oxygenated n-phenylpropyl derivatives of 1-(2-benzhydryloxyethyl)-piperazine and 1-[2-[bis-(4-fluorophenyl)methoxy]ethyl]piperazine, analogues of gbr 12909 (1a) and 12935 (1b), was synthesized and examined for their dopamine (dat) and serotonin (sert) transporter binding properties. |
2003-11-03 |
2023-08-12 |
Not clear |
| Raul R Gainetdinov, Marc G Caro. Monoamine transporters: from genes to behavior. Annual review of pharmacology and toxicology. vol 43. 2003-09-09. PMID:12359863. |
these transporters for dopamine (dat), serotonin (sert), and norepinephrine (net), which are expressed selectively on the corresponding neurons, are established targets of many psychostimulants, antidepressants, and neurotoxins. |
2003-09-09 |
2023-08-12 |
mouse |
| Rohit B Kolhatkar, Sujit K Ghorai, Clifford George, Maarten E A Reith, Aloke K Dutt. Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine. Journal of medicinal chemistry. vol 46. issue 11. 2003-06-23. PMID:12747792. |
all novel compounds were tested for their affinity at the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in competing for the binding of [3h]win 35 428, [3h]citalopram, and [3h]nisoxetine, respectively. |
2003-06-23 |
2023-08-12 |
Not clear |
| Elisabeth Greiner, Thomas Prisinzano, Edward M Johnson, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine. Journal of medicinal chemistry. vol 46. issue 8. 2003-05-08. PMID:12672246. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl-1-benzylpiperidines were examined for their ability to bind to the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2003-05-08 |
2023-08-12 |
Not clear |
| G Berding, Th Brücke, P Odin, D J Brooks, H Kolbe, P Gielow, H Harke, B O Knoop, R Dengler, W H Knap. [[123I]beta-CIT SPECT imaging of dopamine and serotonin transporters in Parkinson's disease and multiple system atrophy. Nuklearmedizin. Nuclear medicine. vol 42. issue 1. 2003-04-17. PMID:12601452. |
definition of the regional pattern of dopamine transporter (dat) dysfunction in advanced parkinson's disease (pd) and evaluation of a potential correlation between dat binding and symptoms; elucidation of the role of dat imaging in the differential diagnosis of pd and multiple system atrophy (msa); assessment and comparison of serotonin transporter (sert) binding in pd and msa. |
2003-04-17 |
2023-08-12 |
Not clear |
| Mark M Goodman, Ping Chen, Christophe Plisson, Laurent Martarello, James Galt, John R Votaw, Clinton D Kilts, Gene Malveaux, Vernon M Camp, Bing Shi, Timothy D Ely, Leonard Howell, Jon McConathy, Charles B Nemerof. Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography. Journal of medicinal chemistry. vol 46. issue 6. 2003-04-07. PMID:12620070. |
competition binding in cells stably expressing the transfected human sert, dopamine transporter (dat), and norepinephrine transporter (net) using [(3)h]citalopram, [(3)h]win 35,428, and [(3)h]nisoxetine, respectively, demonstrated the following order of sert affinity (k(i) in nm): zient (0.05) > nor-cit (0.12) >> eient (1.15) > fluvoxamine (1.46). |
2003-04-07 |
2023-08-12 |
human |
| Toshihiro Dohi, Shigeo Kitayama, Key Kumagai, Wataru Hashimoto, Katsuya Morit. [Pharmacology of monoamine neurotransmitter transporters]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 120. issue 5. 2003-03-12. PMID:12491807. |
following exocytotic release, the biogenic amine neurotransmitters, norepinephrine, dopamine, and serotonin are removed from the synaptic cleft by the respective transporter, net, dat, and sert, located on the plasma membrane and then re-stored into synaptic vesicles by vesicular monoamine transporter, vmat. |
2003-03-12 |
2023-08-12 |
Not clear |
| Päivi Marjamäki, Jörg Zessin, Olli Eskola, Tove Grönroos, Merja Haaparanta, Jörgen Bergman, Pertti Lehikoinen, Sarita Forsback, Peter Brust, Jörg Steinbach, Olof Soli. S-[18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats. Synapse (New York, N.Y.). vol 47. issue 1. 2003-03-07. PMID:12422372. |
the specificity and selectivity of [(18)f]fme-mcn binding to sert was studied by preinjecting blocking doses of serotonin, norepinephrine, and dopamine transporter inhibitors. |
2003-03-07 |
2023-08-12 |
rat |
| M K Hahn, R D Blakel. Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. The pharmacogenomics journal. vol 2. issue 4. 2003-02-10. PMID:12196911. |
the norepinephrine, dopamine and serotonin transporters (net, dat and sert, respectively), limit cellular signaling by recapturing released neurotransmitter, and serve as targets for antidepressants and drugs of abuse, emphasizing the integral role these molecules play in neurotransmission and pathology. |
2003-02-10 |
2023-08-12 |
human |
| Bruce R Stevens, Daniel H Feldman, Zhilin Liu, William R Harve. Conserved tyrosine-147 plays a critical role in the ligand-gated current of the epithelial cation/amino acid transporter/channel CAATCH1. The Journal of experimental biology. vol 205. issue Pt 16. 2003-02-07. PMID:12124378. |
this tyrosine residue is conserved within the third transmembrane domain in members of the na(+):neurotransmitter transporter family (snf), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (sert), dopamine (dat) and norepinephrine (net) transporters. |
2003-02-07 |
2023-08-12 |
xenopus_laevis |
| Kentaro Wakayama, Sumio Ohtsuki, Hitomi Takanaga, Ken-ichi Hosoya, Tetsuya Terasak. Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells. Neuroscience research. vol 44. issue 2. 2002-12-04. PMID:12354632. |
mrna expression of norepinephrine transporter (net) and serotonin transporter (sert) has been detected in a conditionally immortalized mouse brain capillary endothelial cell line (tm-bbb4) used as an in vitro model of the bbb, whereas no dopamine transporter (dat) was detected. |
2002-12-04 |
2023-08-12 |
mouse |