| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Markus Storvik, Jari Tiihonen, Tuija Haukijärvi, Erkki Tupal. Nucleus accumbens serotonin transporters in alcoholics measured by whole-hemisphere autoradiography. Alcohol (Fayetteville, N.Y.). vol 40. issue 3. 2007-05-24. PMID:17418697. |
in addition, there was a strong tendency toward a positive correlation between the sert and dopamine transporter binding in the type 2 alcoholics, but not in the other groups. |
2007-05-24 |
2023-08-12 |
human |
| J W Schwartz, D Piston, L J DeFelic. Molecular microfluorometry: converting arbitrary fluorescence units into absolute molecular concentrations to study binding kinetics and stoichiometry in transporters. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722229. |
cotransport in norepinephrine (net), epinephrine (epit), dopamine (dat), and serotonin (sert) transporters couples downhill na+ flux to uphill transmitter flux. |
2007-05-23 |
2023-08-12 |
Not clear |
| Xiang Liu, Samuel D Banister, MacDonald J Christie, Richard Banati, Steve Meikle, Mark J Coster, Michael Kassio. Trishomocubanes: novel sigma ligands modulate cocaine-induced behavioural effects. European journal of pharmacology. vol 555. issue 1. 2007-04-26. PMID:17113074. |
both compounds have negligible affinity for the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters. |
2007-04-26 |
2023-08-12 |
Not clear |
| Piotr Popik, Martyna Krawczyk, Krystyna Golembiowska, Gabriel Nowak, Aaron Janowsky, Phil Skolnick, Arnold Lippa, Anthony S Basil. Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16636898. |
radioligand binding to the dopamine (dat), norepinephrine (net), and serotonin (sert) transporters is inhibited with k (i) values of 222, 1030, and 740 nm, respectively. |
2007-04-24 |
2023-08-12 |
mouse |
| Daniel Hoyer, Deepak R Thakker, François Natt, Rainer Maier, Dieter Huesken, Matthias Müller, Peter Flor, Herman VAN DER Putten, Markus Schmutz, Graeme Bilbe, John F Crya. Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monoamine transporters and GPCRs: implications for target characterization in psychiatric and neurological disorders. Journal of receptor and signal transduction research. vol 26. issue 5-6. 2007-03-06. PMID:17118797. |
we then targeted endogenous genes, encoding the dopamine (dat) and serotonin transporters (sert). |
2007-03-06 |
2023-08-12 |
mouse |
| Jeffrey S Stehouwer, Nachwa Jarkas, Fanxing Zeng, Ronald J Voll, Larry Williams, Michael J Owens, John R Votaw, Mark M Goodma. Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. Journal of medicinal chemistry. vol 49. issue 23. 2007-01-19. PMID:17154506. |
2beta-carbomethoxy-3beta-(3'-((z)-2-iodoethenyl)phenyl)nortropane (mzient, 1) and 2beta-carbomethoxy-3beta-(3'-((z)-2-bromoethenyl)phenyl)nortropane (mzbrent, 2) were synthesized and evaluated for binding to the human serotonin, dopamine, and norepinephrine transporters (sert, dat, and net, respectively) using transfected cells. |
2007-01-19 |
2023-08-12 |
human |
| Yukio Takamatsu, Hideko Yamamoto, Yasukazu Ogai, Yoko Hagino, Athina Markou, Kazutaka Iked. Fluoxetine as a potential pharmacotherapy for methamphetamine dependence: studies in mice. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105925. |
interestingly, the rewarding effects of cocaine are retained in dopamine transporter (dat) knockout (ko) mice, while serotonin transporter (sert) and dat double ko mice do not exhibit conditioned place preference (cpp) to cocaine. |
2007-01-10 |
2023-08-12 |
mouse |
| Kathelijne Peremans, Ingeborg Goethals, Filip De Vos, A Dobbeleir, Hamphrey Ham, Henri Van Bree, Cees Van Heeringen, Kurt Audenaer. Serotonin transporter and dopamine transporter imaging in the canine brain. Nuclear medicine and biology. vol 33. issue 7. 2007-01-09. PMID:17045171. |
functional imaging with specific sert and dopamine transporter (dat) ligands contributes to the study of the ssri-transporter interaction. |
2007-01-09 |
2023-08-12 |
Not clear |
| Yu-Shin Ding, Kuo-Shyan Lin, Jean Loga. PET imaging of norepinephrine transporters. Current pharmaceutical design. vol 12. issue 30. 2007-01-03. PMID:17073682. |
the fact that all three monoamine (dopamine, norepinephrine, and serotonin) transporters (dat, net and sert) are involved in various neurological and psychiatric diseases further emphasizes the need to develop suitable net ligands so that researchers will be able to probe the contributions of each monoamine transporter system to specific cns disorders. |
2007-01-03 |
2023-08-12 |
Not clear |
| Bertha K Madras, Zhihua Xie, Zhicheng Lin, Amy Jassen, Helen Panas, Laurie Lynch, Ryan Johnson, Eli Livni, Thomas J Spencer, Ali A Bonab, Gregory M Miller, Alan J Fischma. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885432. |
we postulated that modafinil enhances wakefulness by modulating dopamine (dat), norepinephrine (net), or serotonin (sert) transporter activities. |
2006-12-04 |
2023-08-12 |
human |
| Bertha K Madras, Zhihua Xie, Zhicheng Lin, Amy Jassen, Helen Panas, Laurie Lynch, Ryan Johnson, Eli Livni, Thomas J Spencer, Ali A Bonab, Gregory M Miller, Alan J Fischma. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885432. |
in vitro, modafinil inhibited [(3)h]dopamine (ic(50) = 6.4 microm), [(3)h]norepinephrine (ic(50) = 35.6 microm), and [(3)h]serotonin (ic(50) > 500 microm) transport via the human dat, net, and sert. |
2006-12-04 |
2023-08-12 |
human |
| Bertha K Madras, Michele A Fahey, Martin Goulet, Zhicheng Lin, Jacob Bendor, Claudia Goodrich, Peter C Meltzer, David R Elmaleh, Eli Livni, Ali A Bonab, Alan J Fischma. Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885433. |
we postulated that potent dat inhibitors, with low affinity for the serotonin transporter (sert), may elevate endogenously released extracellular dopamine levels to provide therapeutic benefit. |
2006-12-04 |
2023-08-12 |
monkey |
| Aina Westrheim Ravn. Three-dimensional models of neurotransmitter transporters and their interactions with cocaine and S-citalopram. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 7. issue 2. 2006-11-08. PMID:16684682. |
then three-dimensional models of the neurotransmitter transporters hdat, hsert and hnet were constructed based on the nhaa model and studies of ligand binding to mutated dopamine transporter (dat) and serotonin transporter (sert). |
2006-11-08 |
2023-08-12 |
human |
| Guangrong Zheng, David B Horton, Agripina G Deaciuc, Linda P Dwoskin, Peter A Crook. Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorganic & medicinal chemistry letters. vol 16. issue 19. 2006-11-02. PMID:16905316. |
a series of des-keto lobeline analogs has been synthesized and evaluated for their ability to inhibit the dopamine transporter (dat) and serotonin transporter (sert) function and for their affinity for the synaptic vesicle monoamine transporter (vmat2), as well as for alpha4beta2( *) and alpha7( *) neuronal nicotinic acetylcholine receptors (nachrs). |
2006-11-02 |
2023-08-12 |
Not clear |
| Soili Lehto, Tommi Tolmunen, Mikko Joensuu, Pirjo Irmeli Saarinen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Jyrki Kuikka, Johannes Lehtone. Midbrain binding of [123I]nor-beta-CIT in atypical depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 7. 2006-10-31. PMID:16644083. |
altered serotonin (sert) and dopamine transporter (dat) densities have been recorded in major depression. |
2006-10-31 |
2023-08-12 |
Not clear |
| Fanxing Zeng, Nachwa Jarkas, Michael J Owens, Clinton D Kilts, Charles B Nemeroff, Mark M Goodma. Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position. Bioorganic & medicinal chemistry letters. vol 16. issue 17. 2006-10-16. PMID:16784855. |
a series of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position was synthesized, and their binding affinities were determined in cells transfected to express human norepinephrine transporter (net), serotonin transporter (sert), and dopamine transporter (dat) via competition binding assays. |
2006-10-16 |
2023-08-12 |
human |
| Rong Chen, Michael R Tilley, Hua Wei, Fuwen Zhou, Fu-Ming Zhou, San Ching, Ning Quan, Robert L Stephens, Erik R Hill, Timothy Nottoli, Dawn D Han, Howard H G. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 24. 2006-09-11. PMID:16754872. |
there are three known high-affinity targets for cocaine: the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2006-09-11 |
2023-08-12 |
mouse |
| Shijun Zhang, Fernando Fernandez, Stuart Hazeldine, Jeffrey Deschamps, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters. Journal of medicinal chemistry. vol 49. issue 14. 2006-09-11. PMID:16821783. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2006-09-11 |
2023-08-12 |
Not clear |
| Christophe Wersinger, Milan Rusnak, Anita Sidh. Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein. The European journal of neuroscience. vol 24. issue 1. 2006-09-05. PMID:16882008. |
given the considerable homology between dopamine transporters and the serotonin (5-ht) transporter (sert), we examined whether alpha-syn could similarly regulate sert function. |
2006-09-05 |
2023-08-12 |
human |
| John L Musachio, Jinsoo Hong, Masanori Ichise, Nicholas Seneca, Amira K Brown, Jeih-San Liow, Christer Halldin, Robert B Innis, Victor W Pike, Rong He, Jia Zhou, Alan P Kozikowsk. Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors. Bioorganic & medicinal chemistry letters. vol 16. issue 12. 2006-08-16. PMID:16621532. |
[11c]5 and [11c]6 display high affinity for the net in vitro (ki = 0.94 and 0.68 nm, respectively) and significant selectivity over the dopamine (dat) and serotonin transporters (sert). |
2006-08-16 |
2023-08-12 |
Not clear |